product dermagen

Dermagen Skin Care

R 428

Love your skin.
Dermagen is a revolutionary concept in skin care, meticulously developed by Fusion Laboratories. Its scientific formula, which contains Glutathione, Collagen and Co Enzyme Q10, is specially designed to stimulate the body’s circulatory system while nourishing and revitalising your skin.

10% discount for 3 months supply (or more).

Information

Overview

Dermagen is a revolutionary concept in skin care, meticulously developed by Fusion Laboratories. Its scientific formula, which contains Glutathione, Collagen and Co Enzyme Q10, is specially designed to stimulate the body’s circulatory system while nourishing and revitalising your skin.

Dermagen is specifically formulated to

  • Detoxify the skin
  • Treat certain skin disorders
  • Enhance skin clarity
  • Improve skin tone and elasticity
  • Reduce visible signs of ageing

One capsule taken daily activates your skin’s metabolism through the delivery of essential vitamins, minerals and antioxidants.

This nutrient-rich formula provides optimal conditioning for your skin.

THE RESULT
A significantly more radiant appearance.

Technical Information

Proprietary Name and Dosage Form
Dermagen Formulated Skin Care (Capsules)

Composition
Each capsule provides:
Beta-Carotene, Vitamin A, Vitamin D3, Vitamin E, Vitamin C, Zinc, Selenium, Copper, Manganese, Pycnogenol – 96% extract, Grape Seed Extract 95%, Alpha Lipoic Acid, Silica (horsetail herb), Coenzyme Q10, MSM(Methyl Sulfonic Methane), Resveratrol, L-Glutathione, L-Cysteine, L-Glutamine, Bilberry Extract 4:1, Collagen

Pharmacological Classification:
Category D Medicine

Pharmacological  Action
There is new research demonstrating the benefits of anti-oxidants. Studies indicate that certain nutrients make a significant difference in the way an individual’s skin looks and feels and even in how well it ages. Vitamins A, C, D and E are known to improve skin health and appearance.

Indication
This product is indicated as a general supplement where a deficiency of any of the ingredients exists.

Contra-Indications
Diabetics should use this product under the supervision of their healthcare practitioner. Discontinue use at least 2 weeks prior to any surgical procedure. If you suffer from an auto-immune disease avoid using this product.

Warnings
Keep out of reach of children.
Consult a medical practitioner prior to use.

Interaction
If you are using chronic prescription medication, consult your healthcare practitioner before using this product.

Pregnancy and Lactation
Use should be avoided during pregnancy and breastfeeding.

Dosage and Directions for Use
Take 1 capsule daily before breakfast.

Side Effects and Special Precautions
Discontinue the use of this product where there is sensitivity towards any of the ingredients.

Known Symptoms of Overdose and Treatment
No known symptoms.

Identification
Size 0 Pearl Red capsule

Presentation
Printed carton containing Printed glass bottle with 30 red capsules.

Storage Instructions
Store below 25 degrees Celsius.
Protect from light and moisture.

Ingredients

Your skin is an accurate reflection of your general health.

By nourishing your skin with carefully selected quality ingredients you will enjoy healthy glowing skin. 

Glutathione
Glutathione is considered the ‘master antioxidant’. It is effective in the treatment of blemishes and pigmented skin, both of which are caused by oxidative stress. Glutathione binds liver toxins and facilitates the process of waste disposal, thus promoting clearer, healthier skin. The strong antioxidant effect of glutathione keeps cells functioning optimally and also inhibits the development of melanin, which determines skin tone.

Silica
Silica is a foundation mineral, indispensable for the integrity of connective tissue. With ageing, silica levels diminish leading to parched, wrinkled skin, brittle nails and dull hair. Supplementing with this mineral can delay the ageing process by replenishing and sustaining connecting tissue leading to younger looking skin, rich glossy hair and strong nails.

Pycnogenol
The unique properties of pycnogenol render it a fascinating cosmeceutical which supports healthy skin. It functions by binding to collagen and elastin thus inhibiting enzymatic degradation – a process which protects these proteins from destruction.

Pycnogenol also serves as a micro-circulation enhancer thereby delivering a greater quantity of oxygen, nutrients and moisture to the skin as well as aiding detoxification by removal of toxins from the skin. Research shows that by augmenting these respiratory processes, skin elasticity and smoothness is increased, leading to fresher, more youthful complexion.

Studies also support Pycnogenol’s ability to correct hyper-pigmentation, lighten dark spots, reduce the visible effects of photo-aging and UV light damage thus effectively brightening the skin’s appearance.

Beta-Carotene
Beta-Carotene prevents colds, flu, other infections and certain skin disorders. By enhancing overall immunity it repairs the skin and delays the ageing process. Its ability to increase cell turn-over proliferates the outer layers of the skin hence assisting wound healing and preventing scarring. An improved skin texture and tone are thus evident.

Co Enzyme Q 10
This miracle ingredient stimulates collagen production and neutralizes harmful free radicals which are the main cause of ageing and skin damage. It has a profound effect on energizing the skin consequently repairing damage and renewing skin cells – culminating in clearer, brighter skin.

MSM
MSM improves cell wall permeability allowing nutrients to flow freely into the cells, waste and toxins to flow out and water to perfuse readily in both directions. This purification process stimulates collagen production promoting elasticity, healing and repair. Radiance, tone and clarity ensue.

Additional benefits of MSM

  • Oxygen availability is increased
  • MSM reduces inflammation and equalises the pressure on the two sides of the cell membrane.
  • Treats skin conditions – studies have proven that MSM confers healing in eczema, psoriasis, rosacea, acne and other dermatoses.
  • MSM maintains an ideal pH balance
  • MSM helps the body bodies to absorb more nutrients – vitamins and minerals “lock” with MSM, allowing the body to fully utilize them.

Vitamin A
Vitamin A maintains the skin and mucous membranes in a moist healthy condition resisting cell damage. This increased hydration is conducive to the treatment of various skin disorders and also inhibits bacterial and viral proliferation. It also delays the appearance of wrinkles and reverses the harmful effects of sun damage culminating in a younger, healthier look.

Vitamin D
Supplementing with Vitamin D reduces inflammatory skin ailments which include psoriasis, eczema, rosacea, severe acne and other dermatological conditions. The anti -inflammatory effect encourages reconditioning and rejuvenation of the skin.

Vitamin E
Vitamin E is a powerful antioxidant which protects skin cells from the detrimental effects of ultra violet light, environmental pollutants, drugs, and other free radical producing agents. By neutralizing free radicals Vitamin E counteracts this toxic effect. Free radicals are atoms with an uneven number of electrons – a situation which antioxidants -particularly Vitamin E – correct, leaving atoms stable. Fine lines and wrinkles are therefore prevented leaving the skin more vibrant and toned.

Dermatological benefits of Vitamin E

  • Vitamin E causes outer skin layer regeneration
  • Regulates vitamin A in the body, which in itself is important for healthy skin
  • Treats skin disorders
  • Reduces the appearance of stretch marks
  • Minimizes the effects of discoloration and age spots
  • Maintains the skin’s oil balance
  • Strengthens the skin’s barrier function causing a reduction in trans epidermal water loss with better hydration

Vitamin C
Vitamin C has a vital role in maintaining skin health. It is key to healthy connective tissue and the synthesis of collagen – a protein that aids in cell growth, conferring firmness, strength and self-repairing ability.

Zinc
This skin-friendly mineral is one of the most prevalent trace elements in the body. It is fundamentally important in the treatment of acne which is often a symptom of zinc deficiency. Taken orally, zinc regulates the skin’s oil gland activity discouraging acne. Zinc is further known to facilitate healing of blemishes as well as reduction of the inflammatory component of skin disorders.

By encouraging the production of elastin, collagen and dermo-proteins it aids the skin‘s capacity to heal. It also supports the underlying structure of the skin dermo proteins consequently promoting elasticity, tautness and flexibility thus making zinc an invaluable mineral for restoring healthy, youthful looking clear skin.

Selenium
Selenium conditions heart tissue encouraging improved cardiac contractility and circulation. The improvement in micro-circulation induces suppleness, better texture and blemish free skin. Selenium in its detoxifying role combats acne and the effects of injurious free radicals. This allows the skin to retain its quality and ameliorate the effect of aging.

Scientific studies have demonstrated the ability of selenium to deter the damaging effect of the sun’s rays on the skin and protect against ultraviolet-induced damage. Together with vitamin E it has a mutual synergistic effect.

Copper
Copper is considered the most effective skin regeneration and remodeling ingredient. By stimulating the body’s innate restorative processes to increase production of “regular” collagen, it repairs damaged skin by reducing scar tissue – the result healthier new skin.

Manganese
Manganese facilitates mineral transport and absorption in the body. It is also required for collagen assembly in skin cells and is crucial to the skin support system.

Resveratrol
Resveratrol regulates water homeostasis in the skin, thus keeping it ideally hydrated to maintain its beauty, radiance and glow.

Additional benefits

  • Firms and lifts the skin. Administration of this antioxidant keeps the skin looking fresh and supple.
  • Contains anti-aging properties which prolong cell life. Due to this process, the onset of aging is delayed ensuring a youthful look for longer.
  • Removal of wrinkles, fine lines and age spots.
  • Detoxification of the skin.
  • Nourishment of the skin.

L- Cysteine
L-Cysteine is an amino acid which contains sulphur. It advances repair and replaces damaged skin tissues to restore smoother, clearer looking skin.

Its homeostatic pigment function (pheomelanin and eumelanin) is therefore essential in the treatment and regulation of skin tone.

Bilberry Extract
The Bilberry Extract sourced from Northern Europe contains anthocyanins which prevent bacterial infection and resist harmful microbes and pathogens. Bilberry extract strengthens the inner and outer skin layers and improves its protective function.

It impedes premature ageing by facilitating the delivery of oxygen-rich blood to the skin aiding the absorption of nutrients more effectively and therefore maintaining its vibrancy, elasticity and suppleness.

Bilberry Extract also contains quercetin, a skin-conditioning agent that upholds nutrition to the skin enhancing the look, feel, and overall beauty of the skin.

Collagen
Collagen is a protein which is a key structural component of connective skin tissue. It is used for its rejuvenating and hydrating properties promoting firmer, more even toned skin. It also minimises the development of lines and wrinkles consequently delaying the aging process, favouring a glowing, radiant and more youthful complexion for longer.

  • Advances elasticity, and increased hydration of the skin
  • Lightens skin pigmentation
  • Stimulates immunity
  • Encourages hair and nail rejuvenation

Grape Seed
Grape Seed Extract promotes skin health and restores skin elasticity. It is proven that intake of grape seed extract nourishes the skin and has a lightening effect on melasma and other visible hyper-pigmented areas, age spots, and acne. It also improves skin suppleness resulting in a “natural face-lift”.

Alpha Lipoic Acid
Alpha lipoic acid is remarkable in that it treats skin cells from both he inside and outside. It also safeguards the skin against the detrimental effects that sugars have on protein, a process which contributes to premature aging and poor skin quality. It effectively replaces damaged collagen fibres invigorating the skin.

Benefits of Ingredients

Your skin is an accurate reflection of your general health.

By nourishing your skin with carefully selected quality ingredients you will enjoy healthy glowing skin.

Glutathione

Glutathione is considered the ‘master antioxidant’. It is effective in the treatment of blemishes and pigmented skin, both of which are caused by oxidative stress. Glutathione binds liver toxins and facilitates the process of waste disposal, thus promoting clearer, healthier skin. The strong antioxidant effect of glutathione keeps cells functioning optimally and also inhibits the development of melanin, which determines skin tone.

Silica

Silica is a foundational mineral, indispensible for the integrity of connective tissue. With ageing, silica levels diminish leading to parched, wrinkled skin, brittle nails and dull hair. Supplementing with this mineral can delay the aging process by replenishing and sustaining connecting tissue leading to younger looking skin, rich glossy hair and strong nails.

Pycnogenol

The unique properties of Pycnogenol render it a fascinating cosmeceutical which supports healthy skin. It functions by binding to collagen and elastin thus inhibiting enzymatic degradation – a process which protects these proteins from destruction. Pycnogenol also serves as a microcirculation enhancer thereby delivering a greater quantity of oxygen, nutrients and moisture to the skin as well as aiding detoxification by removal of toxins from the skin. Research shows that by augmenting these respiratory processes, skin elasticity and smoothness is increased leading to fresher, more youthful complexion.

Studies also support Pycnogenol’s ability to correct hyper-pigmentation, lighten brown spots, reduce the visible effects of photo-aging and UV light damage thus effectively brightening the skin’s appearance.

Beta-Carotene

Beta-Carotene prevents colds, flu, other infections and certain skin disorders. By enhancing overall immunity it repairs the skin and impedes the aging process. It’s ability to increase cell turn-over proliferates the outer layers of the skin hence assisting wound healing and preventing scarring. An improved skin texture and tone are thus evident.

Co Enzyme Q 10

This miracle ingredient stimulates collagen production and neutralizes harmful free radicals which are the main cause of aging and skin damage. It has a profound effect on energizing the skin consequently repairing damage, renewing skin cells – culminating in fresher, brighter skin.

MSM

MSM improves cell wall permeability allowing nutrients to flow freely into the cells, waste and toxins to flow out and water to perfuse readily in both directions. This purification process stimulates collagen production promoting elasticity, healing and repair. Radiance, tone and clarity ensue.

Additional benefits of MSM:

  • Oxygen availability is increased
  • MSM reduces inflammation and swelling consequently equalizing the pressure on the two sides of the cell membrane
  • Treats skin conditions – studies have proven that MSM confers healing in eczema, psoriasis, rosacea, acne and other dermatoses
  • MSM maintains an ideal pH balance – Sulphur an essential component of insulin, sustains this balance between alkalinity and acidity
  • MSM helps our bodies absorb more nutrients – vitamins and minerals “lock” with MSM, allowing the body to fully utilize them

Vitamin A

Vitamin A maintains the skin and mucous membranes in a moist healthy condition which resists cell damage. This increased hydration is conducive to the treatment of various skin disorders and also inhibits bacterial and viral proliferation. It also delays the appearance of wrinkles and reverses the noxious effects of sun damage creating a younger, healthier look.

Vitamin D3

Supplementing with Vitamin D provides relief from inflammatory skin ailments which include psoriasis, eczema, rosacea, severe acne and other dermatological conditions. The anti -inflammatory effect stimulates reconditioning and rejuvenation of the skin.

Vitamin E

Vitamin E is a powerful antioxidant which protects skin cells from the detrimental effects of ultra violet light, environmental pollution, drugs, and other free radical producing agents. By neutralizing free radicals Vitamin E counteracts this toxic effect. Free radicals are atoms with an uneven number of electrons – a situation which antioxidants -particularly Vitamin E – correct, leaving atoms stable. Fine lines and wrinkles are therefore prevented leaving the skin more vibrant and toned.

Dermatological benefits of Vitamin E:

  • Vitamin E causes outer skin layer regeneration
  • Regulates vitamin A in the body, which in itself is important for healthy skin
  • Treats skin disorders
  • Deterring skin cancer
  • Reduces the appearance of stretch marks
  • Minimizes the effects of discoloration and age spots
  • Maintains the skin’s oil balance
  • Strengthens the skin’s barrier function causing a reduction in trans epidermal water loss

Vitamin C

Vitamin C has a vital role in maintaining skin health. It is key to healthy connective tissue and the synthesis of collagen – a protein that aids in cell growth conferring firmness, strength and self-repairing ability.

Zinc

This skin-friendly mineral is one of the most prevalent trace elements in the body. It is fundamentally important in the treatment of acne which is often a symptom of zinc deficiency. Taken orally, zinc regulates the skin’s oil gland activity discouraging acne. Zinc is further known to facilitate healing of blemishes as well as reduction of the inflammatory component of skin disorders.

By encouraging the production of elastin, collagen and dermo-proteins it aids the skin‘s capacity to heal. It also supports the underlying structure of the skin dermo proteins consequently promoting elasticity, tautness and flexibility thus making ZINC an invaluable mineral for restoring healthy, youthful looking clear skin.

Selenium

Selenium conditions heart tissue urging improved cardiac contractility and circulation. The improvement in microcirculation induces suppleness, better texture and blemish free skin. Selenium in its detoxifying role combats acne and combats the effects of injurious free radicals. This allows the skin to retain its quality and ameliorate the effect of aging.

Scientific studies have demonstrated the ability of selenium to deter the damaging effect of the sun’s radiation on the skin and protect against ultraviolet-induced damage. Working synergistically with vitamin E it has a mutual potency enhancing effect.

Copper

Copper is considered the most effective skin regeneration and remodelling ingredient. By stimulating the body’s innate restorative processes to increase production of “regular” collagen it repairs damaged skin by reducing scar tissue – the result healthier new skin.

Manganese

Manganese facilitates mineral transport and absorption in the body. It is also required for collagen assembly in skin cells and is crucial to the skin support system.

Resveratrol

Resveratrol regulates water homeostasis in the skin, thus keeping it ideally hydrated to maintain its beauty, radiance and glow.

Additional benefits:

  • Firms and lifts the skin. Administration of this antioxidant keeps the skin looking fresh and supple.
  • Contains anti-aging properties which prolong cell life. Due to this process, the onset of aging is delayed ensuring a youthful look for longer.
  • Removal of wrinkles, fine lines and age spots.
  • Detoxification of the skin.
  • Nourishment of the skin.

L- Cysteine

L-Cysteine is an amino acid that contains sulphur. It advances repair and replaces damaged skin tissues to restore smoother, clearer looking skin.

Its homeostatic pigment function (pheomelanin and eumelanin) is therefore essential in the treatment and regulation of skin tone.

Bilberry Extract

The Bilberry Extract found in northern Europe contains anthocyanins which prevent bacterial infection and resist harmful microbes and pathogens. Bilberry extract strengthens the inner and outer skin layers and improves its protective function.

It impedes premature aging by facilitating the delivery of oxygen-rich blood to the skin aiding the absorption of nutrients more effectively and therefore maintaining its vibrancy, elasticity and suppleness.

Bilberry Extract also contains quercetin, a skin-conditioning agent that upholds nutrition to the skin enhancing the look, feel, and overall beauty of the skin.

Collagen

Collagen is a protein that serves as a key structural component of connective skin tissue. It is used for its rejuvenating and hydrating potential promoting firmer, more even toned skin. It also minimises the development of lines and wrinkles consequently delaying the aging process favouring a glowing, radiant & more youthful complexion for longer.

  • Advances elasticity, and increased moisturisation of the skin
  • Lightens skin pigmentation
  • Stimulates immunity
  • Hair and nail rejuvenation

Grape Seed

Grape Seed Extract promotes skin health and restores skin elasticity. It is proven that intake of grape seed extract nourishes the skin and has a lightening effect on melasma and other visible hyper-pigmented areas, age spots, and acne. It also improves skin suppleness resulting in a “natural face-lift”.

Alpha Lipoic Acid

Alpha lipoic acid is remarkable in that it treats skin cells from both the inside and the outside. It also safeguards the skin against the detrimental effects that sugars have on protein, a process which contributes to premature aging and poor skin quality. It effectively replaces damaged collagen fibres invigorating the skin.

Research

  • Y. Rong, et al., “Pycnogenol Protects Vascular Endothelial Cells from t-butyl Hydroperoxide Induced Oxidant Injury,” Biotechnol Ther, 5(3-4), 1994 – 1995, p. 117 – 26.
  • Yamakoshi J, Otsuka F, Sano A, Tokutake S, Saito M, Kikuchi M, Kubota Y., Lightening effect on ultraviolet-induced pigmentation of guinea pig skin by oral administration of a proanthocyanidin-rich extract from grape seeds., Pigment Cell Res. 2003 Dec;16(6):629-38
  • Yamakoshi J, Sano A, Tokutake S, Saito M, Kikuchi M, Kubota Y, Kawachi Y, Otsuka F., Oral intake of proanthocyanidin-rich extract from grape seeds improves chloasma., Phytother Res. 2004 Nov;18(11):895-9.
  • Ivanov V, Ivanova S, Roomi MW, Kalinovsky T, Niedzwiecki A, Rath M., Extracellular matrix-mediated control of aortic smooth muscle cell growth and migration by a combination of ascorbic acid, lysine, proline, and catechins., J Cardiovasc Pharmacol. 2007 Nov;50(5):541-7.
  • Lacroix S, Bouez C, Vidal S, Cenizo V, Reymermier C, Justin V, Vicanová J, Damour O., Supplementation with a complex of active nutrients improved dermal and epidermal characteristics in skin equivalents generated from fibroblasts from young or aged donors., Biogerontology. 2007 Apr;8(2):97-109.
  • Vicanova J, Bouez C, Lacroix S, Lindmark L, Damour O., Epidermal and dermal characteristics in skin equivalent after systemic and topical application of skin care ingredients., Ann N Y Acad Sci. 2006 May;1067:337-42.
  • Katiyar SK., Matrix metalloproteinases in cancer metastasis: molecular targets for prostate cancer prevention by green tea polyphenols and grape seed proanthocyanidins., Endocr Metab Immune Disord Drug Targets. 2006 Mar;6(1):17-24.
  • Maffei Facino R, Carini M, Aldini G, Bombardelli E, Morazzoni P, Morelli R., Free radicals scavenging action and anti-enzyme activities of procyanidines from Vitis vinifera. A mechanism for their capillary protective action., Arzneimittelforschung. 1994 May;44(5):592-601.
  • Corbé C, Boissin JP, Siou A., [Light vision and chorioretinal circulation. Study of the effect of procyanidolic oligomers (Endotelon)], J Fr Ophtalmol. 1988;11(5):453-60. [French]
  • Carini M, Aldini G, Bombardelli E, Morazzoni P, Maffei Facino R., UVB-induced hemolysis of rat erythrocytes: protective effect of procyanidins from grape seeds., Life Sci. 2000 Sep 1;67(15):1799-814.
  • Carini M, Maffei Facino R, Aldini G, Callonii MT, Bombardelli E, Morazzoni P., The protection of polyunsaturated fatty acids in micellar systems against UVB-induced photo-oxidation by procyanidins from Vitis vinifera L., and the protective synergy with vitamin E., Int J Cosmet Sci. 1998 Aug;20(4):203-15.

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2128               Spigset O. Reduced effect of warfarin caused by ubidecarenone. Lancet 1994;334:1372-3. View abstract.

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3366               Rotig A, Appelkvist EL, Geromel V, et al. Quinone-responsive multiple respiratory-chain dysfunction due to widespread coenzyme Q10 deficiency. Lancet 2000;356:391-5. View abstract.

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3368               Kishi T, Watanabe T, Folkers K. Bioenergetics in clinical medicine. XV. Inhibition of coenzyme Q10 enzymes by clinically used adrenergic blockers of B-receptors. Res Commun Chem Pathol Pharmacol 1977;17:157-64. View abstract.

3369               Kishi H, Kishi T, Folkers K. Bioenergetics in clinical medicine. III. Inhibition of coenzyme Q10 enzymes by clinically used anti-hypertensive drugs. Res Commun Chem Pathol Pharmacol 1975;12:533-40. View abstract.

3370               Fuke C, Krikorian SA, Couris RR. Coenzyme Q10: A review of essential functions and clinical trials. US Pharm 2000;25:28-41.

3653               Bertelli A, Ronca G. Carnitine and coenzyme Q10: biochemical properties and functions, synergism and complementary action. Int J Tissue React 1990;12:183-6. View abstract.

3993               Lockwood K, Moesgaard S, Yamamoto T, Folkers K. Progress on therapy of breast cancer with vitamin Q10 and the regression of metastases. Biochem Biophys Res Commun 1995;212:172-7. View abstract.

3995               Lockwood K, Moesgaard S, Folkers K. Partial and complete regression of breast cancer in patients in relation to dosage of coenzyme Q10. Biochem Biophys Res Commun 1994;199:1504-8. View abstract.

4404               Folkers K, Langsjoen P, Willis R, et al. Lovastatin decreases coenzyme Q levels in humans. Proc Natl Acad Sci USA 1990;87:8931-4. View abstract.

4405               Mortensen SA, Leth A, Agner E, et al. Dose-related decrease of serum coenzyme Q10 during treatment with HMG-CoA reductase inhibitors. Mol Aspects Med 1997;18:S137-44. View abstract.

4406               Ghirlanda G, Oradei A, Manto A, et al. Evidence of plasma CoQ10-lowering effect by HMG-CoA reductase inhibitors: A double blind, placebo-controlled study. J Clin Pharmacol 1993;33:226-9. View abstract.

4407               De Pinieux G, Chariot P, Ammi-Said M, et al. Lipid-lowering drugs and mitochondrial function: Effects of HMG-CoA Reductase inhibitors on serum ubiquinone and blood lactate/pyruvate ratio. Br J Clin Pharmacol 1996;42:333-7. View abstract.

4408               Bargossi AM, Grossi G, Fiorella PL, et al. Exogenous CoQ10 supplementation prevents plasma ubiquinone reduction induced by HMG-CoA reductase inhibitors. Mol Aspects Med 1994;15:187-93. View abstract.

4409               Watts GF, Castelluccio C, Rice-Evans C, et al. Plasma coenzyme Q (ubiquinone) concentrations in patients treated with simvastatin. J Clin Pathol 1993;46:1055-7. View abstract.

4410               Hanaki Y, Sugiyama S, Ozawa T, et al. Coenzyme Q10 and coronary artery disease. Clin Investig 1993;71:112-5. View abstract.

4846               Jolliet P, Simon N, Barre J, et al. Plasma coenzyme Q10 concentrations in breast cancer: prognosis and therapeutic consequences. Int J Clin Pharmacol Ther 1998;36:506-9. View abstract.

5090               Khatta M, Alexander BS, Krichten CM, et al. The effect of coenzyme Q10 in patients with congestive heart failure. Ann Intern Med 2000;132:636-40. View abstract.

5158               Portakal O, Ozkaya O, Erden Inal M, et al. Coenzyme Q10 concentrations and antioxidant status in tissues of breast cancer patients. Clin Biochem 2000;33:279-84. View abstract.

5159               Lund EL, Quistorff B, Spang-Thomsen M, Kristjansen PE. Effect of radiation therapy on small-cell lung cancer is reduced by ubiquinone intake. Folia Microbiol (Praha) 1998;43:505-6. View abstract.

5248               Azuma J, Sawamura A, Awata N. Usefulness of taurine in chronic congestive heart failure and its prospective application. Jpn Circ J 1992;56:95-9. View abstract.

6037               Watson PS, Scalia GM, Galbraith A, et al. Lack of effect of coenzyme Q on left ventricular function in patients with congestive heart failure. J Am Coll Cardiol 1999;33:1549-52. View abstract.

6038               Permanetter B, Rossy W, Klein G, et al. Ubiquinone (coenzyme Q10) in the long-term treatment of idiopathic dilated cardiomyopathy. Eur Heart J 1992;13:1528-33. View abstract.

6047               Langsjoen PH, Langsjoen PH, Folkers K. Long-term efficacy and safety of coenzyme Q10 therapy for idiopathic dilated cardiomyopathy. Am J Cardiol 1990;65:521-3. View abstract.

6048               Heck AM, DeWitt BA, Lukes AL. Potential interactions between alternative therapies and warfarin. Am J Health Syst Pharm 2000;57:1221-7. View abstract.

6199               Landbo C, Almdal TP. [Interaction between warfarin and coenzyme Q10]. Ugeskr Laeger 1998;160:3226-7. View abstract.

6407               Morisco C, Trimarco B, Condorelli M. Effect of coenzyme Q10 therapy in patients with congestive heart failure: A long-term, multicenter, randomized study. Clin Investig 1993;71:S134-6. View abstract.

6408               Hofman-Bang C, Rehnqvist N, Swedberg K, et al. Coenzyme Q10 as an adjunctive treatment of congestive heart failure. J Card Fail 1995;1:101-7. View abstract.

6409               Baggio E, Gandini R, Plauncher AC, et al. Italian multicenter study on the safety and efficacy of coenzyme Q10 as adjunctive therapy in heart failure. CoQ10 Drug Surveillance Investigators. Mol Aspects Med 1994;15 Suppl:S287-94. View abstract.

6410               Pizzorno JE, Murray MT, eds. Textbook of Natural Medicine. 2nd ed. New York: Churchill Livingston, 1999.

7000               Greenberg S, Frishman WH. Co-enzyme Q10: a new drug for cardiovascular disease. J Clin Pharmacol 1990;30:596-608. View abstract.

7722               Elsayed NM, Bendich A. Dietary antioxidants: potential effects on oxidative products in cigarette smoke. Nutr Res 2001;21:551-67.

8135               Rozen TD, Oshinsky ML, Gebeline CA, et al. Open label trial of coenzyme Q10 as a migraine preventive. Cephalalgia 2002;22:137-41. View abstract.

8159               Chan A, Reichmann H, Kogel A, et al. Metabolic changes in patients with mitochondrial myopathies and effects of coenzyme Q10 therapy. J Neurol 1998;245:681-5. View abstract.

8160               Sobreira C, Hirano M, Shanske S, et al. Mitochondrial encephalomyopathy with coenzyme Q10 deficiency. Neurology 1997;48:1238-43. View abstract.

8161               Boitier E, Degoul F, Desguerre I, et al. A case of mitochondrial encephalomyopathy associated with a muscle coenzyme Q10 deficiency. J Neurol Sci 1998;156:41-6. View abstract.

8162               Chen RS, Huang CC, Chu NS. Coenzyme Q10 treatment in mitochondrial encephalomyopathies. Short-term double-blind, crossover study. Eur Neurol 1997;37:212-8. View abstract.

8163               Bresolin N, Doriguzzi C, Ponzetto C, et al. Ubidecarenone in the treatment of mitochondrial myopathies: a multi-center double-blind trial. J Neurol Sci 1990;100:70-8. View abstract.

8907               Burke BE, Neuenschwander R, Olson RD. Randomized, double-blind, placebo-controlled trial of coenzyme Q10 in isolated systolic hypertension. South Med J 2001;94:1112-7. View abstract.

8908               Lonnrot K, Porsti I, Alho H, et al. Control of arterial tone after long-term coenzyme Q10 supplementation in senescent rats. Br J Pharmacol 1998;124:1500-6. View abstract.

8909               Soja AM, Mortensen SA. Treatment of congestive heart failure with coenzyme Q10 illuminated by meta-analyses of clinical trials. Mol Aspects Med 1997;18:S159-68. View abstract.

8910               Mortensen SA. Coenzyme Q10 as an adjunctive therapy in patients with congestive heart failure. JACC 2000;36:304-5. View abstract.

8911               Bonetti A, Solito F, Carmosino G, et al. Effect of ubidecarenone oral treatment on aerobic power in middle-aged trained subjects. J Sports Med Phys Fitness 2000;40:51-7. View abstract.

8912               Musumeci O, Naini A, Slonim AE, et al. Familial cerebellar ataxia with muscle coenzyme Q10 deficiency. Neurology 2001;56:849-55. View abstract.

8913               Crane FL. Biochemical functions of coenzyme Q10. J Am Coll Nutr 2001;20:591-8. View abstract.

8914               de Rijke YB, Bredie SJ, Demacker PN, et al. The redox status of coenzyme Q10 in total LDL as an indicator of in vivo oxidative modification. Studies on subjects with familial combined hyperlipidemia. Arterioscler Thromb Vasc Biol 1997;17:127-33. View abstract.

8915               Bleske BE, Willis RA, Anthony M, et al. The effect of pravastatin and atorvastatin on coenzyme Q10. Am Heart J 2001;142:E2. View abstract.

8916               Iwamoto Y, Nakamura R, Folkers K, Morrison RF. Study of periodontal disease and coenzyme Q. Res Commun Chem Pathol Pharmacol 1975;11:265-71. View abstract.

8917               Wilkinson EG, Arnold RM, Folkers K, et al. Bioenergetics in clinical medicine. II. Adjunctive treatment with coenzyme Q in periodontal therapy. Res Commun Chem Pathol Pharmacol 1975;12:111-23. View abstract.

8918               Wilkinson EG, Arnold RM, Folkers K. Bioenergetics in clinical medicine. VI. Adjunctive treatment of periodontal disease with coenzyme Q10. Res Commun Chem Pathol Pharmacol 1976;14:715-9. View abstract.

8938               Shults CW, Oakes D, Kieburtz K, et al. Effects of coenzyme Q10 in early Parkinson disease: evidence of slowing of the functional decline. Arch Neurol 2002;59:1541-50. View abstract.

8939               Shults CW, Beal MF, Fontaine D, et al. Absorption, tolerability, and effects on mitochondrial activity of oral coenzyme Q10 in parkinsonian patients. Neurology 1998;50:793-5. View abstract.

8940               The Huntington Study Group. A randomized, placebo-controlled trial of coenzyme Q10 and remacemide in Huntington’s disease. Neurology 2001;57:397-404. View abstract.

8941               Ferrante RJ, Andreassen OA, Dedeoglu A, et al. Therapeutic effects of coenzyme Q10 and remacemide in transgenic mouse models of Huntington’s disease. J Neurosci 2002;22:1592-9.. View abstract.

8958               Pepping J. Coenzyme Q10. Am J Health-Syst Pharm 1999;56:519-21. View abstract.

8959               Kishi T, Makino K, Okamoto T, et al. Inhibition of myocardial respiration by psychotherapeutic drugs and prevention by coenzyme Q. In: Yamamura Y, Folkers K, Ito Y (eds). Biomedical and clinical aspects of coenzyme Q. Amsterdam: Elsevier/North-Holland Biomedical Press 1980;2:139-54.

9603               Bertelli A, Cerrati A, Giovannini L, et al. Protective action of L-carnitine and coenzyme Q10 against hepatic triglyceride infiltration induced by hyperbaric oxygen and ethanol. Drugs Exp Clin Res 1993;19:65-8.. View abstract.

9890               Hodgson JM, Watts GF, Playford DA, et al. Coenzyme Q10 improves blood pressure and glycaemic control: a controlled trial in subjects with type 2 diabetes. Eur J Clin Nutr 2002;56:1137-42.. View abstract.

10152            Singh RB, Neki NS, Kartikey K, et al. Effect of coenzyme Q10 on risk of atherosclerosis in patients with recent myocardial infarction. Mol Cell Biochem 2003;246:75-82. View abstract.

11031            Langsjoen PH, Langsjoen A, Willis R, Folkers K. Treatment of hypertrophic cardiomyopathy with coenzyme Q10. Mol Aspects Med 1997;18 Suppl:S145-51. View abstract.

11048            Porterfield LM. Why did the response to warfarin change? RN 2000;63:107. View abstract.

11049            Joshi SS, Sawant SV, Shedge A, Halpner AD. Comparative bioavailability of two novel coenzyme Q10 preparations in humans. Int J Clin Pharmacol Ther 2003;41:42-8. View abstract.

11050            Berbel-Garcia A, Barbera-Farre JR, Etessam JP, ET AL. Coenzyme Q 10 improves lactic acidosis, strokelike episodes, and epilepsy in a patient with MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes). Clin Neuropharmacol 2004;27:187-91. View abstract.

11416            Lerman-Sagie T, Rustin P, Lev D, et al. Dramatic improvement in mitochondrial cardiomyopathy following treatment with idebenone. J Inherit Metab Dis 2001;24:28-34. View abstract.

11421            Weyer G, Babej-Dolle RM, Hadler D, et al. A controlled study of 2 doses of idebenone in the treatment of Alzheimer’s disease. Neuropsychobiology 1997;36:73-82. . View abstract.

11427            Gutzmann H, Hadler D. Sustained efficacy and safety of idebenone in the treatment of Alzheimer’s disease: update on a 2-year double-blind multicentre study. J Neural Transm 1998;54:301-10. View abstract.

11872            Sandor PS, Di Clemente L, Coppola G, et al. Efficacy of coenzyme Q10 in migraine prophylaxis: A randomized controlled trial. Neurology 2005;64:713-5. View abstract.

11873            FDA. List of Orphan Designations and Approvals. http://www.fda.gov/orphan/DESIGNAT/list.htm (Accessed 19 June 2004).

11877            Playford DA, Watts GF, Croft KD, Burke V. Combined effect of coenzyme Q10 and fenofibrate on forearm microcirculatory function in type 2 diabetes. Atherosclerosis 2003;168:169-79. View abstract.

11892            Turunen M, Olsson J, Dallner G. Metabolism and function of coenzyme Q. Biochim Biophys Acta 2004;1660:171-99. View abstract.

11893            American Association of Clinical Endocrinologists. American Association of Clinical Endocrinologists medical guidelines for the clinical use of dietary supplements and nutraceuticals. Endocr Pract 2003;9:417-70. View abstract.

11894            Tran MT, Mitchell TM, Kennedy DT, Giles JT. Role of coenzyme Q10 in chronic heart failure, angina, and hypertension. Pharmacotherapy 2001;21:797-806. View abstract.

11895            Ishii N, Senoo-Matsuda N, Miyake K, et al. Coenzyme Q10 can prolong C. elegans lifespan by lowering oxidative stress. Mech Ageing Dev 2004;125:41-6. View abstract.

11896            Lee CK, Pugh TD, Klopp RG, et al. The impact of alpha-lipoic acid, coenzyme Q10 and caloric restriction on life span and gene expression patterns in mice. Free Radic Biol Med 2004;36:1043-57. View abstract.

11897            Welch KM. Current opinions in headache pathogenesis: introduction and synthesis. Curr Opin Neurol 1998;11:193-7. View abstract.

11898            Thompson PD, Clarkson P, Karas RH. Statin-associated myopathy. JAMA 2003;289:1681-90. View abstract.

11899            Thibault A, Samid D, Tompkins AC, et al. Phase I study of lovastatin, an inhibitor of the mevalonate pathway, in patients with cancer. Clin Cancer Res 1996;2:483-91. View abstract.

11900            Kim WS, Kim MM, Choi HJ, et al. Phase II study of high-dose lovastatin in patients with advanced gastric adenocarcinoma. Invest New Drugs 2001;19:81-3. View abstract.

11902            Chello M, Mastroroberto P, Romano R, et al. Protection by coenzyme Q10 of tissue reperfusion injury during abdominal aortic cross-clamping. J Cardiovasc Surg (Torino) 1996;37:229-35. View abstract.

11903            Chello M, Mastroroberto P, Romano R, et al. Protection by coenzyme Q10 from myocardial reperfusion injury during coronary artery bypass grafting. Ann Thorac Surg 1994;58:1427-32. View abstract.

11904            Taggart DP, Jenkins M, Hooper J, et al. Effects of short-term supplementation with coenzyme Q10 on myocardial protection during cardiac operations. Ann Thorac Surg 1996;61:829-33. View abstract.

11905            Engelsen J, Nielsen JD, Winther K. Effect of coenzyme Q10 and Ginkgo biloba on warfarin dosage in stable, long-term warfarin treated outpatients. A randomised, double blind, placebo-crossover trial. Thromb Haemost 2002;87:1075-6. View abstract.

12099            Rundek T, Naini A, Sacco R, et al. Atorvastatin decreases the coenzyme Q10 level in the blood of patients at risk for cardiovascular disease and stroke. Arch Neurol 2004;61:889-92.. View abstract.

12169            Balercia G, Mosca F, Mantero F, et al. Coenzyme Q10 supplementation in infertile men with idiopathic asthenozoospermia: an open, uncontrolled pilot study. Fertil Steril 2004;81:93-8. View abstract.

12170            Berman M, Erman A, Ben-Gal T, et al. Coenzyme Q10 in patients with end-stage heart failure awaiting cardiac transplantation: a randomized, placebo-controlled study. Clin Cardiol 2004;27:295–9. View abstract.

12199            Elshershari H, Ozer S, Ozkutlu S, Ozme S. Potential usefulness of coenzyme Q10 in the treatment of idiopathic dilated cardiomyopathy in children. Int J Cardiol 2003;88:101-2. View abstract.

13223            Soongswang J, Sangtawesin C, Durongpisitkul K, et al. The effect of coenzyme Q10 on idiopathic chronic dilated cardiomyopathy in children. Pediatr Cardiol 2005;26:361-6. View abstract.

14412            Eaton S, Skinner R, Hale JP, et al. Plasma coenzyme Q(10) in children and adolescents undergoing doxorubicin therapy. Clin Chim Acta 2000;302:1-9. View abstract.

14413            Zhou Q, Chowbay B. Effect of coenzyme Q10 on the disposition of doxorubicin in rats. Eur J Drug Metab Pharmacokinet 2002;27:185-92. View abstract.

15115            Berthold HK, Naini A, Di Mauro S, et al. Effect of ezetimibe and/or simvastatin on coenzyme Q10 levels in plasma: a randomised trial. Drug Saf 2006;29:703-12. View abstract.

15255            The NINDS NET-PD Investigators. A randomized clinical trial of coenzyme Q10 and GPI-1485 in early Parkinson disease. Neurology 2007;68:20-8. View abstract.

15256            Hershey AD, Powers SW, Vockell AB, et al. Coenzyme Q10 deficiency and response to supplementation in pediatric and adolescent Migraine. Headache 2007;47:73-80. View abstract.

15395            Storch A, Jost WH, Vieregge P, et al. Randomized, double-blind, placebo-controlled trial on symptomatic effects of coenzyme Q10 in Parkinson disease. Arch Neurol 2007;64:938-44. View abstract.

16008            Caso G, Kelly P, McNurlan MA, Lawson WE. Effect of coenzyme Q10 on myopathic symptoms in patients treated with statins. Am J Cardiol 2007;99:1409-12. View abstract.

16009            Marcoff L, Thompson, PD. The role of coenzyme Q10 in statin-associated myopathy: a systematic review. J Am Coll Cardiol 2007;49:2231-7. View abstract.

17201            Teran E, Hernandez I, Nieto B, et al. Coenzyme Q10 supplementation during pregnancy reduces the risk of pre-eclampsia. Int J Gynaecol Obstet 2009;105:43-5. View abstract.

17413            Safarinejad MR. Efficacy of coenzyme Q-10 on semen parameters, sperm function and reproductive hormones in infertile men. J Urol 2009;182:237-48. View abstract.

17650            Digiesi V, Cantini F, Oradei A, et al. Coenzyme Q10 in essential hypertension. Mol Aspects Med 1994;15 Suppl:s257-63. View abstract.

17651            Yamagami T, Takagi M, Akagami H, et al. Effect of coenzyme Q10 on essential hypertension, a double blind controlled study. In: Folkers KA, Yamamura Y, eds. Biomedical and Clinical Aspects of Coenzyme Q, Vol. 5. Amsterdam: Elsevier Science Publications, 1986:337-43.

17702            Ho MJ, Bellusci A, Wright JM. Blood pressure lowering efficacy of coenzyme Q10 for primary hypertension (review). Cochrane Database Syst Rev 2009;(4):CD007435. View abstract.

17703            Boles RG, Lovett-Barr MR, Preston A, et al. Treatment of cyclic vomiting syndrome with co-enzyme Q10 and amitriptyline, a retrospective study. BMC Neurol 2010;10:10. View abstract.

17704            Lee YJ, Cho WJ, Kim JK, Lee DC. Effects of coenzyme Q10 on arterial stiffness, metabolic parameters, and fatigue in obese subjects: a double-blind randomized controlled study. J Med Food 2011;14:386-90. View abstract.

17705            Cordero MD, Moreno-Fernandez AM, deMiguel M, et al. Coenzyme Q10 distribution in blood is altered in patients with fibromyalgia. Clin Biochem 2009;42:732-5. View abstract.

17716            Lister RE. An open, pilot study to evaluate the potential benefits of coenzyme Q10 combined with Ginkgo biloba extract in fibromyalgia syndrome. J Int Med Res 2002;30:195-9. View abstract.

19206            Galasko D. R., Peskind E., Clark C. M., Quinn J. F., Ringman J. M., Jicha G. A., Cotman C., Cottrell B., Montine T. J., Thomas R. G., Aisen P. Antioxidants for Alzheimer disease: a randomized clinical trial with cerebrospinal fluid biomarker measures. Arch Neurol 2012;69(7):836-841. View abstract.

21651            Leong J. Y., van der Merwe J., Pepe S., Bailey M., Perkins A., Lymbury R., Esmore D., Marasco S., Rosenfeldt F. Perioperative metabolic therapy improves redox status and outcomes in cardiac surgery patients: a randomised trial. Heart Lung Circ 2010;19(10):584-591. View abstract.

30889            Palacka, P., Kucharska, J., Murin, J., Dostalova, K., Okkelova, A., Cizova, M., Waczulikova, I., Moricova, S., and Gvozdjakova, A. Complementary therapy in diabetic patients with chronic complications: a pilot study. Bratisl.Lek.Listy 2010;111(4):205-211. View abstract.

30915            Pfeffer, G., Majamaa, K., Turnbull, D. M., Thorburn, D., and Chinnery, P. F. Treatment for mitochondrial disorders. Cochrane Database.Syst.Rev. 2012;4:CD004426. View abstract.

34283            Marazzi, G., Cacciotti, L., Pelliccia, F., Iaia, L., Volterrani, M., Caminiti, G., Sposato, B., Massaro, R., Grieco, F., and Rosano, G. Long-term effects of nutraceuticals (berberine, red yeast rice, policosanol) in elderly hypercholesterolemic patients. Adv.Ther 2011;28(12):1105-1113. View abstract.

37528            Schiapparelli, P., Allais, G., Castagnoli, Gabellari, I, Rolando, S., Terzi, M. G., and Benedetto, C. Non-pharmacological approach to migraine prophylaxis: part II. Neurol.Sci. 2010;31 Suppl 1:S137-S139. View abstract.

37534            Mauskop, A. Nonmedication, alternative, and complementary treatments for migraine. Continuum (Minneap.Minn.) 2012;18(4):796-806. View abstract.

42069            Nahas, R. Complementary and alternative medicine approaches to blood pressure reduction: An evidence-based review. Can.Fam.Physician 2008;54(11):1529-1533. View abstract.

43894            Abe, K., Matsuo, Y., Kadekawa, J., Inoue, S., and Yanagihara, T. Effect of coenzyme Q10 in patients with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS): evaluation by noninvasive tissue oximetry. J Neurol.Sci. 1-1-1999;162(1):65-68. View abstract.

43895            Barbiroli, B., Iotti, S., Cortelli, P., Martinelli, P., Lodi, R., Carelli, V., and Montagna, P. Low brain intracellular free magnesium in mitochondrial cytopathies. J Cereb.Blood Flow Metab 1999;19(5):528-532. View abstract.

43896            Nielsen, A. N., Mizuno, M., Ratkevicius, A., Mohr, T., Rohde, M., Mortensen, S. A., and Quistorff, B. No effect of antioxidant supplementation in triathletes on maximal oxygen uptake, 31P-NMRS detected muscle energy metabolism and muscle fatigue. Int J Sports Med 1999;20(3):154-158. View abstract.

43897            Blatt, T., Mundt, C., Mummert, C., Maksiuk, T., Wolber, R., Keyhani, R., Schreiner, V., Hoppe, U., Schachtschabel, D. O., and Stab, F. [Modulation of oxidative stresses in human aging skin]. Z.Gerontol.Geriatr. 1999;32(2):83-88. View abstract.

43898            Zhou, M., Zhi, Q., Tang, Y., Yu, D., and Han, J. Effects of coenzyme Q10 on myocardial protection during cardiac valve replacement and scavenging free radical activity in vitro. J Cardiovasc.Surg.(Torino) 1999;40(3):355-361. View abstract.

43899            Lopez-Lluch, G., Barroso, M. P., Martin, S. F., Fernandez-Ayala, D. J., Gomez-Diaz, C., Villalba, J. M., and Navas, P. Role of plasma membrane coenzyme Q on the regulation of apoptosis. Biofactors 1999;9(2-4):171-177. View abstract.

43900            Tomasetti, M., Alleva, R., Solenghi, M. D., and Littarru, G. P. Distribution of antioxidants among blood components and lipoproteins: significance of lipids/CoQ10 ratio as a possible marker of increased risk for atherosclerosis. Biofactors 1999;9(2-4):231-240. View abstract.

43901            Barbiroli, B., Iotti, S., and Lodi, R. Improved brain and muscle mitochondrial respiration with CoQ. An in vivo study by 31P-MR spectroscopy in patients with mitochondrial cytopathies. Biofactors 1999;9(2-4):253-260. View abstract.

43902            Shults, C. W., Haas, R. H., and Beal, M. F. A possible role of coenzyme Q10 in the etiology and treatment of Parkinson’s disease. Biofactors 1999;9(2-4):267-272. View abstract.

43903            Langsjoen, P. H. and Langsjoen, A. M. Overview of the use of CoQ10 in cardiovascular disease. Biofactors 1999;9(2-4):273-284. View abstract.

43904            Munkholm, H., Hansen, H. H., and Rasmussen, K. Coenzyme Q10 treatment in serious heart failure. Biofactors 1999;9(2-4):285-289. View abstract.

43905            Sacher, H. L., Sacher, M. L., Landau, S. W., Kersten, R., Dooley, F., Sacher, A., Sacher, M., Dietrick, K., and Ichkhan, K. The clinical and hemodynamic effects of coenzyme Q10 in congestive cardiomyopathy. Am J Ther 1997;4(2-3):66-72. View abstract.

43906            Kogan, A. K., Syrkin, A. L., Drinitsina, S. V., and Kokanova, I. V. [The antioxidant protection of the heart by coenzyme Q10 in stable stenocardia of effort]. Patol.Fiziol.Eksp.Ter. 1999;4(4):16-19. View abstract.

43907            Portakal, O. and Inal-Erden, M. Effects of pentoxifylline and coenzyme Q10 in hepatic ischemia/reperfusion injury. Clin Biochem 1999;32(6):461-466. View abstract.

43908            Kaikkonen, J., Nyyssonen, K., Tomasi, A., Iannone, A., Tuomainen, T. P., Porkkala-Sarataho, E., and Salonen, J. T. Antioxidative efficacy of parallel and combined supplementation with coenzyme Q10 and d-alpha-tocopherol in mildly hypercholesterolemic subjects: a randomized placebo-controlled clinical study. Free Radic.Res 2000;33(3):329-340. View abstract.

43909            Sinatra, S. T. Coenzyme Q10 and congestive heart failure. Ann.Intern.Med 11-7-2000;133(9):745-746. View abstract.

43910            Gottlieb, S. S., Khatta, M., and Fisher, M. L. Coenzyme Q10 and Congestive Heart Failure. Ann.Intern.Med 11-7-2000;133(9):745-746. View abstract.

43911            Del Mar, C. B., Glasziou, P. P., Spinks, A. B., and Sanders, S. L. Is coenzyme Q10 helpful for patients with idiopathic cardiomyopathy? Med J Aust. 4-16-2001;174(8):421. View abstract.

43912            Lodi, R., Hart, P. E., Rajagopalan, B., Taylor, D. J., Crilley, J. G., Bradley, J. L., Blamire, A. M., Manners, D., Styles, P., Schapira, A. H., and Cooper, J. M. Antioxidant treatment improves in vivo cardiac and skeletal muscle bioenergetics in patients with Friedreich’s ataxia. Ann.Neurol. 2001;49(5):590-596. View abstract.

43913            Gazdikova, K., Gvozdjakova, A., Kucharska, J., Spustova, V., Braunova, Z., and Dzurik, R. [Effect of coenzyme Q10 in patients with kidney diseases]. Cas.Lek.Cesk. 5-24-2001;140(10):307-310. View abstract.

43914            Strong, M. J. and Pattee, G. L. Creatine and coenzyme Q10 in the treatment of ALS. Amyotroph.Lateral.Scler.Other Motor Neuron Disord 2000;1(suppl 4):17-20. View abstract.

43915            Yamagami, T., Shibata, N., and Folkers, K. Bioenergetics in clinical medicine. Studies on coenzyme Q10 and essential hypertension. Res Commun Chem Pathol.Pharmacol 1975;11(2):273-288. View abstract.

43916            Watson, P. S., Scalia, G. M., Gaibraith, A. J., Burstow, D. J., Aroney, C. N., and Bett, J. H. Is coenzyme Q10 helpful for patients with idiopathic cardiomyopathy? Med J Aust. 10-15-2001;175(8):447-448. View abstract.

43917            Vitetta, L., Sali, A., and Reavley, N. J. Is coenzyme Q10 helpful for patients with idiopathic cardiomyopathy? Med J Aust. 10-15-2001;175(8):447-448. View abstract.

43918            Gutzmann, H., Kuhl, K. P., Hadler, D., and Rapp, M. A. Safety and efficacy of idebenone versus tacrine in patients with Alzheimer’s disease: results of a randomized, double-blind, parallel-group multicenter study. Pharmacopsychiatry 2002;35(1):12-18. View abstract.

43919            Miquel, J. Can antioxidant diet supplementation protect against age-related mitochondrial damage? Ann N Y.Acad Sci 2002;959:508-516. View abstract.

43920            Rosenfeldt, F. L., Pepe, S., Linnane, A., Nagley, P., Rowland, M., Ou, R., Marasco, S., and Lyon, W. The effects of ageing on the response to cardiac surgery: protective strategies for the ageing myocardium. Biogerontology. 2002;3(1-2):37-40. View abstract.

43921            Linnane, A. W., Kopsidas, G., Zhang, C., Yarovaya, N., Kovalenko, S., Papakostopoulos, P., Eastwood, H., Graves, S., and Richardson, M. Cellular redox activity of coenzyme Q10: effect of CoQ10 supplementation on human skeletal muscle. Free Radic.Res 2002;36(4):445-453. View abstract.

43922            Jeejeebhoy, F., Keith, M., Freeman, M., Barr, A., McCall, M., Kurian, R., Mazer, D., and Errett, L. Nutritional supplementation with MyoVive repletes essential cardiac myocyte nutrients and reduces left ventricular size in patients with left ventricular dysfunction. Am Heart J 2002;143(6):1092-1100. View abstract.

43923            Kurowska, E. M., Dresser, G., Deutsch, L., Bassoo, E., and Freeman, D. J. Relative bioavailability and antioxidant potential of two coenzyme q10 preparations. Ann.Nutr.Metab 2003;47(1):16-21. View abstract.

43924            Muller, T., Buttner, T., Gholipour, A. F., and Kuhn, W. Coenzyme Q10 supplementation provides mild symptomatic benefit in patients with Parkinson’s disease. Neurosci.Lett. 5-8-2003;341(3):201-204. View abstract.

43925            Singh, R. B., Kartikey, K., Charu, A. S., Niaz, M. A., and Schaffer, S. Effect of taurine and coenzyme Q10 in patients with acute myocardial infarction. Adv.Exp.Med.Biol. 2003;526:41-48. View abstract.

43926            Beyer, R. E. An analysis of the role of coenzyme Q in free radical generation and as an antioxidant. Biochem Cell Biol 1992;70(6):390-403. View abstract.

43927            Snider, I. P., Bazzarre, T. L., Murdoch, S. D., and Goldfarb, A. Effects of coenzyme athletic performance system as an ergogenic aid on endurance performance to exhaustion. Int J Sport Nutr 1992;2(3):272-286. View abstract.

43928            Disdier, P., Harle, J. R., Figarella-Branger, D., Cherif, A. A., Desnuelle, C., and Weiller, P. J. [Ptosis and asthenia manifesting a mitochondrial myopathy]. Rev Med Interne 1992;13(5):381-383. View abstract.

43929            Hanisch, F. and Zierz, S. Only transient increase of serum CoQ subset 10 during long-term CoQ10 therapy in mitochondrial ophthalmoplegia. Eur.J Med.Res 11-12-2003;8(11):485-491. View abstract.

43930            Shults, C. W. Treatments of Parkinson disease: circa 2003. Arch.Neurol. 2003;60(12):1680-1684. View abstract.

43931            Migliore, L., Molinu, S., Naccarati, A., Mancuso, M., Rocchi, A., and Siciliano, G. Evaluation of cytogenetic and DNA damage in mitochondrial disease patients: effects of coenzyme Q10 therapy. Mutagenesis 2004;19(1):43-49. View abstract.

43932            Rosenfeldt, F., Hilton, D., Pepe, S., and Krum, H. Systematic review of effect of coenzyme Q10 in physical exercise, hypertension and heart failure. Biofactors 2003;18(1-4):91-100. View abstract.

43933            Shults, C. W., Flint, Beal M., Song, D., and Fontaine, D. Pilot trial of high dosages of coenzyme Q10 in patients with Parkinson’s disease. Exp.Neurol. 2004;188(2):491-494. View abstract.

43934            Aure, K., Benoist, J. F., Ogier, de Baulny, Romero, N. B., Rigal, O., and Lombes, A. Progression despite replacement of a myopathic form of coenzyme Q10 defect. Neurology 8-24-2004;63(4):727-729. View abstract.

43935            Damian, M. S., Ellenberg, D., Gildemeister, R., Lauermann, J., Simonis, G., Sauter, W., and Georgi, C. Coenzyme Q10 combined with mild hypothermia after cardiac arrest: a preliminary study. Circulation 11-9-2004;110(19):3011-3016. View abstract.

43936            Silver, M. A., Langsjoen, P. H., Szabo, S., Patil, H., and Zelinger, A. Effect of atorvastatin on left ventricular diastolic function and ability of coenzyme Q10 to reverse that dysfunction. Am J Cardiol. 11-15-2004;94(10):1306-1310. View abstract.

43937            Rosenfeldt, F., Marasco, S., Lyon, W., Wowk, M., Sheeran, F., Bailey, M., Esmore, D., Davis, B., Pick, A., Rabinov, M., Smith, J., Nagley, P., and Pepe, S. Coenzyme Q10 therapy before cardiac surgery improves mitochondrial function and in vitro contractility of myocardial tissue. J Thorac.Cardiovasc.Surg. 2005;129(1):25-32. View abstract.

43938            van Dalen, E. C., Caron, H. N., Dickinson, H. O., and Kremer, L. C. Cardioprotective interventions for cancer patients receiving anthracyclines. Cochrane.Database.Syst.Rev 2005;(1):CD003917. View abstract.

43939            Carli, F., Chiellini, E. E., Bellich, B., Macchiavelli, S., and Cadelli, G. Ubidecarenone nanoemulsified composite systems. Int J Pharm 3-3-2005;291(1-2):113-118. View abstract.

43940            Reid, M. S., Casadonte, P., Baker, S., Sanfilipo, M., Braunstein, D., Hitzemann, R., Montgomery, A., Majewska, D., Robinson, J., and Rotrosen, J. A placebo-controlled screening trial of olanzapine, valproate, and coenzyme Q10/L-carnitine for the treatment of cocaine dependence. Addiction 2005;100 Suppl 1:43-57. View abstract.

43941            Forgionne, G. A. Bovine cartilage, coenzyme Q10, and wheat grass therapy for primary peritoneal cancer. J Altern.Complement Med 2005;11(1):161-165. View abstract.

43942            Hoenjet, K. M., Dagnelie, P. C., Delaere, K. P., Wijckmans, N. E., Zambon, J. V., and Oosterhof, G. O. Effect of a nutritional supplement containing vitamin E, selenium, vitamin c and coenzyme Q10 on serum PSA in patients with hormonally untreated carcinoma of the prostate: a randomised placebo-controlled study. Eur Urol 2005;47(4):433-439. View abstract.

43943            Hart, P. E., Lodi, R., Rajagopalan, B., Bradley, J. L., Crilley, J. G., Turner, C., Blamire, A. M., Manners, D., Styles, P., Schapira, A. H., and Cooper, J. M. Antioxidant treatment of patients with Friedreich ataxia: four-year follow-up. Arch.Neurol. 2005;62(4):621-626. View abstract.

43944            Bentler, S. E., Hartz, A. J., and Kuhn, E. M. Prospective observational study of treatments for unexplained chronic fatigue. J Clin Psychiatry 2005;66(5):625-632. View abstract.

43945            Cicero, A. F., Derosa, G., Miconi, A., Laghi, L., Nascetti, S., and Gaddi, A. Possible role of ubiquinone in the treatment of massive hypertriglyceridemia resistant to PUFA and fibrates. Biomed Pharmacother 2005;59(6):312-317. View abstract.

43946            Feher, J., Kovacs, B., Kovacs, I., Schveoller, M., Papale, A., and Balacco, Gabrieli C. Improvement of visual functions and fundus alterations in early age-related macular degeneration treated with a combination of acetyl-L-carnitine, n-3 fatty acids, and coenzyme Q10. Ophthalmologica 2005;219(3):154-166. View abstract.

43947            Maeda, K., Tatsumi, M., Tahara, M., Murata, Y., Kawai, H., and Yasuda, H. [A case of stroke-like episode of MELAS of which progressive spread would be prevented by edaravone]. Rinsho Shinkeigaku 2005;45(6):416-421. View abstract.

43948            Mancini, A., Milardi, D., Conte, G., Festa, R., De Marinis, L., and Littarru, G. P. Seminal antioxidants in humans: preoperative and postoperative evaluation of coenzyme Q10 in varicocele patients. Horm.Metab Res 2005;37(7):428-432. View abstract.

43949            Witte, K. K., Nikitin, N. P., Parker, A. C., von Haehling, S., Volk, H. D., Anker, S. D., Clark, A. L., and Cleland, J. G. The effect of micronutrient supplementation on quality-of-life and left ventricular function in elderly patients with chronic heart failure. Eur Heart J 2005;26(21):2238-2244. View abstract.

43950            Salviati, L., Sacconi, S., Murer, L., Zacchello, G., Franceschini, L., Laverda, A. M., Basso, G., Quinzii, C., Angelini, C., Hirano, M., Naini, A. B., Navas, P., DiMauro, S., and Montini, G. Infantile encephalomyopathy and nephropathy with CoQ10 deficiency: a CoQ10-responsive condition. Neurology 8-23-2005;65(4):606-608. View abstract.

43951            Zaffanello, M. and Zamboni, G. Therapeutic approach in a case of Pearson’s syndrome. Minerva Pediatr 2005;57(3):143-146. View abstract.

43952            Ullmann, U., Metzner, J., Schulz, C., Perkins, J., and Leuenberger, B. A new Coenzyme Q10 tablet-grade formulation (all-Q) is bioequivalent to Q-Gel and both have better bioavailability properties than Q-SorB. J Med.Food 2005;8(3):397-399. View abstract.

43953            Zhou, S., Zhang, Y., Davie, A., Marshall-Gradisnik, S., Hu, H., Wang, J., and Brushett, D. Muscle and plasma coenzyme Q10 concentration, aerobic power and exercise economy of healthy men in response to four weeks of supplementation. J Sports Med Phys.Fitness 2005;45(3):337-346. View abstract.

43954            Salles, J. E., Moises, V. A., Almeida, D. R., Chacra, A. R., and Moises, R. S. Myocardial dysfunction in mitochondrial diabetes treated with Coenzyme Q10. Diabetes Res Clin Pract 2006;72(1):100-103. View abstract.

43955            Ferrante, K. L., Shefner, J., Zhang, H., Betensky, R., O’Brien, M., Yu, H., Fantasia, M., Taft, J., Beal, M. F., Traynor, B., Newhall, K., Donofrio, P., Caress, J., Ashburn, C., Freiberg, B., O’Neill, C., Paladenech, C., Walker, T., Pestronk, A., Abrams, B., Florence, J., Renna, R., Schierbecker, J., Malkus, B., and Cudkowicz, M. Tolerance of high-dose (3,000 mg/day) coenzyme Q10 in ALS. Neurology 12-13-2005;65(11):1834-1836. View abstract.

43956            Mohr, D., Bowry, V. W., and Stocker, R. Dietary supplementation with coenzyme Q10 results in increased levels of ubiquinol-10 within circulating lipoproteins and increased resistance of human low-density lipoprotein to the initiation of lipid peroxidation. Biochim Biophys Acta 6-26-1992;1126(3):247-254. View abstract.

43957            Horvath, R., Schneiderat, P., Schoser, B. G., Gempel, K., Neuen-Jacob, E., Ploger, H., Muller-Hocker, J., Pongratz, D. E., Naini, A., DiMauro, S., and Lochmuller, H. Coenzyme Q10 deficiency and isolated myopathy. Neurology 1-24-2006;66(2):253-255. View abstract.

43958            Chinnery, P., Majamaa, K., Turnbull, D., and Thorburn, D. Treatment for mitochondrial disorders. Cochrane Database Syst.Rev. 2006;(1):CD004426. View abstract.

43959            Rusciani, L., Proietti, I., Rusciani, A., Paradisi, A., Sbordoni, G., Alfano, C., Panunzi, S., De Gaetano, A., and Lippa, S. Low plasma coenzyme Q10 levels as an independent prognostic factor for melanoma progression. J Am Acad Dermatol 2006;54(2):234-241. View abstract.

43960            Tawankanjanachot, I., Channarong, N. S., and Phanthumchinda, K. Auditory symptoms: a critical clue for diagnosis of MELAS. J Med Assoc Thai. 2005;88(11):1715-1720. View abstract.

43961            Levy, G., Kaufmann, P., Buchsbaum, R., Montes, J., Barsdorf, A., Arbing, R., Battista, V., Zhou, X., Mitsumoto, H., Levin, B., and Thompson, J. L. A two-stage design for a phase II clinical trial of coenzyme Q10 in ALS. Neurology 3-14-2006;66(5):660-663. View abstract.

43962            Artuch, R., Brea-Calvo, G., Briones, P., Aracil, A., Galvan, M., Espinos, C., Corral, J., Volpini, V., Ribes, A., Andreu, A. L., Palau, F., Sanchez-Alcazar, J. A., Navas, P., and Pineda, M. Cerebellar ataxia with coenzyme Q10 deficiency: diagnosis and follow-up after coenzyme Q10 supplementation. J Neurol.Sci 7-15-2006;246(1-2):153-158. View abstract.

43963            Hirano, M., Quinzii, C. M., and DiMauro, S. Restoring balance to ataxia with coenzyme Q10 deficiency. J Neurol.Sci 7-15-2006;246(1-2):11-12. View abstract.

43964            Miles, M. V., Patterson, B. J., Schapiro, M. B., Hickey, F. J., Chalfonte-Evans, M., Horn, P. S., and Hotze, S. L. Coenzyme Q10 absorption and tolerance in children with Down syndrome: a dose-ranging trial. Pediatr Neurol. 2006;35(1):30-37. View abstract.

43965            Belaia, O. L., Kalmykova, V. I., Ivanova, L. A., and Kochergina, L. G. [Experience in coenzyme Q10 application in complex therapy of coronary heart disease with dyslipidemia]. Klin Med (Mosk) 2006;84(5):59-62. View abstract.

43966            Islam, J., Uretsky, B. F., and Sierpina, V. S. Heart failure improvement with CoQ10, Hawthorn, and magnesium in a patient scheduled for cardiac resynchronization-defibrillator therapy: a case study. Explore.(NY) 2006;2(4):339-341. View abstract.

43967            Belardinelli, R., Mucaj, A., Lacalaprice, F., Solenghi, M., Principi, F., Tiano, L., and Littarru, G. P. Coenzyme Q10 improves contractility of dysfunctional myocardium in chronic heart failure. Biofactors 2005;25(1-4):137-145. View abstract.

43968            Singh, R. B., Niaz, M. A., Kumar, A., Sindberg, C. D., Moesgaard, S., and Littarru, G. P. Effect on absorption and oxidative stress of different oral Coenzyme Q10 dosages and intake strategy in healthy men. Biofactors 2005;25(1-4):219-224. View abstract.

43969            Gvozdjakova, A., Kucharska, J., Bartkovjakova, M., Gazdikova, K., and Gazdik, F. E. Coenzyme Q10 supplementation reduces corticosteroids dosage in patients with bronchial asthma. Biofactors 2005;25(1-4):235-240. View abstract.

43970            Kang, H. C., Kim, H. D., Lee, Y. M., and Han, S. H. Landau-Kleffner syndrome with mitochondrial respiratory chain-complex I deficiency. Pediatr.Neurol. 2006;35(2):158-161. View abstract.

43971            Belardinelli, R., Mucaj, A., Lacalaprice, F., Solenghi, M., Seddaiu, G., Principi, F., Tiano, L., and Littarru, G. P. Coenzyme Q10 and exercise training in chronic heart failure. Eur Heart J 2006;27(22):2675-2681. View abstract.

43972            Ramelli, G. P., Gallati, S., Weis, J., Krahenbuhl, S., and Burgunder, J. M. Point mutation tRNA(Ser(UCN)) in a child with hearing loss and myoclonus epilepsy. J Child Neurol. 2006;21(3):253-255. View abstract.

43973            Sander, S., Coleman, C. I., Patel, A. A., Kluger, J., and White, C. M. The impact of coenzyme Q10 on systolic function in patients with chronic heart failure. J Card Fail. 2006;12(6):464-472. View abstract.

43974            Donovan, L. E. and Severin, N. E. Maternally inherited diabetes and deafness in a North American kindred: tips for making the diagnosis and review of unique management issues. J Clin Endocrinol.Metab 2006;91(12):4737-4742. View abstract.

43975            Galili, N., Sechman, E. V., Cerny, J., Mehdi, M., Mumtaz, M., Westervelt, P., Maguire, J., and Raza, A. Clinical response of myelodysplastic syndromes patients to treatment with coenzyme Q10. Leuk.Res 2007;31(1):19-26. View abstract.

43976            Rodriguez, M. C., MacDonald, J. R., Mahoney, D. J., Parise, G., Beal, M. F., and Tarnopolsky, M. A. Beneficial effects of creatine, CoQ10, and lipoic acid in mitochondrial disorders. Muscle Nerve 2007;35(2):235-242. View abstract.

43977            Letsas, K. P., Efremidis, M., Pappas, L. K., Gavrielatos, G., Sideris, A., and Charitos, C. Pathophysiology and management of syncope in Kearns-Sayre syndrome. Am Heart Hosp.J 2006;4(4):301-302. View abstract.

43978            Nishino, M., Usami, M., Sugimura, S., and Yoshizaki, S. [Case of drug-induced pneumonitis associated with a dietary supplement containing CoQ10]. Nihon Kokyuki.Gakkai Zasshi 2006;44(10):766-770. View abstract.

43979            Schulz, C., Obermuller-Jevic, U. C., Hasselwander, O., Bernhardt, J., and Biesalski, H. K. Comparison of the relative bioavailability of different coenzyme Q10 formulations with a novel solubilizate (Solu Q10). Int J Food Sci Nutr 2006;57(7-8):546-555. View abstract.

43980            Lopez, L. C., Schuelke, M., Quinzii, C. M., Kanki, T., Rodenburg, R. J., Naini, A., DiMauro, S., and Hirano, M. Leigh syndrome with nephropathy and CoQ10 deficiency due to decaprenyl diphosphate synthase subunit 2 (PDSS2) mutations. Am J Hum.Genet. 2006;79(6):1125-1129. View abstract.

43981            Khan, M., Gross, J., Haupt, H., Jainz, A., Niklowitz, P., Scherer, H., Schmidt, F. P., Klapp, B. F., Reisshauer, A., and Mazurek, B. A pilot clinical trial of the effects of coenzyme Q10 on chronic tinnitus aurium. Otolaryngol.Head Neck Surg 2007;136(1):72-77. View abstract.

43982            Rosenfeldt, F. L., Haas, S. J., Krum, H., Hadj, A., Ng, K., Leong, J. Y., and Watts, G. F. Coenzyme Q10 in the treatment of hypertension: a meta-analysis of the clinical trials. J Hum.Hypertens. 2007;21(4):297-306. View abstract.

43983            Folkers, K., Langsjoen, P., and Langsjoen, P. H. Therapy with coenzyme Q10 of patients in heart failure who are eligible or ineligible for a transplant. Biochem Biophys.Res Commun. 1-15-1992;182(1):247-253. View abstract.

43984            Shah, S. A., Sander, S., Cios, D., Lipeika, J., Kluger, J., and White, C. M. Electrocardiographic and hemodynamic effects of coenzyme Q10 in healthy individuals: a double-blind, randomized controlled trial. Ann Pharmacother 2007;41(3):420-425. View abstract.

43985            Geng, A., Li, B., and Guo, Y. Effects of dietary L-carnitine and coenzyme Q10 at different supplemental ages on growth performance and some immune response in ascites-susceptible broilers. Arch.Anim Nutr. 2007;61(1):50-60. View abstract.

43986            Keith, M., Mazer, C. D., Mikhail, P., Jeejeebhoy, F., Briet, F., and Errett, L. Coenzyme Q10 in patients undergoing CABG: Effect of statins and nutritional supplementation. Nutr Metab Cardiovasc.Dis. 2008;18(2):105-111. View abstract.

43987            Niklowitz, P., Sonnenschein, A., Janetzky, B., Andler, W., and Menke, T. Enrichment of coenzyme Q10 in plasma and blood cells: defense against oxidative damage. Int J Biol Sci 2007;3(4):257-262. View abstract.

43988            Rusciani, L., Proietti, I., Paradisi, A., Rusciani, A., Guerriero, G., Mammone, A., De Gaetano, A., and Lippa, S. Recombinant interferon alpha-2b and coenzyme Q10 as a postsurgical adjuvant therapy for melanoma: a 3-year trial with recombinant interferon-alpha and 5-year follow-up. Melanoma Res 2007;17(3):177-183. View abstract.

43989            Storch, A. [Coenzyme Q10 in Parkinson's disease. Symptomatic or neuroprotective effects?]. Nervenarzt 2007;78(12):1378-1382. View abstract.

43990            Papas, K. A., Sontag, M. K., Pardee, C., Sokol, R. J., Sagel, S. D., Accurso, F. J., and Wagener, J. S. A pilot study on the safety and efficacy of a novel antioxidant rich formulation in patients with cystic fibrosis. J Cyst.Fibros. 2008;7(1):60-67. View abstract.

43991            Tiano, L., Belardinelli, R., Carnevali, P., Principi, F., Seddaiu, G., and Littarru, G. P. Effect of coenzyme Q10 administration on endothelial function and extracellular superoxide dismutase in patients with ischaemic heart disease: a double-blind, randomized controlled study. Eur.Heart J 2007;28(18):2249-2255. View abstract.

43992            Yuvaraj, S., Premkumar, V. G., Vijayasarathy, K., Gangadaran, S. G., and Sachdanandam, P. Augmented antioxidant status in Tamoxifen treated postmenopausal women with breast cancer on co-administration with Coenzyme Q10, Niacin and Riboflavin. Cancer Chemother.Pharmacol 2008;61(6):933-941. View abstract.

43993            Tsujita, Y., Kunitomo, T., Fujii, M., Furukawa, S., Otsuki, H., Fujino, K., Hamamoto, T., Tabata, T., Matsumura, K., Sasaki, T., Saotome, T., Kawai, H., Matsumoto, T., Maeda, K., Horie, M., and Eguchi, Y. A surviving case of mitochondrial cardiomyopathy diagnosed from the symptoms of multiple organ dysfunction syndrome. Int J Cardiol. 8-1-2008;128(1):e43-e45. View abstract.

43994            Satta, A., Grandi, M., Landoni, C. V., Migliori, G. B., Spanevello, A., Vocaturo, G., and Neri, M. Effects of ubidecarenone in an exercise training program for patients with chronic obstructive pulmonary diseases. Clin Ther. 1991;13(6):754-757. View abstract.

43995            Tekle, M., Turunen, M., Dallner, G., Chojnacki, T., and Swiezewska, E. Investigation of coenzyme Q biosynthesis in human fibroblast and HepG2 cells. J Biochem Biophys Methods 4-24-2008;70(6):909-917. View abstract.

43996            Murata, T., Ohtsuka, C., and Terayama, Y. Increased mitochondrial oxidative damage in patients with sporadic amyotrophic lateral sclerosis. J Neurol.Sci 4-15-2008;267(1-2):66-69. View abstract.

43997            Myers, L., Farmer, J. M., Wilson, R. B., Friedman, L., Tsou, A., Perlman, S. L., Subramony, S. H., Gomez, C. M., Ashizawa, T., Wilmot, G. R., Mathews, K. D., Balcer, L. J., and Lynch, D. R. Antioxidant use in Friedreich ataxia. J Neurol.Sci 4-15-2008;267(1-2):174-176. View abstract.

43998            Schallreuter, K. U., Rokos, H., Chavan, B., Gillbro, J. M., Cemeli, E., Zothner, C., Anderson, D., and Wood, J. M. Quinones are reduced by 6-tetrahydrobiopterin in human keratinocytes, melanocytes, and melanoma cells. Free Radic.Biol Med 2-15-2008;44(4):538-546. View abstract.

43999            Lu, C., Zhang, D., Whiteman, M., and Armstrong, J. S. Is antioxidant potential of the mitochondrial targeted ubiquinone derivative MitoQ conserved in cells lacking mtDNA? Antioxid.Redox.Signal. 2008;10(3):651-660. View abstract.

44000            Mizushina, Y., Takeuchi, T., Takakusagi, Y., Yonezawa, Y., Mizuno, T., Yanagi, K., Imamoto, N., Sugawara, F., Sakaguchi, K., Yoshida, H., and Fujita, M. Coenzyme Q10 as a potent compound that inhibits Cdt1-geminin interaction. Biochim.Biophys.Acta 2008;1780(2):203-213. View abstract.

44001            Lim, S. C., Lekshminarayanan, R., Goh, S. K., Ong, Y. Y., Subramaniam, T., Sum, C. F., Ong, C. N., and Lee, B. L. The effect of coenzyme Q10 on microcirculatory endothelial function of subjects with type 2 diabetes mellitus. Atherosclerosis 2008;196(2):966-969. View abstract.

44002            Yang, X., Yang, Y., Li, G., Wang, J., and Yang, E. S. Coenzyme Q10 attenuates beta-amyloid pathology in the aged transgenic mice with Alzheimer presenilin 1 mutation. J Mol.Neurosci. 2008;34(2):165-171. View abstract.

44003            Pineda, M., Arpa, J., Montero, R., Aracil, A., Dominguez, F., Galvan, M., Mas, A., Martorell, L., Sierra, C., Brandi, N., Garcia-Arumi, E., Rissech, M., Velasco, D., Costa, J. A., and Artuch, R. Idebenone treatment in paediatric and adult patients with Friedreich ataxia: long-term follow-up. Eur J Paediatr.Neurol. 2008;12(6):470-475. View abstract.

44004            Senes, M., Erbay, A. R., Yilmaz, F. M., Topkaya, B. C., Zengi, O., Dogan, M., and Yucel, D. Coenzyme Q10 and high-sensitivity C-reactive protein in ischemic and idiopathic dilated cardiomyopathy. Clin Chem.Lab Med 2008;46(3):382-386. View abstract.

44005            Eiholzer, U., Meinhardt, U., Rousson, V., Petrovic, N., Schlumpf, M., and l’Allemand, D. Developmental profiles in young children with Prader-Labhart-Willi syndrome: effects of weight and therapy with growth hormone or coenzyme Q10. Am J Med Genet.A 4-1-2008;146(7):873-880. View abstract.

44006            Mizuno, K., Tanaka, M., Nozaki, S., Mizuma, H., Ataka, S., Tahara, T., Sugino, T., Shirai, T., Kajimoto, Y., Kuratsune, H., Kajimoto, O., and Watanabe, Y. Antifatigue effects of coenzyme Q10 during physical fatigue. Nutrition 2008;24(4):293-299. View abstract.

44007            Kon, M., Tanabe, K., Akimoto, T., Kimura, F., Tanimura, Y., Shimizu, K., Okamoto, T., and Kono, I. Reducing exercise-induced muscular injury in kendo athletes with supplementation of coenzyme Q10. Br J Nutr 2008;100(4):903-909. View abstract.

44008            Miles, M. V., Miles, L., Tang, P. H., Horn, P. S., Steele, P. E., Degrauw, A. J., Wong, B. L., and Bove, K. E. Systematic evaluation of muscle coenzyme Q10 content in children with mitochondrial respiratory chain enzyme deficiencies. Mitochondrion. 2008;8(2):170-180. View abstract.

44009            Murata, T., Ohtsuka, C., and Terayama, Y. Increased mitochondrial oxidative damage and oxidative DNA damage contributes to the neurodegenerative process in sporadic amyotrophic lateral sclerosis. Free Radic.Res 2008;42(3):221-225. View abstract.

44010            Bentinger, M., Tekle, M., Brismar, K., Chojnacki, T., Swiezewska, E., and Dallner, G. Polyisoprenoid epoxides stimulate the biosynthesis of coenzyme Q and inhibit cholesterol synthesis. J Biol.Chem 5-23-2008;283(21):14645-14653. View abstract.

44011            Montero, R., Sanchez-Alcazar, J. A., Briones, P., Hernandez, A. R., Cordero, M. D., Trevisson, E., Salviati, L., Pineda, M., Garcia-Cazorla, A., Navas, P., and Artuch, R. Analysis of coenzyme Q10 in muscle and fibroblasts for the diagnosis of CoQ10 deficiency syndromes. Clin Biochem. 2008;41(9):697-700. View abstract.

44012            LeWitt, P. A. and Taylor, D. C. Protection against Parkinson’s disease progression: clinical experience. Neurotherapeutics. 2008;5(2):210-225. View abstract.

44013            Balercia, G., Buldreghini, E., Vignini, A., Tiano, L., Paggi, F., Amoroso, S., Ricciardo-Lamonica, G., Boscaro, M., Lenzi, A., and Littarru, G. Coenzyme Q10 treatment in infertile men with idiopathic asthenozoospermia: a placebo-controlled, double-blind randomized trial. Fertil.Steril. 2009;91(5):1785-1792. View abstract.

44014            Menke, T. [Coenzyme q10 in childhood: detection methods, reference values and disease-related changes in the coenzyme q10 status]. Georgian.Med News 2008;(156):24-32. View abstract.

44015            Premkumar, V. G., Yuvaraj, S., Sathish, S., Shanthi, P., and Sachdanandam, P. Anti-angiogenic potential of CoenzymeQ10, riboflavin and niacin in breast cancer patients undergoing tamoxifen therapy. Vascul.Pharmacol. 2008;48(4-6):191-201. View abstract.

44016            van Dalen, E. C., Caron, H. N., Dickinson, H. O., and Kremer, L. C. Cardioprotective interventions for cancer patients receiving anthracyclines. Cochrane.Database.Syst.Rev. 2008;(2):CD003917. View abstract.

44017            Santa-Mara, I., Santpere, G., MacDonald, M. J., Gomez de, Barreda E., Hernandez, F., Moreno, F. J., Ferrer, I., and Avila, J. Coenzyme q induces tau aggregation, tau filaments, and Hirano bodies. J Neuropathol.Exp.Neurol. 2008;67(5):428-434. View abstract.

44018            Braun, B., Clarkson, P. M., Freedson, P. S., and Kohl, R. L. Effects of coenzyme Q10 supplementation on exercise performance, VO2max, and lipid peroxidation in trained cyclists. Int J Sport Nutr. 1991;1(4):353-365. View abstract.

44019            Voronkova, K. V. and Meleshkov, M. N. [Noben (idebenone) in the treatment of dementia and memory impairment without dementia]. Zh.Nevrol.Psikhiatr.Im S.S.Korsakova 2008;108(4):27-32. View abstract.

44020            Stamelou, M., Reuss, A., Pilatus, U., Magerkurth, J., Niklowitz, P., Eggert, K. M., Krisp, A., Menke, T., Schade-Brittinger, C., Oertel, W. H., and Hoglinger, G. U. Short-term effects of coenzyme Q10 in progressive supranuclear palsy: a randomized, placebo-controlled trial. Mov Disord. 5-15-2008;23(7):942-949. View abstract.

44021            Pepe, S., Leong, J. Y., Van der Merwe, J., Marasco, S. F., Hadj, A., Lymbury, R., Perkins, A., and Rosenfeldt, F. L. Targeting oxidative stress in surgery: effects of ageing and therapy. Exp.Gerontol. 2008;43(7):653-657. View abstract.

44022            Casarin, A., Jimenez-Ortega, J. C., Trevisson, E., Pertegato, V., Doimo, M., Ferrero-Gomez, M. L., Abbadi, S., Artuch, R., Quinzii, C., Hirano, M., Basso, G., Ocana, C. S., Navas, P., and Salviati, L. Functional characterization of human COQ4, a gene required for Coenzyme Q10 biosynthesis. Biochem.Biophys.Res Commun. 7-18-2008;372(1):35-39. View abstract.

44023            Chew, G. T., Watts, G. F., Davis, T. M., Stuckey, B. G., Beilin, L. J., Thompson, P. L., Burke, V., and Currie, P. J. Hemodynamic effects of fenofibrate and coenzyme Q10 in type 2 diabetic subjects with left ventricular diastolic dysfunction. Diabetes Care 2008;31(8):1502-1509. View abstract.

44024            Harinstein, M. E., Berliner, J. I., Shah, S. J., Taegtmeyer, H., and Gheorghiade, M. Normalization of ejection fraction and resolution of symptoms in chronic severe heart failure is possible with modern medical therapy: clinical observations in 11 patients. Am J Ther 2008;15(3):206-213. View abstract.

44025            Gille, L., Rosenau, T., Kozlov, A. V., and Gregor, W. Ubiquinone and tocopherol: dissimilar siblings. Biochem.Pharmacol 8-1-2008;76(3):289-302. View abstract.

44026            Gruber, J., Schaffer, S., and Halliwell, B. The mitochondrial free radical theory of ageing–where do we stand? Front Biosci 2008;13:6554-6579. View abstract.

44027            Sakata, T., Furuya, R., Shimazu, T., Odamaki, M., Ohkawa, S., and Kumagai, H. Coenzyme Q10 administration suppresses both oxidative and antioxidative markers in hemodialysis patients. Blood Purif. 2008;26(4):371-378. View abstract.

44028            Ravina, B., Romer, M., Constantinescu, R., Biglan, K., Brocht, A., Kieburtz, K., Shoulson, I., and McDermott, M. P. The relationship between CAG repeat length and clinical progression in Huntington’s disease. Mov Disord. 7-15-2008;23(9):1223-1227. View abstract.

44029            Laguna, T. A., Sontag, M. K., Osberg, I., Wagener, J. S., Accurso, F. J., and Sokol, R. J. Decreased total serum coenzyme-Q10 concentrations: a longitudinal study in children with cystic fibrosis. J Pediatr 2008;153(3):402-407. View abstract.

44030            Lekli, I., Das, S., Das, S., Mukherjee, S., Bak, I., Juhasz, B., Bagchi, D., Trimurtulu, G., Krishnaraju, A. V., Sengupta, K., Tosaki, A., and Das, D. K. Coenzyme Q9 provides cardioprotection after converting into coenzyme Q10. J Agric.Food Chem. 7-9-2008;56(13):5331-5337. View abstract.

44031            Sunamori, M., Tanaka, H., Maruyama, T., Sultan, I., Sakamoto, T., and Suzuki, A. Clinical experience of coenzyme Q10 to enhance intraoperative myocardial protection in coronary artery revascularization. Cardiovasc.Drugs Ther 1991;5 Suppl 2:297-300. View abstract.

44032            Belanger, M. C., Mirault, M. E., Dewailly, E., Berthiaume, L., and Julien, P. Environmental contaminants and redox status of coenzyme Q10 and vitamin E in Inuit from Nunavik. Metabolism 2008;57(7):927-933. View abstract.

44033            Wadsworth, T. L., Bishop, J. A., Pappu, A. S., Woltjer, R. L., and Quinn, J. F. Evaluation of coenzyme Q as an antioxidant strategy for Alzheimer’s disease. J Alzheimers.Dis 2008;14(2):225-234. View abstract.

44034            Montini, G., Malaventura, C., and Salviati, L. Early coenzyme Q10 supplementation in primary coenzyme Q10 deficiency. N.Engl.J Med 6-26-2008;358(26):2849-2850. View abstract.

44035            Schmitz-Hubsch, T. and Klockgether, T. An update on inherited ataxias. Curr Neurol.Neurosci.Rep. 2008;8(4):310-319. View abstract.

44036            Jimenez-Caballero, P. E., Mollejo-Villanueva, M., and Alvarez-Tejerina, A. [Mitochondrial encephalopathy due to complex I deficiency. Brain tissue biopsy findings and clinical course following pharmacological]. Rev.Neurol. 7-1-2008;47(1):27-30. View abstract.

44037            Zmitek, J., Smidovnik, A., Fir, M., Prosek, M., Zmitek, K., Walczak, J., and Pravst, I. Relative bioavailability of two forms of a novel water-soluble coenzyme Q10. Ann Nutr Metab 2008;52(4):281-287. View abstract.

44038            Tarnopolsky, M. A. The mitochondrial cocktail: rationale for combined nutraceutical therapy in mitochondrial cytopathies. Adv.Drug Deliv.Rev. 2008;60(13-14):1561-1567. View abstract.

44039            Miles, M. V., Tang, P. H., Miles, L., Steele, P. E., Moye, M. J., and Horn, P. S. Validation and application of an HPLC-EC method for analysis of coenzyme Q10 in blood platelets. Biomed.Chromatogr. 2008;22(12):1403-1408. View abstract.

44040            Tauler, P., Ferrer, M. D., Sureda, A., Pujol, P., Drobnic, F., Tur, J. A., and Pons, A. Supplementation with an antioxidant cocktail containing coenzyme Q prevents plasma oxidative damage induced by soccer. Eur J Appl.Physiol 2008;104(5):777-785. View abstract.

44041            Menke, T., Niklowitz, P., Wiesel, T., and Andler, W. Antioxidant level and redox status of coenzyme Q10 in the plasma and blood cells of children with diabetes mellitus type 1. Pediatr Diabetes 2008;9(6):540-545. View abstract.

44042            Keogh, A., Fenton, S., Leslie, C., Aboyoun, C., Macdonald, P., Zhao, Y. C., Bailey, M., and Rosenfeldt, F. Randomised double-blind, placebo-controlled trial of coenzyme Q, therapy in class II and III systolic heart failure. Heart Lung Circ. 2003;12(3):135-141. View abstract.

44043            Hatanaka, J., Kimura, Y., Lai-Fu, Z., Onoue, S., and Yamada, S. Physicochemical and pharmacokinetic characterization of water-soluble Coenzyme Q(10) formulations. Int J Pharm 11-3-2008;363(1-2):112-117. View abstract.

44044            Puizina-Ivic, N. Skin aging. Acta Dermatovenerol.Alp Panonica.Adriat. 2008;17(2):47-54. View abstract.

44045            Tonon, C. and Lodi, R. Idebenone in Friedreich’s ataxia. Expert.Opin.Pharmacother. 2008;9(13):2327-2337. View abstract.

44046            Esteves, A. R., Arduino, D. M., Swerdlow, R. H., Oliveira, C. R., and Cardoso, S. M. Oxidative stress involvement in alpha-synuclein oligomerization in Parkinson’s disease cybrids. Antioxid.Redox.Signal. 2009;11(3):439-448. View abstract.

44047            Bruno, C. and DiMauro, S. Lipid storage myopathies. Curr Opin.Neurol. 2008;21(5):601-606. View abstract.

44048            Hirayama, A., Kubo, H., Mita, M., Shirota, O., and Yamamoto, Y. High-sensitivity simultaneous analysis of ubiquinol-10 and ubiquinone-10 in human plasma. J Chromatogr.Sci 2008;46(8):717-721. View abstract.

44049            Zheng, A. and Moritani, T. Influence of CoQ10 on autonomic nervous activity and energy metabolism during exercise in healthy subjects. J Nutr Sci Vitaminol.(Tokyo) 2008;54(4):286-290. View abstract.

44050            Makhija, N., Sendasgupta, C., Kiran, U., Lakshmy, R., Hote, M. P., Choudhary, S. K., Airan, B., and Abraham, R. The role of oral coenzyme Q10 in patients undergoing coronary artery bypass graft surgery. J Cardiothorac.Vasc.Anesth. 2008;22(6):832-839. View abstract.

44051            Gregersen, N., Andresen, B. S., Pedersen, C. B., Olsen, R. K., Corydon, T. J., and Bross, P. Mitochondrial fatty acid oxidation defects–remaining challenges. J Inherit.Metab Dis 2008;31(5):643-657. View abstract.

44052            Hargreaves, I. P., Lane, A., and Sleiman, P. M. The coenzyme Q10 status of the brain regions of Parkinson’s disease patients. Neurosci.Lett. 12-5-2008;447(1):17-19. View abstract.

44053            Sawicka, E. and Dlugosz, A. Toluene and P-xylene mixture exerts antagonistic effect on lipid peroxidation in vitro. Int J Occup.Med Environ Health 2008;21(3):201-209. View abstract.

44054            Skough, K., Krossen, C., Heiwe, S., Theorell, H., and Borg, K. Effects of resistance training in combination with coenzyme Q10 supplementation in patients with post-polio: a pilot study. J Rehabil.Med 2008;40(9):773-775. View abstract.

44055            Lowes, D. A., Thottakam, B. M., Webster, N. R., Murphy, M. P., and Galley, H. F. The mitochondria-targeted antioxidant MitoQ protects against organ damage in a lipopolysaccharide-peptidoglycan model of sepsis. Free Radic.Biol.Med 12-1-2008;45(11):1559-1565. View abstract.

44056            Theodossiou, T. A., Papakyriakou, A., and Hothersall, J. S. Molecular modeling and experimental evidence for hypericin as a substrate for mitochondrial complex III; mitochondrial photodamage as demonstrated using specific inhibitors. Free Radic.Biol.Med 12-1-2008;45(11):1581-1590. View abstract.

44057            Mozaffarieh, M., Grieshaber, M. C., Orgul, S., and Flammer, J. The potential value of natural antioxidative treatment in glaucoma. Surv.Ophthalmol. 2008;53(5):479-505. View abstract.

44058            Henchcliffe, C. and Beal, M. F. Mitochondrial biology and oxidative stress in Parkinson disease pathogenesis. Nat.Clin Pract Neurol. 2008;4(11):600-609. View abstract.

44059            Molyneux, S. L., Florkowski, C. M., George, P. M., Pilbrow, A. P., Frampton, C. M., Lever, M., and Richards, A. M. Coenzyme Q10: an independent predictor of mortality in chronic heart failure. J Am Coll.Cardiol. 10-28-2008;52(18):1435-1441. View abstract.

44060            Horvath, R., Gorman, G., and Chinnery, P. F. How can we treat mitochondrial encephalomyopathies? Approaches to therapy. Neurotherapeutics. 2008;5(4):558-568. View abstract.

44061            Caramia, G., Cocchi, M., Tonello, L., and Visci, G. [Childhood obesity: recent advances and an experimental contribution]. Pediatr Med Chir 2008;30(3):121-140. View abstract.

44062            Cheng, B., Yuan, Q. P., Sun, X. X., and Li, W. J. Enhanced production of coenzyme Q10 by overexpressing HMG-CoA reductase and induction with arachidonic acid in Schizosaccharomyces pombe. Appl Biochem.Biotechnol. 2010;160(2):523-531. View abstract.

44063            Kharaeva, Z., Gostova, E., de, Luca C., Raskovic, D., and Korkina, L. Clinical and biochemical effects of coenzyme Q(10), vitamin E, and selenium supplementation to psoriasis patients. Nutrition 2009;25(3):295-302. View abstract.

44064            Cooper, J. M., Korlipara, L. V., Hart, P. E., Bradley, J. L., and Schapira, A. H. Coenzyme Q10 and vitamin E deficiency in Friedreich’s ataxia: predictor of efficacy of vitamin E and coenzyme Q10 therapy. Eur.J Neurol. 2008;15(12):1371-1379. View abstract.

44065            Wang, S. B., Weng, W. C., Lee, N. C., Hwu, W. L., Fan, P. C., and Lee, W. T. Mutation of mitochondrial DNA G13513A presenting with Leigh syndrome, Wolff-Parkinson-White syndrome and cardiomyopathy. Pediatr.Neonatol. 2008;49(4):145-149. View abstract.

44066            Qu, J., Kaufman, Y., and Washington, I. Coenzyme Q10 in the human retina. Invest Ophthalmol.Vis.Sci 2009;50(4):1814-1818. View abstract.

44067            Lee, T. I., Kao, Y. H., Chen, Y. C., and Chen, Y. J. Proinflammatory cytokine and ligands modulate cardiac peroxisome proliferator-activated receptors. Eur.J Clin Invest 2009;39(1):23-30. View abstract.

44068            Flattery, M. Herbal therapies and cardiac side effects. Prog.Cardiovasc.Nurs. 2008;23(4):187-190. View abstract.

44069            Smith, R. A., Adlam, V. J., Blaikie, F. H., Manas, A. R., Porteous, C. M., James, A. M., Ross, M. F., Logan, A., Cocheme, H. M., Trnka, J., Prime, T. A., Abakumova, I., Jones, B. A., Filipovska, A., and Murphy, M. P. Mitochondria-targeted antioxidants in the treatment of disease. Ann N.Y.Acad.Sci 2008;1147:105-111. View abstract.

44070            Chaturvedi, R. K. and Beal, M. F. Mitochondrial approaches for neuroprotection. Ann N.Y.Acad.Sci 2008;1147:395-412. View abstract.

44071            Acworth, I. N., Ullucci, P. A., and Gamache, P. H. Determination of oxidized and reduced CoQ10 and CoQ9 in human plasma/serum using HPLC-ECD. Methods Mol.Biol. 2008;477:245-258. View abstract.

44072            Montero, R., Sanchez-Alcazar, J. A., Briones, P., Navarro-Sastre, A., Gallardo, E., Bornstein, B., Herrero-Martin, D., Rivera, H., Martin, M. A., Marti, R., Garcia-Cazorla, A., Montoya, J., Navas, P., and Artuch, R. Coenzyme Q10 deficiency associated with a mitochondrial DNA depletion syndrome: a case report. Clin Biochem. 2009;42(7-8):742-745. View abstract.

44073            Crane, F. L. The evolution of coenzyme Q. Biofactors 2008;32(1-4):5-11. View abstract.

44074            Mukai, K., Tokunaga, A., Itoh, S., Kanesaki, Y., Ouchi, A., Ohara, K., Nagaoka, S., and Abe, K. Comparison between the free-radical-scavenging activities with vitamin E and ubiquinol in biological systems based on their reaction rates: a research account. Biofactors 2008;32(1-4):49-58. View abstract.

44075            Langsjoen, P. H. and Langsjoen, A. M. Supplemental ubiquinol in patients with advanced congestive heart failure. Biofactors 2008;32(1-4):119-128. View abstract.

44076            Adarsh, K., Kaur, H., and Mohan, V. Coenzyme Q10 (CoQ10) in isolated diastolic heart failure in hypertrophic cardiomyopathy (HCM). Biofactors 2008;32(1-4):145-149. View abstract.

44077            Teran, E., Chedraui, P., Racines-Orbe, M., Vivero, S., Villena, F., Duchicela, F., Nacevilla, L., Schwager, G., and Calle, A. Coenzyme Q10 levels in women with preeclampsia living at different altitudes. Biofactors 2008;32(1-4):185-190. View abstract.

44078            Hidaka, T., Fujii, K., Funahashi, I., Fukutomi, N., and Hosoe, K. Safety assessment of coenzyme Q10 (CoQ10). Biofactors 2008;32(1-4):199-208. View abstract.

44079            Nukui, K., Yamagishi, T., Miyawaki, H., Kettawan, A., Okamoto, T., Belardinelli, R., Tiano, L., Littarru, G. P., and Sato, K. Blood CoQ10 levels and safety profile after single-dose or chronic administration of PureSorb-Q40: animal and human studies. Biofactors 2008;32(1-4):209-219. View abstract.

44080            Morre, D. M., Morre, D. J., Rehmus, W., and Kern, D. Supplementation with CoQ10 lowers age-related (ar) NOX levels in healthy subjects. Biofactors 2008;32(1-4):221-230. View abstract.

44081            Morre, D. J. and Morre, D. M. arNOX activity of saliva as a non-invasive measure of coenzyme Q10 response in human trials. Biofactors 2008;32(1-4):231-235. View abstract.

44082            Inui, M., Ooe, M., Fujii, K., Matsunaka, H., Yoshida, M., and Ichihashi, M. Mechanisms of inhibitory effects of CoQ10 on UVB-induced wrinkle formation in vitro and in vivo. Biofactors 2008;32(1-4):237-243. View abstract.

44083            Prahl, S., Kueper, T., Biernoth, T., Wohrmann, Y., Munster, A., Furstenau, M., Schmidt, M., Schulze, C., Wittern, K. P., Wenck, H., Muhr, G. M., and Blatt, T. Aging skin is functionally anaerobic: importance of coenzyme Q10 for anti aging skin care. Biofactors 2008;32(1-4):245-255. View abstract.

44084            Haginoya, K., Miyabayashi, S., Kikuchi, M., Kojima, A., Yamamoto, K., Omura, K., Uematsu, M., Hino-Fukuyo, N., Tanaka, S., and Tsuchiya, S. Efficacy of idebenone for respiratory failure in a patient with Leigh syndrome: a long-term follow-up study. J Neurol.Sci 3-15-2009;278(1-2):112-114. View abstract.

44085            Rodriguez-Hernandez, A., Cordero, M. D., Salviati, L., Artuch, R., Pineda, M., Briones, P., Gomez, Izquierdo L., Cotan, D., Navas, P., and Sanchez-Alcazar, J. A. Coenzyme Q deficiency triggers mitochondria degradation by mitophagy. Autophagy. 1-1-2009;5(1):19-32. View abstract.

44086            Bodmer, M., Vankan, P., Dreier, M., Kutz, K. W., and Drewe, J. Pharmacokinetics and metabolism of idebenone in healthy male subjects. Eur J Clin Pharmacol. 2009;65(5):493-501. View abstract.

44087            Bergamin, C. S., Rolim, L. C., Dib, S. A., and Moises, R. S. Unusual occurrence of intestinal pseudo obstruction in a patient with maternally inherited diabetes and deafness (MIDD) and favorable outcome with coenzyme Q10. Arq Bras.Endocrinol Metabol. 2008;52(8):1345-1349. View abstract.

44088            Hamilton, S. J., Chew, G. T., and Watts, G. F. Coenzyme Q10 improves endothelial dysfunction in statin-treated type 2 diabetic patients. Diabetes Care 2009;32(5):810-812. View abstract.

44089            Lowes, D. A., Wallace, C., Murphy, M. P., Webster, N. R., and Galley, H. F. The mitochondria targeted antioxidant MitoQ protects against fluoroquinolone-induced oxidative stress and mitochondrial membrane damage in human Achilles tendon cells. Free Radic.Res 2009;43(4):323-328. View abstract.

44090            Dunn, S. P., Bleske, B., Dorsch, M., Macaulay, T., Van, Tassell B., and Vardeny, O. Nutrition and heart failure: impact of drug therapies and management strategies. Nutr Clin Pract 2009;24(1):60-75. View abstract.

44091            Rakoczi, K., Klivenyi, P., and Vecsei, L. [Neuroprotection in Parkinson's disease and other neurodegenerative disorders: preclinical and clinical findings]. Ideggyogy.Sz 1-30-2009;62(1-2):25-34. View abstract.

44092            Celik, T. and Iyisoy, A. Coenzyme Q10 and coronary artery bypass surgery: what we have learned from clinical trials. J Cardiothorac.Vasc.Anesth. 2009;23(6):935-936. View abstract.

44093            Kang, E. Y., Choi, J. W., Gwak, H. S., and Chun, I. K. Comparison of bioavailability of two ubidecarenone products in healthy Korean volunteers. Int J Clin Pharmacol Ther 2009;47(3):207-214. View abstract.

44094            Pandolfo, M. Introduction. Idebenone in the treatment of Friedreich ataxia. J Neurol. 2009;256 Suppl 1:1-2. View abstract.

44095            Meier, T. and Buyse, G. Idebenone: an emerging therapy for Friedreich ataxia. J Neurol. 2009;256 Suppl 1:25-30. View abstract.

44096            Kutz, K., Drewe, J., and Vankan, P. Pharmacokinetic properties and metabolism of idebenone. J Neurol. 2009;256 Suppl 1:31-35. View abstract.

44097            Schulz, J. B., Di Prospero, N. A., and Fischbeck, K. Clinical experience with high-dose idebenone in Friedreich ataxia. J Neurol. 2009;256 Suppl 1:42-45. View abstract.

44098            Liu, Z. X. and Artmann, C. Relative bioavailability comparison of different coenzyme Q10 formulations with a novel delivery system. Altern.Ther Health Med 2009;15(2):42-46. View abstract.

44099            Tsou, A. Y., Friedman, L. S., Wilson, R. B., and Lynch, D. R. Pharmacotherapy for Friedreich ataxia. CNS.Drugs 2009;23(3):213-223. View abstract.

44100            Reiter, M., Rupp, K., Baumeister, P., Zieger, S., and Harreus, U. Antioxidant effects of quercetin and coenzyme Q10 in mini organ cultures of human nasal mucosa cells. Anticancer Res 2009;29(1):33-39. View abstract.

44101            Rinaldi, C., Tucci, T., Maione, S., Giunta, A., De, Michele G., and Filla, A. Low-dose idebenone treatment in Friedreich’s ataxia with and without cardiac hypertrophy. J Neurol. 2009;256(9):1434-1437. View abstract.

44102            Duncan, A. J., Bitner-Glindzicz, M., Meunier, B., Costello, H., Hargreaves, I. P., Lopez, L. C., Hirano, M., Quinzii, C. M., Sadowski, M. I., Hardy, J., Singleton, A., Clayton, P. T., and Rahman, S. A nonsense mutation in COQ9 causes autosomal-recessive neonatal-onset primary coenzyme Q10 deficiency: a potentially treatable form of mitochondrial disease. Am J Hum Genet. 2009;84(5):558-566. View abstract.

44103            D’Andrea, G., Bussone, G., Allais, G., Aguggia, M., D’Onofrio, F., Maggio, M., Moschiano, F., Saracco, M. G., Terzi, M. G., Petretta, V., and Benedetto, C. Efficacy of Ginkgolide B in the prophylaxis of migraine with aura. Neurol.Sci 2009;30 Suppl 1:S121-S124. View abstract.

44104            Voronkova, K. V. and Meleshkov, M. N. Use of Noben (idebenone) in the treatment of dementia and memory impairments without dementia. Neurosci.Behav.Physiol 2009;39(5):501-506. View abstract.

44105            Plecita-Hlavata, L., Jezek, J., and Jezek, P. Pro-oxidant mitochondrial matrix-targeted ubiquinone MitoQ10 acts as anti-oxidant at retarded electron transport or proton pumping within Complex I. Int.J Biochem Cell Biol. 2009;41(8-9):1697-1707. View abstract.

44106            Junyaprasert, V. B., Teeranachaideekul, V., Souto, E. B., Boonme, P., and Muller, R. H. Q10-loaded NLC versus nanoemulsions: stability, rheology and in vitro skin permeation. Int.J Pharm. 7-30-2009;377(1-2):207-214. View abstract.

44107            Bolognesi, M. L., Matera, R., Minarini, A., Rosini, M., and Melchiorre, C. Alzheimer’s disease: new approaches to drug discovery. Curr Opin.Chem Biol. 2009;13(3):303-308. View abstract.

44108            Sinatra, S. T. Metabolic cardiology: an integrative strategy in the treatment of congestive heart failure. Altern.Ther Health Med. 2009;15(3):44-52. View abstract.

44109            Ramirez-Tortosa, M. C., Quiles, J. L., Battino, M., Granados, S., Morillo, J. M., Bompadre, S., Newman, H. N., and Bullon, P. Periodontitis is associated with altered plasma fatty acids and cardiovascular risk markers. Nutr Metab Cardiovasc.Dis 2010;20(2):133-139. View abstract.

44110            Balercia, G., Mancini, A., Paggi, F., Tiano, L., Pontecorvi, A., Boscaro, M., Lenzi, A., and Littarru, G. P. Coenzyme Q10 and male infertility. J Endocrinol Invest 2009;32(7):626-632. View abstract.

44111            Lucangioli, S., Sabrina, F., Mario, C., and Valeria, T. A capillary electrophoretic system based on a novel microemulsion for the analysis of coenzyme Q10 in human plasma by electrokinetic chromatography. Electrophoresis 2009;30(11):1899-1905. View abstract.

44112            Kaji, S., Murayama, K., Nagata, I., Nagasaka, H., Takayanagi, M., Ohtake, A., Iwasa, H., Nishiyama, M., Okazaki, Y., Harashima, H., Eitoku, T., Yamamoto, M., Matsushita, H., Kitamoto, K., Sakata, S., Katayama, T., Sugimoto, S., Fujimoto, Y., Murakami, J., Kanzaki, S., and Shiraki, K. Fluctuating liver functions in siblings with MPV17 mutations and possible improvement associated with dietary and pharmaceutical treatments targeting respiratory chain complex II. Mol.Genet.Metab 2009;97(4):292-296. View abstract.

44113            Gonzalez, R., Ferrin, G., Hidalgo, A. B., Ranchal, I., Lopez-Cillero, P., Santos-Gonzalez, M., Lopez-Lluch, G., Briceno, J., Gomez, M. A., Poyato, A., Villalba, J. M., Navas, P., de la Mata, M., and Muntane, J. N-acetylcysteine, coenzyme Q10 and superoxide dismutase mimetic prevent mitochondrial cell dysfunction and cell death induced by d-galactosamine in primary culture of human hepatocytes. Chem.Biol Interact. 9-14-2009;181(1):95-106. View abstract.

44114            El-ghoroury, E. A., Raslan, H. M., Badawy, E. A., El-Saaid, G. S., Agybi, M. H., Siam, I., and Salem, S. I. Malondialdehyde and coenzyme Q10 in platelets and serum in type 2 diabetes mellitus: correlation with glycemic control. Blood Coagul.Fibrinolysis 2009;20(4):248-251. View abstract.

44115            Udompataikul, M., Sripiroj, P., and Palungwachira, P. An oral nutraceutical containing antioxidants, minerals and glycosaminoglycans improves skin roughness and fine wrinkles. Int.J Cosmet.Sci 2009;31(6):427-435. View abstract.

44116            Ferrer, M. D., Tauler, P., Sureda, A., Pujol, P., Drobnic, F., Tur, J. A., and Pons, A. A soccer match’s ability to enhance lymphocyte capability to produce ROS and induce oxidative damage. Int.J Sport Nutr Exerc.Metab 2009;19(3):243-258. View abstract.

44117            Mestre, T., Ferreira, J., Coelho, M. M., Rosa, M., and Sampaio, C. Therapeutic interventions for disease progression in Huntington’s disease. Cochrane.Database.Syst.Rev. 2009;(3):CD006455. View abstract.

44118            Golomb, B. A., Kwon, E. K., Koperski, S., and Evans, M. A. Amyotrophic lateral sclerosis-like conditions in possible association with cholesterol-lowering drugs: an analysis of patient reports to the University of California, San Diego (UCSD) Statin Effects Study. Drug Saf 2009;32(8):649-661. View abstract.

44119            Parashos, S. A., Swearingen, C. J., Biglan, K. M., Bodis-Wollner, I., Liang, G. S., Ross, G. W., Tilley, B. C., and Shulman, L. M. Determinants of the timing of symptomatic treatment in early Parkinson disease: The National Institutes of Health Exploratory Trials in Parkinson Disease (NET-PD) Experience. Arch Neurol. 2009;66(9):1099-1104. View abstract.

44120            Scarlato, G., Bresolin, N., Moroni, I., Doriguzzi, C., Castelli, E., Comi, G., Angelini, C., and Carenzi, A. Multicenter trial with ubidecarenone: treatment of 44 patients with mitochondrial myopathies. Rev Neurol.(Paris) 1991;147(6-7):542-548. View abstract.

44121            Sikorska, M., Sandhu, J. K., Simon, D. K., Pathiraja, V., Sodja, C., Li, Y., Ribecco-Lutkiewicz, M., Lanthier, P., Borowy-Borowski, H., Upton, A., Raha, S., Pulst, S. M., and Tarnopolsky, M. A. Identification of ataxia-associated mtDNA mutations (m.4052T>C and m.9035T>C) and evaluation of their pathogenicity in transmitochondrial cybrids. Muscle Nerve 2009;40(3):381-394. View abstract.

44122            Gokbel, H., Gul, I., Belviranl, M., and Okudan, N. The effects of coenzyme Q10 supplementation on performance during repeated bouts of supramaximal exercise in sedentary men. J Strength Cond.Res 2010;24(1):97-102. View abstract.

44123            Shin, J. Y., Shin, J. I., Kim, J. S., Yang, Y. S., Hwang, Y., Yang, J. S., Shin, D., Seo, J. H., Jin, Y. S., Park, Y. C., Hwang, J. S., and Kweon, D. H. Assembly of Coenzyme Q10 nanostructure resembling nascent discoidal high density lipoprotein particle. Biochem.Biophys.Res Commun. 10-16-2009;388(2):217-221. View abstract.

44124            Sivitz, W. I. and Yorek, M. A. Mitochondrial dysfunction in diabetes: from molecular mechanisms to functional significance and therapeutic opportunities. Antioxid.Redox.Signal. 2010;12(4):537-577. View abstract.

44125            Xia, S., Xu, S., Zhang, X., Zhong, F., and Wang, Z. Nanoliposomes mediate coenzyme Q10 transport and accumulation across human intestinal Caco-2 cell monolayer. J Agric.Food Chem. 9-9-2009;57(17):7989-7996. View abstract.

44126            Orsucci, D., Filosto, M., Siciliano, G., and Mancuso, M. Electron transfer mediators and other metabolites and cofactors in the treatment of mitochondrial dysfunction. Nutr Rev. 2009;67(8):427-438. View abstract.

44127            Kocharian, A., Shabanian, R., Rafiei-Khorgami, M., Kiani, A., and Heidari-Bateni, G. Coenzyme Q10 improves diastolic function in children with idiopathic dilated cardiomyopathy. Cardiol.Young. 2009;19(5):501-506. View abstract.

44128            Mori, T. A., Burke, V., Puddey, I., Irish, A., Cowpland, C. A., Beilin, L., Dogra, G., and Watts, G. F. The effects of [omega]3 fatty acids and coenzyme Q10 on blood pressure and heart rate in chronic kidney disease: a randomized controlled trial. J Hypertens. 2009;27(9):1863-1872. View abstract.

44129            Lenaz, G. and Genova, M. L. Structural and functional organization of the mitochondrial respiratory chain: a dynamic super-assembly. Int.J Biochem Cell Biol. 2009;41(10):1750-1772. View abstract.

44130            Bentov, Y., Esfandiari, N., Burstein, E., and Casper, R. F. The use of mitochondrial nutrients to improve the outcome of infertility treatment in older patients. Fertil.Steril. 2010;93(1):272-275. View abstract.

44131            Kaufmann, P., Thompson, J. L., Levy, G., Buchsbaum, R., Shefner, J., Krivickas, L. S., Katz, J., Rollins, Y., Barohn, R. J., Jackson, C. E., Tiryaki, E., Lomen-Hoerth, C., Armon, C., Tandan, R., Rudnicki, S. A., Rezania, K., Sufit, R., Pestronk, A., Novella, S. P., Heiman-Patterson, T., Kasarskis, E. J., Pioro, E. P., Montes, J., Arbing, R., Vecchio, D., Barsdorf, A., Mitsumoto, H., and Levin, B. Phase II trial of CoQ10 for ALS finds insufficient evidence to justify phase III. Ann Neurol. 2009;66(2):235-244. View abstract.

44132            Abdul-Rasheed, O. F. and Farid, Y. Y. Development of a new high performance liquid chromatography method for measurement of coenzyme Q10 in healthy blood plasma. Saudi.Med J 2009;30(9):1138-1143. View abstract.

44133            Muta-Takada, K., Terada, T., Yamanishi, H., Ashida, Y., Inomata, S., Nishiyama, T., and Amano, S. Coenzyme Q10 protects against oxidative stress-induced cell death and enhances the synthesis of basement membrane components in dermal and epidermal cells. Biofactors 2009;35(5):435-441. View abstract.

44134            Sival, D. A., du Marchie Sarvaas, G. J., Brouwer, O. F., Uges, D. R., Verschuuren-Bemelmans, C. C., Maurits, N. M., Brunt, E. R., and van der Hoeven, J. H. Neurophysiological evaluation in children with Friedreich’s ataxia. Early Hum.Dev. 2009;85(10):647-651. View abstract.

44135            Patel, B. P. and Hamadeh, M. J. Nutritional and exercise-based interventions in the treatment of amyotrophic lateral sclerosis. Clin Nutr. 2009;28(6):604-617. View abstract.

44136            Isobe, C., Abe, T., and Terayama, Y. Levels of reduced and oxidized coenzyme Q-10 and 8-hydroxy-2′-deoxyguanosine in the CSF of patients with Alzheimer’s disease demonstrate that mitochondrial oxidative damage and/or oxidative DNA damage contributes to the neurodegenerative process. J Neurol. 2010;257(3):399-404. View abstract.

44137            Lee, D. S., Badr, M. S., and Mateika, J. H. Progressive augmentation and ventilatory long-term facilitation are enhanced in sleep apnoea patients and are mitigated by antioxidant administration. J Physiol 11-15-2009;587(Pt 22):5451-5467. View abstract.

44138            Kearney, M., Orrell, R. W., Fahey, M., and Pandolfo, M. Antioxidants and other pharmacological treatments for Friedreich ataxia. Cochrane Database Syst.Rev. 2009;(4):CD007791. View abstract.

44139            Jacobson, B. H., Smith, D. B., Warren, A. J., Glass, R. G., Kline, C., Fedick, J. L., and Stemm, J. Assessment of the effectiveness of a sublingual, ergogenic spray on muscle strength and power. J Strength Cond.Res 2009;23(8):2326-2330. View abstract.

44140            Yang, X., Dai, G., Li, G., and Yang, E. S. Coenzyme Q10 reduces beta-amyloid plaque in an APP/PS1 transgenic mouse model of Alzheimer’s disease. J Mol.Neurosci. 2010;41(1):110-113. View abstract.

44141            Soukoulis, V., Dihu, J. B., Sole, M., Anker, S. D., Cleland, J., Fonarow, G. C., Metra, M., Pasini, E., Strzelczyk, T., Taegtmeyer, H., and Gheorghiade, M. Micronutrient deficiencies an unmet need in heart failure. J Am Coll.Cardiol. 10-27-2009;54(18):1660-1673. View abstract.

44142            Azevedo, O., Vilarinho, L., Almeida, F., Ferreira, F., Guardado, J., Ferreira, M., Lourenco, A., Medeiros, R., and Almeida, J. Cardiomyopathy and kidney disease in a patient with maternally inherited diabetes and deafness caused by the 3243A>G mutation of mitochondrial DNA. Cardiology 2010;115(1):71-74. View abstract.

44143            Fetoni, A. R., Garzaro, M., Ralli, M., Landolfo, V., Sensini, M., Pecorari, G., Mordente, A., Paludetti, G., and Giordano, C. The monitoring role of otoacoustic emissions and oxidative stress markers in the protective effects of antioxidant administration in noise-exposed subjects: a pilot study. Med Sci Monit. 2009;15(11):R1-R8. View abstract.

44144            Chang, A. Y., Chan, J. Y., Chuang, Y. C., and Chan, S. H. Brain stem death as the vital determinant for resumption of spontaneous circulation after cardiac arrest in rats. PLoS.One. 2009;4(11):e7744. View abstract.

44145            Someya, S., Xu, J., Kondo, K., Ding, D., Salvi, R. J., Yamasoba, T., Rabinovitch, P. S., Weindruch, R., Leeuwenburgh, C., Tanokura, M., and Prolla, T. A. Age-related hearing loss in C57BL/6J mice is mediated by Bak-dependent mitochondrial apoptosis. Proc.Natl.Acad.Sci U.S.A 11-17-2009;106(46):19432-19437. View abstract.

44146            Isobe, C., Abe, T., and Terayama, Y. Increase in the oxidized/total coenzyme Q-10 ratio in the cerebrospinal fluid of Alzheimer’s disease patients. Dement.Geriatr.Cogn Disord. 2009;28(5):449-454. View abstract.

44147            Cuperus, R., Leen, R., Tytgat, G. A., Caron, H. N., and van Kuilenburg, A. B. Fenretinide induces mitochondrial ROS and inhibits the mitochondrial respiratory chain in neuroblastoma. Cell Mol.Life Sci 2010;67(5):807-816. View abstract.

44148            Isobe, C., Abe, T., and Terayama, Y. Levels of reduced and oxidized coenzyme Q-10 and 8-hydroxy-2′-deoxyguanosine in the cerebrospinal fluid of patients with living Parkinson’s disease demonstrate that mitochondrial oxidative damage and/or oxidative DNA damage contributes to the neurodegenerative process. Neurosci.Lett. 1-18-2010;469(1):159-163. View abstract.

44149            Sacconi, S., Trevisson, E., Salviati, L., Ayme, S., Rigal, O., Redondo, A. G., Mancuso, M., Siciliano, G., Tonin, P., Angelini, C., Aure, K., Lombes, A., and Desnuelle, C. Coenzyme Q10 is frequently reduced in muscle of patients with mitochondrial myopathy. Neuromuscul.Disord. 2010;20(1):44-48. View abstract.

44150            Molyneux, S. L., Florkowski, C. M., Richards, A. M., Lever, M., Young, J. M., and George, P. M. Coenzyme Q10; an adjunctive therapy for congestive heart failure? N.Z.Med J 10-30-2009;122(1305):74-79. View abstract.

44151            Stocker, R., Bowry, V. W., and Frei, B. Ubiquinol-10 protects human low density lipoprotein more efficiently against lipid peroxidation than does alpha-tocopherol. Proc Natl.Acad Sci U.S.A 3-1-1991;88(5):1646-1650. View abstract.

44152            Gonzalez-Rubio, S., Hidalgo, A. B., Ferrin, G., Bello, R. I., Gonzalez, R., Gahete, M. D., Ranchal, I., Rodriguez, B. A., Barrera, P., Aguilar-Melero, P., Linares, C. I., Castano, J. P., Victor, V. M., de la Mata, M., and Muntane, J. Mitochondrial-driven ubiquinone enhances extracellular calcium-dependent nitric oxide production and reduces glycochenodeoxycholic acid-induced cell death in hepatocytes. Chem Res Toxicol. 2009;22(12):1984-1991. View abstract.

44153            Kerr, D. S. Treatment of mitochondrial electron transport chain disorders: a review of clinical trials over the past decade. Mol.Genet.Metab 2010;99(3):246-255. View abstract.

44154            Beal, M. F. Therapeutic approaches to mitochondrial dysfunction in Parkinson’s disease. Parkinsonism.Relat Disord. 2009;15 Suppl 3:S189-S194. View abstract.

44155            Sun, H. Y. [Clinical study of Wenxikeli treatment of viral myocarditis]. Zhonghua Shi Yan.He.Lin.Chuang.Bing.Du Xue.Za Zhi. 2009;23(2):144-145. View abstract.

44156            Cordero, M. D., de, Miguel M., Moreno Fernandez, A. M., Carmona Lopez, I. M., Garrido, Maraver J., Cotan, D., Gomez, Izquierdo L., Bonal, P., Campa, F., Bullon, P., Navas, P., and Sanchez Alcazar, J. A. Mitochondrial dysfunction and mitophagy activation in blood mononuclear cells of fibromyalgia patients: implications in the pathogenesis of the disease. Arthritis Res Ther 2010;12(1):R17. View abstract.

44157            Minagawa, N., Uehara, M., Seki, S., Nitta, A., and Kogawara, K. [Effects of combined addition of atovaquone and lithium on the in vitro cell growth of the pathogenic yeast Candida albicans]. Yakugaku Zasshi 2010;130(2):247-251. View abstract.

44158            Roland, L., Gagne, A., Belanger, M. C., Boutet, M., Berthiaume, L., Fraser, W. D., Julien, P., and Bilodeau, J. F. Existence of compensatory defense mechanisms against oxidative stress and hypertension in preeclampsia. Hypertens.Pregnancy. 2010;29(1):21-37. View abstract.

44159            Hertz, N. and Lister, R. E. Improved survival in patients with end-stage cancer treated with coenzyme Q(10) and other antioxidants: a pilot study. J Int.Med Res 2009;37(6):1961-1971. View abstract.

44160            Brookman, R. H. and St Cyr, J. A. Metabolic supplementation with enhanced external counterpulsation improves myocardial function in acquired cardiomyopathy: a case report. J Altern.Complement Med 2010;16(3):323-325. View abstract.

44161            Thomas, B. and Beal, M. F. Mitochondrial therapies for Parkinson’s disease. Mov Disord. 2010;25 Suppl 1:S155-S160. View abstract.

44162            Cornelli, U. Treatment of Alzheimer’s disease with a cholinesterase inhibitor combined with antioxidants. Neurodegener.Dis 2010;7(1-3):193-202. View abstract.

44163            Lopes, C. M., Martins-Lopes, P., and Souto, E. B. Nanoparticulate carriers (NPC) for oral pharmaceutics and nutraceutics. Pharmazie 2010;65(2):75-82. View abstract.

44164            Franke, A. A., Morrison, C. M., Bakke, J. L., Custer, L. J., Li, X., and Cooney, R. V. Coenzyme Q10 in human blood: native levels and determinants of oxidation during processing and storage. Free Radic.Biol Med 6-15-2010;48(12):1610-1617. View abstract.

44165            Hauser, R. A. Early pharmacologic treatment in Parkinson’s disease. Am J Manag.Care 2010;16 Suppl Implications:S100-S107. View abstract.

44166            Chen, J. J. Parkinson’s disease: health-related quality of life, economic cost, and implications of early treatment. Am J Manag.Care 2010;16 Suppl Implications:S87-S93. View abstract.

44167            Cadoni, G., Scorpecci, A., Cianfrone, F., Giannantonio, S., Paludetti, G., and Lippa, S. Serum fatty acids and cardiovascular risk factors in sudden sensorineural hearing loss: a case-control study. Ann Otol.Rhinol.Laryngol. 2010;119(2):82-88. View abstract.

44168            Ozaki, A., Muromachi, A., Sumi, M., Sakai, Y., Morishita, K., and Okamoto, T. Emulsification of coenzyme Q10 using gum arabic increases bioavailability in rats and human and improves food-processing suitability. J Nutr Sci Vitaminol.(Tokyo) 2010;56(1):41-47. View abstract.

44169            Bessler, H., Bergman, M., Blumberger, N., Djaldetti, M., and Salman, H. Coenzyme Q10 decreases TNF-alpha and IL-2 secretion by human peripheral blood mononuclear cells. J Nutr Sci Vitaminol.(Tokyo) 2010;56(1):77-81. View abstract.

44170            Kernt, M., Hirneiss, C., Neubauer, A. S., Ulbig, M. W., and Kampik, A. Coenzyme Q10 prevents human lens epithelial cells from light-induced apoptotic cell death by reducing oxidative stress and stabilizing BAX / Bcl-2 ratio. Acta Ophthalmol. 2010;88(3):e78-e86. View abstract.

44171            Salami, A., Mora, R., Dellepiane, M., Manini, G., Santomauro, V., Barettini, L., and Guastini, L. Water-soluble coenzyme Q10 formulation (Q-TER((R))) in the treatment of presbycusis. Acta Otolaryngol. 2010;130(10):1154-1162. View abstract.

44172            Gane, E. J., Weilert, F., Orr, D. W., Keogh, G. F., Gibson, M., Lockhart, M. M., Frampton, C. M., Taylor, K. M., Smith, R. A., and Murphy, M. P. The mitochondria-targeted anti-oxidant mitoquinone decreases liver damage in a phase II study of hepatitis C patients. Liver Int. 2010;30(7):1019-1026. View abstract.

44173            Pardeike, J., Schwabe, K., and Muller, R. H. Influence of nanostructured lipid carriers (NLC) on the physical properties of the Cutanova Nanorepair Q10 cream and the in vivo skin hydration effect. Int.J Pharm. 8-30-2010;396(1-2):166-173. View abstract.

44174            Gerards, M., van den Bosch, B., Calis, C., Schoonderwoerd, K., van, Engelen K., Tijssen, M., de, Coo R., van der Kooi, A., and Smeets, H. Nonsense mutations in CABC1/ADCK3 cause progressive cerebellar ataxia and atrophy. Mitochondrion. 2010;10(5):510-515. View abstract.

44175            Drinkard, B. E., Keyser, R. E., Paul, S. M., Arena, R., Plehn, J. F., Yanovski, J. A., and Di Prospero, N. A. Exercise capacity and idebenone intervention in children and adolescents with Friedreich ataxia. Arch Phys.Med Rehabil. 2010;91(7):1044-1050. View abstract.

44176            Cordero, M. D., Moreno-Fernandez, A. M., Carmona-Lopez, M. I., Sanchez-Alcazar, J. A., Rodriguez, A. F., Navas, P., and de, Miguel M. Mitochondrial dysfunction in skin biopsies and blood mononuclear cells from two cases of fibromyalgia patients. Clin Biochem 2010;43(13-14):1174-1176. View abstract.

44177            Pineda, M., Montero, R., Aracil, A., O’Callaghan, M. M., Mas, A., Espinos, C., Martinez-Rubio, D., Palau, F., Navas, P., Briones, P., and Artuch, R. Coenzyme Q(10)-responsive ataxia: 2-year-treatment follow-up. Mov Disord. 7-15-2010;25(9):1262-1268. View abstract.

44178            Belcaro, G., Cesarone, M. R., Dugall, M., Hosoi, M., Ippolito, E., Bavera, P., and Grossi, M. G. Investigation of Pycnogenol(R) in combination with coenzymeQ10 in heart failure patients (NYHA II/III). Panminerva Med 2010;52(2 Suppl 1):21-25. View abstract.

44179            Lynch, D. R., Perlman, S. L., and Meier, T. A phase 3, double-blind, placebo-controlled trial of idebenone in friedreich ataxia. Arch Neurol. 2010;67(8):941-947. View abstract.

44180            Safarinejad, M. R. Safety and efficacy of coenzyme Q10 supplementation in early chronic Peyronie’s disease: a double-blind, placebo-controlled randomized study. Int J Impot.Res 2010;22(5):298-309. View abstract.

44181            Esposito, M. and Carotenuto, M. Ginkgolide B complex efficacy for brief prophylaxis of migraine in school-aged children: an open-label study. Neurol.Sci 9-25-2010; View abstract.

44182            Glover, E. I., Martin, J., Maher, A., Thornhill, R. E., Moran, G. R., and Tarnopolsky, M. A. A randomized trial of coenzyme Q10 in mitochondrial disorders. Muscle Nerve 2010;42(5):739-748. View abstract.

44183            Sagel, S. D., Sontag, M. K., Anthony, M. M., Emmett, P., and Papas, K. A. Effect of an antioxidant-rich multivitamin supplement in cystic fibrosis. J Cyst.Fibros. 10-18-2010; View abstract.

44184            Guastini, L., Mora, R., Dellepiane, M., Santomauro, V., Giorgio, M., and Salami, A. Water-soluble coenzyme Q10 formulation in presbycusis: long-term effects. Acta Otolaryngol. 2011;131(5):512-517. View abstract.

44185            Ahn, J. H., Yoo, M. H., Lee, H. J., Chung, J. W., and Yoon, T. H. Coenzyme Q10 in combination with steroid therapy for treatment of sudden sensorineural hearing loss: a controlled prospective study. Clin Otolaryngol. 2010;35(6):486-489. View abstract.

44186            Barker, P. D. Reduced G tolerance associated with supplement use. Aviat.Space Environ.Med 2011;82(2):140-143. View abstract.

44187            Shojaei, M., Djalali, M., Khatami, M., Siassi, F., and Eshraghian, M. Effects of carnitine and coenzyme Q10 on lipid profile and serum levels of lipoprotein(a) in maintenance hemodialysis patients on statin therapy. Iran J Kidney Dis 2011;5(2):114-118. View abstract.

44188            Dai, Y. L., Luk, T. H., Yiu, K. H., Wang, M., Yip, P. M., Lee, S. W., Li, S. W., Tam, S., Fong, B., Lau, C. P., Siu, C. W., and Tse, H. F. Reversal of mitochondrial dysfunction by coenzyme Q10 supplement improves endothelial function in patients with ischaemic left ventricular systolic dysfunction: a randomized controlled trial. Atherosclerosis 2011;216(2):395-401. View abstract.

44189            Lagedrost, S. J., Sutton, M. S., Cohen, M. S., Satou, G. M., Kaufman, B. D., Perlman, S. L., Rummey, C., Meier, T., and Lynch, D. R. Idebenone in Friedreich ataxia cardiomyopathy-results from a 6-month phase III study (IONIA). Am Heart J 2011;161(3):639-645. View abstract.

44190            Nadjarzadeh, A., Sadeghi, M. R., Amirjannati, N., Vafa, M. R., Motevalian, S. A., Gohari, M. R., Akhondi, M. A., Yavari, P., and Shidfar, F. Coenzyme Q10 improves seminal oxidative defense but does not affect on semen parameters in idiopathic oligoasthenoteratozoospermia: a randomized double-blind, placebo controlled trial. J Endocrinol.Invest 2011;34(8):e224-e228. View abstract.

44191            Ryo, K., Ito, A., Takatori, R., Tai, Y., Arikawa, K., Seido, T., Yamada, T., Shinpo, K., Tamaki, Y., Fujii, K., Yamamoto, Y., and Saito, I. Effects of coenzyme Q10 on salivary secretion. Clin Biochem 2011;44(8-9):669-674. View abstract.

44192            Buyse, G. M., Goemans, N., van den Hauwe, M., Thijs, D., de Groot, I. J., Schara, U., Ceulemans, B., Meier, T., and Mertens, L. Idebenone as a novel, therapeutic approach for Duchenne muscular dystrophy: results from a 12 month, double-blind, randomized placebo-controlled trial. Neuromuscul.Disord. 2011;21(6):396-405. View abstract.

44193            Fumagalli, S., Fattirolli, F., Guarducci, L., Cellai, T., Baldasseroni, S., Tarantini, F., Di, Bari M., Masotti, G., and Marchionni, N. Coenzyme Q10 terclatrate and creatine in chronic heart failure: a randomized, placebo-controlled, double-blind study. Clin Cardiol. 2011;34(4):211-217. View abstract.

44194            Cooney, R. V., Dai, Q., Gao, Y. T., Chow, W. H., Franke, A. A., Shu, X. O., Li, H., Ji, B., Cai, Q., Chai, W., and Zheng, W. Low plasma coenzyme Q(10) levels and breast cancer risk in Chinese women. Cancer Epidemiol Biomarkers Prev. 2011;20(6):1124-1130. View abstract.

44195            Cordero, M. D., Alcocer-Gomez, E., de, Miguel M., Cano-Garcia, F. J., Luque, C. M., Fernandez-Riejo, P., Fernandez, A. M., and Sanchez-Alcazar, J. A. Coenzyme Q(10): a novel therapeutic approach for Fibromyalgia? case series with 5 patients. Mitochondrion. 2011;11(4):623-625. View abstract.

44196            Lekoubou, A., Kouame-Assouan, A. E., Cho, T. H., Luaute, J., Nighoghossian, N., and Derex, L. Effect of long-term oral treatment with L-arginine and idebenone on the prevention of stroke-like episodes in an adult MELAS patient. Rev.Neurol.(Paris) 2011;167(11):852-855. View abstract.

44197            Slater, S. K., Nelson, T. D., Kabbouche, M. A., Lecates, S. L., Horn, P., Segers, A., Manning, P., Powers, S. W., and Hershey, A. D. A randomized, double-blinded, placebo-controlled, crossover, add-on study of CoEnzyme Q10 in the prevention of pediatric and adolescent migraine. Cephalalgia 2011;31(8):897-905. View abstract.

44198            van Dalen, E. C., Caron, H. N., Dickinson, H. O., and Kremer, L. C. Cardioprotective interventions for cancer patients receiving anthracyclines. Cochrane.Database.Syst.Rev. 2011;(6):CD003917. View abstract.

44199            Gul, I., Gokbel, H., Belviranli, M., Okudan, N., Buyukbas, S., and Basarali, K. Oxidative stress and antioxidant defense in plasma after repeated bouts of supramaximal exercise: the effect of coenzyme Q10. J Sports Med Phys.Fitness 2011;51(2):305-312. View abstract.

44200            Shilov, A. M., Mel’nik, M. V., Voevodina, E. S., Osiia, A. O., and Griaznov, D. A. [Prophylaxis of ischemic heart lesions during chronic heart failure with complex therapy using Q10 coenzyme]. Anesteziol.Reanimatol. 2011;(2):34-38. View abstract.

44201            Spurney, C. F., Rocha, C. T., Henricson, E., Florence, J., Mayhew, J., Gorni, K., Pasquali, L., Pestronk, A., Martin, G. R., Hu, F., Nie, L., Connolly, A. M., and Escolar, D. M. CINRG pilot trial of coenzyme Q10 in steroid-treated Duchenne muscular dystrophy. Muscle Nerve 2011;44(2):174-178. View abstract.

44202            Patchett, D. C. and Grover, M. L. Mitochondrial myopathy presenting as rhabdomyolysis. J Am Osteopath.Assoc. 2011;111(6):404-405. View abstract.

44203            Meier, T., Perlman, S. L., Rummey, C., Coppard, N. J., and Lynch, D. R. Assessment of neurological efficacy of idebenone in pediatric patients with Friedreich’s ataxia: data from a 6-month controlled study followed by a 12-month open-label extension study. J Neurol. 2012;259(2):284-291. View abstract.

44204            Klopstock, T., Yu-Wai-Man, P., Dimitriadis, K., Rouleau, J., Heck, S., Bailie, M., Atawan, A., Chattopadhyay, S., Schubert, M., Garip, A., Kernt, M., Petraki, D., Rummey, C., Leinonen, M., Metz, G., Griffiths, P. G., Meier, T., and Chinnery, P. F. A randomized placebo-controlled trial of idebenone in Leber’s hereditary optic neuropathy. Brain 2011;134(Pt 9):2677-2686. View abstract.

44205            Tang, K. F., Xing, Y., Wu, C. Y., Liu, R. Z., Wang, X. Y., and Xing, J. P. [Tamoxifen combined with coenzyme Q10 for idiopathic oligoasthenospermia]. Zhonghua Nan.Ke.Xue. 2011;17(7):615-618. View abstract.

44206            Traber, G., Baumgartner, M. R., Schwarz, U., Pangalu, A., Donath, M. Y., and Landau, K. Subacute bilateral visual loss in methylmalonic acidemia. J Neuroophthalmol. 2011;31(4):344-346. View abstract.

44207            Mikhin, V. P., Kharchenko, A. V., Rosliakova, E. A., and Cherniatina, M. A. [Application of coenzyme Q(10) in combination therapy of arterial hypertension]. Kardiologiia. 2011;51(6):26-31. View abstract.

44208            Sieswerda, E., van Dalen, E. C., Postma, A., Cheuk, D. K., Caron, H. N., and Kremer, L. C. Medical interventions for treating anthracycline-induced symptomatic and asymptomatic cardiotoxicity during and after treatment for childhood cancer. Cochrane Database Syst.Rev. 2011;(9):CD008011. View abstract.

44209            Simonenko, V. B., Stepaniants, O. S., and Teslia, A. N. [Myocardial cytoprotectors, a reserve therapeutic modality for patients with stable angina of effort]. Klin.Med (Mosk) 2011;89(4):34-36. View abstract.

44210            Lee, B. J., Huang, Y. C., Chen, S. J., and Lin, P. T. Coenzyme Q10 supplementation reduces oxidative stress and increases antioxidant enzyme activity in patients with coronary artery disease. Nutrition 2012;28(3):250-255. View abstract.

44211            Young, J. M., Florkowski, C. M., Molyneux, S. L., McEwan, R. G., Frampton, C. M., Nicholls, M. G., Scott, R. S., and George, P. M. A randomized, double-blind, placebo-controlled crossover study of coenzyme Q10 therapy in hypertensive patients with the metabolic syndrome. Am J Hypertens. 2012;25(2):261-270. View abstract.

44212            Liu, J., Wang, L., Zhan, S. Y., and Xia, Y. Coenzyme Q10 for Parkinson’s disease. Cochrane Database Syst.Rev. 2011;(12):CD008150. View abstract.

44213            Young, J. M., Molyneux, S. L., Florkowski, C. M., Frampton, C. M., George, P. M., and Scott, R. S. Pharmacokinetic comparison of a generic coenzyme Q(1)(0) solubilizate and a formulation with soybean phytosterols. Phytother.Res. 2012;26(7):1092-1096. View abstract.

44214            Lee, B. J., Huang, Y. C., Chen, S. J., and Lin, P. T. Effects of coenzyme Q10 supplementation on inflammatory markers (high-sensitivity C-reactive protein, interleukin-6, and homocysteine) in patients with coronary artery disease. Nutrition 2012;28(7-8):767-772. View abstract.

44215            Kearney, M., Orrell, R. W., Fahey, M., and Pandolfo, M. Antioxidants and other pharmacological treatments for Friedreich ataxia. Cochrane Database Syst.Rev. 2012;4:CD007791. View abstract.

44216            Mischley, L. K., Allen, J., and Bradley, R. Coenzyme Q10 deficiency in patients with Parkinson’s disease. J.Neurol.Sci. 7-15-2012;318(1-2):72-75. View abstract.

44217            Hernandez-Ojeda, J., Cardona-Munoz, E. G., Roman-Pintos, L. M., Troyo-Sanroman, R., Ortiz-Lazareno, P. C., Cardenas-Meza, M. A., Pascoe-Gonzalez, S., and Miranda-Diaz, A. G. The effect of ubiquinone in diabetic polyneuropathy: a randomized double-blind placebo-controlled study. J.Diabetes Complications 2012;26(4):352-358. View abstract.

44218            Bookstaver, D. A., Burkhalter, N. A., and Hatzigeorgiou, C. Effect of coenzyme Q10 supplementation on statin-induced myalgias. Am.J.Cardiol. 8-15-2012;110(4):526-529. View abstract.

44219            Cyrus-Hajmassy, M. [Bilateral visual deterioration in excessive tobacco and alcohol consumption]. Ophthalmologe 2012;109(9):901-906. View abstract.

44220            Mortensen, S. A., Vadhanavikit, S., Muratsu, K., and Folkers, K. Coenzyme Q10: clinical benefits with biochemical correlates suggesting a scientific breakthrough in the management of chronic heart failure. Int J Tissue React. 1990;12(3):155-162. View abstract.

44221            Langsjoen, P. H., Folkers, K., Lyson, K., Muratsu, K., Lyson, T., and Langsjoen, P. Pronounced increase of survival of patients with cardiomyopathy when treated with coenzyme Q10 and conventional therapy. Int J Tissue React. 1990;12(3):163-168. View abstract.

44222            Langsjoen, P. H., Langsjoen, P. H., and Folkers, K. A six-year clinical study of therapy of cardiomyopathy with coenzyme Q10. Int J Tissue React. 1990;12(3):169-171. View abstract.

44223            Manzoli, U., Rossi, E., Littarru, G. P., Frustaci, A., Lippa, S., Oradei, A., and Aureli, V. Coenzyme Q10 in dilated cardiomyopathy. Int J Tissue React. 1990;12(3):173-178. View abstract.

44224            Armstrong, M. J. and Miyasaki, J. M. Evidence-based guideline: pharmacologic treatment of chorea in Huntington disease: report of the guideline development subcommittee of the American Academy of Neurology. Neurology 8-7-2012;79(6):597-603. View abstract.

44225            Larijani, V. N., Ahmadi, N., Zeb, I., Khan, F., Flores, F., and Budoff, M. Beneficial effects of aged garlic extract and coenzyme Q10 on vascular elasticity and endothelial function: the FAITH randomized clinical trial. Nutrition 2013;29(1):71-75. View abstract.

44226            Cordero, M. D., Cotan, D., del-Pozo-Martin, Y., Carrion, A. M., de, Miguel M., Bullon, P., and Sanchez-Alcazar, J. A. Oral coenzyme Q10 supplementation improves clinical symptoms and recovers pathologic alterations in blood mononuclear cells in a fibromyalgia patient. Nutrition 2012;28(11-12):1200-1203. View abstract.

44227            Bloomer, R. J., Canale, R. E., McCarthy, C. G., and Farney, T. M. Impact of oral ubiquinol on blood oxidative stress and exercise performance. Oxid.Med.Cell Longev. 2012;2012:465020. View abstract.

44228            Fogagnolo, P., Sacchi, M., Ceresara, G., Paderni, R., Lapadula, P., Orzalesi, N., and Rossetti, L. The effects of topical coenzyme Q10 and vitamin E D-alpha-tocopheryl polyethylene glycol 1000 succinate after cataract surgery: a clinical and in vivo confocal study. Ophthalmologica 2013;229(1):26-31. View abstract.

44229            Stacpoole, P. W., DeGrauw, T. J., Feigenbaum, A. S., Hoppel, C., Kerr, D. S., McCandless, S. E., Miles, M. V., Robinson, B. H., and Tang, P. H. Design and implementation of the first randomized controlled trial of coenzyme CoQ(1)(0) in children with primary mitochondrial diseases. Mitochondrion. 2012;12(6):623-629. View abstract.

44230            Kato, T., Yoneda, S., Kako, T., Koketsu, M., Hayano, I., and Fujinami, T. Reduction in blood viscosity by treatment with coenzyme Q10 in patients with ischemic heart disease. Int J Clin Pharmacol Ther.Toxicol 1990;28(3):123-126. View abstract.

44231            Busetto, G. M., Koverech, A., Messano, M., Antonini, G., De, Berardinis E., and Gentile, V. Prospective open-label study on the efficacy and tolerability of a combination of nutritional supplements in primary infertile patients with idiopathic astenoteratozoospermia. Arch.Ital.Urol.Androl 2012;84(3):137-140. View abstract.

44232            Fotino, A. D., Thompson-Paul, A. M., and Bazzano, L. A. Effect of coenzyme Q(1)(0) supplementation on heart failure: a meta-analysis. Am.J.Clin.Nutr. 2013;97(2):268-275. View abstract.

44233            Deichmann, R. E., Lavie, C. J., and Dornelles, A. C. Impact of coenzyme Q-10 on parameters of cardiorespiratory fitness and muscle performance in older athletes taking statins. Phys.Sportsmed. 2012;40(4):88-95. View abstract.

44234            Barboni, P., Valentino, M. L., La, Morgia C., Carbonelli, M., Savini, G., De, Negri A., Simonelli, F., Sadun, F., Caporali, L., Maresca, A., Liguori, R., Baruzzi, A., Zeviani, M., and Carelli, V. Idebenone treatment in patients with OPA1-mutant dominant optic atrophy. Brain 2013;136(Pt 2):e231. View abstract.

44235            Klopstock, T., Metz, G., Yu-Wai-Man, P., Buchner, B., Gallenmuller, C., Bailie, M., Nwali, N., Griffiths, P. G., von, Livonius B., Reznicek, L., Rouleau, J., Coppard, N., Meier, T., and Chinnery, P. F. Persistence of the treatment effect of idebenone in Leber’s hereditary optic neuropathy. Brain 2013;136(Pt 2):e230. View abstract.

44236            Desnuelle, C., Pellissier, J. F., Serratrice, G., Pouget, J., and Turnbull, D. M. [Kearns-Sayre syndrome: mitochondrial encephalomyopathy caused by deficiency of the respiratory chain]. Rev Neurol (Paris) 1989;145(12):842-850. View abstract.

44237            Langsjoen, P. H., Folkers, K., Lyson, K., Muratsu, K., Lyson, T., and Langsjoen, P. Effective and safe therapy with coenzyme Q10 for cardiomyopathy. Klin Wochenschr 7-1-1988;66(13):583-590. View abstract.

44238            Karlsson, J., Sylven, C., Jansson, E., Book, K., Muratsu, K., and Folkers, K. Coenzyme Q10 and key enzyme activities in papillary muscle related to left ventricle function in mitral valve disease. Mol.Cell Biochem 1988;84(1):59-64. View abstract.

44239            Bresolin, N., Bet, L., Ferrante, C., Binda, A., Carenzi, A., Moggio, M., Comi, G., and Scarlato, G. Immunological and biochemical studies and pilot therapeutic trial with ubidecarenone in Kearns-Sayre patients. Adv Neurol 1988;48:239-256. View abstract.

44240            Bresolin, N., Bet, L., Binda, A., Moggio, M., Comi, G., Nador, F., Ferrante, C., Carenzi, A., and Scarlato, G. Clinical and biochemical correlations in mitochondrial myopathies treated with coenzyme Q10. Neurology 1988;38(6):892-899. View abstract.

44241            Ghiringhelli, G. [Therapy with ubidecarenone in various cardiopathies with and without decompensation. Comparison with a standard therapy]. Boll.Chim.Farm. 1986;125(3):28S-33S. View abstract.

44242            Tomono, Y., Hasegawa, J., Seki, T., Motegi, K., and Morishita, N. Pharmacokinetic study of deuterium-labelled coenzyme Q10 in man. Int J Clin Pharmacol Ther.Toxicol 1986;24(10):536-541. View abstract.

44243            Goda, S., Hamada, T., Ishimoto, S., Kobayashi, T., Goto, I., and Kuroiwa, Y. Clinical improvement after administration of coenzyme Q10 in a patient with mitochondrial encephalomyopathy. J Neurol. 1987;234(1):62-63. View abstract.

44244            Folkers, K. and Wolaniuk, A. Research on coenzyme Q10 in clinical medicine and in immunomodulation. Drugs Exp.Clin Res 1985;11(8):539-545. View abstract.

44245            Oda, T. Effect of coenzyme Q10 on stress-induced cardiac dysfunction in paediatric patients with mitral valve prolapse: a study by stress echocardiography. Drugs Exp.Clin Res 1985;11(8):557-576. View abstract.

44246            Langsjoen, P. H., Vadhanavikit, S., and Folkers, K. Effective treatment with coenzyme Q10 of patients with chronic myocardial disease. Drugs Exp.Clin Res 1985;11(8):577-579. View abstract.

44247            Mortensen, S. A., Vadhanavikit, S., Baandrup, U., and Folkers, K. Long-term coenzyme Q10 therapy: a major advance in the management of resistant myocardial failure. Drugs Exp.Clin Res 1985;11(8):581-593. View abstract.

44248            Folkers, K., Vadhanavikit, S., and Mortensen, S. A. Biochemical rationale and myocardial tissue data on the effective therapy of cardiomyopathy with coenzyme Q10. Proc Natl.Acad Sci U.S.A 1985;82(3):901-904. View abstract.

44249            Langsjoen, P. H., Vadhanavikit, S., and Folkers, K. Response of patients in classes III and IV of cardiomyopathy to therapy in a blind and crossover trial with coenzyme Q10. Proc.Natl.Acad.Sci U.S.A 1985;82(12):4240-4244. View abstract.

44250            Folkers, K., Wolaniuk, J., Simonsen, R., Morishita, M., and Vadhanavikit, S. Biochemical rationale and the cardiac response of patients with muscle disease to therapy with coenzyme Q10. Proc.Natl.Acad.Sci U.S.A 1985;82(13):4513-4516. View abstract.

44251            Ogasahara, S., Nishikawa, Y., Yorifuji, S., Soga, F., Nakamura, Y., Takahashi, M., Hashimoto, S., Kono, N., and Tarui, S. Treatment of Kearns-Sayre syndrome with coenzyme Q10. Neurology 1986;36(1):45-53. View abstract.

44252            Ogasahara, S., Yorifuji, S., Nishikawa, Y., Takahashi, M., Wada, K., Hazama, T., Nakamura, Y., Hashimoto, S., Kono, N., and Tarui, S. Improvement of abnormal pyruvate metabolism and cardiac conduction defect with coenzyme Q10 in Kearns-Sayre syndrome. Neurology 1985;35(3):372-377. View abstract.

44253            Gini, M., Schiavi, M., and Mazzola, C. [Ubidecarenone (coenzyme Q10) in the therapy of chronic cor pulmonale]. Boll.Chim.Farm. 1985;124(4):21S-28S. View abstract.

44254            Okamoto, T., Fukui, K., Nakamoto, M., Kishi, T., Okishio, T., Yamagami, T., Kanamori, N., Kishi, H., and Hiraoka, E. High-performance liquid chromatography of coenzyme Q-related compounds and its application to biological materials. J Chromatogr. 7-12-1985;342(1):35-46. View abstract.

44255            Barkworth, M. F., Dyde, C. J., Johnson, K. I., and Schnelle, K. An early phase I study to determine the tolerance, safety and pharmacokinetics of idebenone following multiple oral doses. Arzneimittelforschung 1985;35(11):1704-1707. View abstract.

44256            Matsumura, T., Saji, S., Nakamura, R., and Folkers, K. Evidence for enhanced treatment of periodontal disease by therapy with coenzyme Q. Int J Vitam.Nutr Res 1973;43(4):537-548. View abstract.

44257            Littarru, G. P., Nakamura, R., Ho, L., Folkers, K., and Kuzell, W. C. Deficiency of coenzyme Q 10 in gingival tissue from patients with periodontal disease. Proc.Natl.Acad.Sci U.S.A 1971;68(10):2332-2335. View abstract.

44258            Redfearn, E. R. Mode of action of ubiquinones (coenzymes Q) in electron transport systems. Vitam Horm 1966;24:465-488. View abstract.

44259            Okuyama, S. and Mishina, H. Principia of cancer therapy. VI. Application of ubiquinone ointment for intractable radiation ulcers: an expanded cytochrome C effect? Sci Rep.Res Inst.Tohoku Univ [Med] 1983;30(1-4):36-39. View abstract.

44260            Okamura, T., Sunamori, M., Amano, J., Hirooka, Y., Ozeki, M., Tanaka, A., and Suzuki, A. Combined treatment of coenzyme Q10 and aprotinin with intraaortic balloon pumping following aorto-coronary bypass surgery. Jpn.J Surg 1984;14(2):97-103. View abstract.

44261            Ishihara, Y., Uchida, Y., Kitamura, S., and Takaku, F. [Effect of coenzyme Q10 on guinea pig trachea and lung]. Nihon Kyobu Shikkan Gakkai Zasshi 1984;22(4):249-254. View abstract.

44262            Tajima, M. [Chronic cardiotoxicity of anthracycline derivatives and possible prevention by coenzyme Q10]. Gan No Rinsho 1984;30(9 Suppl):1211-1216. View abstract.

44263            Oda, T. and Hamamoto, K. Effect of coenzyme Q10 on the stress-induced decrease of cardiac performance in pediatric patients with mitral valve prolapse. Jpn.Circ.J 1984;48(12):1387. View abstract.

44264            Suzuki, H., Naitoh, T., Kuniyoshi, S., Banba, N., Kuroda, H., Suzuki, Y., Hiraiwa, M., Yamazaki, N., Ishikawa, M., Hashigami, Y., and . Cardiac performance and coenzyme Q10 in thyroid disorders. Endocrinol Jpn. 1984;31(6):755-761. View abstract.

44265            Cortes, E. P., Gupta, M., Chou, C., Amin, V. C., and Folkers, K. Adriamycin cardiotoxicity: early detection by systolic time interval and possible prevention by coenzyme Q10. Cancer Treat.Rep. 1978;62(6):887-891. View abstract.

44266            Okuma, K., Furuta, I., and Ota, K. [Protective effect of coenzyme Q10 in cardiotoxicity induced by adriamycin]. Gan To Kagaku Ryoho 1984;11(3):502-508. View abstract.

44267            Tsubaki, K., Horiuchi, A., Kitani, T., Taniguchi, N., Masaoka, T., Shibata, H., Yonezawa, T., Tsubakio, T., Kawagoe, H., Shinohara, Y., and . [Investigation of the preventive effect of CoQ10 against the side- effects of anthracycline antineoplastic agents]. Gan To Kagaku Ryoho 1984;11(7):1420-1427. View abstract.

44268            Tanaka, J., Tominaga, R., Yoshitoshi, M., Matsui, K., Komori, M., Sese, A., Yasui, H., and Tokunaga, K. Coenzyme Q10: the prophylactic effect on low cardiac output following cardiac valve replacement. Ann.Thorac.Surg. 1982;33(2):145-151. View abstract.

44269            Takimoto, M., Sakurai, T., Kodama, K., Yokoi, H., Suzuki, Y., Enomoto, K., and Okada, N. [Protective effect of CoQ 10 administration on cardial toxicity in FAC therapy]. Gan To Kagaku Ryoho 1982;9(1):116-121. View abstract.

44270            Folkers, K., Drzewoski, J., Richardson, P. C., Ellis, J., Shizukuishi, S., and Baker, L. Bioenergetics in clinical medicine. XVI. Reduction of hypertension in patients by therapy with coenzyme Q10. Res Commun.Chem Pathol.Pharmacol 1981;31(1):129-140. View abstract.

44271            Suzuki, Y., Kadowaki, H., Atsumi, Y., Hosokawa, K., Katagiri, H., Kadowaki, T., Oka, Y., Uyama, K., Mokubo, A., Asahina, T., and . A case of diabetic amyotrophy associated with 3243 mitochondrial tRNA(leu; UUR) mutation and successful therapy with coenzyme Q10. Endocr.J 1995;42(2):141-145. View abstract.

44272            Laaksonen, R., Riihimaki, A., Laitila, J., Martensson, K., Tikkanen, M. J., and Himberg, J. J. Serum and muscle tissue ubiquinone levels in healthy subjects. J Lab Clin Med 1995;125(4):517-521. View abstract.

44273            Mancini, A., De, Marinis L., Oradei, A., Hallgass, M. E., Conte, G., Pozza, D., and Littarru, G. P. Coenzyme Q10 concentrations in normal and pathological human seminal fluid. J Androl 1994;15(6):591-594. View abstract.

44274            Tsuyama, Y., Adachi-Usami, E., and Takeda, N. A case of Kearns-Shy syndrome with later onset. Ophthalmologica 1993;206(3):149-151. View abstract.

44275            Kuklinski, B., Weissenbacher, E., and Fahnrich, A. Coenzyme Q10 and antioxidants in acute myocardial infarction. Mol.Aspects Med 1994;15 Suppl:s143-s147. View abstract.

44276            Oda, T. Recovery of load-induced left ventricular diastolic dysfunction by coenzyme Q10: echocardiographic study. Mol.Aspects Med 1994;15 Suppl:s149-s154. View abstract.

44277            Morisco, C., Nappi, A., Argenziano, L., Sarno, D., Fonatana, D., Imbriaco, M., Nicolai, E., Romano, M., Rosiello, G., and Cuocolo, A. Noninvasive evaluation of cardiac hemodynamics during exercise in patients with chronic heart failure: effects of short-term coenzyme Q10 treatment. Mol.Aspects Med 1994;15 Suppl:s155-s163. View abstract.

44278            Langsjoen, H., Langsjoen, P., Langsjoen, P., Willis, R., and Folkers, K. Usefulness of coenzyme Q10 in clinical cardiology: a long-term study. Mol.Aspects Med 1994;15 Suppl:s165-s175. View abstract.

44279            Iarussi, D., Auricchio, U., Agretto, A., Murano, A., Giuliano, M., Casale, F., Indolfi, P., and Iacono, A. Protective effect of coenzyme Q10 on anthracyclines cardiotoxicity: control study in children with acute lymphoblastic leukemia and non- Hodgkin lymphoma. Mol.Aspects Med 1994;15 Suppl:s207-s212. View abstract.

44280            Lockwood, K., Moesgaard, S., Hanioka, T., and Folkers, K. Apparent partial remission of breast cancer in ‘high risk’ patients supplemented with nutritional antioxidants, essential fatty acids and coenzyme Q10. Mol.Aspects Med 1994;15 Suppl:s231-s240. View abstract.

44281            Mancini, A., Conte, B., De, Marinis L., Hallgass, M. E., Pozza, D., Oradei, A., and Littarru, G. P. Coenzyme Q10 levels in human seminal fluid: diagnostic and clinical implications. Mol.Aspects Med 1994;15 Suppl:s249-s255. View abstract.

44282            Folkers, K., Moesgaard, S., and Morita, M. A one year bioavailability study of coenzyme Q10 with 3 months withdrawal period. Mol.Aspects Med 1994;15 Suppl:s281-s285. View abstract.

44283            Weber, C., Jakobsen, T. S., Mortensen, S. A., Paulsen, G., and Holmer, G. Effect of dietary coenzyme Q10 as an antioxidant in human plasma. Mol.Aspects Med 1994;15 Suppl:s97-s102. View abstract.

44284            Ishiyama, T., Morita, Y., Toyama, S., Yamagami, T., and Tsukamoto, N. A clinical study of the effect of coenzyme Q on congestive heart failure. Jpn.Heart J 1976;17(1):32-42. View abstract.

44285            Berio, A. and Piazzi, A. Improvement of Kearns-Sayre syndrome with controlled carbohydrate intake and coenzyme Q10 therapy. Ophthalmologica 1994;208(6):342-343. View abstract.

44286            Yamagami, T., Shibata, N., and Folkers, K. Bioenergetics in clinical medicine. VIII. Adminstration of coenzyme Q10 to patients with essential hypertension. Res Commun.Chem.Pathol.Pharmacol 1976;14(4):721-727. View abstract.

44287            Weber, C., Sejersgard, Jakobsen T., Mortensen, S. A., Paulsen, G., and Holmer, G. Antioxidative effect of dietary coenzyme Q10 in human blood plasma. Int J Vitam.Nutr Res 1994;64(4):311-315. View abstract.

44288            Rengo, F., Abete, P., Landino, P., Leosco, D., Covelluzzi, F., Vitale, D., Fedi, V., and Ferrara, N. Role of metabolic therapy in cardiovascular disease. Clin Investig. 1993;71(8 Suppl):S124-S128. View abstract.

44289            Lampertico, M. and Comis, S. Italian multicenter study on the efficacy and safety of coenzyme Q10 as adjuvant therapy in heart failure. Clin Investig. 1993;71(8 Suppl):S129-S133. View abstract.

44290            Langsjoen, P. H., Langsjoen, P. H., and Folkers, K. Isolated diastolic dysfunction of the myocardium and its response to CoQ10 treatment. Clin Investig. 1993;71(8 Suppl):S140-S144. View abstract.

44291            Baggio, E., Gandini, R., Plancher, A. C., Passeri, M., and Carmosino, G. Italian multicenter study on the safety and efficacy of coenzyme Q10 as adjunctive therapy in heart failure (interim analysis). The CoQ10 Drug Surveillance Investigators. Clin Investig. 1993;71(8 Suppl):S145-S149. View abstract.

44292            Judy, W. V., Stogsdill, W. W., and Folkers, K. Myocardial preservation by therapy with coenzyme Q10 during heart surgery. Clin Investig. 1993;71(8 Suppl):S155-S161. View abstract.

44293            Fujimoto, S., Kurihara, N., Hirata, K., and Takeda, T. Effects of coenzyme Q10 administration on pulmonary function and exercise performance in patients with chronic lung diseases. Clin Investig. 1993;71(8 Suppl):S162-S166. View abstract.

44294            Chen, Y. F., Lin, Y. T., and Wu, S. C. Effectiveness of coenzyme Q10 on myocardial preservation during hypothermic cardioplegic arrest. J Thorac.Cardiovasc.Surg. 1994;107(1):242-247. View abstract.

44295            Tribble, D. L., van den Berg, J. J., Motchnik, P. A., Ames, B. N., Lewis, D. M., Chait, A., and Krauss, R. M. Oxidative susceptibility of low density lipoprotein subfractions is related to their ubiquinol-10 and alpha-tocopherol content. Proc Natl.Acad Sci U.S.A 2-1-1994;91(3):1183-1187. View abstract.

44296            Matthews, P. M., Ford, B., Dandurand, R. J., Eidelman, D. H., O’Connor, D., Sherwin, A., Karpati, G., Andermann, F., and Arnold, D. L. Coenzyme Q10 with multiple vitamins is generally ineffective in treatment of mitochondrial disease. Neurology 1993;43(5):884-890. View abstract.

44297            Folkers, K., Morita, M., and McRee, J., Jr. The activities of coenzyme Q10 and vitamin B6 for immune responses. Biochem Biophys.Res Commun. 5-28-1993;193(1):88-92. View abstract.

44298            Porter, D. A., Costill, D. L., Zachwieja, J. J., Krzeminski, K., Fink, W. J., Wagner, E., and Folkers, K. The effect of oral coenzyme Q10 on the exercise tolerance of middle- aged, untrained men. Int J Sports Med 1995;16(7):421-427. View abstract.

44299            Laaksonen, R., Fogelholm, M., Himberg, J. J., Laakso, J., and Salorinne, Y. Ubiquinone supplementation and exercise capacity in trained young and older men. Eur.J Appl.Physiol Occup.Physiol 1995;72(1-2):95-100. View abstract.

44300            Gold, R., Seibel, P., Reinelt, G., Schindler, R., Landwehr, P., Beck, A., and Reichmann, H. Phosphorus magnetic resonance spectroscopy in the evaluation of mitochondrial myopathies: results of a 6-month therapy study with coenzyme Q. Eur.Neurol. 1996;36(4):191-196. View abstract.

44301            Lagendijk, J., Ubbink, J. B., and Vermaak, W. J. Measurement of the ratio between the reduced and oxidized forms of coenzyme Q10 in human plasma as a possible marker of oxidative stress. J Lipid Res 1996;37(1):67-75. View abstract.

44302            Ranen, N. G., Peyser, C. E., Coyle, J. T., Bylsma, F. W., Sherr, M., Day, L., Folstein, M. F., Brandt, J., Ross, C. A., and Folstein, S. E. A controlled trial of idebenone in Huntington’s disease. Mov Disord. 1996;11(5):549-554. View abstract.

44303            Malm, C., Svensson, M., Sjoberg, B., Ekblom, B., and Sjodin, B. Supplementation with ubiquinone-10 causes cellular damage during intense exercise. Acta Physiol Scand. 1996;157(4):511-512. View abstract.

44304            Ma, A., Zhang, W., and Liu, Z. Effect of protection and repair of injury of mitochondrial membrane- phospholipid on prognosis in patients with dilated cardiomyopathy. Blood Press Suppl 1996;3:53-55. View abstract.

44305            Prieme, H., Loft, S., Nyyssonen, K., Salonen, J. T., and Poulsen, H. E. No effect of supplementation with vitamin E, ascorbic acid, or coenzyme Q10 on oxidative DNA damage estimated by 8-oxo-7,8-dihydro-2′- deoxyguanosine excretion in smokers. Am J Clin Nutr 1997;65(2):503-507. View abstract.

44306            Koroshetz, W. J., Jenkins, B. G., Rosen, B. R., and Beal, M. F. Energy metabolism defects in Huntington’s disease and effects of coenzyme Q10. Ann.Neurol. 1997;41(2):160-165. View abstract.

44307            Lagendijk, J., Ubbink, J. B., Delport, R., Vermaak, W. J., and Human, J. A. Ubiquinol/ubiquinone ratio as marker of oxidative stress in coronary artery disease. Res Commun.Mol Pathol.Pharmacol. 1997;95(1):11-20. View abstract.

44308            Karlsson, J., Lin, L., Sylven, C., and Jansson, E. Muscle ubiquinone in healthy physically active males. Mol.Cell Biochem 3-23-1996;156(2):169-172. View abstract.

44309            Karlsson, J., Lin, L., Gunnes, S., Sylven, C., and Astrom, H. Muscle ubiquinone in male effort angina patients. Mol.Cell Biochem 3-23-1996;156(2):173-178. View abstract.

44310            Karlsson, J., Gunnes, S., and Semb, B. Muscle fibers, ubiquinone and exercise capacity in effort angina. Mol Cell Biochem 3-23-1996;156(2):179-184. View abstract.

44311            Kim, Y., Sawada, Y., Fujiwara, G., Chiba, H., and Nishimura, T. Therapeutic effect of co-enzyme Q10 on idiopathic dilated cardiomyopathy: assessment by iodine-123 labelled 15-(p-iodophenyl)- 3(R,S)-methylpentadecanoic acid myocardial single-photon emission tomography. Eur.J Nucl.Med 1997;24(6):629-634. View abstract.

44312            Yamashita, S. and Yamamoto, Y. Simultaneous detection of ubiquinol and ubiquinone in human plasma as a marker of oxidative stress. Anal.Biochem 7-15-1997;250(1):66-73. View abstract.

44313            Villalba, J. M., Navarro, F., Gomez-Diaz, C., Arroyo, A., Bello, R. I., and Navas, P. Role of cytochrome b5 reductase on the antioxidant function of coenzyme Q in the plasma membrane. Mol.Aspects Med 1997;18 Suppl:S7-13. View abstract.

44314            Oda, T. Recovery of the systolic time intervals by coenzyme Q10 in patients with a load-induced cardiac dysfunction. Mol.Aspects Med 1997;18 Suppl:S153-S158. View abstract.

44315            Suzuki, Y., Taniyama, M., Muramatsu, T., Atsumi, Y., Hosokawa, K., Asahina, T., Shimada, A., Murata, C., and Matsuoka, K. Diabetes mellitus associated with 3243 mitochondrial tRNA(Leu(UUR)) mutation: clinical features and coenzyme Q10 treatment. Mol.Aspects Med 1997;18 Suppl:S181-S188. View abstract.

44316            Strijks, E., Kremer, H. P., and Horstink, M. W. Q10 therapy in patients with idiopathic Parkinson’s disease. Mol.Aspects Med. 1997;18 Suppl:S237-S240. View abstract.

44317            Weber, C., Bysted, A., and Holmer, G. Coenzyme Q10 in the diet–daily intake and relative bioavailability. Mol.Aspects Med 1997;18 Suppl:S251-S254. View abstract.

44318            Ylikoski, T., Piirainen, J., Hanninen, O., and Penttinen, J. The effect of coenzyme Q10 on the exercise performance of cross-country skiers. Mol.Aspects Med 1997;18 Suppl:S283-S290. View abstract.

44319            Mizuno, M., Quistorff, B., Theorell, H., Theorell, M., and Chance, B. Effects of oral supplementation of coenzyme Q10 on 31P-NMR detected skeletal muscle energy metabolism in middle-aged post-polio subjects and normal volunteers. Mol.Aspects Med 1997;18 Suppl:S291-S298. View abstract.

44320            Sinatra, S. T. Refractory congestive heart failure successfully managed with high dose coenzyme Q10 administration. Mol.Aspects Med 1997;18 Suppl:S299-S305. View abstract.

44321            Shults, C. W., Haas, R. H., Passov, D., and Beal, M. F. Coenzyme Q10 levels correlate with the activities of complexes I and II/III in mitochondria from parkinsonian and nonparkinsonian subjects. Ann.Neurol. 1997;42(2):261-264. View abstract.

44322            Barbiroli, B., Frassineti, C., Martinelli, P., Iotti, S., Lodi, R., Cortelli, P., and Montagna, P. Coenzyme Q10 improves mitochondrial respiration in patients with mitochondrial cytopathies. An in vivo study on brain and skeletal muscle by phosphorous magnetic resonance spectroscopy. Cell Mol.Biol (Noisy.-le-grand) 1997;43(5):741-749. View abstract.

44323            Sinatra, S. T. Coenzyme Q10: a vital therapeutic nutrient for the heart with special application in congestive heart failure. Conn.Med 1997;61(11):707-711. View abstract.

44324            Costeff, H., Apter, N., Elpeleg, O. N., Prialnic, M., and Bohles, H. J. Ineffectiveness of oral coenzyme Q10 supplementation in 3- methylglutaconic aciduria, type 3. Brain Dev. 1998;20(1):33-35. View abstract.

44325            Chopra, R. K., Goldman, R., Sinatra, S. T., and Bhagavan, H. N. Relative bioavailability of coenzyme Q10 formulations in human subjects. Int J Vitam.Nutr Res 1998;68(2):109-113. View abstract.

44326            Mancini, A., Conte, G., Milardi, D., De Marinis, L., and Littarru, G. P. Relationship between sperm cell ubiquinone and seminal parameters in subjects with and without varicocele. Andrologia 1998;30(1):1-4. View abstract.

44327            Palomaki, A., Malminiemi, K., Solakivi, T., and Malminiemi, O. Ubiquinone supplementation during lovastatin treatment: effect on LDL oxidation ex vivo. J Lipid Res 1998;39(7):1430-1437. View abstract.

44328            Zhang, Y., Eriksson, M., Dallner, G., and Appelkvist, E. L. Analysis of ubiquinone and tocopherol levels in normal and hyperlipidemic human plasma. Lipids 1998;33(8):811-815. View abstract.

44329            Kaikkonen, J., Kosonen, L., Nyyssonen, K., Porkkala-Sarataho, E., Salonen, R., Korpela, H., and Salonen, J. T. Effect of combined coenzyme Q10 and d-alpha-tocopheryl acetate supplementation on exercise-induced lipid peroxidation and muscular damage: a placebo-controlled double-blind study in marathon runners. Free Radic.Res 1998;29(1):85-92. View abstract.

44330            Singh, R. B., Wander, G. S., Rastogi, A., Shukla, P. K., Mittal, A., Sharma, J. P., Mehrotra, S. K., Kapoor, R., and Chopra, R. K. Randomized, double-blind placebo-controlled trial of coenzyme Q10 in patients with acute myocardial infarction. Cardiovasc.Drugs Ther. 1998;12(4):347-353. View abstract.

44331            Karlsson J, Diamant B Folkers K and et al. Skeleton muscle and blood CoQ10 in health and disease. In: Lenaz G, Barnabei O Rabbi A and Battino M. Highlights in Ubiquinone Research. London: Taylor & Francis;1990.

44332            Folkers K. Critique of coenzyme Q in biochemical and biomedical research and in ten years of clinical research on cardiovascular disease. J Mol Med 2002;2:431-460.

44333            Pogessi L, Galanti G, Corneglio M, and et al. Effect of coenzyme Q10 on left ventricular function in patients with dilative cardiomyopathy. Curr Ther Res 1991;49 :878-886.

44334            SA Mortensen, A Kumar P Dolliner KJ Filipiak D Pella U Alehagen G Steurer GP Littarru F Rosenfeldt. The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure. Results from the Q-SYMBIO study. European Journal of Heart Failure 2013;15:S1-S20.

44335            Yikoski T, Piirainen J, Hanninen O, and et al. The effect of coenzyme Q10 on the exercise performance of cross-country skiers. Molec Aspects Med 1997;18 Suppl:s283-s290.

44336            Mazzola C, Guffanti EE, Vaccarella A, and et al. Noninvasive assessment of coenzyme Q10 in patients with chronic stable effort angina and moderate heart failure. Current Therapeutic Research 1987;41(6):923-932.

44337            Schardt F, Welzel D, Scheiss W, and et al. Effect of coenzyme Q10 on ischemia-induced ST-segment depression: a double-blind, placebo-controlled, crossover study. In: Folkers, K and Yamamura, Y. Biomedical and Clinical Aspects of Coenzyme Q10. Amsterdam: Elsevier;1985.

44338            Roberts J. The effects of coenzyme Q10 on excercise performance. Med Sci Sports Exerc 1990;22((suppl)):S87.

44339            Judy WV, Folkers K, and Hall JH. Improved long-term survival in conezyme Q10 treated chronic heart failure patients compared to conventionally treated patients. In: Folkers K, Littarru GP, and Yamagami T. Biomedical and clinical aspects of coenzyme Q. Amsterdam: Elsevier Science Publishers;1991.

44340            Judy, W. V., Hall, J. H., Toth, P. D., and Folkers, K. Double blind double cross over study of coenzyme Q10 in heart failure. In: Folkers, K. and Yamamura, Y. Biomedical and Clinical Aspects of Coenzyme Q10. Amsterdam: Elsevier;1986.

44341            Langsjoen PH. Treatment of patients with human immunodeficiency virus infection with coenzyme Q10. Biomedical and Clinical Aspects of Coenzyme Q10. Amsterdam: Elsevier;1991.

44342            Yamagami T, Takagi M, Akagami H, and et al. Effect of coenzyme Q10 on essential hypertension: a double-blind controlled study. In: Folkers K and Yamamura Y. Biomedical and Clinical Aspects on Coenzyme Q. Amsterdam: Elsevier;1986.

44343            Digiesi V, Cantini F, and Brodbeck B. Effect of coenzyme Q10 on essential arterial hypertension. Current Therapeutic Research 1990;47(5):841-845.

44344            Balercia G, Arnaldi G, Lucarelli G, and et al. Effects of exogenous CoQ10 administration in patients with idiopathic asthenozoospermia. International Journal of Andrology 2000;Suppl 23:43.

44345            Kelly P, Vasu S Getato M McNurlan M Lawson WE. Coenzyme Q10 improves myopathic pain in statin treated patients (abstr). J Am Coll Cardiol 2005;45:3A.

44346            Young JM, Florkowski CM Molyneux SL McEwan RG Frampton CM George PM. Coenzyme Q10 does not improve simvastatin tolerability in dyslipidemic patients with prior statin-induced myalgia. Circulation 2007;114:II41.

44347            Singh RB, Khanna HK, and Niaz MA. Randomized, double-blind placebo-controlled trial of coenzyme Q10 in chronic renal failure: discovery of a new role. J Nutr Environ Med 2000;10:281-288.

44348            van Gaal L, Folkers K and Yamamura Y. Exploratory study of coenzyme Q10 in obesity. In: Folkers K and Yamura Y. Biomedical and Clinical Aspects of Coenzyme Q. Amsterdam: Elsevier Science Publications;1984.

44349            Oda T. Coenzyme Q10 therapy on the cardiac dysfunction in patients with mitral valve prolapse: dose vs effect and dose vs serum level of coenzyme Q10. In: Folkers K and Yamamura Y. Biomedical and Clinical Aspects of Coenzyme Q10. Amsterdam: Elsevier Science;1986.

44350            Compagnoni G, Bargossi A, Azzali A, and et al. Q10 (Ubiquinone) plasma levels in mother and neonate. 1822. Pediatric Research 1996;39(4):306.

44351            Mari D, Alleva R, Tomasetti M, and et al. Reduction of chemotoxicity and enhancement of antioxidant capacity of plasma in cancer patients treated with conventional therapy plus CoQ10. First Conference of the International Coenzyme Q10 Association 2002;

44352            Serra G, Lissoni F, Piemonti C, and et al. Evaluation of coenzyme Q10 in patients with moderate heart failure and chronic stable effort angina. In: Folkers K, Littaru GP, and Yamagami T. Biomedical and clinical aspects of coenzyme Q. Amsterdam: Elsevier Science Publishers;1991.

44353            Teerlink T, Musch EE, Baker SJL, and et al. Resistance of low density lipoprotein against in vitro oxidation is associated with its coenzyme Q10 content in type 2 diabetes. First Conference of the International Coenzyme Q10 Association 2002;

44354            Teran E, Feelisch M, Sazanov L, and et al. Inhibition of purified mitochondrial complex I by nitric oxide may be mediated by direct reaction with ubiquinone. Acta Physiologica Scandinavica.Supplementum 1999;167(645):5.

44355            Shumaev KB, Ruuge EK, Lankin VZ, and et al. Effect of coenzyme Q on the formation of tocopheroxyl radicals in model systems. First Conference of the International Coenzyme Q10 Association 2002;

44356            Finckh B, Boda V, Horn A, and et al. Reduced and oxidized plasma coenzyme Q10 as part of a complex monitoring of oxidative stress in micro blood samples from preterm babies. First Conference of the International Coenzyme Q10 Association 2002;

44357            Lyon W, Pepe S, Marasco S, and et al. Effect of topical and systemic coenzyme Q10 therapy on cardiac Q10 content and mitochondrial function. The Australian and New Zealand Journal of Surgery 2000;70 Supplement:A47-A48.

44358            Digiesi V, Cantini F, Bisi G, and et al. Mechanism of action of coenzyme Q10 in essential hypertension. Current Therapeutic Research 1992;51(5):668-672.

44359            Weber C, Bysted A, and Holmer G. Intestinal absorption of coenzyme Q10 administered in a meal or as capsules to healthy subjects. Nutrition Research 1997;17(6):941-945.

44360            Wahlqvist ML, Wattanapenpaiboon N, Savige GS, and et al. Bioavailability of two different formulations of coenzyme Q10 in healthy subjects. Asia Pac J Clin Nutr 1998;7(1):37-40.

44361            Scararmucci A, Arnaldi G, Balercia G, and et al. Coenzyme Q10 determination in idiopathic oligoasthenospermia and varicocele. Int J Andrology 1997;20:95.

44362            Becker K. Ubiquinone-10 plasma concentrations in healthy European children. Redox Report 1995;1:97-98.

44363            Folkers K. Perspectives from research on vitamins and hormones. J Chem Educ 1984;61(9):747-756.

44364            Schneeberger, W., Muller-Steinwachs, J., Anda, L. P., Fuchs, W., Zilliken, F., Lyson, K., Muratsu, K., and Folkers, K. A clinical double-blind and crossover trial with coenzyme Q10 on patients with cardiac disease. In: Folkers, K. and Yamamura, Y. Biomedical and Clinical Aspects of Coenzyme Q. Amsterdam: Elsevier;1986.

44365            Ursini T. Coenzyme Q10 treatment of heart failure in the elderly: preliminary results. In: Folkers K, Littarru GP and Yamagami T. Biomedical and Clinical Aspects of Coenzyme Q. Amsterdam: Elsevier;1991.

44366            Muller-Steinwachs, J, Anda, LP, and Zilliken, F. Eine klinische Doppel-blind-studie mit CoQ10 und vitamin E bei hertzkranken patienten. De Orthomoleculaire Koerier 1990;5(24):4-11.

44367            Syrkin A, Kogan A, Drynitsina S, and et al. The effect of soluble form of coenzyme Q10 on the oxygen free radical processes and clinical course in patients with coronary heart disease – stable angina pectoris. First Conference of the International Coenzyme Q10 Association 2002;

44368            Beyer RE, Nordenbrand K, and Ernster L. The function of coenzyme Q in free radical production and as an antioxidant: a review. Chemica Scripta 1987;27:145-153.

44369            Weber M, Andler W, Enzmann F, and et al. Increased oxidative stress in glycogen storage disease type IB: preliminary results of an antioxidative treatment with coenzyme Q10, selenium and ascorbic acid. First Conference of the International Coenzyme Q10 Association 2002;

44370            Centre for Reviews and Dissemination. Idebenone (SNT-MC17) for Friedreich’s ataxia: horizon scanning technology briefing (Project record). 2013;

44371            Imanaka K, Izumiyama K, and Sakaguchi T et al. Effect of coenzyme Q10 and azelastin on protecting radiation pneumonitis with lung cancer. Journal of Japan Society for Cancer Therapy 1994;29:2010-2015.

44372            Wander GS, Singh RB, and Shukla PK. Randomized double blind trial of hydrosoluble coenzyme Q10 in hypertensives with oxidative stress and coronary artery disease. First Conference of the International Coenzyme Q10 Association 2002;

44373            Wyss V, Lubich T Ganzit GP Cesaretti D Fiorella PL Dei C Rocini C Bargossi AM Battistoni R Lippi A Grossi G Sprovieri G Battino M. Remarks on prolonged ubiquinone administration in physical exercise. Highlights in Ubiquinone Research 1990;303-308.

44374            Zeppilli P, Merlino B De Luca A Palmieri V Santini C Vannicelli R La Rosa Gangi M Cacese R Cameli S Servidei S Ricci E Silvestri G Lippa S Oradei A Littarru GP. Influence of coenzyme Q10 on physical work capacity in athletes, sedentary people and patients with mitochondrial disease. Biochemical and clinical aspects of Coenzyme Q10. 1991;6

44375            Amadio E, Palermo R Peloni G Littarru G. Effect of CoQ10 administration on V02max and diastolic function in athletes. Biomedical and clinical aspects of Coenzyme Q10. 1991;525-533.

44376            Fiorella PL, Bargossi AM Grossi G Motta R Senaldi R Battino M Sassi S Sprovieri G Lubich T. Metabolic effects of coenzyme Q10 treatment in high level athletes. Biomedical and clinical aspects of Coenzyme Q10 1991;513-520.

44377            Wilkinson EG, Arnold RM, Folkers K, and et al. Bioenergetics in clinical medicine. II. Adjunctive treatment with coenzyme Q in periodontal therapy. Research Communications in Chemical Pathology and Pharmacology 1975;12(1):111-124.

44378            Scaglione F, Lundstrom B, Barbieri B, and et al. Coenzyme Q10 as an immunoenhancer. A single blind placebo-controlled and randomized clinical study [abstract]. First Conference of the International Coenzyme Q10 Association 1998;

44379            Gvozdjakova A, Kucharska J, Lepies P, and et al. Decreased level of sperm coenzyme Q10, mitochondrial respiration and energy production in infertile patients therapeutic effect on coenzyme Q10 (a pilot study). First Conference of the International Coenzyme Q10 Association 2002;

44380            Servidei S, Spinazzola A, Crociani P, and et al. Replacement therapy is effective in familial mitochondrial encephalomyopathy with muscle coenzyme Q10 deficiency. Neurology 1996;46:A420.

44381            Bresolin N, Cossutta E, Angelini C, and et al. Fifty patients with mitochondrial myopathy treated with ubidecarenone. First multicentric study. J Neurology 1988;235:S79.

44382            Oda T. Effect of coenzyme Q10 on load-induced cardiac dysfunction: double blind study and investigation of dose-response relationship. In: Lenaz G, Barnabei O Rabbi A and et al. Highlights in Ubiquinone Research. London: Taylor and Francis;1990.

44383            Oda T. Dose-effect relationship and critical dose of coenzyme Q10 on load-induced cardiac dysfunction in pediatric patients with mitral valve prolapse. In: Folkers K, Littarru GP and Yamagami T. Biomedical and Clinical Aspects of Coenzyme Q10. Amsterdam: Elsevier Science;1991.

44384            Judy WV, Willis RA, and Folkers K. Regression of prostate cancer and plasma specific antigens (PSA) in patients on treatment with COQ10. First Conference of the International Coenzyme Q10 Association 2002;

44385            Aoki S and Yamaguchi K. [Clinical experiences in use of cinnarizine and CoQ10 for treatment of sensorineural tinnitus]. Shinyaku to Rinsho 1970;29:1541-1546.

44386            Rastogi SS, Singh RB, and Shukla PK. Randomized, double blind, placebo controlled trial of hydrosoluble coenzyme Q10 in patients with hyperinsulinemia. First Conference of the International Coenzyme Q10 Association 2002;

44387            Gvozdjakova A, Kucharska J, Braunova Z, and et al. Beneficial effect of CoQ10 on the antioxidative status and metabolism of fats and sugars in diabetic patients. First Conference of the International Coenzyme Q10 Association 2002;

44388            Koroshetz WJ. Care-HD: NINDS multicenter trial in Huntington’s disease to test whether specific doses of coenzyme Q10 and remacemide slow disease progression. First Conference of the International Coenzyme Q10 Association 2002;

44389            Feigin A, Kieburtz K, Como P, and et al. An open-label trial of coenzyme Q10 (CoQ) in Huntington’s disease (HD) [abstract]. Neurology 1994;44(suppl 2):A397-A398.

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2431               Grosse Duweler K, Rohdewald P. Urinary metabolites of French maritime pine bark extract in humans. Pharmazie 2000;55:364-8. View abstract.

2433               Packer L, Midori H, Toshikazu Y, eds. Antioxidant Food Supplements in Human Health. San Diego: Academic Press, 1999.

2435               Rice-Evans CA, Packer L, eds. Flavonoids in Health and Disease. Manhattan, NY: Marcel Dekker, Inc., 1998.

2451               Arcangeli P. Pycnogenol in chronic venous insufficiency. Fitoterapia 2000;71:236-44. View abstract.

2462               Petrassi C, Mastromarino A, Spartera C. Pycnogenol in chronic venous insufficiency. Phytomedicine 2000;7:383-8. View abstract.

2493               Schmidtke I, Schoop W. Pycnogenol: stasis oedema and its medical treatment. Schweizerische Zeitschrift fur GanzheitsMedizin 1995;3:114-5.

2536               Spadea L, Balestrazzi E. Treatment of vascular retinopathies with pycnogenol. Phytother Res 2001;15:219-23. View abstract.

2542               Watson RR. Reduction of cardiovascular disease risk factors by French maritime pine bark extract. CVR&R 1999;June:326-9.

2543               Rohdewald P. Bioavailability and metabolism of pycnogenol. Eur Bull Drug Res 1999;7:5-7.

2544               Gulati OP. Pycnogenol in venous disorders: a review. Eur Bull Drug Res 1999;7:8-13.

2545               Rohdewald P. Reducing the risk for stroke and heart infarction with pycnogenol. Eur Bull Drug Res 1999;7:14-18.

2553               Wang S, Tan D, Zhao Y, et al. The effect of pycnogenol on the microcirculation, platelet function and ischemic myocardium in patients with coronary artery diseases. Eur Bull Drug Res 1999;7:19-25.

2554               Pavlovic P. Improved endurance by use of antioxidants. Eur Bull Drug Res 1999;7:26-9.

2555               Kohama T, Suzuki N. The treatment of gynecological disorders with pycnogenol. Eur Bull Drug Res 1999;7:30-2.

2556               Roseff SJ, Gulati R. Improvement of sperm quality by pycnogenol. Eur Bull Drug Res 1999;7:33-6.

2635               Tixier JM, et al. Evidence by in vivo and in vitro studies that binding of pycnogenols to elastin affects its rate of degradation by elastases. Biochem Pharmacol 1984;33:3933-9. View abstract.

2636               Liu FJ, Zhang YX, Lau BH. Pycnogenol enhances immune and haemopoietic functions in senescence-accelerated mice. Cell Mol Life Sci 1998;54:1168-72. View abstract.

2637               Fitzpatrick DF, Bing, Rohdewald P. Endothelium-dependent vascular effects of Pycnogenol. J Cardiovasc Pharmacol 1998;32:509-15. View abstract.

2641               Dauer A, Metzner P, Schimmer O. Proanthocyanidins from the bark of Hamamelis virginiana exhibit antimutagenic properties against nitroaromatic compounds. Planta Med 1998;64:324-7. View abstract.

3283               Putter M, Grotemeyer KH, Wurthwein G, et al. Inhibition of smoking-induced platelet aggregation by aspirin and pycnogenol. Thromb Res 1999;95:155-61. View abstract.

3285               Mensink RP, Katan MB. An epidemiological and an experimental study on the effect of olive oil on total serum and HDL cholesterol in healthy volunteers. Eur J Clin Nutr 1989;43 Suppl 2:43-8. View abstract.

5056               Ohnishi ST, Ohnishi T, Ogunmola GB. Sickle cell anemia: a potential nutritional approach for a molecular disease. Nutrition 2000;16:330-8. View abstract.

6558               Heiman SW. Pycnogenol for ADHD? J Am Acad Child Adolesc Psychiatry 1999;38:357-8. View abstract.

7693               Koch R. Comparative study of venostatin and pycnogenol in chronic venous insufficiency. Phytother Res 2002:16:S1-S5. Phytother Res 2002:16:S1-S5. View abstract.

7694               Jialal I, Devaraj S, Hirany S, et al. The effect of pycnogenol supplementation on markers of inflammation. Alternative Therapies 2001;7:S17.

7695               Cheshier JE, Ardestani-Kaboudanian S, Liang B, et al. Immunomodulation by pycnogenol in retrovirus-induced or ethanol-fed mice. Life Sci 1996;58:87-96. View abstract.

7696               Saliou C, Rimbach G, Molni H, McLaughlin L, Hosseini S, Lee J, et al. Solar ultraviolet-induced erythema in human skin and nuclear factor-kappa-b-dependent gene expression in keratinocytes are modulated by a French Maritime pine bark extract. Free Radic Biol Med 2001;30:154-60. View abstract.

7697               Park YC, Rimbach G, Saliou C, et al. Activity of monomeric, dimeric, and trimeric flavonoids on NO production, TNF-alpha secretion, and NF-KB-dependent gene expression in RAW 264.7 macrophages. FEBS Letters 2000:465;93-7. View abstract.

7698               Virgili F, Kim D, Packer L. Procyanidins extracted from pine bark protect alpha-tocopherol in ECV 304 endothelial cells challenged by activated RAW 264.7 macrophages: role of nitric oxide and peroxynitrite. FEBS Letters 1998;431:315-8. View abstract.

7699               Liu F, Lau BHS, Peng Q, Shah V. Pycnogenol protects vascular endothelial cells from beta-amyloid-induced injury. Biol Pharm Bull 2000;23:735-7. View abstract.

8307               Hasegawa N. Inhibition of lipogenesis by pycnogenol. Phytother Res 2000;14:472-3. View abstract.

9984               Tenenbaum S, Paull JC, Sparrow EP, et al. An experimental comparison of Pycnogenol and methylphenidate in adults with Attention-Deficit/Hyperactivity Disorder (ADHD). J Atten Disord 2002;6:49-60.. View abstract.

10212            Virgili F, Pagana G, Bourne L, et al. Ferulic acid excretion as a marker of consumption of a French maritime pine (Pinus maritima) bark extract. Free Radic Biol Med 2000;28:1249-56.. View abstract.

10213            Bito T, Roy S, Sen CK, Packer L. Pine bark extract pycnogenol downregulates IFN-gamma-induced adhesion of T cells to human keratinocytes by inhibiting inducible ICAM-1 expression. Free Radic Biol Med 2000;28:219-27.. View abstract.

10214            Hosseini S, Lee J, Sepulveda RT, et al. A randomized, double-blind, placebo-controlled, prospective, 16 week crossover study to determine the role of pycnogenol in modifying blood pressure in mildly hypertensive patients. Nutr Res 2001;21:1251-60.

10416            Stanislavov R, Nikolova V. Treatment of erectile dysfunction with pycnogenol and L-arginine. J Sex Marital Ther 2003;29:207-13.. View abstract.

12012            Durackova Z, Trebaticky B, Novotny V, et al. Lipid metabolism and erectile function improvement by Pycnogenol, extract from the bark of Pinus pinaster in patients suffering from erectile dysfunction-a pilot study. Nutr Res 2003;23:1189-98.

12075            Cesarone MR, Belcaro G, Nicolaides AN, et al. Prevention of venous thrombosis in long-haul flights with Flite Tabs: The LONFLIT-FLITE randomized, controlled trial. Angiology 2003;54:531-9. View abstract.

13120            Lau BH, Riesen SK, Truong KP, et al. Pycnogenol as an adjunct in the management of childhood asthma. J Asthma 2004;41:825-32. View abstract.

14899            Yang HM, Liao MF, Zhu SY, et al. A randomised, double-blind, placebo-controlled trial on the effect of Pycnogenol on the climacteric syndrome in peri-menopausal women. Acta Obstet Gynecol Scand 2007;86:978-85. View abstract.

15422            Blazso G, Gabor M, Schonlau F, Rohdewald P. Pycnogenol accelerates wound healing and reduces scar formation. Phytother Res 2004;18:579-81. View abstract.

15423            Kohama T, Inoue M. Pycnogenol alleviates pain associated with pregnancy. Phytother Res 2006;20:232-4. View abstract.

15424            Kohama T, Suzuki N, Ohno S, Inoue M. Analgesic efficacy of French maritime pine bark extract in dysmenorrhea: an open clinical trial. J Reprod Med 2004;49:828-32. View abstract.

15521            Liu X, Zhou HJ, Rohdewald P. French maritime pine bark extract pycnogenol dose-dependently lowers glucose in type 2 diabetic patients (letter). Diabetes Care 2004;27:839. View abstract.

15522            Liu X, Wei J, Tan F, et al. Antidiabetic effect of Pycnogenol French maritime pine bark extract in patients with diabetes type II. Life Sci 2004;75:2505-13. View abstract.

15523            Cesarone MR, Belcaro G, Rohdewald P, et al. Improvement of diabetic microangiopathy with Pycnogenol: A prospective, controlled study. Angiology 2006;57:431-6. View abstract.

15524            Vinciguerra G, Belcaro G, Cesarone MR, et al. Cramps and muscular pain: prevention with Pyconogenol in normal subjects, venous patients, athletes, claudicants and in diabetic microangiopathy. Angiology 2006;57:331-9. View abstract.

16906            Belcaro G, Cesarone MR, Ricci A, et al. Control of edema in hypertensive subjects treated with calcium antagonist (nifedipine) or angiotensin-converting enzyme inhibitors with pycnogenol. Clin Appl Thromb Hemost 2006;12:440-4. View abstract.

17300            Wilson D, Evans M, Guthrie N et al. A randomized, double-blind, placebo-controlled exploratory study to evaluate the potential of pycnogenol for improving allergic rhinitis symptoms. Phytother Res 2010;24:1115-9. View abstract.

32061            Stanislavov, R., Nikolova, V., and Rohdewald, P. Improvement of seminal parameters with Prelox: a randomized, double-blind, placebo-controlled, cross-over trial. Phytother.Res 2009;23(3):297-302. View abstract.

32149            Ledda, A., Belcaro, G., Cesarone, M. R., Dugall, M., and Schonlau, F. Investigation of a complex plant extract for mild to moderate erectile dysfunction in a randomized, double-blind, placebo-controlled, parallel-arm study. BJU.Int. 2010;106(7):1030-1033. View abstract.

35456            Steigerwalt, R. D., Gianni, B., Paolo, M., Bombardelli, E., Burki, C., and Schonlau, F. Effects of Mirtogenol on ocular blood flow and intraocular hypertension in asymptomatic subjects. Mol Vis 2008;14:1288-1292. View abstract.

36926            Clark, C. E., Arnold, E., Lasserson, T. J., and Wu, T. Herbal interventions for chronic asthma in adults and children: a systematic review and meta-analysis. Prim.Care Respir.J 2010;19(4):307-314. View abstract.

44178            Belcaro, G., Cesarone, M. R., Dugall, M., Hosoi, M., Ippolito, E., Bavera, P., and Grossi, M. G. Investigation of Pycnogenol(R) in combination with coenzymeQ10 in heart failure patients (NYHA II/III). Panminerva Med 2010;52(2 Suppl 1):21-25. View abstract.

50835            Huynh, H. T. and Teel, R. W. Effects of pycnogenol on the microsomal metabolism of the tobacco-specific nitrosamine NNK as a function of age. Cancer Lett 10-23-1998;132(1-2):135-139. View abstract.

50836            Huynh, H. T. and Teel, R. W. Effects of intragastrically administered Pycnogenol on NNK metabolism in F344 rats. Anticancer Res 1999;19(3A):2095-2099. View abstract.

50837            Packer, L., Rimbach, G., and Virgili, F. Antioxidant activity and biologic properties of a procyanidin-rich extract from pine (Pinus maritima) bark, pycnogenol. Free Radic.Biol Med 1999;27(5-6):704-724. View abstract.

50838            Asset, G., Bauge, E., Wolff, R. L., Fruchart, J. C., and Dallongeville, J. Pinus pinaster oil affects lipoprotein metabolism in apolipoprotein E-deficient mice. J Nutr 1999;129(11):1972-1978. View abstract.

50839            Hasegawa, N. Stimulation of lipolysis by pycnogenol. Phytother Res 1999;13(7):619-620. View abstract.

50840            Kobayashi, M. S., Han, D., and Packer, L. Antioxidants and herbal extracts protect HT-4 neuronal cells against glutamate-induced cytotoxicity. Free Radic.Res 2000;32(2):115-124. View abstract.

50841            Rimbach, G., Virgili, F., Park, Y. C., and Packer, L. Effect of procyanidins from Pinus maritima on glutathione levels in endothelial cells challenged by 3-morpholinosydnonimine or activated macrophages. Redox.Rep 1999;4(4):171-177. View abstract.

50842            Bors, W., Michel, C., and Stettmaier, K. Electron paramagnetic resonance studies of radical species of proanthocyanidins and gallate esters. Arch Biochem Biophys. 2-15-2000;374(2):347-355. View abstract.

50843            Moini, H., Arroyo, A., Vaya, J., and Packer, L. Bioflavonoid effects on the mitochondrial respiratory electron transport chain and cytochrome c redox state. Redox.Rep 1999;4(1-2):35-41. View abstract.

50844            Araghi-Niknam, M., Hosseini, S., Larson, D., Rohdewald, P., and Watson, R. R. Pine bark extract reduces platelet aggregation. Integr.Med. 3-21-2000;2(2):73-77. View abstract.

50845            Asset, G., Bauge, E., Wolff, R. L., Fruchart, J. C., and Dallongeville, J. Comparison of maritime pine oil and fish oil effects on plasma lipoproteins in apolipoprotein E-deficient mice. Prostaglandins Leukot.Essent.Fatty Acids 2000;62(5):307-310. View abstract.

50846            Peng, Q., Wei, Z., and Lau, B. H. Pycnogenol inhibits tumor necrosis factor-alpha-induced nuclear factor kappa B activation and adhesion molecule expression in human vascular endothelial cells. Cell Mol Life Sci 2000;57(5):834-841. View abstract.

50847            Huynh, H. T. and Teel, R. W. Selective induction of apoptosis in human mammary cancer cells (MCF-7) by pycnogenol. Anticancer Res 2000;20(4):2417-2420. View abstract.

50848            Cho, K. J., Yun, C. H., Yoon, D. Y., Cho, Y. S., Rimbach, G., Packer, L., and Chung, A. S. Effect of bioflavonoids extracted from the bark of Pinus maritima on proinflammatory cytokine interleukin-1 production in lipopolysaccharide-stimulated RAW 264.7. Toxicol Appl.Pharmacol 10-1-2000;168(1):64-71. View abstract.

50849            Kim, J., Chehade, J., Pinnas, J. L., and Mooradian, A. D. Effect of select antioxidants on malondialdehyde modification of proteins. Nutrition 2000;16(11-12):1079-1081. View abstract.

50850            Moini, H., Guo, Q., and Packer, L. Protein binding of procyanidins: studies using polyacrylamide gel electrophoresis and French maritime pine bark extract. Methods Enzymol. 2001;335:333-337. View abstract.

50851            Stefanescu, M., Matache, C., Onu, A., Tanaseanu, S., Dragomir, C., Constantinescu, I., Schonlau, F., Rohdewald, P., and Szegli, G. Pycnogenol efficacy in the treatment of systemic lupus erythematosus patients. Phytother Res 2001;15(8):698-704. View abstract.

50852            Kim, H. C. and Healey, J. M. Effects of pine bark extract administered to immunosuppressed adult mice infected with Cryptosporidium parvum. Am J Chin Med 2001;29(3-4):469-475. View abstract.

50853            Cho, K. J., Yun, C. H., Packer, L., and Chung, A. S. Inhibition mechanisms of bioflavonoids extracted from the bark of Pinus maritima on the expression of proinflammatory cytokines. Ann N Y Acad Sci 2001;928:141-156. View abstract.

50854            Moini, H., Guo, Q., and Packe, L. Xanthine oxidase and xanthine dehydrogenase inhibition by the procyanidin-rich French maritime pine bark extract, pycnogenol: a protein binding effect. Adv.Exp Med Biol 2002;505:141-149. View abstract.

50855            Peng, Q. L., Buz’Zard, A. R., and Lau, B. H. Pycnogenol protects neurons from amyloid-beta peptide-induced apoptosis. Brain Res Mol Brain Res 7-15-2002;104(1):55-65. View abstract.

50856            Buz’Zard, A. R., Peng, Q., and Lau, B. H. Kyolic and Pycnogenol increase human growth hormone secretion in genetically-engineered keratinocytes. Growth Horm.IGF.Res. 2002;12(1):34-40. View abstract.

50857            Kimbrough, C., Chun, M., dela, Roca G., and Lau, B. H. PYCNOGENOL chewing gum minimizes gingival bleeding and plaque formation. Phytomedicine 2002;9(5):410-413. View abstract.

50858            Ni, Z., Mu, Y., and Gulati, O. Treatment of melasma with Pycnogenol. Phytother.Res. 2002;16(6):567-571. View abstract.

50859            Roseff, S. J. Improvement in sperm quality and function with French maritime pine tree bark extract. J Reprod Med 2002;47(10):821-824. View abstract.

50860            Horakova, L., Licht, A., Sandig, G., Jakstadt, M., Durackova, Z., and Grune, T. Standardized extracts of flavonoids increase the viability of PC12 cells treated with hydrogen peroxide: effects on oxidative injury. Arch Toxicol 2003;77(1):22-29. View abstract.

50861            Devaraj, S., Vega-Lopez, S., Kaul, N., Schonlau, F., Rohdewald, P., and Jialal, I. Supplementation with a pine bark extract rich in polyphenols increases plasma antioxidant capacity and alters the plasma lipoprotein profile. Lipids 2002;37(10):931-934. View abstract.

50862            Sharma, S. C., Sharma, S., and Gulati, O. P. Pycnogenol inhibits the release of histamine from mast cells. Phytother Res 2003;17(1):66-69. View abstract.

50863            Hosseini, S., Pishnamazi, S., Sadrzadeh, S. M., Farid, F., Farid, R., and Watson, R. R. Pycnogenol((R)) in the Management of Asthma. J Med Food 2001;4(4):201-209. View abstract.

50864            Maritim, A., Dene, B. A., Sanders, R. A., and Watkins, J. B., III. Effects of pycnogenol treatment on oxidative stress in streptozotocin-induced diabetic rats. J Biochem Mol Toxicol 2003;17(3):193-199. View abstract.

50865            Sharma, S. C., Sharma, S., and Gulati, O. P. Pycnogenol prevents haemolytic injury in G6PD deficient human erythrocytes. Phytother Res 2003;17(6):671-674. View abstract.

50866            Zhang, D., Tao, Y., Gao, J., Zhang, C., Wan, S., Chen, Y., Huang, X., Sun, X., Duan, S., Schonlau, F., Rohdewald, P., and Zhao, B. Pycnogenol in cigarette filters scavenges free radicals and reduces mutagenicity and toxicity of tobacco smoke in vivo. Toxicol Ind Health 2002;18(5):215-224. View abstract.

50867            Liu, X., Wei, J., Tan, F., Zhou, S., Wurthwein, G., and Rohdewald, P. Pycnogenol, French maritime pine bark extract, improves endothelial function of hypertensive patients. Life Sci 1-2-2004;74(7):855-862. View abstract.

50868            Ahn, J., Grun, I. U., and Mustapha, A. Antimicrobial and antioxidant activities of natural extracts in vitro and in ground beef. J Food Prot. 2004;67(1):148-155. View abstract.

50869            Grimm, T., Schafer, A., and Hogger, P. Antioxidant activity and inhibition of matrix metalloproteinases by metabolites of maritime pine bark extract (pycnogenol). Free Radic.Biol Med 3-15-2004;36(6):811-822. View abstract.

50870            Sime, S. and Reeve, V. E. Protection from inflammation, immunosuppression and carcinogenesis induced by UV radiation in mice by topical Pycnogenol. Photochem.Photobiol. 2004;79(2):193-198. View abstract.

50871            Siler-Marsiglio, K. I., Shaw, G., and Heaton, M. B. Pycnogenol and vitamin E inhibit ethanol-induced apoptosis in rat cerebellar granule cells. J Neurobiol. 2004;59(3):261-271. View abstract.

50872            Sivonova, M., Waczulikova, I., Kilanczyk, E., Hrnciarova, M., Bryszewska, M., Klajnert, B., and Durackova, Z. The effect of Pycnogenol on the erythrocyte membrane fluidity. Gen Physiol Biophys. 2004;23(1):39-51. View abstract.

50873            Siler-Marsiglio, K. I., Paiva, M., Madorsky, I., Serrano, Y., Neeley, A., and Heaton, M. B. Protective mechanisms of pycnogenol in ethanol-insulted cerebellar granule cells. J Neurobiol. 2004;61(2):267-276. View abstract.

50874            Belcaro, G., Cesarone, M. R., Rohdewald, P., Ricci, A., Ippolito, E., Dugall, M., Griffin, M., Ruffini, I., Acerbi, G., Vinciguerra, M. G., Bavera, P., Di Renzo, A., Errichi, B. M., and Cerritelli, F. Prevention of venous thrombosis and thrombophlebitis in long-haul flights with pycnogenol. Clin Appl.Thromb.Hemost. 2004;10(4):373-377. View abstract.

50875            Kim, Y. G. and Park, H. Y. The effects of Pycnogenol on DNA damage in vitro and expression of superoxide dismutase and HP1 in Escherichia coli SOD and catalase deficient mutant cells. Phytother.Res 2004;18(11):900-905. View abstract.

50876            Nelson, A. B., Lau, B. H., Ide, N., and Rong, Y. Pycnogenol inhibits macrophage oxidative burst, lipoprotein oxidation, and hydroxyl radical-induced DNA damage. Drug Dev.Ind Pharm 1998;24(2):139-144. View abstract.

50877            Berryman, A. M., Maritim, A. C., Sanders, R. A., and Watkins, J. B., III. Influence of treatment of diabetic rats with combinations of pycnogenol, beta-carotene, and alpha-lipoic acid on parameters of oxidative stress. J Biochem Mol Toxicol 2004;18(6):345-352. View abstract.

50878            Dene, B. A., Maritim, A. C., Sanders, R. A., and Watkins, J. B., III. Effects of antioxidant treatment on normal and diabetic rat retinal enzyme activities. J Ocul.Pharmacol Ther 2005;21(1):28-35. View abstract.

50879            Mochizuki, M. and Hasegawa, N. Therapeutic efficacy of pycnogenol in experimental inflammatory bowel diseases. Phytother Res 2004;18(12):1027-1028. View abstract.

50880            Mochizuki, M. and Hasegawa, N. Pycnogenol stimulates lipolysis in 3t3-L1 cells via stimulation of beta-receptor mediated activity. Phytother Res 2004;18(12):1029-1030. View abstract.

50881            Segger, D. and Schonlau, F. Supplementation with Evelle improves skin smoothness and elasticity in a double-blind, placebo-controlled study with 62 women. J Dermatolog.Treat. 2004;15(4):222-226. View abstract.

50882            Huang, W. W., Yang, J. S., Lin, C. F., Ho, W. J., and Lee, M. R. Pycnogenol induces differentiation and apoptosis in human promyeloid leukemia HL-60 cells. Leuk.Res 2005;29(6):685-692. View abstract.

50883            Cesarone, M. R., Belcaro, G., Rohdewald, P., Pellegrini, L., Ippolito, E., Scoccianti, M., Ricci, A., Dugall, M., Cacchio, M., Ruffini, I., Fano, F., Acerbi, G., Vinciguerra, M. G., Bavera, P., Di Renzo, A., Errichi, B. M., and Mucci, F. Prevention of edema in long flights with Pycnogenol. Clin Appl.Thromb.Hemost. 2005;11(3):289-294. View abstract.

50884            Thornfeldt, C. Cosmeceuticals containing herbs: fact, fiction, and future. Dermatol.Surg. 2005;31(7 Pt 2):873-880. View abstract.

50885            Torras, M. A., Faura, C. A., Schonlau, F., and Rohdewald, P. Antimicrobial activity of Pycnogenol. Phytother Res 2005;19(7):647-648. View abstract.

50886            Baumann, L. How to prevent photoaging? J Invest Dermatol. 2005;125(4):xii-xiii. View abstract.

50887            Belcaro, G., Cesarone, M. R., Errichi, B. M., Ledda, A., Di Renzo, A., Stuard, S., Dugall, M., Pellegrini, L., Rohdewald, P., Ippolito, E., Ricci, A., Cacchio, M., Ruffini, I., Fano, F., and Hosoi, M. Venous ulcers: microcirculatory improvement and faster healing with local use of Pycnogenol. Angiology 2005;56(6):699-705. View abstract.

50888            Schafer, A., Chovanova, Z., Muchova, J., Sumegova, K., Liptakova, A., Durackova, Z., and Hogger, P. Inhibition of COX-1 and COX-2 activity by plasma of human volunteers after ingestion of French maritime pine bark extract (Pycnogenol). Biomed.Pharmacother. 2006;60(1):5-9. View abstract.

50889            Grimm, T., Chovanova, Z., Muchova, J., Sumegova, K., Liptakova, A., Durackova, Z., and Hogger, P. Inhibition of NF-kappaB activation and MMP-9 secretion by plasma of human volunteers after ingestion of maritime pine bark extract (Pycnogenol). J Inflamm.(Lond) 2006;3:1. View abstract.

50890            Chayasirisobhon, S. Use of a pine bark extract and antioxidant vitamin combination product as therapy for migraine in patients refractory to pharmacologic medication. Headache 2006;46(5):788-793. View abstract.

50891            Trebaticka, J., Kopasova, S., Hradecna, Z., Cinovsky, K., Skodacek, I., Suba, J., Muchova, J., Zitnanova, I., Waczulikova, I., Rohdewald, P., and Durackova, Z. Treatment of ADHD with French maritime pine bark extract, Pycnogenol. Eur.Child Adolesc.Psychiatry 2006;15(6):329-335. View abstract.

50892            Cesarone, M. R., Belcaro, G., Rohdewald, P., Pellegrini, L., Ledda, A., Vinciguerra, G., Ricci, A., Gizzi, G., Ippolito, E., Fano, F., Dugall, M., Acerbi, G., Cacchio, M., Di Renzo, A., Hosoi, M., Stuard, S., and Corsi, M. Comparison of Pycnogenol and Daflon in treating chronic venous insufficiency: a prospective, controlled study. Clin Appl Thromb.Hemost. 2006;12(2):205-212. View abstract.

50893            Golanski, J., Muchova, J., Golanski, R., Durackova, Z., Markuszewski, L., and Watala, C. Does pycnogenol intensify the efficacy of acetylsalicylic acid in the inhibition of platelet function? In vitro experience. Postepy Hig.Med Dosw.(Online.) 2006;60:316-321. View abstract.

50894            Grimm, T., Skrabala, R., Chovanova, Z., Muchova, J., Sumegova, K., Liptakova, A., Durackova, Z., and Hogger, P. Single and multiple dose pharmacokinetics of maritime pine bark extract (pycnogenol) after oral administration to healthy volunteers. BMC.Clin Pharmacol 2006;6:4. View abstract.

50895            Ahn, J., Grun, I. U., and Mustapha, A. Effects of plant extracts on microbial growth, color change, and lipid oxidation in cooked beef. Food Microbiol. 2007;24(1):7-14. View abstract.

50896            Belcaro, G., Cesarone, M. R., Errichi, B. M., Ledda, A., Di, Renzo A., Stuard, S., Dugall, M., Pellegrini, L., Gizzi, G., Rohdewald, P., Ippolito, E., Ricci, A., Cacchio, M., Cipollone, G., Ruffini, I., Fano, F., and Hosoi, M. Diabetic ulcers: microcirculatory improvement and faster healing with pycnogenol. Clin.Appl.Thromb.Hemost. 2006;12(3):318-323. View abstract.

50897            Voss, P., Horakova, L., Jakstadt, M., Kiekebusch, D., and Grune, T. Ferritin oxidation and proteasomal degradation: protection by antioxidants. Free Radic.Res 2006;40(7):673-683. View abstract.

50898            Dvorakova, M., Sivonova, M., Trebaticka, J., Skodacek, I., Waczulikova, I., Muchova, J., and Durackova, Z. The effect of polyphenolic extract from pine bark, Pycnogenol on the level of glutathione in children suffering from attention deficit hyperactivity disorder (ADHD). Redox.Rep. 2006;11(4):163-172. View abstract.

50899            Chovanova, Z., Muchova, J., Sivonova, M., Dvorakova, M., Zitnanova, I., Waczulikova, I., Trebaticka, J., Skodacek, I., and Durackova, Z. Effect of polyphenolic extract, Pycnogenol, on the level of 8-oxoguanine in children suffering from attention deficit/hyperactivity disorder. Free Radic.Res 2006;40(9):1003-1010. View abstract.

50900            Cesarone, M. R., Belcaro, G., Rohdewald, P., Pellegrini, L., Ledda, A., Vinciguerra, G., Ricci, A., Gizzi, G., Ippolito, E., Fano, F., Dugall, M., Acerbi, G., Cacchio, M., Di Renzo, A., Hosoi, M., Stuard, S., and Corsi, M. Rapid relief of signs/symptoms in chronic venous microangiopathy with pycnogenol: a prospective, controlled study. Angiology 2006;57(5):569-576. View abstract.

50901            Nikolova, V., Stanislavov, R., Vatev, I., Nalbanski, B., and Punevska, M. [Sperm parameters in male idiopathic infertility after treatment with prelox]. Akush.Ginekol.(Sofiia) 2007;46(5):7-12. View abstract.

50902            Dvorakova, M., Jezova, D., Blazicek, P., Trebaticka, J., Skodacek, I., Suba, J., Iveta, W., Rohdewald, P., and Durackova, Z. Urinary catecholamines in children with attention deficit hyperactivity disorder (ADHD): modulation by a polyphenolic extract from pine bark (pycnogenol). Nutr.Neurosci. 2007;10(3-4):151-157. View abstract.

50903            Belcaro, G., Cesarone, M. R., Errichi, S., Zulli, C., Errichi, B. M., Vinciguerra, G., Ledda, A., Di Renzo, A., Stuard, S., Dugall, M., Pellegrini, L., Errichi, S., Gizzi, G., Ippolito, E., Ricci, A., Cacchio, M., Cipollone, G., Ruffini, I., Fano, F., Hosoi, M., and Rohdewald, P. Treatment of osteoarthritis with Pycnogenol. The SVOS (San Valentino Osteo-arthrosis Study). Evaluation of signs, symptoms, physical performance and vascular aspects. Phytother.Res. 2008;22(4):518-523. View abstract.

50904            Suzuki, N., Uebaba, K., Kohama, T., Moniwa, N., Kanayama, N., and Koike, K. French maritime pine bark extract significantly lowers the requirement for analgesic medication in dysmenorrhea: a multicenter, randomized, double-blind, placebo-controlled study. J Reprod.Med. 2008;53(5):338-346. View abstract.

50905            Cisar, P., Jany, R., Waczulikova, I., Sumegova, K., Muchova, J., Vojtassak, J., Durackova, Z., Lisy, M., and Rohdewald, P. Effect of pine bark extract (Pycnogenol) on symptoms of knee osteoarthritis. Phytother.Res. 2008;22(8):1087-1092. View abstract.

50906            Ryan, J., Croft, K., Mori, T., Wesnes, K., Spong, J., Downey, L., Kure, C., Lloyd, J., and Stough, C. An examination of the effects of the antioxidant Pycnogenol on cognitive performance, serum lipid profile, endocrinological and oxidative stress biomarkers in an elderly population. J Psychopharmacol. 2008;22(5):553-562. View abstract.

50907            Belcaro, G., Cesarone, M. R., Errichi, S., Zulli, C., Errichi, B. M., Vinciguerra, G., Ledda, A., Di Renzo, A., Stuard, S., Dugall, M., Pellegrini, L., Gizzi, G., Ippolito, E., Ricci, A., Cacchio, M., Cipollone, G., Ruffini, I., Fano, F., Hosoi, M., and Rohdewald, P. Variations in C-reactive protein, plasma free radicals and fibrinogen values in patients with osteoarthritis treated with Pycnogenol. Redox.Rep. 2008;13(6):271-276. View abstract.

50908            Zibadi, S., Rohdewald, P. J., Park, D., and Watson, R. R. Reduction of cardiovascular risk factors in subjects with type 2 diabetes by Pycnogenol supplementation. Nutr.Res. 2008;28(5):315-320. View abstract.

50909            Rucklidge, J. J., Johnstone, J., and Kaplan, B. J. Nutrient supplementation approaches in the treatment of ADHD. Expert.Rev.Neurother. 2009;9(4):461-476. View abstract.

50910            Belcaro, G., Cesarone, M., Silvia, E., Ledda, A., Stuard, S., G V, Dougall, M., Cornelli, U., Hastings, C., and Schonlau, F. Daily consumption of Reliv Glucaffect for 8 weeks significantly lowered blood glucose and body weight in 50 subjects. Phytother.Res. 4-29-2009; View abstract.

50911            Steigerwalt, R., Belcaro, G., Cesarone, M. R., Di, Renzo A., Grossi, M. G., Ricci, A., Dugall, M., Cacchio, M., and Schonlau, F. Pycnogenol improves microcirculation, retinal edema, and visual acuity in early diabetic retinopathy. J.Ocul.Pharmacol.Ther. 2009;25(6):537-540. View abstract.

50912            Belcaro, G., Cesarone, M. R., Errichi, B., Di, Renzo A., Grossi, M. G., Ricci, A., Dugall, M., Cornelli, U., Cacchio, M., and Rohdewald, P. Pycnogenol treatment of acute hemorrhoidal episodes. Phytother.Res. 2010;24(3):438-444. View abstract.

50913            Cesarone, M. R., Belcaro, G., Stuard, S., Schonlau, F., Di, Renzo A., Grossi, M. G., Dugall, M., Cornelli, U., Cacchio, M., Gizzi, G., and Pellegrini, L. Kidney flow and function in hypertension: protective effects of pycnogenol in hypertensive participants–a controlled study. J.Cardiovasc.Pharmacol.Ther. 2010;15(1):41-46. View abstract.

50914            Ferri, C. and Grassi, D. Antioxidants and beneficial microvascular effects: is this the remedy? Hypertension 2010;55(6):1310-1311. View abstract.

50915            Cesarone, M. R., Belcaro, G., Rohdewald, P., Pellegrini, L., Ledda, A., Vinciguerra, G., Ricci, A., Ippolito, E., Fano, F., Dugall, M., Cacchio, M., Di, Renzo A., Hosoi, M., Stuard, S., and Corsi, M. Improvement of signs and symptoms of chronic venous insufficiency and microangiopathy with Pycnogenol: a prospective, controlled study. Phytomedicine. 2010;17(11):835-839. View abstract.

50916            Stuard, S., Belcaro, G., Cesarone, M. R., Ricci, A., Dugall, M., Cornelli, U., Gizzi, G., Pellegrini, L., and Rohdewald, P. J. Kidney function in metabolic syndrome may be improved with Pycnogenol(R). Panminerva Med. 2010;52(2 Suppl 1):27-32. View abstract.

50917            Grossi, M. G., Belcaro, G., Cesarone, M. R., Dugall, M., Hosoi, M., Cacchio, M., Ippolito, E., and Bavera, P. Improvement in cochlear flow with Pycnogenol(R) in patients with tinnitus: a pilot evaluation. Panminerva Med. 2010;52(2 Suppl 1):63-67. View abstract.

50918            Reuter, J., Wolfle, U., Korting, H. C., and Schempp, C. Which plant for which skin disease? Part 2: Dermatophytes, chronic venous insufficiency, photoprotection, actinic keratoses, vitiligo, hair loss, cosmetic indications. J.Dtsch.Dermatol.Ges. 2010;8(11):866-873. View abstract.

50919            Drieling, R. L., Gardner, C. D., Ma, J., Ahn, D. K., and Stafford, R. S. No beneficial effects of pine bark extract on cardiovascular disease risk factors. Arch.Intern.Med. 9-27-2010;170(17):1541-1547. View abstract.

50920            Pavone, C., Abbadessa, D., Tarantino, M. L., Oxenius, I., Lagana, A., Lupo, A., and Rinella, M. [Associating Serenoa repens, Urtica dioica and Pinus pinaster. Safety and efficacy in the treatment of lower urinary tract symptoms. Prospective study on 320 patients]. Urologia. 2010;77(1):43-51. View abstract.

50921            Henrotin, Y., Lambert, C., Couchourel, D., Ripoll, C., and Chiotelli, E. Nutraceuticals: do they represent a new era in the management of osteoarthritis? – a narrative review from the lessons taken with five products. Osteoarthritis.Cartilage. 2011;19(1):1-21. View abstract.

50922            Dvorakova, M., Paduchova, Z., Muchova, J., Durackova, Z., and Collins, A. R. How does pycnogenol(R) influence oxidative damage to DNA and its repair ability in elderly people? Prague.Med.Rep. 2010;111(4):263-271. View abstract.

50923            Ohkita, M., Kiso, Y., and Matsumura, Y. Pharmacology in health foods: improvement of vascular endothelial function by French maritime pine bark extract (Flavangenol). J.Pharmacol.Sci. 2011;115(4):461-465. View abstract.

50924            Aoki, H., Nagao, J., Ueda, T., Strong, J. M., Schonlau, F., Yu-Jing, S., Lu, Y., and Horie, S. Clinical assessment of a supplement of Pycnogenol(R) and L-arginine in Japanese patients with mild to moderate erectile dysfunction. Phytother.Res. 2012;26(2):204-207. View abstract.

50925            Errichi, B. M., Belcaro, G., Hosoi, M., Cesarone, M. R., Dugall, M., Feragalli, B., Bavera, P., Hosoi, M., Zulli, C., Corsi, M., Ledda, A., Luzzi, R., and Ricci, A. Prevention of post thrombotic syndrome with Pycnogenol(R) in a twelve month study. Panminerva Med. 2011;53(3 Suppl 1):21-27. View abstract.

50926            Belcaro, G., Luzzi, R., Cesinaro Di, Rocco P., Cesarone, M. R., Dugall, M., Feragalli, B., Errichi, B. M., Ippolito, E., Grossi, M. G., Hosoi, M., Errichi, S., Cornelli, U., Ledda, A., and Gizzi, G. Pycnogenol(R) improvements in asthma management. Panminerva Med. 2011;53(3 Suppl 1):57-64. View abstract.

50927            Errichi, S., Bottari, A., Belcaro, G., Cesarone, M. R., Hosoi, M., Cornelli, U., Dugall, M., Ledda, A., and Feragalli, B. Supplementation with Pycnogenol(R) improves signs and symptoms of menopausal transition. Panminerva Med. 2011;53(3 Suppl 1):65-70. View abstract.

50928            Luzzi, R., Belcaro, G., Zulli, C., Cesarone, M. R., Cornelli, U., Dugall, M., Hosoi, M., and Feragalli, B. Pycnogenol(R) supplementation improves cognitive function, attention and mental performance in students. Panminerva Med. 2011;53(3 Suppl 1):75-82. View abstract.

50929            Enseleit, F., Sudano, I., Periat, D., Winnik, S., Wolfrum, M., Flammer, A. J., Frohlich, G. M., Kaiser, P., Hirt, A., Haile, S. R., Krasniqi, N., Matter, C. M., Uhlenhut, K., Hogger, P., Neidhart, M., Luscher, T. F., Ruschitzka, F., and Noll, G. Effects of Pycnogenol on endothelial function in patients with stable coronary artery disease: a double-blind, randomized, placebo-controlled, cross-over study. Eur.Heart J. 2012;33(13):1589-1597. View abstract.

50930            Mach, J., Midgley, A. W., Dank, S., Grant, R. S., and Bentley, D. J. The effect of antioxidant supplementation on fatigue during exercise: potential role for NAD+(H). Nutrients. 2010;2(3):319-329. View abstract.

50931            Marini, A., Grether-Beck, S., Jaenicke, T., Weber, M., Burki, C., Formann, P., Brenden, H., Schonlau, F., and Krutmann, J. Pycnogenol(R) effects on skin elasticity and hydration coincide with increased gene expressions of collagen type I and hyaluronic acid synthase in women. Skin Pharmacol.Physiol 2012;25(2):86-92. View abstract.

50932            Schoonees, A., Visser, J., Musekiwa, A., and Volmink, J. Pycnogenol((R)) for the treatment of chronic disorders. Cochrane.Database.Syst.Rev. 2012;2:CD008294. View abstract.

50933            Schoonees, A., Visser, J., Musekiwa, A., and Volmink, J. Pycnogenol(R) (extract of French maritime pine bark) for the treatment of chronic disorders. Cochrane.Database.Syst.Rev. 2012;4:CD008294. View abstract.

50934            Perera, N., Liolitsa, D., Iype, S., Croxford, A., Yassin, M., Lang, P., Ukaegbu, O., and van, Issum C. Phlebotonics for haemorrhoids. Cochrane.Database.Syst.Rev. 2012;8:CD004322. View abstract.

50935            Furumura, M., Sato, N., Kusaba, N., Takagaki, K., and Nakayama, J. Oral administration of French maritime pine bark extract (Flavangenol((R))) improves clinical symptoms in photoaged facial skin. Clin.Interv.Aging 2012;7:275-286. View abstract.

50936            Rong, Y., Li, L., Shah, V., and Lau, B. H. Pycnogenol protects vascular endothelial cells from t-butyl hydroperoxide induced oxidant injury. Biotechnol Ther 1994;5(3-4):117-126. View abstract.

50937            van Jaarsveld, H., Kuyl, J. M., Schulenburg, D. H., and Wiid, N. M. Effect of flavonoids on the outcome of myocardial mitochondrial ischemia/reperfusion injury. Res Commun.Mol Pathol.Pharmacol 1996;91(1):65-75. View abstract.

50938            Noda, Y., Anzai, K., Mori, A., Kohno, M., Shinmei, M., and Packer, L. Hydroxyl and superoxide anion radical scavenging activities of natural source antioxidants using the computerized JES-FR30 ESR spectrometer system. Biochem Mol Biol Int 1997;42(1):35-44. View abstract.

50939            Macrides, T. A., Shihata, A., Kalafatis, N., and Wright, P. F. A comparison of the hydroxyl radical scavenging properties of the shark bile steroid 5 beta-scymnol and plant pycnogenols. Biochem Mol Biol Int 1997;42(6):1249-1260. View abstract.

50940            Virgili, F., Kobuchi, H., and Packer, L. Procyanidins extracted from Pinus maritima (Pycnogenol): scavengers of free radical species and modulators of nitrogen monoxide metabolism in activated murine RAW 264.7 macrophages. Free Radic.Biol Med 1998;24(7-8):1120-1129. View abstract.

50941            Wei, Z., Peng, Q., and Lau, B. Pycnogenol enhances endothelial cell antioxidant defenses. Redox Report 1997;3:219-224.

50942            Wang S, Tan D Zhao Y et al. The effect of pycnogenol on the microcirculation, platelet function and ischemic myocardium in patients with coronary artery diseases. Eur Bull Drug Res 1999;7:19-25.

50943            Hosseini, S., Lee, J., Sepulveda, R. T., Fagan, T., Rohdewald, P., and Watson, R. R. A randomized, double blind, placebo controlled, prospective 16 week crossover study to determine the role of Pycnogenol(R) in modifying blood pressure in mildly hypertensive patients. Nutr.Res. 2001;21(9):67-76.

50944            Schmidtke I, Schoop W. Pycnogenol: stasis oedema and its medical treatment. Schweizerische Zeitschrift fur GanzheitsMedizin 1995;3:114-115.

50945            Kohama T, Negami M. Effect of Low-dose French Maritime Pine Bark Extract on Climacteric Syndrome in 170 Perimenopausal Women: A Randomized, Double-blind, Placebo-controlled Trial. J Reproductive Med 2013;58(1):39-47.

50946            Durackova, Z., Trebaticky, B., Novotny, V., Zitnanova, A., and Breza, J. Lipid metabolism and erectile dysfunction improvement by Pycnogenol(R), extract from the bark of Pinus pinaster in patients suffering from erectile dysfunction — a pilot study. Nutr.Res. 2003;23:1189-1198.

50947            Jialal I, Devaraj S Hirany S et al. The effect of pycnogenol supplementation on markers of inflammation. Alternative Therapies 2001;7:S17.

50948            Rohdewald P. Reducing the risk for stroke and heart infarction with pycnogenol. Eur Bull Drug Res 1999;7:14-18.

50949            Rohdewald P. Bioavailability and metabolism of pycnogenol. Eur Bull Drug Res 1999;7:5-7.

50950            Hosseini S, Pishnamazi S Sadrzadeh SMH Farid F Farid R Watson RR. Pycnogenol in the management of asthma. J Medicinal Food 2001;4(4):201-209.

50951            Durackova, B. Trebatický V. Novotný I. Žit®anová J. Breza. Lipid metabolism and erectile function improvement by Pycnogenol®, extract from the bark of Pinus pinaster in patients suffering from erectile dysfunction – a pilot study. Nutrition Research 2003;23(9):1189-1198.

50952            Roseff SJ, Gulati R. Improvement of sperm quality by pycnogenol. Eur Bull Drug Res 1999;7:33-36.

50953            Farid R, Mirfeizi Z Mirheidari M Z Rezaieyazdi Mansouri H Esmaelli H. Pycnogenol® supplementation reduces pain and stiffness and improves physical function in adults with knee osteoarthritis. Nutrition Research 2007;27(11):692-697.

 

proanthocyanidin extract on the lipid profile of hypercholesterolemic subjects: a pilot study. J Med 2000;31(5-6):227-246. View abstract.

49778            Shivashankara, A. R., Azmidah, A., Haniadka, R., Rai, M. P., Arora, R., and Baliga, M. S. Dietary agents in the prevention of alcohol-induced hepatotoxicty: preclinical observations. Food Funct. 2012;3(2):101-109. View abstract.

50780            Agarwal, C., Tyagi, A., and Agarwal, R. Gallic acid causes inactivating phosphorylation of cdc25A/cdc25C-cdc2 via ATM-Chk2 activation, leading to cell cycle arrest, and induces apoptosis in human prostate carcinoma DU145 cells. Mol.Cancer Ther 2006;5(12):3294-3302. View abstract.

50895            Ahn, J., Grun, I. U., and Mustapha, A. Effects of plant extracts on microbial growth, color change, and lipid oxidation in cooked beef. Food Microbiol. 2007;24(1):7-14. View abstract.

50974            Bonnet, D., Mejdoubi, S., Sommet, A., and Alric, L. [Acute hepatitis probably induced by Fumaria and Vitis vinifera tinctoria herbal products]. Gastroenterol.Clin.Biol. 2007;31(11):1041-1042. View abstract.

52927            Lu, R. and Serrero, G. Resveratrol, a natural product derived from grape, exhibits antiestrogenic activity and inhibits the growth of human breast cancer cells. J Cell Physiol 1999;179(3):297-304. View abstract.

52928            Ye, X., Krohn, R. L., Liu, W., Joshi, S. S., Kuszynski, C. A., McGinn, T. R., Bagchi, M., Preuss, H. G., Stohs, S. J., and Bagchi, D. The cytotoxic effects of a novel IH636 grape seed proanthocyanidin extract on cultured human cancer cells. Mol.Cell Biochem 1999;196(1-2):99-108. View abstract.

52929            Ozturk, H. S., Kacmaz, M., Cimen, M. Y., and Durak, I. Red wine and black grape strengthen blood antioxidant potential. Nutrition 1999;15(11-12):954-955. View abstract.

52930            Palma, M., Taylor, L. T., Varela, R. M., Cutler, S. J., and Cutler, H. G. Fractional extraction of compounds from grape seeds by supercritical fluid extraction and analysis for antimicrobial and agrochemical activities. J Agric.Food Chem 1999;47(12):5044-5048. View abstract.

52931            Keevil, J. G., Osman, H. E., Reed, J. D., and Folts, J. D. Grape juice, but not orange juice or grapefruit juice, inhibits human platelet aggregation. J Nutr. 2000;130(1):53-56. View abstract.

52932            Paul, B., Masih, I., Deopujari, J., and Charpentier, C. Occurrence of resveratrol and pterostilbene in age-old darakchasava, an ayurvedic medicine from India. J Ethnopharmacol. 12-15-1999;68(1-3):71-76. View abstract.

52933            Durak, I., Avci, A., Kacmaz, M., Buyukkocak, S., Cimen, M. Y., Elgun, S., and Ozturk, H. S. Comparison of antioxidant potentials of red wine, white wine, grape juice and alcohol. Curr.Med Res Opin. 1999;15(4):316-320. View abstract.

52934            Sahach, V. F., Shymans’ka, T. V., Zul’fiharov, O. S., Ovchynnikova, O. H., and Hozhenko, A. I. [The effect of a grape extract on the contractile activity of the myocardium and on the coronary flow of the isolated guinea pig heart]. Fiziol.Zh. 1999;45(5):117-121. View abstract.

52935            Cabras, P., Angioni, A., Caboni, P., Garau, V. L., Melis, M., Pirisi, F. M., and Cabitza, F. Distribution of folpet on the grape surface after treatment. J Agric.Food Chem 2000;48(3):915-916. View abstract.

52936            Gabetta, B., Fuzzati, N., Griffini, A., Lolla, E., Pace, R., Ruffilli, T., and Peterlongo, F. Characterization of proanthocyanidins from grape seeds. Fitoterapia 2000;71(2):162-175. View abstract.

52937            Hsieh, T. C. and Wu, J. M. Grape-derived chemopreventive agent resveratrol decreases prostate-specific antigen (PSA) expression in LNCaP cells by an androgen receptor (AR)-independent mechanism. Anticancer Res 2000;20(1A):225-228. View abstract.

52938            Shirataki, Y., Kawase, M., Saito, S., Kurihara, T., Tanaka, W., Satoh, K., Sakagami, H., and Motohashi, N. Selective cytotoxic activity of grape peel and seed extracts against oral tumor cell lines. Anticancer Res 2000;20(1A):423-426. View abstract.

52939            Berthier, L., Marchal, R., Debray, H., Bonnet, E., Jeandet, P., and Maujean, A. Isolation of isolectins from Vitis vinifera L. Cv. Chardonnay grape berries. J Agric.Food Chem 1999;47(6):2193-2197. View abstract.

52940            Koide, T., Kamei, H., Hashimoto, Y., Kojima, T., and Hasegawa, M. Antitumor effect of hydrolyzed anthocyanin from grape rinds and red rice. Cancer Biother.Radiopharm. 1996;11(4):273-277. View abstract.

52941            Tamura, H. and Matsui, M. Inhibitory effects of green tea and grape juice on the phenol sulfotransferase activity of mouse intestines and human colon carcinoma cell line, Caco-2. Biol.Pharm Bull. 2000;23(6):695-699. View abstract.

52942            Agarwal, C., Sharma, Y., Zhao, J., and Agarwal, R. A polyphenolic fraction from grape seeds causes irreversible growth inhibition of breast carcinoma MDA-MB468 cells by inhibiting mitogen-activated protein kinases activation and inducing G1 arrest and differentiation. Clin.Cancer Res 2000;6(7):2921-2930. View abstract.

52943            Young, J. F., Dragsted, L. O., Daneshvar, B., Lauridsen, S. T., Hansen, M., and Sandstrom, B. The effect of grape-skin extract on oxidative status. Br J Nutr 2000;84(4):505-513. View abstract.

52944            Joshi, S. S., Kuszynski, C. A., Bagchi, M., and Bagchi, D. Chemopreventive effects of grape seed proanthocyanidin extract on Chang liver cells. Toxicology 11-30-2000;155(1-3):83-90. View abstract.

52945            de, Santi C., Pietrabissa, A., Mosca, F., and Pacifici, G. M. Glucuronidation of resveratrol, a natural product present in grape and wine, in the human liver. Xenobiotica 2000;30(11):1047-1054. View abstract.

52946            Sen, C. K. and Bagchi, D. Regulation of inducible adhesion molecule expression in human endothelial cells by grape seed proanthocyanidin extract. Mol.Cell Biochem. 2001;216(1-2):1-7. View abstract.

52947            Bagchi, D., Ray, S. D., Patel, D., and Bagchi, M. Protection against drug- and chemical-induced multiorgan toxicity by a novel IH636 grape seed proanthocyanidin extract. Drugs Exp.Clin.Res 2001;27(1):3-15. View abstract.

52948            Al, Nasir F., Jiries, A. G., Batarseh, M. I., and Beese, F. Pesticides and trace metals residue in grape and home made wine in Jordan. Environ.Monit.Assess. 2001;66(3):253-263. View abstract.

52949            Ray, S. D., Parikh, H., Hickey, E., Bagchi, M., and Bagchi, D. Differential effects of IH636 grape seed proanthocyanidin extract and a DNA repair modulator 4-aminobenzamide on liver microsomal cytochrome 4502E1-dependent aniline hydroxylation. Mol Cell Biochem 2001;218(1-2):27-33. View abstract.

52950            Banerjee, B. and Bagchi, D. Beneficial effects of a novel ih636 grape seed proanthocyanidin extract in the treatment of chronic pancreatitis. Digestion 2001;63(3):203-206. View abstract.

52951            Khanna, S., Roy, S., Bagchi, D., Bagchi, M., and Sen, C. K. Upregulation of oxidant-induced VEGF expression in cultured keratinocytes by a grape seed proanthocyanidin extract. Free Radic.Biol.Med 7-1-2001;31(1):38-42. View abstract.

52952            Kundu, J. K., Rouf, A. S., Hossain, M. N., Hasan, C. M., and Rashid, M. A. Antitumor activity of epifriedelanol from Vitis trifolia. Fitoterapia 2000;71(5):577-579. View abstract.

52953            Joshi, S. S., Kuszynski, C. A., and Bagchi, D. The cellular and molecular basis of health benefits of grape seed proanthocyanidin extract. Curr.Pharm Biotechnol. 2001;2(2):187-200. View abstract.

52954            Chou, E. J., Keevil, J. G., Aeschlimann, S., Wiebe, D. A., Folts, J. D., and Stein, J. H. Effect of ingestion of purple grape juice on endothelial function in patients with coronary heart disease. Am J Cardiol 9-1-2001;88(5):553-555. View abstract.

52955            Fournier, J. [Grape sugar manufacture assays under Premier Empire]. Rev.Hist Pharm (Paris) 1999;47(322):227-234. View abstract.

52956            Bub, A., Watzl, B., Heeb, D., Rechkemmer, G., and Briviba, K. Malvidin-3-glucoside bioavailability in humans after ingestion of red wine, dealcoholized red wine and red grape juice. Eur.J Nutr. 2001;40(3):113-120. View abstract.

52957            Carini, M., Stefani, R., Aldini, G., Ozioli, M., and Facino, R. M. Procyanidins from Vitis vinifera seeds inhibit the respiratory burst of activated human neutrophils and lysosomal enzyme release. Planta Med 2001;67(8):714-717. View abstract.

52958            Bhat, K. P. L., Kosmeder, J. W., and Pezzuto, J. M. Biological effects of resveratrol. Antioxid.Redox.Signal. 2001;3(6):1041-1064. View abstract.

52959            Li, S., Zhong, J., and Sun, F. [Study on the protective effect of grape procyanidins on DNA damage induced by irradiation]. Zhonghua Yu Fang Yi.Xue.Za Zhi. 2000;34(3):131-133. View abstract.

52960            Nair, N., Mahajan, S., Chawda, R., Kandaswami, C., Shanahan, T. C., and Schwartz, S. A. Grape seed extract activates Th1 cells in vitro. Clin.Diagn.Lab Immunol. 2002;9(2):470-476. View abstract.

52961            Torres, J. L., Lozano, C., Julia, L., Sanchez-Baeza, F. J., Anglada, J. M., Centelles, J. J., and Cascante, M. Cysteinyl-flavan-3-ol conjugates from grape procyanidins. Antioxidant and antiproliferative properties. Bioorg.Med Chem 2002;10(8):2497-2509. View abstract.

52962            Fitzpatrick, D. F., Bing, B., Maggi, D. A., Fleming, R. C., and O’Malley, R. M. Vasodilating procyanidins derived from grape seeds. Ann.N.Y.Acad.Sci. 2002;957:78-89. View abstract.

52963            Preuss, H. G., Bagchi, D., and Bagchi, M. Protective effects of a novel niacin-bound chromium complex and a grape seed proanthocyanidin extract on advancing age and various aspects of syndrome X. Ann.N.Y.Acad.Sci. 2002;957:250-259. View abstract.

52964            Bagchi, D., Bagchi, M., Stohs, Sj, Ray, S. D., Sen, C. K., and Preuss, H. G. Cellular protection with proanthocyanidins derived from grape seeds. Ann.N.Y.Acad.Sci. 2002;957:260-270. View abstract.

52965            Cui, J., Cordis, G. A., Tosaki, A., Maulik, N., and Das, D. K. Reduction of myocardial ischemia reperfusion injury with regular consumption of grapes. Ann.N.Y.Acad.Sci. 2002;957:302-307. View abstract.

52966            Chidambara Murthy, K. N., Singh, R. P., and Jayaprakasha, G. K. Antioxidant activities of grape (Vitis vinifera) pomace extracts. J Agric.Food Chem 10-9-2002;50(21):5909-5914. View abstract.

52967            Simonetti, P., Ciappellano, S., Gardana, C., Bramati, L., and Pietta, P. Procyanidins from Vitis vinifera seeds: in vivo effects on oxidative stress. J Agric.Food Chem 10-9-2002;50(21):6217-6221. View abstract.

52968            Khanna, S., Venojarvi, M., Roy, S., Sharma, N., Trikha, P., Bagchi, D., Bagchi, M., and Sen, C. K. Dermal wound healing properties of redox-active grape seed proanthocyanidins. Free Radic.Biol.Med 10-15-2002;33(8):1089-1096. View abstract.

52969            Cui, J., Juhasz, B., Tosaki, A., Maulik, N., and Das, D. K. Cardioprotection with grapes. J Cardiovasc.Pharmacol. 2002;40(5):762-769. View abstract.

52970            Agarwal, C., Singh, R. P., and Agarwal, R. Grape seed extract induces apoptotic death of human prostate carcinoma DU145 cells via caspases activation accompanied by dissipation of mitochondrial membrane potential and cytochrome c release. Carcinogenesis 2002;23(11):1869-1876. View abstract.

52971            Kalin, R., Righi, A., Del, Rosso A., Bagchi, D., Generini, S., Cerinic, M. M., and Das, D. K. Activin, a grape seed-derived proanthocyanidin extract, reduces plasma levels of oxidative stress and adhesion molecules (ICAM-1, VCAM-1 and E-selectin) in systemic sclerosis. Free Radic.Res 2002;36(8):819-825. View abstract.

52972            O’Byrne, D. J., Devaraj, S., Grundy, S. M., and Jialal, I. Comparison of the antioxidant effects of Concord grape juice flavonoids alpha-tocopherol on markers of oxidative stress in healthy adults. Am J Clin.Nutr. 2002;76(6):1367-1374. View abstract.

52973            Nair, M. P., Kandaswami, C., Mahajan, S., Nair, H. N., Chawda, R., Shanahan, T., and Schwartz, S. A. Grape seed extract proanthocyanidins downregulate HIV-1 entry coreceptors, CCR2b, CCR3 and CCR5 gene expression by normal peripheral blood mononuclear cells. Biol.Res 2002;35(3-4):421-431. View abstract.

52974            Shanmuganayagam, D., Beahm, M. R., Osman, H. E., Krueger, C. G., Reed, J. D., and Folts, J. D. Grape seed and grape skin extracts elicit a greater antiplatelet effect when used in combination than when used individually in dogs and humans. J Nutr. 2002;132(12):3592-3598. View abstract.

52975            Torres, J. L., Varela, B., Garcia, M. T., Carilla, J., Matito, C., Centelles, J. J., Cascante, M., Sort, X., and Bobet, R. Valorization of grape (Vitis vinifera) byproducts. Antioxidant and biological properties of polyphenolic fractions differing in procyanidin composition and flavonol content. J Agric.Food Chem 12-18-2002;50(26):7548-7555. View abstract.

52976            Natella, F., Belelli, F., Gentili, V., Ursini, F., and Scaccini, C. Grape seed proanthocyanidins prevent plasma postprandial oxidative stress in humans. J Agric.Food Chem 12-18-2002;50(26):7720-7725. View abstract.

52977            Billard, C., Izard, J. C., Roman, V., Kern, C., Mathiot, C., Mentz, F., and Kolb, J. P. Comparative antiproliferative and apoptotic effects of resveratrol, epsilon-viniferin and vine-shots derived polyphenols (vineatrols) on chronic B lymphocytic leukemia cells and normal human lymphocytes. Leuk.Lymphoma 2002;43(10):1991-2002. View abstract.

52978            Katsuzaki, H., Hibasami, H., Ohwaki, S., Ishikawa, K., Imai, K., Date, K., Kimura, Y., and Komiya, T. Cyanidin 3-O-beta-D-glucoside isolated from skin of black Glycine max and other anthocyanins isolated from skin of red grape induce apoptosis in human lymphoid leukemia Molt 4B cells. Oncol.Rep. 2003;10(2):297-300. View abstract.

52979            Bagchi, D., Ray, S. D., Bagchi, M., Preuss, H. G., and Stohs, S. J. Mechanistic pathways of antioxidant cytoprotection by a novel IH636 grape seed proanthocyanidin extract. Indian J Exp.Biol. 2002;40(6):717-726. View abstract.

52980            Tyagi, A., Agarwal, R., and Agarwal, C. Grape seed extract inhibits EGF-induced and constitutively active mitogenic signaling but activates JNK in human prostate carcinoma DU145 cells: possible role in antiproliferation and apoptosis. Oncogene 3-6-2003;22(9):1302-1316. View abstract.

52981            Bagchi, D., Sen, C. K., Ray, S. D., Das, D. K., Bagchi, M., Preuss, H. G., and Vinson, J. A. Molecular mechanisms of cardioprotection by a novel grape seed proanthocyanidin extract. Mutat.Res 2003;523-524:87-97. View abstract.

52982            Sovak, M. Grape Extract, Resveratrol, and Its Analogs: A Review. J Med Food 2001;4(2):93-105. View abstract.

52983            Brown, K. L., Shefler, A., Cohen, G., DeMunter, C., Pigott, N., and Goldman, A. P. Near-fatal grape aspiration with complicating acute lung injury successfully treated with extracorporeal membrane oxygenation. Pediatr Crit Care Med 2003;4(2):243-245. View abstract.

52984            Frank, T., Netzel, M., Strass, G., Bitsch, R., and Bitsch, I. Bioavailability of anthocyanidin-3-glucosides following consumption of red wine and red grape juice. Can J Physiol Pharmacol. 2003;81(5):423-435. View abstract.

52985            Schaefer, E., Peil, H., Ambrosetti, L., and Petrini, O. Oedema protective properties of the red vine leaf extract AS 195 (Folia vitis viniferae) in the treatment of chronic venous insufficiency. A 6-week observational clinical trial. Arzneimittelforschung. 2003;53(4):243-246. View abstract.

52986            Shafiee, M., Carbonneau, M. A., Urban, N., Descomps, B., and Leger, C. L. Grape and grape seed extract capacities at protecting LDL against oxidation generated by Cu2+, AAPH or SIN-1 and at decreasing superoxide THP-1 cell production. A comparison to other extracts or compounds. Free Radic.Res 2003;37(5):573-584. View abstract.

52987            Piver, B., Berthou, F., Dreano, Y., and Lucas, D. Differential inhibition of human cytochrome P450 enzymes by epsilon-viniferin, the dimer of resveratrol: comparison with resveratrol and polyphenols from alcoholized beverages. Life Sci. 7-18-2003;73(9):1199-1213. View abstract.

52988            Sano, A., Yamakoshi, J., Tokutake, S., Tobe, K., Kubota, Y., and Kikuchi, M. Procyanidin B1 is detected in human serum after intake of proanthocyanidin-rich grape seed extract. Biosci.Biotechnol.Biochem. 2003;67(5):1140-1143. View abstract.

52989            Nees, S., Weiss, D. R., Reichenbach-Klinke, E., Rampp, F., Heilmeier, B., Kanbach, J., and Esperester, A. Protective effects of flavonoids contained in the red vine leaf on venular endothelium against the attack of activated blood components in vitro. Arzneimittelforschung. 2003;53(5):330-341. View abstract.

52990            Dhanalakshmi, S., Agarwal, R., and Agarwal, C. Inhibition of NF-kappaB pathway in grape seed extract-induced apoptotic death of human prostate carcinoma DU145 cells. Int J Oncol. 2003;23(3):721-727. View abstract.

52991            Aldini, G., Carini, M., Piccoli, A., Rossoni, G., and Facino, R. M. Procyanidins from grape seeds protect endothelial cells from peroxynitrite damage and enhance endothelium-dependent relaxation in human artery: new evidences for cardio-protection. Life Sci. 10-17-2003;73(22):2883-2898. View abstract.

52992            Vigna, G. B., Costantini, F., Aldini, G., Carini, M., Catapano, A., Schena, F., Tangerini, A., Zanca, R., Bombardelli, E., Morazzoni, P., Mezzetti, A., Fellin, R., and Maffei, Facino R. Effect of a standardized grape seed extract on low-density lipoprotein susceptibility to oxidation in heavy smokers. Metabolism 2003;52(10):1250-1257. View abstract.

52993            Singletary, K. W., Stansbury, M. J., Giusti, M., Van Breemen, R. B., Wallig, M., and Rimando, A. Inhibition of rat mammary tumorigenesis by concord grape juice constituents. J Agric.Food Chem 12-3-2003;51(25):7280-7286. View abstract.

52994            Wang, H., Race, E. J., and Shrikhande, A. J. Anthocyanin transformation in Cabernet Sauvignon wine during aging. J Agric.Food Chem 12-31-2003;51(27):7989-7994. View abstract.

52995            Singh, R. P., Tyagi, A. K., Dhanalakshmi, S., Agarwal, R., and Agarwal, C. Grape seed extract inhibits advanced human prostate tumor growth and angiogenesis and upregulates insulin-like growth factor binding protein-3. Int.J Cancer 2-20-2004;108(5):733-740. View abstract.

52996            Larrosa, M., Tomas-Barberan, F. A., and Espin, J. C. Grape polyphenol resveratrol and the related molecule 4-hydroxystilbene induce growth inhibition, apoptosis, S-phase arrest, and upregulation of cyclins A, E, and B1 in human SK-Mel-28 melanoma cells. J Agric.Food Chem 7-30-2003;51(16):4576-4584. View abstract.

52997            Vayalil, P. K., Mittal, A., and Katiyar, S. K. Proanthocyanidins from grape seeds inhibit expression of matrix metalloproteinases in human prostate carcinoma cells, which is associated with the inhibition of activation of MAPK and NF kappa B. Carcinogenesis 2004;25(6):987-995. View abstract.

52998            Agarwal, C., Singh, R. P., Dhanalakshmi, S., and Agarwal, R. Anti-angiogenic efficacy of grape seed extract in endothelial cells. Oncol.Rep. 2004;11(3):681-685. View abstract.

52999            Shi, J., Yu, J., Pohorly, J. E., and Kakuda, Y. Polyphenolics in grape seeds-biochemistry and functionality. J Med Food 2003;6(4):291-299. View abstract.

53000            Palenzuela, B., Arce, L., Macho, A., Munoz, E., Rios, A., and Valcarcel, M. Bioguided extraction of polyphenols from grape marc by using an alternative supercritical-fluid extraction method based on a liquid solvent trap. Anal.Bioanal.Chem 2004;378(8):2021-2027. View abstract.

53001            Shao, Z. H., Vanden Hoek, T. L., Li, C. Q., Schumacker, P. T., Becker, L. B., Chan, K. C., Qin, Y., Yin, J. J., and Yuan, C. S. Synergistic effect of Scutellaria baicalensis and grape seed proanthocyanidins on scavenging reactive oxygen species in vitro. Am J Chin Med 2004;32(1):89-95. View abstract.

53002            Laurent, C., Besancon, P., Auger, C., Rouanet, J. M., and Caporiccio, B. Grape seed extract affects proliferation and differentiation of human intestinal Caco-2 cells. J Agric.Food Chem 6-2-2004;52(11):3301-3308. View abstract.

53003            Rawn, D. F., Roscoe, V., Krakalovich, T., and Hanson, C. N-methyl carbamate concentrations and dietary intake estimates for apple and grape juices available on the retail market in Canada. Food Addit.Contam 2004;21(6):555-563. View abstract.

53004            Rosa, C. A., Magnoli, C. E., Fraga, M. E., Dalcero, A. M., and Santana, D. M. Occurrence of ochratoxin A in wine and grape juice marketed in Rio de Janeiro, Brazil. Food Addit.Contam 2004;21(4):358-364. View abstract.

53005            Kalus, U., Koscielny, J., Grigorov, A., Schaefer, E., Peil, H., and Kiesewetter, H. Improvement of cutaneous microcirculation and oxygen supply in patients with chronic venous insufficiency by orally administered extract of red vine leaves AS 195: a randomised, double-blind, placebo-controlled, crossover study. Drugs R.D. 2004;5(2):63-71. View abstract.

53006            Larrosa, M., Tomas-Barberan, F. A., and Espin, J. C. The grape and wine polyphenol piceatannol is a potent inducer of apoptosis in human SK-Mel-28 melanoma cells. Eur.J Nutr. 2004;43(5):275-284. View abstract.

53007            Ward, N. C., Croft, K. D., Puddey, I. B., and Hodgson, J. M. Supplementation with grape seed polyphenols results in increased urinary excretion of 3-hydroxyphenylpropionic Acid, an important metabolite of proanthocyanidins in humans. J Agric.Food Chem 8-25-2004;52(17):5545-5549. View abstract.

53008            Sugisawa, A., Inoue, S., and Umegaki, K. Grape seed extract prevents H(2)O(2)-induced chromosomal damage in human lymphoblastoid cells. Biol.Pharm Bull. 2004;27(9):1459-1461. View abstract.

53009            Nomoto, H., Iigo, M., Hamada, H., Kojima, S., and Tsuda, H. Chemoprevention of colorectal cancer by grape seed proanthocyanidin is accompanied by a decrease in proliferation and increase in apoptosis. Nutr Cancer 2004;49(1):81-88. View abstract.

53010            Bejaoui, H., Mathieu, F., Taillandier, P., and Lebrihi, A. Ochratoxin A removal in synthetic and natural grape juices by selected oenological Saccharomyces strains. J Appl.Microbiol. 2004;97(5):1038-1044. View abstract.

53011            Nishikawa, M., Ariyoshi, N., Kotani, A., Ishii, I., Nakamura, H., Nakasa, H., Ida, M., Nakamura, H., Kimura, N., Kimura, M., Hasegawa, A., Kusu, F., Ohmori, S., Nakazawa, K., and Kitada, M. Effects of continuous ingestion of green tea or grape seed extracts on the pharmacokinetics of midazolam. Drug Metab Pharmacokinet. 2004;19(4):280-289. View abstract.

53012            Albers, A. R., Varghese, S., Vitseva, O., Vita, J. A., and Freedman, J. E. The antiinflammatory effects of purple grape juice consumption in subjects with stable coronary artery disease. Arterioscler.Thromb.Vasc.Biol. 2004;24(11):e179-e180. View abstract.

53013            Rapeanu, G., Van, Loey A., Smout, C., and Hendrickx, M. Thermostability of Victoria grape (Vitis vinifera ssp. sativa) polyphenoloxidase. Commun.Agric.Appl.Biol.Sci. 2004;69(2):231-234. View abstract.

53014            Mitjans, M., del, Campo J., Abajo, C., Martinez, V., Selga, A., Lozano, C., Torres, J. L., and Vinardell, M. P. Immunomodulatory activity of a new family of antioxidants obtained from grape polyphenols. J Agric.Food Chem 12-1-2004;52(24):7297-7299. View abstract.

53015            Clifton, P. M. Effect of Grape Seed Extract and Quercetin on Cardiovascular and Endothelial Parameters in High-Risk Subjects. J Biomed.Biotechnol. 2004;2004(5):272-278. View abstract.

53016            Yamakoshi, J., Sano, A., Tokutake, S., Saito, M., Kikuchi, M., Kubota, Y., Kawachi, Y., and Otsuka, F. Oral intake of proanthocyanidin-rich extract from grape seeds improves chloasma. Phytother Res 2004;18(11):895-899. View abstract.

53017            de Lange, D. W., Scholman, W. L., Kraaijenhagen, R. J., Akkerman, J. W., and van de Wiel, A. Alcohol and polyphenolic grape extract inhibit platelet adhesion in flowing blood. Eur.J Clin.Invest 2004;34(12):818-824. View abstract.

53018            Park, Y. K., Kim, J. S., and Kang, M. H. Concord grape juice supplementation reduces blood pressure in Korean hypertensive men: double-blind, placebo controlled intervention trial. Biofactors 2004;22(1-4):145-147. View abstract.

53019            Hansen, A. S., Marckmann, P., Dragsted, L. O., Finne Nielsen, I. L., Nielsen, S. E., and Gronbaek, M. Effect of red wine and red grape extract on blood lipids, haemostatic factors, and other risk factors for cardiovascular disease. Eur.J Clin.Nutr. 2005;59(3):449-455. View abstract.

53020            Ng, W., Mankotia, M., Pantazopoulos, P., Neil, R. J., and Scott, P. M. Ochratoxin A in wine and grape juice sold in Canada. Food Addit.Contam 2004;21(10):971-981. View abstract.

53021            Jo, J. Y., Gonzalez de, Mejia E., and Lila, M. A. Effects of grape cell culture extracts on human topoisomerase II catalytic activity and characterization of active fractions. J Agric.Food Chem 4-6-2005;53(7):2489-2498. View abstract.

53022            Durak, I., Cetin, R., Devrim, E., and Erguder, I. B. Effects of black grape extract on activities of DNA turn-over enzymes in cancerous and non cancerous human colon tissues. Life Sci. 5-6-2005;76(25):2995-3000. View abstract.

53023            Combina, M., Mercado, L., Borgo, P., Elia, A., Jofre, V., Ganga, A., Martinez, C., and Catania, C. Yeasts associated to Malbec grape berries from Mendoza, Argentina. J Appl.Microbiol. 2005;98(5):1055-1061. View abstract.

53024            Erguder, I. B., Cetin, R., Devrim, E., Kilicoglu, B., Avci, A., and Durak, I. Effects of cyclosporine on oxidant/antioxidant status in rat ovary tissues: protective role of black grape extract. Int.Immunopharmacol. 2005;5(7-8):1311-1315. View abstract.

53025            Sharma, S. D. and Katiyar, S. K. Dietary grape-seed proanthocyanidin inhibition of ultraviolet B-induced immune suppression is associated with induction of IL-12. Carcinogenesis 2006;27(1):95-102. View abstract.

53026            Laurent, C., Besancon, P., and Caporiccio, B. Ethanol and polyphenolic free wine matrix stimulate the differentiation of human intestinal Caco-2 cells. Influence of their association with a procyanidin-rich grape seed extract. J Agric.Food Chem 7-13-2005;53(14):5541-5548. View abstract.

53027            Puiggros, F., Llopiz, N., Ardevol, A., Blade, C., Arola, L., and Salvado, M. J. Grape seed procyanidins prevent oxidative injury by modulating the expression of antioxidant enzyme systems. J Agric.Food Chem 7-27-2005;53(15):6080-6086. View abstract.

53028            Zern, T. L., Wood, R. J., Greene, C., West, K. L., Liu, Y., Aggarwal, D., Shachter, N. S., and Fernandez, M. L. Grape polyphenols exert a cardioprotective effect in pre- and postmenopausal women by lowering plasma lipids and reducing oxidative stress. J Nutr. 2005;135(8):1911-1917. View abstract.

53029            Morre, D. M. and Morre, D. J. Anticancer activity of grape and grape skin extracts alone and combined with green tea infusions. Cancer Lett. 7-18-2006;238(2):202-209. View abstract.

53030            Coimbra, S. R., Lage, S. H., Brandizzi, L., Yoshida, V., and da Luz, P. L. The action of red wine and purple grape juice on vascular reactivity is independent of plasma lipids in hypercholesterolemic patients. Braz.J Med Biol.Res 2005;38(9):1339-1347. View abstract.

53031            Vitseva, O., Varghese, S., Chakrabarti, S., Folts, J. D., and Freedman, J. E. Grape seed and skin extracts inhibit platelet function and release of reactive oxygen intermediates. J Cardiovasc.Pharmacol. 2005;46(4):445-451. View abstract.

53032            Larronde, F., Richard, T., Delaunay, J. C., Decendit, A., Monti, J. P., Krisa, S., and Merillon, J. M. New stilbenoid glucosides isolated from Vitis vinifera cell suspension cultures (cv. Cabernet Sauvignon). Planta Med 2005;71(9):888-890. View abstract.

53033            Tao, H. Y., Wu, C. F., Zhou, Y., Gong, W. H., Zhang, X., Iribarren, P., Zhao, Y. Q., Le, Y. Y., and Wang, J. M. The grape component resveratrol interferes with the function of chemoattractant receptors on phagocytic leukocytes. Cell Mol.Immunol. 2004;1(1):50-56. View abstract.

53034            Yi, W., Fischer, J., and Akoh, C. C. Study of anticancer activities of muscadine grape phenolics in vitro. J Agric.Food Chem 11-2-2005;53(22):8804-8812. View abstract.

53035            Garcia-Alonso, M., Rimbach, G., Sasai, M., Nakahara, M., Matsugo, S., Uchida, Y., Rivas-Gonzalo, J. C., and De Pascual-Teresa, S. Electron spin resonance spectroscopy studies on the free radical scavenging activity of wine anthocyanins and pyranoanthocyanins. Mol.Nutr.Food Res 2005;49(12):1112-1119. View abstract.

53036            Lekakis, J., Rallidis, L. S., Andreadou, I., Vamvakou, G., Kazantzoglou, G., Magiatis, P., Skaltsounis, A. L., and Kremastinos, D. T. Polyphenolic compounds from red grapes acutely improve endothelial function in patients with coronary heart disease. Eur.J Cardiovasc.Prev.Rehabil. 2005;12(6):596-600. View abstract.

53037            Godichaud, S., Si-Tayeb, K., Auge, N., Desmouliere, A., Balabaud, C., Payrastre, B., Negre-Salvayre, A., and Rosenbaum, J. The grape-derived polyphenol resveratrol differentially affects epidermal and platelet-derived growth factor signaling in human liver myofibroblasts. Int.J Biochem.Cell Biol. 2006;38(4):629-637. View abstract.

53038            Faria, A., Mateus, N., de, Freitas, V, and Calhau, C. Modulation of MPP+ uptake by procyanidins in Caco-2 cells: involvement of oxidation/reduction reactions. FEBS Lett 1-9-2006;580(1):155-160. View abstract.

53039            Furzer, G. S., Veldhuis, L., and Hall, J. C. Development and comparison of three diagnostic immunoassay formats for the detection of azoxystrobin. J Agric.Food Chem 2-8-2006;54(3):688-693. View abstract.

53040            Barthomeuf, C., Lamy, S., Blanchette, M., Boivin, D., Gingras, D., and Beliveau, R. Inhibition of sphingosine-1-phosphate- and vascular endothelial growth factor-induced endothelial cell chemotaxis by red grape skin polyphenols correlates with a decrease in early platelet-activating factor synthesis. Free Radic.Biol.Med 2-15-2006;40(4):581-590. View abstract.

53041            Baliga, M. S. and Katiyar, S. K. Chemoprevention of photocarcinogenesis by selected dietary botanicals. Photochem.Photobiol.Sci. 2006;5(2):243-253. View abstract.

53042            Do, Q. T., Renimel, I., Andre, P., Lugnier, C., Muller, C. D., and Bernard, P. Reverse pharmacognosy: application of selnergy, a new tool for lead discovery. The example of epsilon-viniferin. Curr.Drug Discov.Technol. 2005;2(3):161-167. View abstract.

53043            Veluri, R., Singh, R. P., Liu, Z., Thompson, J. A., Agarwal, R., and Agarwal, C. Fractionation of grape seed extract and identification of gallic acid as one of the major active constituents causing growth inhibition and apoptotic death of DU145 human prostate carcinoma cells. Carcinogenesis 2006;27(7):1445-1453. View abstract.

53044            Monsieur, R. and Van, Snick G. [Efficacy of the red vine leaf extract AS 195 in Chronic Venous Insufficiency]. Praxis.(Bern.1994.) 1-25-2006;95(6):187-190. View abstract.

53045            Jo, J. Y., Gonzalez de, Mejia E., and Lila, M. A. Catalytic inhibition of human DNA topoisomerase II by interactions of grape cell culture polyphenols. J Agric.Food Chem 3-22-2006;54(6):2083-2087. View abstract.

53046            Faria, A., Calhau, C., de, Freitas, V, and Mateus, N. Procyanidins as antioxidants and tumor cell growth modulators. J Agric Food Chem 3-22-2006;54(6):2392-2397. View abstract.

53047            Hu, H. and Qin, Y. M. Grape seed proanthocyanidin extract induced mitochondria-associated apoptosis in human acute myeloid leukaemia 14.3D10 cells. Chin Med J (Engl.) 3-5-2006;119(5):417-421. View abstract.

53048            Brooker, S., Martin, S., Pearson, A., Bagchi, D., Earl, J., Gothard, L., Hall, E., Porter, L., and Yarnold, J. Double-blind, placebo-controlled, randomised phase II trial of IH636 grape seed proanthocyanidin extract (GSPE) in patients with radiation-induced breast induration. Radiother.Oncol 2006;79(1):45-51. View abstract.

53049            Prokop, J., Abrman, P., Seligson, A. L., and Sovak, M. Resveratrol and its glycon piceid are stable polyphenols. J Med Food 2006;9(1):11-14. View abstract.

53050            Mantena, S. K., Baliga, M. S., and Katiyar, S. K. Grape seed proanthocyanidins induce apoptosis and inhibit metastasis of highly metastatic breast carcinoma cells. Carcinogenesis 2006;27(8):1682-1691. View abstract.

53051            Rabovsky, A., Cuomo, J., and Eich, N. Measurement of plasma antioxidant reserve after supplementation with various antioxidants in healthy subjects. Clin Chim Acta 2006;371(1-2):55-60. View abstract.

53052            Katiyar, S. K. Matrix metalloproteinases in cancer metastasis: molecular targets for prostate cancer prevention by green tea polyphenols and grape seed proanthocyanidins. Endocr.Metab Immune.Disord Drug Targets. 2006;6(1):17-24. View abstract.

53053            Mantena, S. K. and Katiyar, S. K. Grape seed proanthocyanidins inhibit UV-radiation-induced oxidative stress and activation of MAPK and NF-kappaB signaling in human epidermal keratinocytes. Free Radic.Biol Med 5-1-2006;40(9):1603-1614. View abstract.

53054            Skovgaard, G. R., Jensen, A. S., and Sigler, M. L. Effect of a novel dietary supplement on skin aging in post-menopausal women. Eur J Clin Nutr 2006;60(10):1201-1206. View abstract.

53055            Wright, T. I., Spencer, J. M., and Flowers, F. P. Chemoprevention of nonmelanoma skin cancer. J Am.Acad.Dermatol. 2006;54(6):933-946. View abstract.

53056            Kaur, M., Agarwal, R., and Agarwal, C. Grape seed extract induces anoikis and caspase-mediated apoptosis in human prostate carcinoma LNCaP cells: possible role of ataxia telangiectasia mutated-p53 activation. Mol.Cancer Ther 2006;5(5):1265-1274. View abstract.

53057            Kijima, I., Phung, S., Hur, G., Kwok, S. L., and Chen, S. Grape seed extract is an aromatase inhibitor and a suppressor of aromatase expression. Cancer Res 6-1-2006;66(11):5960-5967. View abstract.

53058            Wang, Z., Chen, Y., Labinskyy, N., Hsieh, T. C., Ungvari, Z., and Wu, J. M. Regulation of proliferation and gene expression in cultured human aortic smooth muscle cells by resveratrol and standardized grape extracts. Biochem.Biophys.Res Commun. 7-21-2006;346(1):367-376. View abstract.

53059            Iriti, M. and Faoro, F. Grape phytochemicals: a bouquet of old and new nutraceuticals for human health. Med Hypotheses 2006;67(4):833-838. View abstract.

53060            Davalos, A., Fernandez-Hernando, C., Cerrato, F., Martinez-Botas, J., Gomez-Coronado, D., Gomez-Cordoves, C., and Lasuncion, M. A. Red grape juice polyphenols alter cholesterol homeostasis and increase LDL-receptor activity in human cells in vitro. J Nutr. 2006;136(7):1766-1773. View abstract.

53061            O’Brien, N. M., Carpenter, R., O’Callaghan, Y. C., O’Grady, M. N., and Kerry, J. P. Modulatory effects of resveratrol, citroflavan-3-ol, and plant-derived extracts on oxidative stress in U937 cells. J Med Food 2006;9(2):187-195. View abstract.

53062            Castilla, P., Echarri, R., Davalos, A., Cerrato, F., Ortega, H., Teruel, J. L., Lucas, M. F., Gomez-Coronado, D., Ortuno, J., and Lasuncion, M. A. Concentrated red grape juice exerts antioxidant, hypolipidemic, and antiinflammatory effects in both hemodialysis patients and healthy subjects. Am J Clin.Nutr. 2006;84(1):252-262. View abstract.

53063            Jo, J. Y., de Mejia, E. G., and Lila, M. A. Cytotoxicity of bioactive polymeric fractions from grape cell culture on human hepatocellular carcinoma, murine leukemia and non-cancerous PK15 kidney cells. Food Chem Toxicol. 2006;44(10):1758-1767. View abstract.

53064            Yanez, M., Fraiz, N., Cano, E., and Orallo, F. (-)-Trans-epsilon-viniferin, a polyphenol present in wines, is an inhibitor of noradrenaline and 5-hydroxytryptamine uptake and of monoamine oxidase activity. Eur.J Pharmacol. 8-7-2006;542(1-3):54-60. View abstract.

53065            Fumagalli, F., Rossoni, M., Iriti, M., di, Gennaro A., Faoro, F., Borroni, E., Borgo, M., Scienza, A., Sala, A., and Folco, G. From field to health: a simple way to increase the nutraceutical content of grape as shown by NO-dependent vascular relaxation. J Agric.Food Chem 7-26-2006;54(15):5344-5349. View abstract.

53066            Ugartondo, V., Mitjans, M., Lozano, C., Torres, J. L., and Vinardell, M. P. Comparative study of the cytotoxicity induced by antioxidant epicatechin conjugates obtained from grape. J Agric.Food Chem 9-6-2006;54(18):6945-6950. View abstract.

53067            Zhang, F. L., Gao, H. Q., Wu, J. M., Ma, Y. B., You, B. A., Li, B. Y., and Xuan, J. H. Selective inhibition by grape seed proanthocyanidin extracts of cell adhesion molecule expression induced by advanced glycation end products in endothelial cells. J Cardiovasc.Pharmacol 2006;48(2):47-53. View abstract.

53068            Hakimuddin, F., Paliyath, G., and Meckling, K. Treatment of mcf-7 breast cancer cells with a red grape wine polyphenol fraction results in disruption of calcium homeostasis and cell cycle arrest causing selective cytotoxicity. J Agric.Food Chem 10-4-2006;54(20):7912-7923. View abstract.

53069            Suppasrivasuseth, J., Bellantone, R. A., Plakogiannis, F. M., and Stagni, G. Permeability and retention studies of (-)epicatechin gel formulations in human cadaver skin. Drug Dev Ind Pharm 2006;32(9):1007-1017. View abstract.

53070            A review of evidence on red vine leaf extract in the prevention and management of venous disease. J Wound Care 2006;15(9):393-396. View abstract.

53071            Kaur, M., Singh, R. P., Gu, M., Agarwal, R., and Agarwal, C. Grape seed extract inhibits in vitro and in vivo growth of human colorectal carcinoma cells. Clin Cancer Res 10-15-2006;12(20 Pt 1):6194-6202. View abstract.

53072            Kar, P., Laight, D., Shaw, K. M., and Cummings, M. H. Flavonoid-rich grapeseed extracts: a new approach in high cardiovascular risk patients? Int J Clin Pract 2006;60(11):1484-1492. View abstract.

53073            Davalos, A., Castilla, P., Gomez-Cordoves, C., and Bartolome, B. Quercetin is bioavailable from a single ingestion of grape juice. Int.J Food Sci.Nutr. 2006;57(5-6):391-398. View abstract.

53074            Lin, A. D., Mannikarottu, A., Kogan, B. A., Whitbeck, C., Leggett, R. E., and Levin, R. M. Effect of bilateral in vivo ischemia/reperfusion on the activities of superoxide dismutase and catalase: response to a standardized grape suspension. Mol.Cell Biochem. 2007;296(1-2):11-16. View abstract.

53075            Rathel, T. R., Samtleben, R., Vollmar, A. M., and Dirsch, V. M. Activation of endothelial nitric oxide synthase by red wine polyphenols: impact of grape cultivars, growing area and the vinification process. J Hypertens. 2007;25(3):541-549. View abstract.

53076            Agarwal, C., Veluri, R., Kaur, M., Chou, S. C., Thompson, J. A., and Agarwal, R. Fractionation of high molecular weight tannins in grape seed extract and identification of procyanidin B2-3,3′-di-O-gallate as a major active constituent causing growth inhibition and apoptotic death of DU145 human prostate carcinoma cells. Carcinogenesis 2007;28(7):1478-1484. View abstract.

53077            Urios, P., Grigorova-Borsos, A. M., and Sternberg, M. Flavonoids inhibit the formation of the cross-linking AGE pentosidine in collagen incubated with glucose, according to their structure. Eur J Nutr 2007;46(3):139-146. View abstract.

53078            Sharma, S. D., Meeran, S. M., and Katiyar, S. K. Dietary grape seed proanthocyanidins inhibit UVB-induced oxidative stress and activation of mitogen-activated protein kinases and nuclear factor-kappaB signaling in in vivo SKH-1 hairless mice. Mol.Cancer Ther 2007;6(3):995-1005. View abstract.

53079            Nikitina, N. A., Sobenin, I. A., Myasoedova, V. A., Korennaya, V. V., Mel’nichenko, A. A., Khalilov, E. M., and Orekhov, A. N. Antiatherogenic effect of grape flavonoids in an ex vivo model. Bull.Exp.Biol.Med 2006;141(6):712-715. View abstract.

53080            Samet, J. M. and Coultas, D. B. Reduced forced vital capacity in California grape workers. What does it mean? Am Rev.Respir.Dis 1992;145(2 Pt 1):255-256. View abstract.

53081            Gamsky, T. E., McCurdy, S. A., Samuels, S. J., and Schenker, M. B. Reduced FVC among California grape workers. Am Rev.Respir.Dis 1992;145(2 Pt 1):257-262. View abstract.

53082            Petit, P., Granier, T., d’Estaintot, B. L., Manigand, C., Bathany, K., Schmitter, J. M., Lauvergeat, V., Hamdi, S., and Gallois, B. Crystal structure of grape dihydroflavonol 4-reductase, a key enzyme in flavonoid biosynthesis. J Mol.Biol. 5-18-2007;368(5):1345-1357. View abstract.

53083            Meeran, S. M. and Katiyar, S. K. Grape seed proanthocyanidins promote apoptosis in human epidermoid carcinoma A431 cells through alterations in Cdki-Cdk-cyclin cascade, and caspase-3 activation via loss of mitochondrial membrane potential. Exp Dermatol 2007;16(5):405-415. View abstract.

53084            Sivarooban, T., Hettiarachchy, N. S., and Johnson, M. G. Inhibition of Listeria monocytogenes using nisin with grape seed extract on turkey frankfurters stored at 4 and 10 degrees C. J Food Prot. 2007;70(4):1017-1020. View abstract.

53085            Ma, L., Gao, H. Q., Li, B. Y., Ma, Y. B., You, B. A., and Zhang, F. L. Grape seed proanthocyanidin extracts inhibit vascular cell adhesion molecule expression induced by advanced glycation end products through activation of peroxisome proliferators-activated receptor gamma. J Cardiovasc.Pharmacol. 2007;49(5):293-298. View abstract.

53086            Stagos, D., Spanou, C., Margariti, M., Stathopoulos, C., Mamuris, Z., Kazantzoglou, G., Magiatis, P., and Kouretas, D. Cytogenetic effects of grape extracts (Vitis vinifera) and polyphenols on mitomycin C-induced sister chromatid exchanges (SCEs) in human blood lymphocytes. J Agric.Food Chem 6-27-2007;55(13):5246-5252. View abstract.

53087            de Lange, D. W., Verhoef, S., Gorter, G., Kraaijenhagen, R. J., van de Wiel, A., and Akkerman, J. W. Polyphenolic grape extract inhibits platelet activation through PECAM-1: an explanation for the French paradox. Alcohol Clin.Exp.Res 2007;31(8):1308-1314. View abstract.

53088            Parker, M., Pollnitz, A. P., Cozzolino, D., Francis, I. L., and Herderich, M. J. Identification and quantification of a marker compound for ‘pepper’ aroma and flavor in shiraz grape berries by combination of chemometrics and gas chromatography-mass spectrometry. J Agric.Food Chem 7-25-2007;55(15):5948-5955. View abstract.

53089            Etheridge, A. S., Black, S. R., Patel, P. R., So, J., and Mathews, J. M. An in vitro evaluation of cytochrome P450 inhibition and P-glycoprotein interaction with goldenseal, Ginkgo biloba, grape seed, milk thistle, and ginseng extracts and their constituents. Planta Med 2007;73(8):731-741. View abstract.

53090            Sano, A., Uchida, R., Saito, M., Shioya, N., Komori, Y., Tho, Y., and Hashizume, N. Beneficial effects of grape seed extract on malondialdehyde-modified LDL. J Nutr Sci Vitaminol.(Tokyo) 2007;53(2):174-182. View abstract.

53091            Singletary, K. W., Jung, K. J., and Giusti, M. Anthocyanin-rich grape extract blocks breast cell DNA damage. J Med Food 2007;10(2):244-251. View abstract.

53092            Cornacchione, S., Sadick, N. S., Neveu, M., Talbourdet, S., Lazou, K., Viron, C., Renimel, I., de, Queral D., Kurfurst, R., Schnebert, S., Heusele, C., Andre, P., and Perrier, E. In vivo skin antioxidant effect of a new combination based on a specific Vitis vinifera shoot extract and a biotechnological extract. J Drugs Dermatol 2007;6(6 Suppl):s8-13. View abstract.

53093            Ugartondo, V., Mitjans, M., Tourino, S., Torres, J. L., and Vinardell, M. P. Comparative antioxidant and cytotoxic effect of procyanidin fractions from grape and pine. Chem Res Toxicol. 2007;20(10):1543-1548. View abstract.

53094            Tangolar, S. G., Ozogul, Y., Tangolar, S., and Torun, A. Evaluation of fatty acid profiles and mineral content of grape seed oil of some grape genotypes. Int.J Food Sci.Nutr. 2009;60(1):32-39. View abstract.

53095            Engelbrecht, A. M., Mattheyse, M., Ellis, B., Loos, B., Thomas, M., Smith, R., Peters, S., Smith, C., and Myburgh, K. Proanthocyanidin from grape seeds inactivates the PI3-kinase/PKB pathway and induces apoptosis in a colon cancer cell line. Cancer Lett. 12-8-2007;258(1):144-153. View abstract.

53096            Edirisinghe, I., Burton-Freeman, B., and Tissa, Kappagoda C. Mechanism of the endothelium-dependent relaxation evoked by a grape seed extract. Clin.Sci.(Lond) 2008;114(4):331-337. View abstract.

53097            Shenoy, S. F., Keen, C. L., Kalgaonkar, S., and Polagruto, J. A. Effects of grape seed extract consumption on platelet function in postmenopausal women. Thromb.Res 2007;121(3):431-432. View abstract.

53098            Erdogrul, O. Pesticide residues in liquid pekmez (grape molasses). Environ.Monit.Assess. 2008;144(1-3):323-328. View abstract.

53099            Ohno, M., Ka, T., Inokuchi, T., Moriwaki, Y., Yamamoto, A., Takahashi, S., Tsutsumi, Z., Tsuzita, J., Yamamoto, T., and Nishiguchi, S. Effects of exercise and grape juice ingestion in combination on plasma concentrations of purine bases and uridine. Clin.Chim.Acta 2008;388(1-2):167-172. View abstract.

53100            Koo, M., Kim, S. H., Lee, N., Yoo, M. Y., Ryu, S. Y., Kwon, D. Y., and Kim, Y. S. 3-Hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase inhibitory effect of Vitis vinifera. Fitoterapia 2008;79(3):204-206. View abstract.

53101            Brannan, R. G. Effect of grape seed extract on physicochemical properties of ground, salted, chicken thigh meat during refrigerated storage at different relative humidity levels. J Food Sci. 2008;73(1):C36-C40. View abstract.

53102            Olas, B., Wachowicz, B., Tomczak, A., Erler, J., Stochmal, A., and Oleszek, W. Comparative anti-platelet and antioxidant properties of polyphenol-rich extracts from: berries of Aronia melanocarpa, seeds of grape and bark of Yucca schidigera in vitro. Platelets. 2008;19(1):70-77. View abstract.

53103            Kuo, P. L. and Hsu, Y. L. The grape and wine constituent piceatannol inhibits proliferation of human bladder cancer cells via blocking cell cycle progression and inducing Fas/membrane bound Fas ligand-mediated apoptotic pathway. Mol.Nutr.Food Res 2008;52(4):408-418. View abstract.

53104            Marel, A. K., Lizard, G., Izard, J. C., Latruffe, N., and Delmas, D. Inhibitory effects of trans-resveratrol analogs molecules on the proliferation and the cell cycle progression of human colon tumoral cells. Mol.Nutr.Food Res 2008;52(5):538-548. View abstract.

53105            Katiyar, S. K. Grape seed proanthocyanidines and skin cancer prevention: inhibition of oxidative stress and protection of immune system. Mol.Nutr.Food Res 2008;52 Suppl 1:S71-S76. View abstract.

53106            Castilla, P., Davalos, A., Teruel, J. L., Cerrato, F., Fernandez-Lucas, M., Merino, J. L., Sanchez-Martin, C. C., Ortuno, J., and Lasuncion, M. A. Comparative effects of dietary supplementation with red grape juice and vitamin E on production of superoxide by circulating neutrophil NADPH oxidase in hemodialysis patients. Am J Clin.Nutr. 2008;87(4):1053-1061. View abstract.

53107            Huang, T. T., Shang, X. J., Yao, G. H., Ge, J. P., Teng, W. H., Sun, Y., and Huang, Y. F. [Grape seed extract inhibits the growth of prostate cancer PC-3 cells]. Zhonghua Nan.Ke.Xue. 2008;14(4):331-333. View abstract.

53108            Jimenez, J. P., Serrano, J., Tabernero, M., Arranz, S., Diaz-Rubio, M. E., Garcia-Diz, L., Goni, I., and Saura-Calixto, F. Effects of grape antioxidant dietary fiber in cardiovascular disease risk factors. Nutrition 2008;24(7-8):646-653. View abstract.

53109            Stankovic, M., Tesevic, V., Vajs, V., Todorovic, N., Milosavljevic, S., and Godevac, D. Antioxidant properties of grape seed extract on human lymphocyte oxidative defence. Planta Med 2008;74(7):730-735. View abstract.

53110            Mahadeswaraswamy, Y. H., Nagaraju, S., Girish, K. S., and Kemparaju, K. Local tissue destruction and procoagulation properties of Echis carinatus venom: inhibition by Vitis vinifera seed methanol extract. Phytother.Res 2008;22(7):963-969. View abstract.

53111            Iriti, M. Melatonin in grape, not just a myth, maybe a panacea. J Pineal Res 2009;46(3):353. View abstract.

53112            Punathil, T. and Katiyar, S. K. Inhibition of non-small cell lung cancer cell migration by grape seed proanthocyanidins is mediated through the inhibition of nitric oxide, guanylate cyclase, and ERK1/2. Mol.Carcinog. 2009;48(3):232-242. View abstract.

53113            Liu, J. Y. and Zhong, J. Y. [Study on protective effect of grape procyanidins in radiation injury in radiation-contacted persons]. Zhonghua Yu Fang Yi.Xue.Za Zhi. 2008;42(4):264-267. View abstract.

53114            Chaves, A. A., Joshi, M. S., Coyle, C. M., Brady, J. E., Dech, S. J., Schanbacher, B. L., Baliga, R., Basuray, A., and Bauer, J. A. Vasoprotective endothelial effects of a standardized grape product in humans. Vascul.Pharmacol. 2009;50(1-2):20-26. View abstract.

53115            Ono, K., Condron, M. M., Ho, L., Wang, J., Zhao, W., Pasinetti, G. M., and Teplow, D. B. Effects of grape seed-derived polyphenols on amyloid beta-protein self-assembly and cytotoxicity. J Biol.Chem 11-21-2008;283(47):32176-32187. View abstract.

53116            Xie, Q., Bedran-Russo, A. K., and Wu, C. D. In vitro remineralization effects of grape seed extract on artificial root caries. J Dent. 2008;36(11):900-906. View abstract.

53117            Ahmed, T., Sajid, M., Singh, T., Saini, G. S., Monif, T., Saha, N., and Pillai, K. K. Influence of grape juice and orange juice on the pharmacokinetics and pharmacodynamics of diltiazem in healthy human male subjects. Int.J Clin.Pharmacol.Ther 2008;46(10):511-518. View abstract.

53118            Wang, M. L., Suo, X., Gu, J. H., Zhang, W. W., Fang, Q., and Wang, X. Influence of grape seed proanthocyanidin extract in broiler chickens: effect on chicken coccidiosis and antioxidant status. Poult.Sci. 2008;87(11):2273-2280. View abstract.

53119            Sivarooban, T., Hettiarachchy, N. S., and Johnson, M. G. Transmission electron microscopy study of Listeria monocytogenes treated with nisin in combination with either grape seed or green tea extract. J Food Prot. 2008;71(10):2105-2109. View abstract.

53120            Kaur, M., Mandair, R., Agarwal, R., and Agarwal, C. Grape seed extract induces cell cycle arrest and apoptosis in human colon carcinoma cells. Nutr.Cancer 2008;60 Suppl 1:2-11. View abstract.

53121            Kaliora, A. C., Kountouri, A. M., Karathanos, V. T., Koumbi, L., Papadopoulos, N. G., and Andrikopoulos, N. K. Effect of Greek raisins (Vitis vinifera L.) from different origins on gastric cancer cell growth. Nutr.Cancer 2008;60(6):792-799. View abstract.

53122            Novak, I., Janeiro, P., Seruga, M., and Oliveira-Brett, A. M. Ultrasound extracted flavonoids from four varieties of Portuguese red grape skins determined by reverse-phase high-performance liquid chromatography with electrochemical detection. Anal.Chim.Acta 12-23-2008;630(2):107-115. View abstract.

53123            Thomas, P., Wang, Y. J., Zhong, J. H., Kosaraju, S., O’Callaghan, N. J., Zhou, X. F., and Fenech, M. Grape seed polyphenols and curcumin reduce genomic instability events in a transgenic mouse model for Alzheimer’s disease. Mutat.Res 2-10-2009;661(1-2):25-34. View abstract.

53124            Hakimuddin, F., Tiwari, K., Paliyath, G., and Meckling, K. Grape and wine polyphenols down-regulate the expression of signal transduction genes and inhibit the growth of estrogen receptor-negative MDA-MB231 tumors in nu/nu mouse xenografts. Nutr.Res 2008;28(10):702-713. View abstract.

53125            Leifert, W. R. and Abeywardena, M. Y. Cardioprotective actions of grape polyphenols. Nutr.Res 2008;28(11):729-737. View abstract.

53126            Leifert, W. R. and Abeywardena, M. Y. Grape seed and red wine polyphenol extracts inhibit cellular cholesterol uptake, cell proliferation, and 5-lipoxygenase activity. Nutr.Res 2008;28(12):842-850. View abstract.

53127            Chira, K., Schmauch, G., Saucier, C., Fabre, S., and Teissedre, P. L. Grape variety effect on proanthocyanidin composition and sensory perception of skin and seed tannin extracts from bordeaux wine grapes (Cabernet Sauvignon and Merlot) for two consecutive vintages (2006 and 2007). J Agric.Food Chem 1-28-2009;57(2):545-553. View abstract.

53128            Gao, N., Budhraja, A., Cheng, S., Yao, H., Zhang, Z., and Shi, X. Induction of apoptosis in human leukemia cells by grape seed extract occurs via activation of c-Jun NH2-terminal kinase. Clin.Cancer Res 1-1-2009;15(1):140-149. View abstract.

53129            Medina, I., Lois, S., Lizarraga, D., Pazos, M., Tourino, S., Cascante, M., and Torres, J. L. Functional fatty fish supplemented with grape procyanidins. Antioxidant and proapoptotic properties on colon cell lines. J Agric.Food Chem 5-17-2006;54(10):3598-3603. View abstract.

53130            Lu, J., Zhang, K., Chen, S., and Wen, W. Grape seed extract inhibits VEGF expression via reducing HIF-1alpha protein expression. Carcinogenesis 2009;30(4):636-644. View abstract.

53131            Wen, W., Lu, J., Zhang, K., and Chen, S. Grape seed extract inhibits angiogenesis via suppression of the vascular endothelial growth factor receptor signaling pathway. Cancer Prev.Res (Phila) 2008;1(7):554-561. View abstract.

53132            Zi, S. X., Ma, H. J., Li, Y., Liu, W., Yang, Q. Q., Zhao, G., and Lian, S. Oligomeric proanthocyanidins from grape seeds effectively inhibit ultraviolet-induced melanogenesis of human melanocytes in vitro. Int.J Mol.Med 2009;23(2):197-204. View abstract.

53133            Shang, X. J., Yin, H. L., Ge, J. P., Sun, Y., Teng, W. H., and Huang, Y. F. [Grape seed extract induces morphological changes of prostate cancer PC-3 cells]. Zhonghua Nan.Ke.Xue. 2008;14(12):1090-1093. View abstract.

53134            Zhang, F. J., Yang, J. Y., Mou, Y. H., Sun, B. S., Ping, Y. F., Wang, J. M., Bian, X. W., and Wu, C. F. Inhibition of U-87 human glioblastoma cell proliferation and formyl peptide receptor function by oligomer procyanidins (F2) isolated from grape seeds. Chem Biol.Interact. 5-15-2009;179(2-3):419-429. View abstract.

53135            Akhtar, S., Meeran, S. M., Katiyar, N., and Katiyar, S. K. Grape seed proanthocyanidins inhibit the growth of human non-small cell lung cancer xenografts by targeting insulin-like growth factor binding protein-3, tumor cell proliferation, and angiogenic factors. Clin.Cancer Res 2-1-2009;15(3):821-831. View abstract.

53136            Pickering, G. J., Karthik, A., Inglis, D., Sears, M., and Ker, K. Detection thresholds for 2-isopropyl-3-methoxypyrazine in Concord and Niagara grape juice. J Food Sci. 2008;73(6):S262-S266. View abstract.

53137            Ha, do T., Chen, Q. C., Hung, T. M., Youn, U. J., Ngoc, T. M., Thuong, P. T., Kim, H. J., Seong, Y. H., Min, B. S., and Bae, K. Stilbenes and oligostilbenes from leaf and stem of Vitis amurensis and their cytotoxic activity. Arch.Pharm Res 2009;32(2):177-183. View abstract.

53138            Rao, A. V., Shen, H., Agarwal, A., Yatcilla, M. T., and Agarwal, S. Bioabsorption and in vivo antioxidant properties of grape extract biovin((r)): a human intervention study. J Med Food 2000;3(1):15-22. View abstract.

53139            Castillo-Pichardo, L., Martinez-Montemayor, M. M., Martinez, J. E., Wall, K. M., Cubano, L. A., and Dharmawardhane, S. Inhibition of mammary tumor growth and metastases to bone and liver by dietary grape polyphenols. Clin.Exp.Metastasis 2009;26(6):505-516. View abstract.

53140            Cheah, K. Y., Howarth, G. S., Yazbeck, R., Wright, T. H., Whitford, E. J., Payne, C., Butler, R. N., and Bastian, S. E. Grape seed extract protects IEC-6 cells from chemotherapy-induced cytotoxicity and improves parameters of small intestinal mucositis in rats with experimentally-induced mucositis. Cancer Biol.Ther 2009;8(4):382-390. View abstract.

53141            Hsu, C. P., Lin, Y. H., Chou, C. C., Zhou, S. P., Hsu, Y. C., Liu, C. L., Ku, F. M., and Chung, Y. C. Mechanisms of grape seed procyanidin-induced apoptosis in colorectal carcinoma cells. Anticancer Res 2009;29(1):283-289. View abstract.

53142            Amico, V., Barresi, V., Chillemi, R., Condorelli, D. F., Sciuto, S., Spatafora, C., and Tringali, C. Bioassay-guided isolation of antiproliferative compounds from grape (Vitis vinifera) stems. Nat.Prod.Commun. 2009;4(1):27-34. View abstract.

53143            Wang, Y. J., Thomas, P., Zhong, J. H., Bi, F. F., Kosaraju, S., Pollard, A., Fenech, M., and Zhou, X. F. Consumption of grape seed extract prevents amyloid-beta deposition and attenuates inflammation in brain of an Alzheimer’s disease mouse. Neurotox.Res 2009;15(1):3-14. View abstract.

53144            Davalos, A., de la Pena, G., Sanchez-Martin, C. C., Teresa, Guerra M., Bartolome, B., and Lasuncion, M. A. Effects of red grape juice polyphenols in NADPH oxidase subunit expression in human neutrophils and mononuclear blood cells. Br J Nutr. 2009;102(8):1125-1135. View abstract.

53145            Chen, C., Liu, C., Zhang, J., Yang, Q., and Teng, F. [Grape seed extract inhibit proliferation of breast cancer cell MCF-7 and decrease the gene expression of survivin]. Zhongguo Zhong.Yao Za Zhi. 2009;34(4):433-437. View abstract.

53146            Mahadeswaraswamy, Y. H., Devaraja, S., Kumar, M. S., Goutham, Y. N., and Kemparaju, K. Inhibition of local effects of Indian Daboia/Vipera russelli venom by the methanolic extract of grape (Vitis vinifera L.) seeds. Indian J Biochem.Biophys. 2009;46(2):154-160. View abstract.

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2539               Xiao Dong S, Zhi Ping Z, Zhong Xiao W, et al. Possible enhancement of the first-pass metabolism of phenacetin by ingestion of grape juice in Chinese subjects. Br J Clin Pharmacol 1999;48:638-40. View abstract.

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10157            Bagchi D, Bagchi M, Stohs SJ, et al. Cellular protection with proanthocyanidins derived from grape seeds. Ann N Y Acad Sci 2002;957:260-70.

10223            Pataki T, Bak I, Kovacs P, et al. Grape seed proanthocyanidins improved cardiac recovery during reperfusion after ischemia in isolated rat hearts. Am J Clin Nutr 2002;75:894-9.

10224            Agarwal C, Sharma Y, Agarwal R. Anticarcinogenic effect of a polyphenolic fraction isolated from grape seeds in human prostate carcinoma DU145 cells: modulation of mitogenic signaling and cell-cycle regulators and induction of G1 arrest and apoptosis. Mol Carcinog 2000;28:129-38.. View abstract.

11094            Greenblatt DJ, von Moltke LL, Perloff ES, et al. Interaction of flurbiprofen with cranberry juice, grape juice, tea, and fluconazole: in vitro and clinical studies. Clin Pharmacol Ther 2006;79:125-33. View abstract.

12213            Lynn A, Hovanec L, Brandt J. A Controlled Trial of Aromatherapy for Agitation in Nursing Home Patients with Dementia. J Alt Comp Med 2004;431-7. View abstract.

13162            Ward NC, Hodgson JM, Croft KD, et al. The combination of vitamin C and grape-seed polyphenols increases blood pressure: a randomized, double-blind, placebo-controlled trial. J Hypertens 2005;23:427-34.. View abstract.

15145            Meng X, Maliakal P, Lu H, et al. Urinary and plasma levels of resveratrol and quercetin in humans, mice, and rats after ingestion of pure compounds and grape juice. J Agric Food Chem 2004;52:935-42. View abstract.

18228            Barona J, Aristizabal JC, Blesso CN, et al. Grape polyphenols reduce blood pressure and increase flow-mediated vasodilation in men with metabolic syndrome. J Nutr 2012;142:1626-32. View abstract.

20536            Gupta H, Pawar D, Riva A, Bombardelli E, and Morazzoni P. A randomized, double-blind, placebo-controlled trial to evaluate efficacy and tolerability of an optimized botanical combination in the management of patients with primary hypercholesterolemia and mixed dyslipidemia. Phytother Res 2012;26(2):265-272. View abstract.

42585            Preuss, H. G., Wallerstedt, D., Talpur, N., Tutuncuoglu, S. O., Echard, B., Myers, A., Bui, M., and Bagchi, D. Effects of niacin-bound chromium and grape seed

53147            Kaur, M., Velmurugan, B., Rajamanickam, S., Agarwal, R., and Agarwal, C. Gallic acid, an active constituent of grape seed extract, exhibits anti-proliferative, pro-apoptotic and anti-tumorigenic effects against prostate carcinoma xenograft growth in nude mice. Pharm Res 2009;26(9):2133-2140. View abstract.

53148            Chacon, M. R., Ceperuelo-Mallafre, V., Maymo-Masip, E., Mateo-Sanz, J. M., Arola, L., Guitierrez, C., Fernandez-Real, J. M., Ardevol, A., Simon, I., and Vendrell, J. Grape-seed procyanidins modulate inflammation on human differentiated adipocytes in vitro. Cytokine 2009;47(2):137-142. View abstract.

53149            Sivaprakasapillai, B., Edirisinghe, I., Randolph, J., Steinberg, F., and Kappagoda, T. Effect of grape seed extract on blood pressure in subjects with the metabolic syndrome. Metabolism 2009;58(12):1743-1746. View abstract.

53150            Lazze, M. C., Pizzala, R., Gutierrez Pecharroman, F. J., Gaton, Garnica P., Antolin Rodriguez, J. M., Fabris, N., and Bianchi, L. Grape waste extract obtained by supercritical fluid extraction contains bioactive antioxidant molecules and induces antiproliferative effects in human colon adenocarcinoma cells. J Med Food 2009;12(3):561-568. View abstract.

53151            Sandra, D., Radha, M., Harishkumar, M., Yuichi, N., Sayuri, O., and Masugi, M. Downregulation of urokinase-type plasminogen activator and plasminogen activator inhibitor-1 by grape seed proanthocyanidin extract. Phytomedicine. 2010;17(1):42-46. View abstract.

53152            Percival, S. S. Grape consumption supports immunity in animals and humans. J Nutr. 2009;139(9):1801S-1805S. View abstract.

53153            Kaur, M., Agarwal, C., and Agarwal, R. Anticancer and cancer chemopreventive potential of grape seed extract and other grape-based products. J Nutr. 2009;139(9):1806S-1812S. View abstract.

53154            Wu, C. D. Grape products and oral health. J Nutr. 2009;139(9):1818S-1823S. View abstract.

53155            Kar, P., Laight, D., Rooprai, H. K., Shaw, K. M., and Cummings, M. Effects of grape seed extract in Type 2 diabetic subjects at high cardiovascular risk: a double blind randomized placebo controlled trial examining metabolic markers, vascular tone, inflammation, oxidative stress and insulin sensitivity. Diabet.Med 2009;26(5):526-531. View abstract.

53156            Park, Y. K., Lee, S. H., Park, E., Kim, J. S., and Kang, M. H. Changes in antioxidant status, blood pressure, and lymphocyte DNA damage from grape juice supplementation. Ann.N.Y.Acad.Sci. 2009;1171:385-390. View abstract.

53157            Xu, Y., Khaoustov, V. I., Wang, H., Yu, J., Tabassam, F., and Yoffe, B. Freeze-dried grape powder attenuates mitochondria- and oxidative stress-mediated apoptosis in liver cells. J Agric.Food Chem 10-14-2009;57(19):9324-9331. View abstract.

53158            Hsu, Y. L., Liang, H. L., Hung, C. H., and Kuo, P. L. Syringetin, a flavonoid derivative in grape and wine, induces human osteoblast differentiation through bone morphogenetic protein-2/extracellular signal-regulated kinase 1/2 pathway. Mol.Nutr.Food Res 2009;53(11):1452-1461. View abstract.

53159            Kidd, P. M. Bioavailability and activity of phytosome complexes from botanical polyphenols: the silymarin, curcumin, green tea, and grape seed extracts. Altern.Med.Rev. 2009;14(3):226-246. View abstract.

53160            Kim, E. J., Park, H., Park, S. Y., Jun, J. G., and Park, J. H. The grape component piceatannol induces apoptosis in DU145 human prostate cancer cells via the activation of extrinsic and intrinsic pathways. J Med Food 2009;12(5):943-951. View abstract.

53161            Shin, D. Y., Lee, W. S., Kim, S. H., Kim, M. J., Yun, J. W., Lu, J. N., Lee, S. J., Tsoy, I., Kim, H. J., Ryu, C. H., Kim, G. Y., Kang, H. S., Shin, S. C., and Choi, Y. H. Anti-invasive activity of anthocyanins isolated from Vitis coignetiae in human hepatocarcinoma cells. J Med Food 2009;12(5):967-972. View abstract.

53162            La, V. D., Bergeron, C., Gafner, S., and Grenier, D. Grape seed extract suppresses lipopolysaccharide-induced matrix metalloproteinase (MMP) secretion by macrophages and inhibits human MMP-1 and -9 activities. J Periodontol. 2009;80(11):1875-1882. View abstract.

53163            Long, J., Gao, H., Sun, L., Liu, J., and Zhao-Wilson, X. Grape extract protects mitochondria from oxidative damage and improves locomotor dysfunction and extends lifespan in a Drosophila Parkinson’s disease model. Rejuvenation.Res 2009;12(5):321-331. View abstract.

53164            Di, Cagno R., Mazzacane, F., Rizzello, C. G., De, Angelis M., Giuliani, G., Meloni, M., De, Servi B., and Gobbetti, M. Synthesis of gamma-aminobutyric acid (GABA) by Lactobacillus plantarum DSM19463: functional grape must beverage and dermatological applications. Appl.Microbiol.Biotechnol. 2010;86(2):731-741. View abstract.

53165            van Dorsten, F. A., Grun, C. H., van Velzen, E. J., Jacobs, D. M., Draijer, R., and van Duynhoven, J. P. The metabolic fate of red wine and grape juice polyphenols in humans assessed by metabolomics. Mol.Nutr.Food Res 2010;54(7):897-908. View abstract.

53166            Krikorian, R., Nash, T. A., Shidler, M. D., Shukitt-Hale, B., and Joseph, J. A. Concord grape juice supplementation improves memory function in older adults with mild cognitive impairment. Br J Nutr. 2010;103(5):730-734. View abstract.

53167            Kaliora, A. C., Kountouri, A. M., and Karathanos, V. T. Antioxidant properties of raisins (Vitis vinifera L.). J Med Food 2009;12(6):1302-1309. View abstract.

53168            Yun, J. W., Lee, W. S., Kim, M. J., Lu, J. N., Kang, M. H., Kim, H. G., Kim, D. C., Choi, E. J., Choi, J. Y., Kim, H. G., Lee, Y. K., Ryu, C. H., Kim, G., Choi, Y. H., Park, O. J., and Shin, S. C. Characterization of a profile of the anthocyanins isolated from Vitis coignetiae Pulliat and their anti-invasive activity on HT-29 human colon cancer cells. Food Chem Toxicol. 2010;48(3):903-909. View abstract.

53169            Cai, H., Marczylo, T. H., Teller, N., Brown, K., Steward, W. P., Marko, D., and Gescher, A. J. Anthocyanin-rich red grape extract impedes adenoma development in the Apc(Min) mouse: pharmacodynamic changes and anthocyanin levels in the murine biophase. Eur.J Cancer 2010;46(4):811-817. View abstract.

53170            Kamiyama, M., Kishimoto, Y., Tani, M., Andoh, K., Utsunomiya, K., and Kondo, K. Inhibition of low-density lipoprotein oxidation by Nagano purple grape (Vitis viniferaxVitis labrusca). J Nutr.Sci.Vitaminol.(Tokyo) 2009;55(6):471-478. View abstract.

53171            Overman, A., Bumrungpert, A., Kennedy, A., Martinez, K., Chuang, C. C., West, T., Dawson, B., Jia, W., and McIntosh, M. Polyphenol-rich grape powder extract (GPE) attenuates inflammation in human macrophages and in human adipocytes exposed to macrophage-conditioned media. Int.J Obes.(Lond) 2010;34(5):800-808. View abstract.

53172            Matias, A. A., Serra, A. T., Silva, A. C., Perdigao, R., Ferreira, T. B., Marcelino, I., Silva, S., Coelho, A. V., Alves, P. M., and Duarte, C. M. Portuguese winemaking residues as a potential source of natural anti-adenoviral agents. Int.J Food Sci.Nutr. 2010;61(4):357-368. View abstract.

53173            Song, X., Siriwardhana, N., Rathore, K., Lin, D., and Wang, H. C. Grape seed proanthocyanidin suppression of breast cell carcinogenesis induced by chronic exposure to combined 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and benzo[a]pyrene. Mol.Carcinog. 2010;49(5):450-463. View abstract.

53174            Hashemi, M., Kelishadi, R., Hashemipour, M., Zakerameli, A., Khavarian, N., Ghatrehsamani, S., and Poursafa, P. Acute and long-term effects of grape and pomegranate juice consumption on vascular reactivity in paediatric metabolic syndrome. Cardiol Young. 2010;20(1):73-77. View abstract.

53175            Ingersoll, G. L., Wasilewski, A., Haller, M., Pandya, K., Bennett, J., He, H., Hoffmire, C., and Berry, C. Effect of concord grape juice on chemotherapy-induced nausea and vomiting: results of a pilot study. Oncol.Nurs.Forum 2010;37(2):213-221. View abstract.

53176            Patil, J. A., Patil, A. J., Sontakke, A. V., and Govindwar, S. P. Occupational pesticides exposure of sprayers of grape gardens in western Maharashtra (India): effects on liver and kidney function. J Basic Clin.Physiol Pharmacol. 2009;20(4):335-355. View abstract.

53177            Oliveira-Freitas, V. L., Dalla, Costa T., Manfro, R. C., Cruz, L. B., and Schwartsmann, G. Influence of purple grape juice in cyclosporine bioavailability. J Ren Nutr. 2010;20(5):309-313. View abstract.

53178            Argarate, N., Arestin, M., Ramon-Azcon, J., Alfaro, B., Barranco, A., Sanchez-Baeza, F., and Marco, M. P. Evaluation of immunoassays as an alternative for the rapid determination of pesticides in wine and grape samples. J AOAC Int. 2010;93(1):2-11. View abstract.

53179            Chuang, C. C., Bumrungpert, A., Kennedy, A., Overman, A., West, T., Dawson, B., and McIntosh, M. K. Grape powder extract attenuates tumor necrosis factor alpha-mediated inflammation and insulin resistance in primary cultures of human adipocytes. J Nutr.Biochem. 2011;22(1):89-94. View abstract.

53180            Kiyici, A., Okudan, N., Gokbel, H., and Belviranli, M. The effect of grape seed extracts on serum paraoxonase activities in streptozotocin-induced diabetic rats. J Med Food 2010;13(3):725-728. View abstract.

53181            Hollis, J. H., Houchins, J. A., Blumberg, J. B., and Mattes, R. D. Effects of concord grape juice on appetite, diet, body weight, lipid profile, and antioxidant status of adults. J Am Coll.Nutr. 2009;28(5):574-582. View abstract.

53182            Meng, C. K., Zweigenbaum, J., Furst, P., and Blanke, E. Finding and confirming nontargeted pesticides using GC/MS, LC/quadrupole-time-of-flight MS, and databases. J AOAC Int. 2010;93(2):703-711. View abstract.

53183            Weekes, L. N., Walsh, D., Ferguson, H., and Ross, C. F. Impact of Multicolored Asian Lady Beetles on the sensory properties of Concord and Niagara grape juice. J Food Sci. 2010;75(1):S68-S73. View abstract.

53184            Fan, W., Xu, Y., Jiang, W., and Li, J. Identification and quantification of impact aroma compounds in 4 nonfloral Vitis vinifera varieties grapes. J Food Sci. 2010;75(1):S81-S88. View abstract.

53185            Uchino, R., Madhyastha, R., Madhyastha, H., Dhungana, S., Nakajima, Y., Omura, S., and Maruyama, M. NFkappaB-dependent regulation of urokinase plasminogen activator by proanthocyanidin-rich grape seed extract: effect on invasion by prostate cancer cells. Blood Coagul.Fibrinolysis 2010;21(6):528-533. View abstract.

53186            Kim, S. J., Lee, Y. H., Han, M. D., Mar, W., Kim, W. K., and Nam, K. W. Resveratrol, purified from the stem of Vitis coignetiae Pulliat, inhibits food intake in C57BL/6J Mice. Arch.Pharm Res 2010;33(5):775-780. View abstract.

53187            Feng, Z., Wei, R. B., Hong, Q., Cui, S. Y., and Chen, X. M. Grape seed extract enhances eNOS expression and NO production through regulating calcium-mediated AKT phosphorylation in H2O2-treated endothelium. Cell Biol.Int. 2010;34(10):1055-1061. View abstract.

53188            Dinicola, S., Cucina, A., Pasqualato, A., Proietti, S., D’Anselmi, F., Pasqua, G., Santamaria, A. R., Coluccia, P., Lagana, A., Antonacci, D., Giuliani, A., and Bizzarri, M. Apoptosis-inducing factor and caspase-dependent apoptotic pathways triggered by different grape seed extracts on human colon cancer cell line Caco-2. Br J Nutr. 2010;104(6):824-832. View abstract.

53189            Maestre, R., Micol, V., Funes, L., and Medina, I. Incorporation and interaction of grape seed extract in membranes and relation with efficacy in muscle foods. J Agric.Food Chem 7-28-2010;58(14):8365-8374. View abstract.

53190            Khoshbaten, M., Aliasgarzadeh, A., Masnadi, K., Farhang, S., Tarzamani, M. K., Babaei, H., Kiani, J., Zaare, M., and Najafipoor, F. Grape seed extract to improve liver function in patients with nonalcoholic fatty liver change. Saudi.J Gastroenterol. 2010;16(3):194-197. View abstract.

53191            Shah, N. P., Ding, W. K., Fallourd, M. J., and Leyer, G. Improving the stability of probiotic bacteria in model fruit juices using vitamins and antioxidants. J Food Sci. 2010;75(5):M278-M282. View abstract.

53192            Janle, E. M., Lila, M. A., Grannan, M., Wood, L., Higgins, A., Yousef, G. G., Rogers, R. B., Kim, H., Jackson, G. S., Ho, L., and Weaver, C. M. Pharmacokinetics and tissue distribution of 14C-labeled grape polyphenols in the periphery and the central nervous system following oral administration. J Med Food 2010;13(4):926-933. View abstract.

53193            Zhang, F. J., Yang, J. Y., Mou, Y. H., Sun, B. S., Wang, J. M., and Wu, C. F. Oligomer procyanidins from grape seeds induce a paraptosis-like programmed cell death in human glioblastoma U-87 cells. Pharm Biol. 2010;48(8):883-890. View abstract.

53194            Jing, Yu, Yumin, Xu, Khaoustov, V., and Yoffe, B. Identification of components of grape powder with anti-apoptotic effects. Toxicol.Ind.Health 2011;27(1):19-28. View abstract.

53195            van Mierlo, L. A., Zock, P. L., van der Knaap, H. C., and Draijer, R. Grape polyphenols do not affect vascular function in healthy men. J Nutr. 2010;140(10):1769-1773. View abstract.

53196            Green, B., Yao, X., Ganguly, A., Xu, C., Dusevich, V., Walker, M. P., and Wang, Y. Grape seed proanthocyanidins increase collagen biodegradation resistance in the dentin/adhesive interface when included in an adhesive. J Dent. 2010;38(11):908-915. View abstract.

53197            Gross, G., Jacobs, D. M., Peters, S., Possemiers, S., van, Duynhoven J., Vaughan, E. E., and van de Wiele, T. In vitro bioconversion of polyphenols from black tea and red wine/grape juice by human intestinal microbiota displays strong interindividual variability. J Agric.Food Chem 9-22-2010;58(18):10236-10246. View abstract.

53198            Choi, Y., Lee, S. M., Kim, Y., Yoon, J., Jeong, H. S., and Lee, J. A tocotrienol-rich fraction from grape seeds inhibits oxidative stress induced by tert-butyl hydroperoxide in HepG2 cells. J Med Food 2010;13(5):1240-1246. View abstract.

53199            Dohadwala, M. M., Hamburg, N. M., Holbrook, M., Kim, B. H., Duess, M. A., Levit, A., Titas, M., Chung, W. B., Vincent, F. B., Caiano, T. L., Frame, A. A., Keaney, J. F., Jr., and Vita, J. A. Effects of Concord grape juice on ambulatory blood pressure in prehypertension and stage 1 hypertension. Am J Clin.Nutr. 2010;92(5):1052-1059. View abstract.

53200            Wang, J., Santa-Maria, I., Ho, L., Ksiezak-Reding, H., Ono, K., Teplow, D. B., and Pasinetti, G. M. Grape derived polyphenols attenuate tau neuropathology in a mouse model of Alzheimer’s disease. J Alzheimers.Dis 2010;22(2):653-661. View abstract.

53201            Park, M. K., Park, J. S., Cho, M. L., Oh, H. J., Heo, Y. J., Woo, Y. J., Heo, Y. M., Park, M. J., Park, H. S., Park, S. H., Kim, H. Y., and Min, J. K. Grape seed proanthocyanidin extract (GSPE) differentially regulates Foxp3(+) regulatory and IL-17(+) pathogenic T cell in autoimmune arthritis. Immunol.Lett. 3-30-2011;135(1-2):50-58. View abstract.

53202            Liu, T., Zhao, J., Li, H., and Ma, L. Evaluation on anti-hepatitis viral activity of Vitis vinifer L. Molecules. 2010;15(10):7415-7422. View abstract.

53203            Chao, C. L., Chang, N. C., Weng, C. S., Lee, K. R., Kao, S. T., Hsu, J. C., and Ho, F. M. Grape seed extract ameliorates tumor necrosis factor-alpha-induced inflammatory status of human umbilical vein endothelial cells. Eur.J Nutr. 2011;50(6):401-409. View abstract.

53204            Rowe, C. A., Nantz, M. P., Nieves, C., Jr., West, R. L., and Percival, S. S. Regular consumption of concord grape juice benefits human immunity. J Med Food 2011;14(1-2):69-78. View abstract.

53205            Kulkarni, S., DeSantos, F. A., Kattamuri, S., Rossi, S. J., and Brewer, M. S. Effect of grape seed extract on oxidative, color and sensory stability of a pre-cooked, frozen, re-heated beef sausage model system. Meat.Sci. 2011;88(1):139-144. View abstract.

53206            Rabe, E., Stucker, M., Esperester, A., Schafer, E., and Ottillinger, B. Efficacy and tolerability of a red-vine-leaf extract in patients suffering from chronic venous insufficiency–results of a double-blind placebo-controlled study. Eur.J Vasc.Endovasc.Surg. 2011;41(4):540-547. View abstract.

53207            Park, S. Y., Lee, Y. H., Choi, K. C., Seong, A. R., Choi, H. K., Lee, O. H., Hwang, H. J., and Yoon, H. G. Grape seed extract regulates androgen receptor-mediated transcription in prostate cancer cells through potent anti-histone acetyltransferase activity. J Med Food 2011;14(1-2):9-16. View abstract.

53208            Li, B. Y., Li, X. L., Gao, H. Q., Zhang, J. H., Cai, Q., Cheng, M., and Lu, M. Grape seed procyanidin B2 inhibits advanced glycation end product-induced endothelial cell apoptosis through regulating GSK3beta phosphorylation. Cell Biol.Int. 2011;35(7):663-669. View abstract.

53209            Kolodziejczyk, J., Malinowska, J., Olas, B., Stochmal, A., Oleszek, W., and Erler, J. The polyphenol-rich extract from grape seeds suppresses toxicity of homocysteine and its thiolactone on the fibrinolytic system. Thromb.Res 2011;127(5):489-491. View abstract.

53210            Jia, Z., Song, Z., Zhao, Y., Wang, X., and Liu, P. Grape seed proanthocyanidin extract protects human lens epithelial cells from oxidative stress via reducing NF-small ka, CyrillicB and MAPK protein expression. Mol.Vis 2011;17:210-217. View abstract.

53211            Kaur, M., Tyagi, A., Singh, R. P., Sclafani, R. A., Agarwal, R., and Agarwal, C. Grape seed extract upregulates p21 (Cip1) through redox-mediated activation of ERK1/2 and posttranscriptional regulation leading to cell cycle arrest in colon carcinoma HT29 cells. Mol.Carcinog. 2011;50(7):553-562. View abstract.

53212            Inoue, J., Tanaka, M., Nanmoku, M., Yashiro, T., and Sato, R. Stabilization of small heterodimer partner mRNA by grape seed procyanidins extract in cultured hepatocytes. Mol.Nutr.Food Res 2011;55(7):1052-1058. View abstract.

53213            Kedzierska, M., Olas, B., Wachowicz, B., Stochmal, A., Oleszek, W., and Erler, J. Changes of platelet antioxidative enzymes during oxidative stress: the protective effect of polyphenol-rich extract from berries of Aronia melanocarpa and grape seeds. Platelets. 2011;22(5):385-389. View abstract.

53214            Huber, K. and Superti-Furga, G. After the grape rush: sirtuins as epigenetic drug targets in neurodegenerative disorders. Bioorg.Med Chem 6-15-2011;19(12):3616-3624. View abstract.

53215            Fredericks, I. N., du, Toit M., and Krugel, M. Efficacy of ultraviolet radiation as an alternative technology to inactivate microorganisms in grape juices and wines. Food Microbiol. 2011;28(3):510-517. View abstract.

53216            Hsia, S. M., Wang, K. L., and Wang, P. S. Effects of resveratrol, a grape polyphenol, on uterine contraction and Ca(2)+ mobilization in rats in vivo and in vitro. Endocrinology 2011;152(5):2090-2099. View abstract.

53217            Wang, K. T., Chen, L. G., Tseng, S. H., Huang, J. S., Hsieh, M. S., and Wang, C. C. Anti-inflammatory effects of resveratrol and oligostilbenes from Vitis thunbergii var. taiwaniana against lipopolysaccharide-induced arthritis. J Agric.Food Chem 4-27-2011;59(8):3649-3656. View abstract.

53218            Martinez-Gil, A. M., Garde-Cerdan, T., Martinez, L., Alonso, G. L., and Salinas, M. R. Effect of oak extract application to Verdejo grapevines on grape and wine aroma. J Agric.Food Chem 4-13-2011;59(7):3253-3263. View abstract.

53219            Matito, C., Agell, N., Sanchez-Tena, S., Torres, J. L., and Cascante, M. Protective effect of structurally diverse grape procyanidin fractions against UV-induced cell damage and death. J Agric.Food Chem 5-11-2011;59(9):4489-4495. View abstract.

53220            Eyheraguibel, B., Richard, C., Ledoigt, G., and Ter, Halle A. Inhibition of herbicide photodegradation by plant products. J Agric.Food Chem 5-11-2011;59(9):4868-4873. View abstract.

53221            Lluis, L., Munoz, M., Nogues, M. R., Sanchez-Martos, V., Romeu, M., Giralt, M., Valls, J., and Sola, R. Toxicology evaluation of a procyanidin-rich extract from grape skins and seeds. Food Chem Toxicol. 2011;49(6):1450-1454. View abstract.

53222            Kim, H., Kim, J. Y., Song, H. S., Park, K. U., Mun, K. C., and Ha, E. Grape seed proanthocyanidin extract inhibits interleukin-17-induced interleukin-6 production via MAPK pathway in human pulmonary epithelial cells. Naunyn Schmiedebergs Arch.Pharmacol. 2011;383(6):555-562. View abstract.

53223            Hudec, J., Mazur, R., Trebichalsky, P., Lacko-Bartosova, M., Losak, T., Musilova, J., Chlebo, P., and Kovacik, P. Effect of a polyamine biosynthesis inhibitor on the quality of grape and red wine. J Sci.Food Agric. 8-30-2011;91(11):2045-2052. View abstract.

53224            Su, X. and D’Souza, D. H. Grape seed extract for control of human enteric viruses. Appl.Environ.Microbiol. 2011;77(12):3982-3987. View abstract.

53225            Li, B. Y., Li, X. L., Cai, Q., Gao, H. Q., Cheng, M., Zhang, J. H., Wang, J. F., Yu, F., and Zhou, R. H. Induction of lactadherin mediates the apoptosis of endothelial cells in response to advanced glycation end products and protective effects of grape seed procyanidin B2 and resveratrol. Apoptosis. 2011;16(7):732-745. View abstract.

53226            Richard, T., Poupard, P., Nassra, M., Papastamoulis, Y., Iglesias, M. L., Krisa, S., Waffo-Teguo, P., Merillon, J. M., and Monti, J. P. Protective effect of epsilon-viniferin on beta-amyloid peptide aggregation investigated by electrospray ionization mass spectrometry. Bioorg.Med Chem 5-15-2011;19(10):3152-3155. View abstract.

53227            Song, P., Zhang, R., Wang, X., He, P., Tan, L., and Ma, X. Dietary grape-seed procyanidins decreased postweaning diarrhea by modulating intestinal permeability and suppressing oxidative stress in rats. J Agric.Food Chem 6-8-2011;59(11):6227-6232. View abstract.

53228            Over, K. F., Hettiarachchy, N. S., Perumalla, A. V., Johnson, M. G., Meullenet, J. F., Dickson, J. S., Holtzbauer, M. J., Niebuhr, S. E., and Davis, B. Antilisterial activity and consumer acceptance of irradiated chicken breast meat vacuum-infused with grape seed and green tea extracts and tartaric acid. J Food Sci. 2010;75(7):M455-M461. View abstract.

53229            Cefola, M., Pace, B., Buttaro, D., Santamaria, P., and Serio, F. Postharvest evaluation of soilless-grown table grape during storage in modified atmosphere. J Sci.Food Agric. 2011;91(12):2153-2159. View abstract.

53230            Pan, X., Dai, Y., Li, X., Niu, N., Li, W., Liu, F., Zhao, Y., and Yu, Z. Inhibition of arsenic-induced rat liver injury by grape seed exact through suppression of NADPH oxidase and TGF-beta/Smad activation. Toxicol.Appl.Pharmacol. 8-1-2011;254(3):323-331. View abstract.

53231            Pacifico, S., D’Abrosca, B., Scognamiglio, M., Gallicchio, M., Potenza, N., Piccolella, S., Russo, A., Monaco, P., and Fiorentino, A. Metabolic profiling of strawberry grape ( Vitis x labruscana cv. ‘Isabella’) components by nuclear magnetic resonance (NMR) and evaluation of their antioxidant and antiproliferative properties. J Agric.Food Chem 7-27-2011;59(14):7679-7687. View abstract.

53232            Spanou, C., Veskoukis, A. S., Stagos, D., Liadaki, K., Anastasiadi, M., Haroutounian, S. A., Tsouka, M., Tzanakouli, E., and Kouretas, D. Effects of grape extracts on the in vitro activity of enzymes involved in oxidative stress regulation. In Vivo 2011;25(4):657-662. View abstract.

53233            Li, Q. Z., Cho, H. S., Jeun, S. H., Kim, K. J., Choi, S. J., and Sung, K. W. Effects of grape seed proanthocyanidin on 5-hydroxytryptamine(3) receptors in NCB-20 neuroblastoma cells. Biol.Pharm Bull. 2011;34(7):1109-1115. View abstract.

53234            Vaid, M., Singh, T., and Katiyar, S. K. Grape seed proanthocyanidins inhibit melanoma cell invasiveness by reduction of PGE2 synthesis and reversal of epithelial-to-mesenchymal transition. PLoS.One. 2011;6(6):e21539. View abstract.

53235            Kikalishvili, B. I., Zurabashvili, D. Z., Nikolaishvili, M. N., Zurabashvili, Z. A., and Giorgobiani, I. B. [The most biological important constances of Rkatsiteli grape oil and its effect as a 5% and 10% food-additive]. Georgian.Med News 2011;(195):85-87. View abstract.

53236            Feringa, H. H., Laskey, D. A., Dickson, J. E., and Coleman, C. I. The effect of grape seed extract on cardiovascular risk markers: a meta-analysis of randomized controlled trials. J Am Diet.Assoc. 2011;111(8):1173-1181. View abstract.

53237            Pires, K. M., Valenca, S. S., Resende, A. C., Porto, L. C., Queiroz, E. F., Moreira, D. D., and de Moura, R. S. Grape skin extract reduced pulmonary oxidative response in mice exposed to cigarette smoke. Med Sci.Monit. 2011;17(8):BR187-BR195. View abstract.

53238            Haniadka, R., Popouri, S., Palatty, P. L., Arora, R., and Baliga, M. S. Medicinal plants as antiemetics in the treatment of cancer: a review. Integr.Cancer Ther. 2012;11(1):18-28. View abstract.

53239            Vidhya, S., Srinivasulu, S., Sujatha, M., and Mahalaxmi, S. Effect of grape seed extract on the bond strength of bleached enamel. Oper.Dent. 2011;36(4):433-438. View abstract.

53240            Fraternale, D., De, Bellis R., Calcabrini, C., Potenza, L., Cucchiarini, L., Mancini, U., Dacha, M., and Ricci, D. Aqueous extract from Vitis vinifera tendrils is able to enrich keratinocyte antioxidant defences. Nat.Prod.Commun. 2011;6(9):1315-1319. View abstract.

53241            Trotta, M., Cesaretti, M., Conzi, R., Derchi, L. E., and Borgonovo, G. Elderly male with mesogastric pain. Small bowel obstruction caused by an intact fresh grape. Ann.Emerg.Med 2011;58(4):e1-e2. View abstract.

53242            Giacosa, A., Adam-Blondon, A. F., Baer-Sinnott, S., Barale, R., Bavaresco, L., Di, Gaspero G., Dugo, L., Ellison, R. C., Gerbi, V., Gifford, D., Janssens, J., La, Vecchia C., Negri, E., Pezzotti, M., Santi, L., Santi, L., and Rondanelli, M. Alcohol and wine in relation to cancer and other diseases. Eur J Cancer Prev. 2012;21(1):103-108. View abstract.

53243            Katiyar, S. K., Singh, T., Prasad, R., Sun, Q., and Vaid, M. Epigenetic alterations in ultraviolet radiation-induced skin carcinogenesis: interaction of bioactive dietary components on epigenetic targets. Photochem.Photobiol. 2012;88(5):1066-1074. View abstract.

53244            Mercolini, L., Mandrioli, R., and Raggi, M. A. Content of melatonin and other antioxidants in grape-related foodstuffs: measurement using a MEPS-HPLC-F method. J Pineal Res 2012;53(1):21-28. View abstract.

53245            Gazzani, G., Daglia, M., and Papetti, A. Food components with anticaries activity. Curr Opin Biotechnol. 2012;23(2):153-159. View abstract.

53246            Catteau, C., Trentesaux, T., Delfosse, C., and Rousset, M. M. [Consumption of fruit juices and fruit drinks: impact on the health of children and teenagers, the dentist's point of view]. Arch Pediatr. 2012;19(2):118-124. View abstract.

53247            Marzulli, G., Magrone, T., Kawaguchi, K., Kumazawa, Y., and Jirillo, E. Fermented grape marc (FGM): immunomodulating properties and its potential exploitation in the treatment of neurodegenerative diseases. Curr Pharm.Des 2012;18(1):43-50. View abstract.

53248            Ruiz-Garcia, Y., Romero-Cascales, I., Gil-Munoz, R., Fernandez-Fernandez, J. I., Lopez-Roca, J. M., and Gomez-Plaza, E. Improving grape phenolic content and wine chromatic characteristics through the use of two different elicitors: methyl jasmonate versus benzothiadiazole. J Agric.Food Chem 2-8-2012;60(5):1283-1290. View abstract.

53249            Fang, M., Liu, R., Xiao, Y., Li, F., Wang, D., Hou, R., and Chen, J. Biomodification to dentin by a natural crosslinker improved the resin-dentin bonds. J Dent. 2012;40(6):458-466. View abstract.

53250            Zheng, Y. Y., Viswanathan, B., Kesarwani, P., and Mehrotra, S. Dietary agents in cancer prevention: an immunological perspective. Photochem.Photobiol. 2012;88(5):1083-1098. View abstract.

53251            Jacobs, D. M., Fuhrmann, J. C., van Dorsten, F. A., Rein, D., Peters, S., van Velzen, E. J., Hollebrands, B., Draijer, R., van, Duynhoven J., and Garczarek, U. Impact of short-term intake of red wine and grape polyphenol extract on the human metabolome. J Agric.Food Chem 3-28-2012;60(12):3078-3085. View abstract.

53252            Yang, H., Lee, B. K., Kook, K. H., Jung, Y. S., and Ahn, J. Protective effect of grape seed extract against oxidative stress-induced cell death in a staurosporine-differentiated retinal ganglion cell line. Curr Eye Res 2012;37(4):339-344. View abstract.

53253            Cherniack, E. P. A berry thought-provoking idea: the potential role of plant polyphenols in the treatment of age-related cognitive disorders. Br J Nutr 2012;108(5):794-800. View abstract.

53254            Tome-Carneiro, J., Gonzalvez, M., Larrosa, M., Yanez-Gascon, M. J., Garcia-Almagro, F. J., Ruiz-Ros, J. A., Garcia-Conesa, M. T., Tomas-Barberan, F. A., and Espin, J. C. One-year consumption of a grape nutraceutical containing resveratrol improves the inflammatory and fibrinolytic status of patients in primary prevention of cardiovascular disease. Am J Cardiol. 8-1-2012;110(3):356-363. View abstract.

53255            Rababah, T. M., Al-u’datt, M., Almajwal, A., Brewer, S., Feng, H., Al-Mahasneh, M., Ereifej, K., and Yang, W. Evaluation of the nutraceutical, physiochemical and sensory properties of raisin jam. J Food Sci 2012;77(6):C609-C613. View abstract.

53256            Tome-Carneiro, J., Gonzalvez, M., Larrosa, M., Garcia-Almagro, F. J., Aviles-Plaza, F., Parra, S., Yanez-Gascon, M. J., Ruiz-Ros, J. A., Garcia-Conesa, M. T., Tomas-Barberan, F. A., and Espin, J. C. Consumption of a grape extract supplement containing resveratrol decreases oxidized LDL and ApoB in patients undergoing primary prevention of cardiovascular disease: a triple-blind, 6-month follow-up, placebo-controlled, randomized trial. Mol.Nutr Food Res 2012;56(5):810-821. View abstract.

53257            Prabhakar, A. R., Sharma, D., and Sugandhan, S. Comparative evaluation of the remineralising effects and surface microhardness of glass ionomer cement containing grape seed extract and casein phosphopeptide – amorphous calcium phosphate: an in vitro study. Eur Arch Paediatr.Dent. 2012;13(3):138-143. View abstract.

53258            Islam, S. M., Hiraishi, N., Nassar, M., Sono, R., Otsuki, M., Takatsura, T., Yiu, C., and Tagami, J. In vitro effect of hesperidin on root dentin collagen and de/re-mineralization. Dent.Mater.J 2012;31(3):362-367. View abstract.

53259            Stockley, C., Teissedre, P. L., Boban, M., Di, Lorenzo C., and Restani, P. Bioavailability of wine-derived phenolic compounds in humans: a review. Food Funct. 2012;3(10):995-1007. View abstract.

53260            De, Groote D., Van, Belleghem K., Deviere, J., Van, Brussel W., Mukaneza, A., and Amininejad, L. Effect of the intake of resveratrol, resveratrol phosphate, and catechin-rich grape seed extract on markers of oxidative stress and gene expression in adult obese subjects. Ann Nutr Metab 2012;61(1):15-24. View abstract.

53261            Mildner-Szkudlarz, S., Bajerska, J., Zawirska-Wojtasiak, R., and Gorecka, D. White grape pomace as a source of dietary fibre and polyphenols and its effect on physical and nutraceutical characteristics of wheat biscuits. J Sci Food Agric. 2013;93(2):389-395. View abstract.

53262            Milella, R. A., Antonacci, D., Crupi, P., Incampo, F., Carrieri, C., Semeraro, N., and Colucci, M. Skin extracts from 2 Italian table grapes (Italia and Palieri) inhibit tissue factor expression by human blood mononuclear cells. J Food Sci 2012;77(8):H154-H159. View abstract.

53263            Jeronimo, E., Alfaia, C. M., Alves, S. P., Dentinho, M. T., Prates, J. A., Vasta, V., Santos-Silva, J., and Bessa, R. J. Effect of dietary grape seed extract and Cistus ladanifer L. in combination with vegetable oil supplementation on lamb meat quality. Meat.Sci 2012;92(4):841-847. View abstract.

53264            Rotches-Ribalta, M., Andres-Lacueva, C., Estruch, R., Escribano, E., and Urpi-Sarda, M. Pharmacokinetics of resveratrol metabolic profile in healthy humans after moderate consumption of red wine and grape extract tablets. Pharmacol Res 2012;66(5):375-382. View abstract.

53265            Pasinetti, G. M. Novel role of red wine-derived polyphenols in the prevention of Alzheimer’s disease dementia and brain pathology: experimental approaches and clinical implications. Planta Med 2012;78(15):1614-1619. View abstract.

53266            Benjamin, S., Sharma, R., Thomas, S. S., and Nainan, M. T. Grape seed extract as a potential remineralizing agent: a comparative in vitro study. J Contemp.Dent.Pract. 2012;13(4):425-430. View abstract.

53267            Chuang, C. C., Shen, W., Chen, H., Xie, G., Jia, W., Chung, S., and McIntosh, M. K. Differential effects of grape powder and its extract on glucose tolerance and chronic inflammation in high-fat-fed obese mice. J Agric.Food Chem 12-26-2012;60(51):12458-12468. View abstract.

53268            Barona, J., Blesso, C. N., Andersen, C. J., Park, Y., Lee, J., and Fernandez, M. L. Grape consumption increases anti-inflammatory markers and upregulates peripheral nitric oxide synthase in the absence of dyslipidemias in men with metabolic syndrome. Nutrients. 2012;4(12):1945-1957. View abstract.

53269            Chang, W. C. and Hsu, F. L. Inhibition of platelet aggregation and arachidonate metabolism in platelets by procyanidins. Prostaglandins Leukot.Essent.Fatty Acids 1989;38(3):181-188. View abstract.

53270            McCurdy, S. A., Wiggins, P., Schenker, M. B., Munn, S., Shaieb, A. M., Weinbaum, Z., Goldsmith, D., McGillis, S. T., Berman, B., and Samuels, S. Assessing dermatitis in epidemiologic studies: occupational skin disease among California grape and tomato harvesters. Am J Ind.Med 1989;16(2):147-157. View abstract.

53271            Nakamura, K., Ono, T., Tamura, R., Indo, M., Takashima, Y., and Kawasaki, M. Characteristics of rat lateral hypothalamic neuron responses to smell and taste in emotional behavior. Brain Res 7-3-1989;491(1):15-32. View abstract.

53272            Winter, C. K. and Kurtz, P. H. Factors influencing grape worker susceptibility to skin rashes. Bull.Environ.Contam Toxicol. 1985;35(3):418-426. View abstract.

53273            Meunier, M. T., Villie, F., Jonadet, M., Bastide, J., and Bastide, P. Inhibition of angiotensin I converting enzyme by flavanolic compounds: in vitro and in vivo studies. Planta Med 1987;53(1):12-15. View abstract.

53274            Boissin, J. P., Corbe, C., and Siou, A. [Chorioretinal circulation and dazzling: use of procyanidol oligomers (Endotelon)]. Bull.Soc.Ophtalmol.Fr. 1988;88(2):173-179. View abstract.

53275            Yamasaki, R., Dekio, S., and Jidoi, J. Contact dermatitis from grape bud. Contact Dermatitis 1985;12(4):226-227. View abstract.

53276            Corbe, C., Boissin, J. P., and Siou, A. [Light vision and chorioretinal circulation. Study of the effect of procyanidolic oligomers (Endotelon)]. J Fr.Ophtalmol. 1988;11(5):453-460. View abstract.

53277            Soyeux, A., Seguin, J. P., Le, Devehat C., and Bertrand, A. [Endotelon. Diabetic retinopathy and hemorheology (preliminary study)]. Bull.Soc Ophtalmol.Fr. 1987;87(12):1441-1444. View abstract.

53278            Cox, J. and Grigg, M. Small bowel obstruction by an intact grape. J Am Geriatr.Soc 1986;34(7):550. View abstract.

53279            Sousa, J., Nath, J., and Ong, T. Dietary factors affecting the urinary mutagenicity assay system. II. The absence of mutagenic activity in human urine following consumption of red wine or grape juice. Mutat.Res 1985;156(3):171-176. View abstract.

53280            Baruch, J. [Effect of Endotelon in postoperative edema. Results of a double-blind study versus placebo in 32 female patients]. Ann.Chir Plast.Esthet. 1984;29(4):393-395. View abstract.

53281            Lagrue, G., Olivier-Martin, F., and Grillot, A. [A study of the effects of procyanidol oligomers on capillary resistance in hypertension and in certain nephropathies (author's transl)]. Sem Hop 9-18-1981;57(33-36):1399-1401. View abstract.

53282            Wegrowski, J., Robert, A. M., and Moczar, M. The effect of procyanidolic oligomers on the composition of normal and hypercholesterolemic rabbit aortas. Biochem Pharmacol 11-1-1984;33(21):3491-3497. View abstract.

53283            Abdushelishvili, G. V., Grigorashvili, G. Z., and Topuridze, E. P. [Biomedical evaluation of the protein concentrate obtained from grape seeds]. Vopr.Pitan. 1983;(6):44-48. View abstract.

53284            Faircloth, D. E. and Robison, W. J. Obstruction of the sigmoid colon by grape seeds. JAMA 11-27-1981;246(21):2430. View abstract.

53285            Marguerie, C. and Drouet, M. [Occupational eosinophilic lung in a grape grower: role of sulfites]. Allerg.Immunol.(Paris) 1995;27(5):163-167. View abstract.

53286            Oshima, Y., Namao, K., Kamijou, A., Matsuoka, S., Nakano, M., Terao, K., and Ohizumi, Y. Powerful hepatoprotective and hepatotoxic plant oligostilbenes, isolated from the Oriental medicinal plant Vitis coignetiae (Vitaceae). Experientia 1-15-1995;51(1):63-66. View abstract.

53287            Maffei, Facino R., Carini, M., Aldini, G., Bombardelli, E., Morazzoni, P., and Morelli, R. Free radicals scavenging action and anti-enzyme activities of procyanidines from Vitis vinifera. A mechanism for their capillary protective action. Arzneimittelforschung. 1994;44(5):592-601. View abstract.

53288            Yabe, N., Sudo, T., Iizuka, M., and Matsui, H. A hidden mitogenic activity of Vitis (grape) extract for human lymphocytes in the presence of monocytes or serum. In Vitro Cell Dev.Biol.Anim 1994;30A(6):349-352. View abstract.

53289            Henriet, J. P. [Veno-lymphatic insufficiency. 4,729 patients undergoing hormonal and procyanidol oligomer therapy]. Phlebologie. 1993;46(2):313-325. View abstract.

53290            Fitzpatrick, D. F., Hirschfield, S. L., and Coffey, R. G. Endothelium-dependent vasorelaxing activity of wine and other grape products. Am J Physiol 1993;265(2 Pt 2):H774-H778. View abstract.

53291            Lanningham-Foster, L., Chen, C., Chance, D. S., and Loo, G. Grape extract inhibits lipid peroxidation of human low density lipoprotein. Biol.Pharm Bull. 1995;18(10):1347-1351. View abstract.

53292            Zimmerli, B. and Dick, R. Ochratoxin A in table wine and grape-juice: occurrence and risk assessment. Food Addit.Contam 1996;13(6):655-668. View abstract.

53293            Bagchi, D., Garg, A., Krohn, R. L., Bagchi, M., Tran, M. X., and Stohs, S. J. Oxygen free radical scavenging abilities of vitamins C and E, and a grape seed proanthocyanidin extract in vitro. Res Commun Mol Pathol.Pharmacol 1997;95(2):179-189. View abstract.

53294            Ledig, M., Holownia, A., Copin, J. C., Tholey, G., and Anokhina, I. Development of glial cells cultured from prenatally alcohol treated rat brain: effect of supplementation of the maternal alcohol diet with a grape extract. Neurochem.Res 1996;21(3):313-317. View abstract.

53295            Merillon, J. M., Fauconneau, B., Teguo, P. W., Barrier, L., Vercauteren, J., and Huguet, F. Antioxidant activity of the stilbene astringin, newly extracted from Vitis vinifera cell cultures. Clin.Chem 1997;43(6 Pt 1):1092-1093. View abstract.

53296            Folts, J. D., Begolli, B., Shanmuganayagam, D., Osman, H., and Maalej, N. Inhibition of platelet activity with red wine and grape products. Biofactors 1997;6(4):411-414. View abstract.

53297            Miyagi, Y., Miwa, K., and Inoue, H. Inhibition of human low-density lipoprotein oxidation by flavonoids in red wine and grape juice. Am J Cardiol 12-15-1997;80(12):1627-1631. View abstract.

53298            Aslan, Y., Erduran, E., Mocan, H., Gedik, Y., Okten, A., Soylu, H., and Deger, O. Absorption of iron from grape-molasses and ferrous sulfate: a comparative study in normal subjects and subjects with iron deficiency anemia. Turk.J Pediatr 1997;39(4):465-471. View abstract.

53299            Day, A. P., Kemp, H. J., Bolton, C., Hartog, M., and Stansbie, D. Effect of concentrated red grape juice consumption on serum antioxidant capacity and low-density lipoprotein oxidation. Ann.Nutr.Metab 1997;41(6):353-357. View abstract.

53300            Yamakoshi, J., Kataoka, S., Koga, T., and Ariga, T. Proanthocyanidin-rich extract from grape seeds attenuates the development of aortic atherosclerosis in cholesterol-fed rabbits. Atherosclerosis 1999;142(1):139-149. View abstract.

53301            Brito, FF., Martinez, A., Palacios, R., Mur, P., Gomez, E., Galindo, P. A., Borja, J., and Martinez, J. Rhinoconjunctivitis and asthma caused by vine pollen: a case report. J Allergy Clin Immunol 1999;103(2 Pt 1):262-266. View abstract.

53302            Butkhup, L., Chowtivannakul, S., Gaensakoo, R., Prathepha, P., and Samappito, S. Study of the phenolic composition of Shiraz red grape cultivar (Vitis vinifera L.) cultivated in North-eastern Thailand and its antioxidant and antimicrobial activity. South African Journal of Enology and Viticulture 2010;31(2):89-98.

53303            Murgov, I., Acikbas, M., and Nikolova, R. Antimicrobial activity of citric acid and grape seed extract on pathogenic microorganisms and lactobacilli. Scientific Works of the University of Food Technologies – Plovdiv 2008;55(1):367-372.

53304            Krešic, G., Dragovic-Uzelac, V., Saftic, M., and Blazevic, N. Cereal bakery products enriched with bioflavonoids – new possibilities of functional food. Flour – Bread ’01: Proceedings of International Congress, 3rd Croatian Congress of Cereal Technologists, Opatija, Croatia 2002;111-121.

53305            Araghi-Niknam M, Hosseini S, Larson D, and et al. Pine bark extract reduces platelet aggregation. Integr Med 2000;2(2):73-77.

53306            Dartenuc P, Marache P, and Choussat H. [Capillary resistance in geriatry. Study of a microangioprotector: endotelon.]. Bordeaux Medicale 1980;13:903-907.

53307            Thebaut JF, Thebaut P, and Vin F. Study of Endotelon in the functional manifestations of peripheral venous insufficiency. Results of a double-blind study of 92 patients. Gazette Medicale 1985;92(1):96-100.

53308            Delacroix P. [Double-blind study of Endotelon in chronic venous insufficiency] [translated from French]. La Revue de Medecine 1981;31(27-28):1793-1802.

53309            Lesbre FX and Tigaud JD. [The effect of Endotelon on the capillary fragility index of a specified controlled group: cirrhosis patients]. Gazette Medicale de France 1983;90(24):2333-2337.

53310            Lafay, S., Jan, C., Nardon, K., Lemaire, B., Ibarra, A., Roller, M., Houvenaeghel, M., Juhel, C., and Cara, L. Grape extract improves antioxidant status and physical performance in elite male athletes. Journal of Sports Science & Medicine 2009;8(3):468.

53311            Skarpan´ska-Stejnborn, A., Basta, P., Pilaczyn´ska-Szczesniak, L., and Horoszkiewicz-Hassan, M. Black grape extract supplementation attenuates blood oxidative stress in response to acute exercise. Biology of Sport 2010;27(1):41-46.

53312            Bernstein CK, Deng C, Shuklah R, and et al. Double blind placebo controlled (DBPC) study of grapeseed extract in the treatment of seasonal allergic rhinitis (SAR). J Allergy Clin Immunol 2001;107(2):s311.

53313            Arne JL. [Contribution to the study of procyanidolic oligomers: Endotelon in diabetic retinopathy (based on 30 cases).]. Gaz Med France 1982;89(30):3610-3614.

53314            Fromantin M. [OPC in the treatment of capillary weakness and retinopathy in diabetics. A propos of 26 cases]. Med Int 1982;16(11):432-434.

53315            Verin MM, Vildy A, and Maurin JF. [Retinopathies and OPC]. Bordeaux Medicale 1978;11(16):1467-1474.

53316            Parienti J and Pareinti-Amsellem J. [Post-traumatic edemas in sports: a controlled test of endotelon]. Gaz Med France 1983;90(3):231-235.

53317            Sarrat L. [Therapeutic relief of functional problems of the lower legs by Endotelon, a microangioprotector]. Bordeaux Med 1981;14:685-688.

53318            Pecking A, Desperez-Curely JP, and Megret G. OPC (Endotelon) in the treatment of post-therapy lymphedemas of the upper extremities. Int’l d’Antiologie 1989.

53319            Piper, J., Kohler, S., Niestroj, M., and Malek, F. A. Medical nutrition therapy of patients with atherosclerotic vascular diseases and hypertension by means of perilla oil and black grape extract as dietary food for special medical purposes. Diätetische Intervention mit Perilla-Öl und Rotweintrauben-Extrakt als ergänzende bilanzierte Diät bei Patienten mit atherosklerotischen Gefässerkrankungen und Bluthochdruck 2005;20(1):20-26.

53320            Shchelkunov, D. F., Dudkin, M. S., and Danilova, E. I. The influence of dietary fibre on indicators of gastrointestinal tract activity in rats. Voprosy Pitaniya 2000;69(6):18-21.

53321            Eriz, G., Sanhueza, V., Roeckel, M., and Fernandez, K. Inhibition of the angiotensin-converting enzyme by grape seed and skin proanthocyanidins extracted from Vitis vinífera L. cv. País. LWT – Food Science and Technology 2011;44(4):860-865.

53322            Voronina, L., Zagayko, A., and Strel’chenko, K. Grape substances effect on antioxidant-prooxidant status and some parameters of lipid metabolism in blood serum of hamsters with metabolic syndrome. Annales Universitatis Mariae Curie-Skodowska.Sectio DDD, Pharmacia 2004;17(2):281-284.

53323            Al-Awwadi, N., Bornet, A., Delbosc, S., Cristol, J. P., Auger, C., Rouanet, J. M., Cros, G., and Teissedre, P. L. Skins and seeds grape polyphenolic extracts (anthocyanins, procyanidins and oligomers) reduce oxidative stress and NADPH oxidase activation in insulin resistance-induced cardiac hypertrophy and cardiovascular complications in the fructose fed rat. Bulletin de l’OIV 2005;78(891-892):361-375.

53324            Nuttall SL, Kendall MJ, Bombardelli E, and et al. An evaluation of the antioxidant activity of a standardized grape seed extract, Leucoselect. Journal of Clinical Pharmacology and Therapeutics 1998;23:385-389.

53325            Aguirre, M. J., Chen, Y. Y., Isaacs, M., Matsuhiro, B., Mendoza, L., and Torres, S. Electrochemical behaviour and antioxidant capacity of anthocyanins from Chilean red wine, grape and raspberry. Food Chemistry 2010;121(1):44-48.

53326            Caillet, S., Salmieri, S., and Lacroix, M. Evaluation of free radical scavenging properties of grape phenolic extracts by a fast colorimetric method. Acta Horticulturae 2007;744:425-429.

53327            Pazos, M., Gallardo, J. M., Torres, J. L., and Medina, I. Activity of grape polyphenols as inhibitors of the oxidation of fish lipids and frozen fish muscle. Food Chemistry 2005;92(3):547-557.

53328            Jongberg, S., Skov, S. H., Torngren, M. A., Skibsted, L. H., and Lund, M. N. Effect of white grape extract and modified atmosphere packaging on lipid and protein oxidation in chill stored beef patties. Food Chemistry 2011;128(2):276-283.

53329            Shirahigue, L. D., Plata-Ovideo, M., de Alencar, S. M., D’Arce, M. A. B. R., de Souza Vieira, T. M. F., Oldoni, T. L. C., and Contreras-Castillo, C. J. Wine industry residue as antioxidant in cooked chicken meat. International Journal of Food Science & Technology 2010;45(5):863-870.

53330            Han, J., Britten, M., St-Gelais, D., Champagne, C. P., Fustier, P., Salmieri, S., and Lacroix, M. Polyphenolic compounds as functional ingredients in cheese. Food Chemistry 2011;124(4):1589-1594.

53331            Tebib K et al. Polymeric grape seed tannins prevent plasma cholesterol changes in high-cholesterol-fed rats. Food Chem 1994;49:403-406.

53332            Treeby, M. T., Holzapfel, B. P., Walker, R. R., and Nicholas, P. R. Profiles of free amino acids in grapes of grafted Chardonnay grapevines. Australian Journal of Grape and Wine Research 1998;4(3):121-126.

53333            Arevalo Villena, M., Diez Perez, J., Ubeda, J. F., Navascues, E., and Briones, A. I. A rapid method for quantifying aroma precursors: Application to grape extract, musts and wines made from several varieties. Food Chemistry 2006;99:183-190.

53334            Sarneckis, C. J., Dambergs, R. G., Jones, P., Mercurio, M., Herderich, M. J., and Smith, P. A. Quantification of condensed tannins by precipitation with methyl cellulose: development and validation of an optimised tool for grape and wine analysis. Australian Journal of Grape and Wine Research 2006;12(1):39-49.

53335            Pinelo, M., Rubilar, M., Sineiro, J., and Nunez, M. J. A thermal treatment to increase the antioxidant capacity of natural phenols: catechin, resveratrol and grape extract cases. European Food Research and Technology 2005;3-4:284-290.

53336            Amsellem M, Masson JM, Negui B, and et al. [Endotelon in the treatment of venolymphatic problems in premenstrual syndrome. Multicenter study on 165 patients]. Tempo Medical 1987;282 :46-51.

53337            Bombardelli E and Morazonni P. Vitis vinifera L. Fitoterapia 1995;66(4):291-317.

 

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3540               Ziegler D, Hanefeld M, Ruhnau K, et al. Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: A 7-month, multicenter, randomized, controlled trial (ALADIN III Study). Diabetes Care 1999;22:1296-301. View abstract.

3541               Reljanovic M, Reichel G, Rett K, et al. Treatment of diabetic polyneuropathy with the antioxidant thioctic acid (alpha-lipoic acid): A 2-year, multicenter, randomized, double-blind, placebo-controlled trial (ALADIN II). Alpha Lipoic Acid in Diabetic Neuropathy [abstract]. Free Radic Res 1999;31:171-7. View abstract.

3542               Ziegler D, Schatz H, Conrad F, et al. Effects of treatment with the antioxidant alpha-lipoic acid on cardiac autonomic neuropathy in NIDDM patients. Diabetes Care 1997;20:369-73. View abstract.

3544               Streeper RS, Henriksen EJ, Jacob S, et al. Differential effects of lipoic acid stereoisomers on glucose metabolism in insulin-resistant skeletal muscle. Am J Physiol 1997;273:E185-91. View abstract.

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3557               Ziegler D, Hanefeld M, Ruhnau KJ, et al. Treatment of symptomatic diabetic peripheral neuropathy with the antioxidant alpha-lipoic acid: A 3-week, multicentre randomized controlled trial (ALADIN Study). Diabetologia 1995;38:1425-33. View abstract.

3868               Ruhnau KJ, Meissner HP, Finn JR, et al. Effects of 3-week oral treatment with the antioxidant thioctic acid (alpha-lipoic acid) in symptomatic diabetic polyneuropathy. Diabet Med 1999;16:1040-3. View abstract.

3869               Sachse G, Willms B. Efficacy of thioctic acid in the therapy of peripheral diabetic neuropathy. Hormone Metab Res Suppl 1980;9:105-7. View abstract.

3870               Gleiter CH, Schreeb KH, Freudenthaler S, et al. Lack of interaction between thioctic acid, glibenclamide and acarbose. Br J Clin Pharmacol 1999;48:819-25. View abstract.

3871               Packer L, Witt EH, Tritschler HJ. Alpha-Lipoic acid as a biological antioxidant. Free Radic Biol Med 1995;19:227-50. View abstract.

3872               Teichert J, Kern J, Tritschler HJ. Investigations on the pharmacokinetics of alpha-lipoic acid in healthy volunteers. Int J Clin Pharmacol Ther 1998;36:625-8. View abstract.

3873               Nagamatsu M, Nickander KK, Schmelzer JD, et al. Lipoic acid improves nerve blood flow, reduces oxidative stress, and improves distal nerve conduction in experimental diabetic neuropathy. Diabet Care 1995;18:1160-7. View abstract.

3874               Jacob S, Henriksen EJ, Tritschler HJ, et al. Improvement of insulin-stimulated glucose-disposal in type 2 diabetes after repeated parenteral administration of thioctic acid. Exp Clin Endocrinol Diabet 1996;104:284-8. View abstract.

3875               Jacob S, Henriksen EJ, Schiemann AL, et al. Enhancement of glucose disposal in patients with type 2 diabetes by alpha-lipoic acid. Arzneimittelforschung 1995;45:872-4. View abstract.

3876               Jacob S, Ruus P, Hermann R, et al. Oral administration of RAC-alpha-lipoic acid modulates insulin sensitivity in patients with type-2 diabetes mellitus: a placebo-controlled, pilot trial. Free Rad Biol Med 1999;27:309-14. View abstract.

3877               Haramaki N, Assadnazari H, Zimmer G, et al. The influence of vitamin E and dihydrolipoic acid on cardiac energy and glutathione status under hypoxia-reoxygenation. Biochem Mol Biol Int 1995;37:591-7. View abstract.

3878               Kishi Y, Schmelzer JD, Yao JK, et al. Alpha-lipoic acid: effect on glucose uptake, sorbitol pathway, and energy metabolism in experimental diabetic neuropathy. Diabetes 1999;48:2045-51. View abstract.

3879               Bustamante J, Lodge JK, Marcocci L, et al. Alpha-lipoic acid in liver metabolism and disease. Free Rad Biol Med 1998;24:1023-39. View abstract.

3880               Marshall AW, Graul RS, Morgan MY, Sherlock S. Treatment of alcohol-related liver disease with thioctic acid: a six-month, randomized, double-blind trial. Gut 1982;23:1088-93. View abstract.

3881               Conlon BJ, Aran JM, Erre JP, Smith DW. Attenuation of aminoglycoside-induced cochlear damage with the metabolic antioxidant alpha-lipoic acid. Hear Res 1999;128:40-4. View abstract.

3882               Vilas GL, Aldonatti C, San Martin de Viale LC, Rios de Molina MC. Effect of Alpha-lipoic acid amide on hexachlorobenzene porphyria. Biochem Mol Biol Int 1999;47:815-23. View abstract.

3883               Gurer H, Ozgunes H, Oztezcan S, Ercal N. Antioxidant role of alpha-lipoic acid in lead toxicity. Free Rad Biol Med 1999;27:75-81. View abstract.

3884               Altenkirch H, Stoltenburg-Didinger G, Wagner HM, et al. Effects of lipoic acid in hexacarbon-induced neuropathy. Neurotoxicol Teratol 1990;12:619-22. View abstract.

3885               Fuchs J, Schofer H, Milbradt R, et al. Studies on lipoate effects on blood redox state in human immunodeficiency virus infected patients. Arzneimittelforschung 1993;43:1359-62. View abstract.

8946               Segermann J, Hotze A, Ulrich H, Rao GS. Effect of alpha-lipoic acid on the peripheral conversion of thyroxine to triiodothyronine and on serum lipid-, protein- and glucose levels. Arzneimittelforschung 1991;41:1294-8. View abstract.

10148            Ametov AS, Barinov A, Dyck PJ, et al. The sensory symptoms of diabetic polyneuropathy are improved with alpha-lipoic acid. Diabetes Care 2003;26:770-6.. View abstract.

12021            Beitner H. Randomized, placebo controlled, double-blind study on the clinical efficacy of a cream containing 5% alpha-lipoic acid related to photoaging of facial skin. Br J Dermatol 2003;149:841-9. View abstract.

12106            Ziegler D, Nowak H, Kempler P, et al. Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: A meta-analysis. Diabet Med 2004;21:114-21. View abstract.

12152            Sauer J, Tabet N, Howard R. Alpha lipoic acid for dementia. Cochrane Database Syst Rev 2004;(1):CD004244. View abstract.

14010            Block G, Jensen C, Dietrich M, et al. Plasma C-reactive protein concentrations in active and passive smokers: influence of antioxidant supplementation. J Am Coll Nutr 2004;23:141-7. View abstract.

16391            Vincent HK, Bourguignon CM, Vincent KR, Taylor AG. Effects of alpha-lipoic acid supplementation in peripheral arterial disease: a pilot study. J Alt Complement Med 2007;13:577-84. View abstract.

16392            Furukawa N, Miyamura N, Nishida K, et al. Possible relevance of alpha lipoic acid contained in a health supplement in a case of insulin autoimmune syndrome. Diabetes Res Clin Pract 2007;75:366-7. View abstract.

19206            Galasko D. R., Peskind E., Clark C. M., Quinn J. F., Ringman J. M., Jicha G. A., Cotman C., Cottrell B., Montine T. J., Thomas R. G., Aisen P. Antioxidants for Alzheimer disease: a randomized clinical trial with cerebrospinal fluid biomarker measures. Arch Neurol 2012;69(7):836-841. View abstract.

19209            Sun Y. D., Dong Y. D., Fan R., Zhai L. L., Bai Y. L., Jia L. H. Effect of (R)-a-lipoic acid supplementation on serum lipids and antioxidative ability in patients with age-related macular degeneration. Ann Nutr Metab 2012;60(4):293-297. View abstract.

19210            Dell’Anna M. L., Mastrofrancesco A., Sala R., Venturini M., Ottaviani M., Vidolin A. P., Leone G., Calzavara P. G., Westerhof W., Picardo, M. Antioxidants and narrow band-UVB in the treatment of vitiligo: a double-blind placebo controlled trial. Clin Exp Dermatol 2007;32(6):631-636. View abstract.

19219            Witman M. A., McDaniel J., Fjeldstad A. S., Ives S. J., Zhao J., Nativi J. N., Stehlik J., Wray D. W., Richardson R. S. A differing role of oxidative stress in the regulation of central and peripheral hemodynamics during exercise in heart failure. Am J Physiol Heart Circ Physiol 2012;303(10):H1237-H1244. View abstract.

20473            Han T., Bai J., Liu W., Hu Y. A systematic review and meta-analysis of a-lipoic acid in the treatment of diabetic peripheral neuropathy. Eur J Endocrinol 2012;167(4):465-471. View abstract.

20474            Lopez-D’alessandro E., Escovich L. Combination of alpha lipoic acid and gabapentin, its efficacy in the treatment of Burning Mouth Syndrome: a randomized, double-blind, placebo controlled trial. Med Oral Patol Oral Cir Bucal 2011;16(5):e635-e640. View abstract.

20475            Ziegler D., Ametov A., Barinov A., Dyck P. J., Gurieva I., Low P. A., Munzel U., Yakhno N., Raz I., Novosadova M., Maus J., Samigullin, R. Oral treatment with alpha-lipoic acid improves symptomatic diabetic polyneuropathy: the SYDNEY 2 trial. Diabetes Care 2006;29(11):2365-2370. View abstract.

20478            Gu X. M., Zhang S. S., Wu J. C., Tang Z. Y., Lu Z. Q., Li H., Liu C., Chen L., Ning, G. [Efficacy and safety of high-dose a-lipoic acid in the treatment of diabetic polyneuropathy]. Zhonghua Yi Xue Za Zhi 2010;90(35):2473-2476. View abstract.

20479            ). Ziegler D., Low P. A., Litchy W. J., Boulton A. J., Vinik A. I., Freeman R., Samigullin R., Tritschler H., Munzel U., Maus J., Schütte K., Dyck P. J. Efficacy and safety of antioxidant treatment with a-lipoic acid over 4 years in diabetic polyneuropathy: the NATHAN 1 trial. Diabetes Care 2011;34(9):2054-2060. View abstract.

20480            Ametov A. S., Novosadova M. V., Barinov A. N., Samigullin R., Trischler H. J. [Long-term effect of 3-week intravenous alpha-lipoic acid administration in symptomatic diabetic polyneutropathy with clinical manifestations]. Ter Arkh 2010;82(12):61-64. View abstract.

20481            Liu F., Zhang Y., Yang M., Liu B., Shen Y. D., Jia W. P., Xiang K. S. [Curative effect of alpha-lipoic acid on peripheral neuropathy in type 2 diabetes: a clinical study]. Zhonghua Yi Xue Za Zhi 2007;87(38):2706-2709. View abstract.

20482            Haak E., Usadel K. H., Kusterer K., Amini P., Frommeyer R., Tritschler H. J., Haak T. Effects of alpha-lipoic acid on microcirculation in patients with peripheral diabetic neuropathy. Exp Clin Endocrinol Diabetes 2000;108(3):168-174. View abstract.

20483            Sadykova H. G., Nazhmutdinova, D. K. [Structural and functional condition of the left ventricle in patients with type 2 diabetes mellitus complicated with diabetic autonomic neuropathy]. Lik Sprava 2009;(1-2):22-28. View abstract.

20484            Volchegorskii I. A., Alekseev M. N., Volchegorskaia M. I., Rassokhina L. M. [Effect of alpha-lipoic acid and mexidol on neuro- and the affective status in patients at early stages of diabetic foot syndrome]. Klin Med (Mosk) 2008;86(10):52-59. View abstract.

20485            Tankova T., Koev D., Dakovska, L. Alpha-lipoic acid in the treatment of autonomic diabetic neuropathy (controlled, randomized, open-label study). Rom J Intern Med 2004;42(2):457-464. View abstract.

20486            Jörg J., Metz F., Scharafinski, H. [Drug treatment of diabetic polyneuropathy with alpha-lipoic acid or vitamin B preparations. A clinical and neurophysiologic study]. Nervenarzt 1988;59(1):36-44. View abstract.

20487            Burekovic A., Terzic M., Alajbegovic S., Vukojevic Z., Hadzic N. The role of alpha-lipoic acid in diabetic polyneuropathy treatment. Bosn J Basic Med Sci 2008;8(4):341-345. View abstract.

20488            Bertolotto F., Massone A. Combination of alpha lipoic acid and superoxide dismutase leads to physiological and symptomatic improvements in diabetic neuropathy. Drugs R D 2012;12(1):29-34. View abstract.

20489            Ranieri M., Sciuscio M., Cortese A. M., Santamato A., Di Teo L., Ianieri G., Bellomo R. G., Stasi M., Megna M. The use of alpha-lipoic acid (ALA), gamma linolenic acid (GLA) and rehabilitation in the treatment of back pain: effect on health-related quality of life. Int J Immunopathol Pharmacol 2009;22(3 Suppl):45-50. View abstract.

20490            Porasuphatana S., Suddee S., Nartnampong A., Konsil J., Harnwong B., Santaweesuk A. Glycemic and oxidative status of patients with type 2 diabetes mellitus following oral administration of alpha-lipoic acid: a randomized double-blinded placebo-controlled study. Asia Pac J Clin Nutr 2012;21(1):12-21. View abstract.

20491            Haritoglou C., Gerss J., Hammes H. P., Kampik A., Ulbig M. W. Alpha-lipoic acid for the prevention of diabetic macular edema. Ophthalmologica 2011;226(3):127-137. View abstract.

20492            Lukaszuk J., Schultz T., Prawitz A., Hofmann E. R-Alpha Lipoic Acid Effect on HbA1c in Type-2 Diabetics. Journal of Complementary and Integrative Medicine 2009;6(1):1-14.

20493            Ansar H., Mazloom Z., Kazemi F., Hejazi N. Effect of alpha-lipoic acid on blood glucose, insulin resistance and glutathione peroxidase of type 2 diabetic patients. Saudi Med J 2011;32(6):584-588. View abstract.

20494            de Oliveira A. M., Rondó P. H., Luzia L. A., D’Abronzo F. H., Illison V. K. The effects of lipoic acid and a-tocopherol supplementation on the lipid profile and insulin sensitivity of patients with type 2 diabetes mellitus: a randomized, double-blind, placebo-controlled trial. Diabetes Res Clin Pract 2011;92(2):253-260. View abstract.

20495            Mazloom Z., Ansar H. The Effect of Alpha-Lipoic Acid on Blood Pressure in Type 2 Diabetics. Iranian Journal of Endocrinology and Metabolism 2009;11(3):245-250.

20496            Volchegorskii I. A., Rassokhina L. M., Koliadich M. I., Alekseev M. I. [Comparative study of alpha-lipoic acid and mexidol effects on affective status, cognitive functions and quality of life in diabetes mellitus patients]. Eksp Klin Farmakol 2011;74(11):17-23. View abstract.

20498            Du X., Edelstein D., Brownlee M. Oral benfotiamine plus alpha-lipoic acid normalises complication-causing pathways in type 1 diabetes. Diabetologia 2008;51(10):1930-1932. View abstract.

20499            Baillie J. K., Thompson A. A., Irving J. B., Bates M. G., Sutherland A. I., Macnee W., Maxwell S. R., Webb D. J. Oral antioxidant supplementation does not prevent acute mountain sickness: double blind, randomized placebo-controlled trial. QJM 2009;102(5):341-348. View abstract.

20500            Hager K., Kenklies M., McAfoose J., Engel J., Münch G. Alpha-lipoic acid as a new treatment option for Alzheimer’s disease–a 48 months follow-up analysis. J Neural Transm Suppl 2007;(72):189-193. View abstract.

20501            Lott I. T., Doran E., Nguyen V. Q., Tournay A., Head E., Gillen D. L. Down syndrome and dementia: a randomized, controlled trial of antioxidant supplementation. Am J Med Genet A 2011;155A(8):1939-1948. View abstract.

21564            Filina A. A., Davydova N. G., Endrikhovskii S. N., Shamshinova A. M. [Lipoic acid as a means of metabolic therapy of open-angle glaucoma]. Vestn Oftalmol 1995;111(4):6-8. View abstract.

21651            Leong J. Y., van der Merwe J., Pepe S., Bailey M., Perkins A., Lymbury R., Esmore D., Marasco S., Rosenfeldt F. Perioperative metabolic therapy improves redox status and outcomes in cardiac surgery patients: a randomised trial. Heart Lung Circ 2010;19(10):584-591. View abstract.

21653            Di Geronimo G., Caccese A. F., Caruso L., Soldati A., Passaretti U. Treatment of carpal tunnel syndrome with alpha-lipoic acid. Eur Rev Med Pharmacol Sci 2009;13(2):133-139. View abstract.

21655            Jariwalla R. J., Lalezari J., Cenko D., Mansour S. E., Kumar A., Gangapurkar B., Nakamura D. Restoration of blood total glutathione status and lymphocyte function following alpha-lipoic acid supplementation in patients with HIV infection. J Altern Complement Med 2008;14(2):139-146. View abstract.

21656            Rahman S. T., Merchant N., Haque T., Wahi J., Bhaheetharan S., Ferdinand K. C., Khan B. V. The impact of lipoic acid on endothelial function and proteinuria in quinapril-treated diabetic patients with stage I hypertension: results from the QUALITY study. J Cardiovasc Pharmacol Ther 2012;17(2):139-145. View abstract.

21657            Zhang Y., Han P., Wu N., He B., Lu Y., Li S., Liu Y., Zhao S., Liu L., Li Y. Amelioration of lipid abnormalities by a-lipoic acid through antioxidative and anti-inflammatory effects. Obesity (Silver Spring) 2011;19(8):1647-1653. View abstract.

21658            Khabbazi T., Mahdavi R., Safa J., Pour-Abdollahi P. Effects of alpha-lipoic acid supplementation on inflammation, oxidative stress, and serum lipid profile levels in patients with end-stage renal disease on hemodialysis. J Ren Nutr 2012;22(2):244-250. View abstract.

21659            Chang J. W., Lee E. K., Kim T. H., Min W. K., Chun S., Lee K. U., Kim S. B., Park J. S. Effects of alpha-lipoic acid on the plasma levels of asymmetric dimethylarginine in diabetic end-stage renal disease patients on hemodialysis: a pilot study. Am J Nephrol 2007;27(1):70-74. View abstract.

21660            Magis D., Ambrosini A., Sandor P., Jacquy J., Laloux P., Schoenen J. A randomized double-blind placebo-controlled trial of thioctic acid in migraine prophylaxis. Headache 2007;47(1):52-57. View abstract.

21661            Carbone M., Pentenero M., Carrozzo M., Ippolito A., Gandolfo S. Lack of efficacy of alpha-lipoic acid in burning mouth syndrome: a double-blind, randomized, placebo-controlled study. Eur J Pain 2009;13(5):492-496. View abstract.

21662            López-Jornet P., Camacho-Alonso F., and Leon-Espinosa, S. Efficacy of alpha lipoic acid in burning mouth syndrome: a randomized, placebo-treatment study. J Oral Rehabil 2009;36(1):52-57. View abstract.

21663            Marino R., Torretta S., Capaccio P., Pignataro L., Spadari F. Different therapeutic strategies for burning mouth syndrome: preliminary data. J Oral Pathol Med 2010;39(8):611-616. View abstract.

21664            Cavalcanti D. R., da Silveira F. R. Alpha lipoic acid in burning mouth syndrome–a randomized double-blind placebo-controlled trial. J Oral Pathol Med 2009;38(3):254-261. View abstract.

21665            Femiano F., Scully C. Burning mouth syndrome (BMS): double blind controlled study of alpha-lipoic acid (thioctic acid) therapy. J Oral Pathol Med 2002;31(5):267-269. View abstract.

21666            Femiano F., Gombos F., Scully C. Burning Mouth Syndrome: open trial of psychotherapy alone, medication with alpha-lipoic acid (thioctic acid), and combination therapy. Med Oral 2004;9(1):8-13. View abstract.

21667            Femiano F., Gombos F., Scully C., Busciolano M., Luca P. D. Burning mouth syndrome (BMS): controlled open trial of the efficacy of alpha-lipoic acid (thioctic acid) on symptomatology. Oral Dis 2000;6(5):274-277. View abstract.

21668            Femiano F., Gombos F., Scully C. Burning mouth syndrome: the efficacy of lipoic acid on subgroups. J Eur Acad Dermatol Venereol 2004;18(6):676-678. View abstract.

21669            Korkina L. G., Afanas’ef I. B., Diplock A. T. Antioxidant therapy in children affected by irradiation from the Chernobyl nuclear accident. Biochem Soc Trans 1993;21 ( Pt 3)(3):314S. View abstract.

21670            Bae S. C., Jung W. J., Lee E. J., Yu R., Sung M. K. Effects of antioxidant supplements intervention on the level of plasma inflammatory molecules and disease severity of rheumatoid arthritis patients. J Am Coll Nutr 2009;28(1):56-62. View abstract.

21671            Memeo A., Loiero M. Thioctic acid and acetyl-L-carnitine in the treatment of sciatic pain caused by a herniated disc: a randomized, double-blind, comparative study. Clin Drug Investig 2008;28(8):495-500. View abstract.

21672            Thom E. A randomized, double-blind, placebo-controlled study on the clinical efficacy of oral treatment with DermaVite on ageing symptoms of the skin. J Int Med Res 2005;33(3):267-272. View abstract.

21673            Podymova S. D., Davletshina I. V. [Efficacy of using alpha-lipoic acid (berlition) in patients with nonalcoholic steatohepatitis]. Eksp Klin Gastroenterol 2008;(5):77-84. View abstract.

21674            Koh E. H., Lee W. J., Lee S. A., Kim E. H., Cho E. H., Jeong E., Kim D. W., Kim M. S., Park J. Y., Park K. G., Lee H. J., Lee I. K., Lim S., Jang H. C., Lee K. H., Lee K. U. Effects of alpha-lipoic Acid on body weight in obese subjects. Am J Med 2011;124(1):85-88. View abstract.

21676            Alleva R., Tomasetti M., Sartini D., Emanuelli M., Nasole E., Di Donato F., Borghi B., Santarelli L., Neuzil J. alpha-Lipoic acid modulates extracellular matrix and angiogenesis gene expression in non-healing wounds treated with hyperbaric oxygen therapy. Mol Med 2008;14(3-4):175-183. View abstract.

21677            Alleva R., Nasole E., Di Donato F., Borghi B., Neuzil J., Tomasetti M. alpha-Lipoic acid supplementation inhibits oxidative damage, accelerating chronic wound healing in patients undergoing hyperbaric oxygen therapy. Biochem Biophys Res Commun 2005;333(2):404-410. View abstract.

21678            Schimmelpfennig W, Renger F, Wack R, et al. [Results of a prospective double-blind study with alpha-lipoic acid against placebo in alcoholic liver damage] (Ergebnisse einer prospektiven Doppelblindstudie mit Alpha-Liponsäure gegen Plazebo bei alkoholischen Leberschäden). Dtsch Gesundheitswes 1983;38(18):690-693

30715            Lee, T. and Dugoua, J. J. Nutritional supplements and their effect on glucose control. Curr.Diab.Rep. 2011;11(2):142-148. View abstract.

30787            Breithaupt-Grogler, K., Niebch, G., Schneider, E., Erb, K., Hermann, R., Blume, H. H., Schug, B. S., and Belz, G. G. Dose-proportionality of oral thioctic acid–coincidence of assessments via pooled plasma and individual data. Eur J Pharm Sci 1999;8(1):57-65. View abstract.

30788            Khanna, S., Atalay, M., Laaksonen, D. E., Gul, M., Roy, S., and Sen, C. K. Alpha-lipoic acid supplementation: tissue glutathione homeostasis at rest and after exercise. J Appl.Physiol 1999;86(4):1191-1196. View abstract.

30789            Mitsui, Y., Schmelzer, J. D., Zollman, P. J., Mitsui, M., Tritschler, H. J., and Low, P. A. Alpha-lipoic acid provides neuroprotection from ischemia-reperfusion injury of peripheral nerve. J Neurol.Sci. 2-1-1999;163(1):11-16. View abstract.

30790            Haak, E. S., Usadel, K. H., Kohleisen, M., Yilmaz, A., Kusterer, K., and Haak, T. The effect of alpha-lipoic acid on the neurovascular reflex arc in patients with diabetic neuropathy assessed by capillary microscopy. Microvasc.Res. 1999;58(1):28-34. View abstract.

30791            Borcea, V., Nourooz-Zadeh, J., Wolff, S. P., Klevesath, M., Hofmann, M., Urich, H., Wahl, P., Ziegler, R., Tritschler, H., Halliwell, B., and Nawroth, P. P. alpha-Lipoic acid decreases oxidative stress even in diabetic patients with poor glycemic control and albuminuria. Free Radic.Biol.Med. 1999;22(11-12):1495-1500. View abstract.

30792            Ziegler, D., Reljanovic, M., Mehnert, H., and Gries, F. A. Alpha-lipoic acid in the treatment of diabetic polyneuropathy in Germany: current evidence from clinical trials. Exp Clin Endocrinol.Diabetes 1999;107(7):421-430. View abstract.

30793            Yaworsky, K., Somwar, R., Ramlal, T., Tritschler, H. J., and Klip, A. Engagement of the insulin-sensitive pathway in the stimulation of glucose transport by alpha-lipoic acid in 3T3-L1 adipocytes. Diabetologia 2000;43(3):294-303. View abstract.

30794            Jain, S. K. and Lim, G. Lipoic acid decreases lipid peroxidation and protein glycosylation and increases (Na(+) + K(+))- and Ca(++)-ATPase activities in high glucose- treated human erythrocytes. Free Radic.Biol.Med 2000;29(11):1122-1128. View abstract.

30795            Bailey, D. M. and Davies, B. Acute mountain sickness; prophylactic benefits of antioxidant vitamin supplementation at high altitude. High Alt Med Biol 2001;2(1):21-29. View abstract.

30796            Morcos, M., Borcea, V., Isermann, B., Gehrke, S., Ehret, T., Henkels, M., Schiekofer, S., Hofmann, M., Amiral, J., Tritschler, H., Ziegler, R., Wahl, P., and Nawroth, P. P. Effect of alpha-lipoic acid on the progression of endothelial cell damage and albuminuria in patients with diabetes mellitus: an exploratory study. Diabetes Res Clin Pract 2001;52(3):175-183. View abstract.

30797            Konrad, D., Somwar, R., Sweeney, G., Yaworsky, K., Hayashi, M., Ramlal, T., and Klip, A. The antihyperglycemic drug alpha-lipoic acid stimulates glucose uptake via both GLUT4 translocation and GLUT4 activation: potential role of p38 mitogen-activated protein kinase in GLUT4 activation. Diabetes 2001;50(6):1464-1471. View abstract.

30798            Heitzer, T., Finckh, B., Albers, S., Krohn, K., Kohlschutter, A., and Meinertz, T. Beneficial effects of alpha-lipoic acid and ascorbic acid on endothelium-dependent, nitric oxide-mediated vasodilation in diabetic patients: relation to parameters of oxidative stress. Free Radic.Biol Med 7-1-2001;31(1):53-61. View abstract.

30799            Ford, I., Cotter, M. A., Cameron, N. E., and Greaves, M. The effects of treatment with alpha-lipoic acid or evening primrose oil on vascular hemostatic and lipid risk factors, blood flow, and peripheral nerve conduction in the streptozotocin-diabetic rat. Metabolism 2001;50(8):868-875. View abstract.

30800            Evans, J. L., Heymann, C. J., Goldfine, I. D., and Gavin, L. A. Pharmacokinetics, tolerability, and fructosamine-lowering effect of a novel, controlled-release formulation of alpha-lipoic acid. Endocr.Pract. 2002;8(1):29-35. View abstract.

30801            Femiano, F. Burning mouth syndrome (BMS): an open trial of comparative efficacy of alpha-lipoic acid (thioctic acid) with other therapies. Minerva Stomatol. 2002;51(9):405-409. View abstract.

30802            Mantovani, G., Maccio, A., Madeddu, C., Mura, L., Gramignano, G., Lusso, M. R., Massa, E., Mocci, M., and Serpe, R. Antioxidant agents are effective in inducing lymphocyte progression through cell cycle in advanced cancer patients: assessment of the most important laboratory indexes of cachexia and oxidative stress. J Mol Med 2003;81(10):664-673. View abstract.

30803            Kagan, V. E., Shvedova, A., Serbinova, E., Khan, S., Swanson, C., Powell, R., and Packer, L. Dihydrolipoic acid–a universal antioxidant both in the membrane and in the aqueous phase. Reduction of peroxyl, ascorbyl and chromanoxyl radicals. Biochem.Pharmacol 10-20-1992;44(8):1637-1649. View abstract.

30804            Busse, E., Zimmer, G., Schopohl, B., and Kornhuber, B. Influence of alpha-lipoic acid on intracellular glutathione in vitro and in vivo. Arzneimittelforschung 1992;42(6):829-831. View abstract.

30805            Teichert, J., Hermann, R., Ruus, P., and Preiss, R. Plasma kinetics, metabolism, and urinary excretion of alpha-lipoic acid following oral administration in healthy volunteers. J Clin Pharmacol 2003;43(11):1257-1267. View abstract.

30806            Wollin, S. D. and Jones, P. J. alpha-Lipoic Acid and Cardiovascular Disease. J Nutr. 2003;133(11):3327-3330. View abstract.

30807            Smith, A. R. and Hagen, T. M. Vascular endothelial dysfunction in aging: loss of Akt-dependent endothelial nitric oxide synthase phosphorylation and partial restoration by (R)-alpha-lipoic acid. Biochem Soc Trans. 2003;31(Pt 6):1447-1449. View abstract.

30808            Hahm, J. R., Kim, B. J., and Kim, K. W. Clinical experience with thioctacid (thioctic acid) in the treatment of distal symmetric polyneuropathy in Korean diabetic patients. J Diabetes Complications 2004;18(2):79-85. View abstract.

30809            Kravchuk, IuA, Mekhtiev, S. N., Uspenskii, IuP, Grinevich, V. B., and Koblov, S. V. [Device laboratory and postmortem parallels in alcoholic hepatitis during combined therapy using thioctic (alpha-lipoic) acid]. Klin.Med (Mosk) 2004;82(6):55-57. View abstract.

30810            Jang, W. G., Kim, H. S., Park, K. G., Park, Y. B., Yoon, K. H., Han, S. W., Hur, S. H., Park, K. S., and Lee, I. K. Analysis of proteome and transcriptome of tumor necrosis factor alpha stimulated vascular smooth muscle cells with or without alpha lipoic acid. Proteomics. 2004;4(11):3383-3393. View abstract.

30811            Marracci, G. H., McKeon, G. P., Marquardt, W. E., Winter, R. W., Riscoe, M. K., and Bourdette, D. N. Alpha lipoic acid inhibits human T-cell migration: implications for multiple sclerosis. J Neurosci.Res 11-1-2004;78(3):362-370. View abstract.

30812            Bruckner, I., Bustan, C., Adamescu, E., and Dobjanschi, C. Diabetic neuropathy–choices of treatment. Rom.J Intern Med 2002;40(1-4):53-60. View abstract.

30813            Negrisanu, G., Rosu, M., Bolte, B., Lefter, D., and Dabelea, D. Effects of 3-month treatment with the antioxidant alpha-lipoic acid in diabetic peripheral neuropathy. Rom.J Intern Med 1999;37(3):297-306. View abstract.

30814            Doggrell, S. A. Alpha-lipoic acid, an anti-obesity agent? Expert.Opin.Investig.Drugs 2004;13(12):1641-1643. View abstract.

30815            Sola, S., Mir, M. Q., Cheema, F. A., Khan-Merchant, N., Menon, R. G., Parthasarathy, S., and Khan, B. V. Irbesartan and lipoic acid improve endothelial function and reduce markers of inflammation in the metabolic syndrome: results of the Irbesartan and Lipoic Acid in Endothelial Dysfunction (ISLAND) study. Circulation 1-25-2005;111(3):343-348. View abstract.

30816            Cicero, A. F., Derosa, G., and Gaddi, A. What do herbalists suggest to diabetic patients in order to improve glycemic control? Evaluation of scientific evidence and potential risks. Acta Diabetol. 2004;41(3):91-98. View abstract.

30817            Zakrzewska, J. M., Forssell, H., and Glenny, A. M. Interventions for the treatment of burning mouth syndrome. Cochrane.Database.Syst Rev 2005;(1):CD002779. View abstract.

30818            Wenzel, U., Nickel, A., and Daniel, H. alpha-Lipoic acid induces apoptosis in human colon cancer cells by increasing mitochondrial respiration with a concomitant O2-*-generation. Apoptosis. 2005;10(2):359-368. View abstract.

30819            Gregus, Z., Stein, A. F., Varga, F., and Klaassen, C. D. Effect of lipoic acid on biliary excretion of glutathione and metals. Toxicol Appl Pharmacol 1992;114(1):88-96. View abstract.

30820            Lee, W. J., Song, K. H., Koh, E. H., Won, J. C., Kim, H. S., Park, H. S., Kim, M. S., Kim, S. W., Lee, K. U., and Park, J. Y. Alpha-lipoic acid increases insulin sensitivity by activating AMPK in skeletal muscle. Biochem.Biophys.Res Commun. 7-8-2005;332(3):885-891. View abstract.

30821            Tankova, T., Cherninkova, S., and Koev, D. Treatment for diabetic mononeuropathy with alpha-lipoic acid. Int J Clin.Pract. 2005;59(6):645-650. View abstract.

30822            Koh, J. M., Lee, Y. S., Byun, C. H., Chang, E. J., Kim, H., Kim, Y. H., Kim, H. H., and Kim, G. S. Alpha-lipoic acid suppresses osteoclastogenesis despite increasing the receptor activator of nuclear factor kappaB ligand/osteoprotegerin ratio in human bone marrow stromal cells. J Endocrinol. 2005;185(3):401-413. View abstract.

30823            Weiss, C., Bierhaus, A., Nawroth, P. P., and Bartsch, P. Effects of supplementation with alpha-lipoic acid on exercise-induced activation of coagulation. Metabolism 2005;54(6):815-820. View abstract.

30824            Byun, C. H., Koh, J. M., Kim, D. K., Park, S. I., Lee, K. U., and Kim, G. S. alpha-Lipoic Acid Inhibits TNF-alpha-Induced Apoptosis in Human Bone Marrow Stromal Cells. J Bone Miner.Res 2005;20(7):1125-1135. View abstract.

30825            Cakatay, U. Pro-oxidant actions of alpha-lipoic acid and dihydrolipoic acid. Med Hypotheses 2006;66(1):110-117. View abstract.

30826            Sung, M. J., Kim, W., Ahn, S. Y., Cho, C. H., Koh, G. Y., Moon, S. O., Kim, D. H., Lee, S., Kang, K. P., Jang, K. Y., and Park, S. K. Protective effect of alpha-lipoic acid in lipopolysaccharide-induced endothelial fractalkine expression. Circ.Res 10-28-2005;97(9):880-890. View abstract.

30827            Lee, W. J., Lee, I. K., Kim, H. S., Kim, Y. M., Koh, E. H., Won, J. C., Han, S. M., Kim, M. S., Jo, I., Oh, G. T., Park, I. S., Youn, J. H., Park, S. W., Lee, K. U., and Park, J. Y. Alpha-lipoic acid prevents endothelial dysfunction in obese rats via activation of AMP-activated protein kinase. Arterioscler.Thromb.Vasc.Biol 2005;25(12):2488-2494. View abstract.

30828            Mackenzie, G. G., Zago, M. P., Erlejman, A. G., Aimo, L., Keen, C. L., and Oteiza, P. I. alpha-Lipoic acid and N-acetyl cysteine prevent zinc deficiency-induced activation of NF-kappaB and AP-1 transcription factors in human neuroblastoma IMR-32 cells. Free Radic.Res 2006;40(1):75-84. View abstract.

30829            Bregovskii, V. B., Posokhina, O. V., and Karpova, I. A. [Predictors of alpha-lipoic acid treatment efficacy in diabetic polyneuropathy of the lower limbs]. Ter.Arkh. 2005;77(10):15-19. View abstract.

30830            Tarnopolsky, M. A. and Raha, S. Mitochondrial myopathies: diagnosis, exercise intolerance, and treatment options. Med Sci Sports Exerc. 2005;37(12):2086-2093. View abstract.

30831            Kidd, P. M. Neurodegeneration from mitochondrial insufficiency: nutrients, stem cells, growth factors, and prospects for brain rebuilding using integrative management. Altern Med Rev 2005;10(4):268-293. View abstract.

30832            Dudka, J. Decrease in NADPH-cytochrome P450 reductase activity of the human heart, Liver and lungs in the presence of alpha-lipoic acid. Ann Nutr Metab 2006;50(2):121-125. View abstract.

30833            Berkson, B. M., Rubin, D. M., and Berkson, A. J. The long-term survival of a patient with pancreatic cancer with metastases to the liver after treatment with the intravenous alpha-lipoic acid/low-dose naltrexone protocol. Integr.Cancer Ther 2006;5(1):83-89. View abstract.

30834            Mantovani, G., Maccio, A., Madeddu, C., Gramignano, G., Lusso, M. R., Serpe, R., Massa, E., Astara, G., and Deiana, L. A phase II study with antioxidants, both in the diet and supplemented, pharmaconutritional support, progestagen, and anti-cyclooxygenase-2 showing efficacy and safety in patients with cancer-related anorexia/cachexia and oxidative stress. Cancer Epidemiol.Biomarkers Prev. 2006;15(5):1030-1034. View abstract.

30835            Cakatay, U. and Kayali, R. An overdose of alpha lipoic acid may cause trace element deficiency in diabetes mellitus. Med Hypotheses 2006;67(3):672-673. View abstract.

30836            Bergqvist-Karlsson, A., Thelin, I., and Bergendorff, O. Contact dermatitis to alpha-lipoic acid in an anti-wrinkle cream. Contact Dermatitis 2006;55(1):56-57. View abstract.

30837            Suarez, P. and Clark, G. T. Burning mouth syndrome: an update on diagnosis and treatment methods. J Calif.Dent.Assoc. 2006;34(8):611-622. View abstract.

30838            Jameel, N. M., Shekhar, M. A., and Vishwanath, B. S. Alpha-lipoic acid: an inhibitor of secretory phospholipase A2 with anti-inflammatory activity. Life Sci 12-14-2006;80(2):146-153. View abstract.

30839            Dunschede, F., Erbes, K., Kircher, A., Westermann, S., Seifert, J., Schad, A., Oliver, K., Kiemer, A. K., and Theodor, J. Reduction of ischemia reperfusion injury after liver resection and hepatic inflow occlusion by alpha-lipoic acid in humans. World J Gastroenterol 11-14-2006;12(42):6812-6817. View abstract.

30840            Kamenova, P. Improvement of insulin sensitivity in patients with type 2 diabetes mellitus after oral administration of alpha-lipoic acid. Hormones.(Athens.) 2006;5(4):251-258. View abstract.

30841            Pershadsingh, H. A. Alpha-lipoic acid: physiologic mechanisms and indications for the treatment of metabolic syndrome. Expert.Opin Investig.Drugs 2007;16(3):291-302. View abstract.

30842            Zhang, W. J., Wei, H., Hagen, T., and Frei, B. Alpha-lipoic acid attenuates LPS-induced inflammatory responses by activating the phosphoinositide 3-kinase/Akt signaling pathway. Proc Natl Acad Sci U.S.A 3-6-2007;104(10):4077-4082. View abstract.

30843            Rooney, J. P. The role of thiols, dithiols, nutritional factors and interacting ligands in the toxicology of mercury. Toxicology 5-20-2007;234(3):145-156. View abstract.

30844            Tang, J., Wingerchuk, D. M., Crum, B. A., Rubin, D. I., and Demaerschalk, B. M. Alpha-lipoic acid may improve symptomatic diabetic polyneuropathy. Neurologist. 2007;13(3):164-167. View abstract.

30845            McCormick, R. K. Osteoporosis: integrating biomarkers and other diagnostic correlates into the management of bone fragility. Altern.Med Rev. 2007;12(2):113-145. View abstract.

30846            Vossler, S., Fullert, S., Schneider, F., Haak, E., Haak, T., Samigullin, R., Tritschler, H., Tooke, J. E., and Konrad, T. Pharmacodynamic effects of orally administered dexlipotam on endothelial function in type 2-diabetic patients. Int.J Clin Pharmacol.Ther 2007;45(7):385-393. View abstract.

30847            Moreira, P. I., Harris, P. L., Zhu, X., Santos, M. S., Oliveira, C. R., Smith, M. A., and Perry, G. Lipoic acid and N-acetyl cysteine decrease mitochondrial-related oxidative stress in Alzheimer disease patient fibroblasts. J Alzheimers.Dis 2007;12(2):195-206. View abstract.

30848            Zembron-Lacny, A., Szyszka, K., and Szygula, Z. Effect of cysteine derivatives administration in healthy men exposed to intense resistance exercise by evaluation of pro-antioxidant ratio. J Physiol Sci 2007;57(6):343-348. View abstract.

30849            Janson, M. Orthomolecular medicine: the therapeutic use of dietary supplements for anti-aging. Clin Interv.Aging 2006;1(3):261-265. View abstract.

30850            Mignini, F., Streccioni, V., Tomassoni, D., Traini, E., and Amenta, F. Comparative crossover, randomized, open-label bioequivalence study on the bioequivalence of two formulations of thioctic acid in healthy volunteers. Clin Exp.Hypertens. 2007;29(8):575-586. View abstract.

30851            Xiang, G. D., Sun, H. L., Zhao, L. S., Hou, J., Yue, L., and Xu, L. The antioxidant alpha-lipoic acid improves endothelial dysfunction induced by acute hyperglycaemia during OGTT in impaired glucose tolerance. Clin Endocrinol.(Oxf) 2008;68(5):716-723. View abstract.

30852            Huang, E. A. and Gitelman, S. E. The effect of oral alpha-lipoic acid on oxidative stress in adolescents with type 1 diabetes mellitus. Pediatr.Diabetes 2008;9(3 Pt 2):69-73. View abstract.

30853            Mantovani, G., Maccio, A., Madeddu, C., Gramignano, G., Serpe, R., Massa, E., Dessi, M., Tanca, F. M., Sanna, E., Deiana, L., Panzone, F., Contu, P., and Floris, C. Randomized phase III clinical trial of five different arms of treatment for patients with cancer cachexia: interim results. Nutrition 2008;24(4):305-313. View abstract.

30854            Kim, E., Park, D. W., Choi, S. H., Kim, J. J., and Cho, H. S. A preliminary investigation of alpha-lipoic acid treatment of antipsychotic drug-induced weight gain in patients with schizophrenia. J Clin Psychopharmacol. 2008;28(2):138-146. View abstract.

30855            Al’-Zamil’, M. K. and Brezheva, E. V. [Implication of alpha-lipoic acid preparations in the treatment of diabetic neuropathy]. Zh.Nevrol.Psikhiatr.Im S.S.Korsakova 2008;108(2):27-30. View abstract.

30856            Ghibu, S., Richard, C., Delemasure, S., Vergely, C., Mogosan, C., and Muresan, A. [An endogenous dithiol with antioxidant properties: alpha-lipoic acid, potential uses in cardiovascular diseases]. Ann Cardiol.Angeiol.(Paris) 2008;57(3):161-165. View abstract.

30857            Wray, D. W., Uberoi, A., Lawrenson, L., Bailey, D. M., and Richardson, R. S. Oral antioxidants and cardiovascular health in the exercise-trained and untrained elderly: a radically different outcome. Clin Sci (Lond) 2009;116(5):433-441. View abstract.

30858              Kolesnichenko, L. S., Kulinskii, V. I., Shprakh, V. V., Bardymov, V. V.,

Verlan, N. V., Gubina, L. P., Pensionerova, G. A., Sergeeva, M. P., Stanevich, L. M., and Filippova, G. T. [The blood glutathione system in cerebral vascular diseases and its treatment with alpha-lipoic acid]. Zh.Nevrol.Psikhiatr.Im S.S.Korsakova 2008;108(9):36-40. View abstract.

30859            Hatzitolios, A., Iliadis, F., Katsiki, N., and Baltatzi, M. Is the anti-hypertensive effect of dietary supplements via aldehydes reduction evidence based? A systematic review. Clin Exp.Hypertens. 2008;30(7):628-639. View abstract.

30860            Bangma, H. R., Smit, G. P., Kuks, J. B., Grevink, R. G., and Wolffenbuttel, B. H. [Two patients with mitochondrial respiratory chain disease]. Ned.Tijdschr.Geneeskd. 10-18-2008;152(42):2298-2301. View abstract.

30861            Singh, U. and Jialal, I. Alpha-lipoic acid supplementation and diabetes. Nutr Rev. 2008;66(11):646-657. View abstract.

30862            Spisakova, M., Cizek, Z., and Melkova, Z. Ethacrynic and alpha-lipoic acids inhibit vaccinia virus late gene expression. Antiviral Res 2009;81(2):156-165. View abstract.

30863            Bartlett, H. E. and Eperjesi, F. Nutritional supplementation for type 2 diabetes: a systematic review. Ophthalmic Physiol Opt. 2008;28(6):503-523. View abstract.

30864            Zembron-Lacny, A., Slowinska-Lisowska, M., Szygula, Z., Witkowski, K., and Szyszka, K. The comparison of antioxidant and hematological properties of N-acetylcysteine and alpha-lipoic acid in physically active males. Physiol Res 2009;58(6):855-861. View abstract.

30865            Statsenko, M. E., Poletaeva, L. V., Turkina, S. V., Apukhtin, A. F., and Dudchenko, G. P. [Mildronate effects on oxidant stress in type 2 diabetic patients with diabetic peripheral (sensomotor) neuropathy]. Ter.Arkh. 2008;80(10):27-30. View abstract.

30866            Martins, V. D., Manfredini, V., Peralba, M. C., and Benfato, M. S. Alpha-lipoic acid modifies oxidative stress parameters in sickle cell trait subjects and sickle cell patients. Clin Nutr 2009;28(2):192-197. View abstract.

30867            Ruktanonchai, U., Bejrapha, P., Sakulkhu, U., Opanasopit, P., Bunyapraphatsara, N., Junyaprasert, V., and Puttipipatkhachorn, S. Physicochemical characteristics, cytotoxicity, and antioxidant activity of three lipid nanoparticulate formulations of alpha-lipoic acid. AAPS PharmSciTech 2009;10(1):227-234. View abstract.

30868            Sun-Edelstein, C. and Mauskop, A. Foods and supplements in the management of migraine headaches. Clin J Pain 2009;25(5):446-452. View abstract.

30869            Zembron-Lacny, A., Slowinska-Lisowska, M., Szygula, Z., Witkowski, K., Stefaniak, T., and Dziubek, W. Assessment of the antioxidant effectiveness of alpha-lipoic acid in healthy men exposed to muscle-damaging exercise. J Physiol Pharmacol. 2009;60(2):139-143. View abstract.

30870            Piechota, A. and Goraca, A. [The comparison of alpha-lipoic acid, melatonin, vitamin C and trolox effectiveness in decreasing DNA stand brakes and increasing plasma antioxidant power]. Pol.Merkur Lekarski. 2009;27(157):19-21. View abstract.

30871            Harris, R. A., Nishiyama, S. K., Wray, D. W., Tedjasaputra, V., Bailey, D. M., and Richardson, R. S. The effect of oral antioxidants on brachial artery flow-mediated dilation following 5 and 10 min of ischemia. Eur J Appl.Physiol 2009;107(4):445-453. View abstract.

30872            Rivinius, C. Burning mouth syndrome: Identification, diagnosis, and treatment. J Am Acad.Nurse Pract. 2009;21(8):423-429. View abstract.

30873            Rutkove, S. B. A 52-year-old woman with disabling peripheral neuropathy: review of diabetic polyneuropathy. JAMA 10-7-2009;302(13):1451-1458. View abstract.

30874            Wray, D. W., Nishiyama, S. K., Monnet, A., Wary, C., Duteil, S. S., Carlier, P. G., and Richardson, R. S. Antioxidants and aging: NMR-based evidence of improved skeletal muscle perfusion and energetics. Am J Physiol Heart Circ.Physiol 2009;297(5):H1870-H1875. View abstract.

30875            Gianturco, V., Bellomo, A., D’Ottavio, E., Formosa, V., Iori, A., Mancinella, M., Troisi, G., and Marigliano, V. Impact of therapy with alpha-lipoic acid (ALA) on the oxidative stress in the controlled NIDDM: a possible preventive way against the organ dysfunction? Arch.Gerontol.Geriatr. 2009;49 Suppl 1:129-133. View abstract.

30876            Lee, S. H., Kim, M. J., Kim, B. J., Kim, S. R., Chun, S., Ryu, J. S., Kim, G. S., Lee, M. C., Koh, J. M., and Chung, S. J. Homocysteine-lowering therapy or antioxidant therapy for bone loss in Parkinson’s disease. Mov Disord. 2-15-2010;25(3):332-340. View abstract.

30877            Donato, A. J., Uberoi, A., Bailey, D. M., Wray, D. W., and Richardson, R. S. Exercise-induced brachial artery vasodilation: effects of antioxidants and exercise training in elderly men. Am J Physiol Heart Circ.Physiol 2010;298(2):H671-H678. View abstract.

30878            Mittermayer, F., Pleiner, J., Francesconi, M., and Wolzt, M. Treatment with alpha-lipoic acid reduces asymmetric dimethylarginine in patients with type 2 diabetes mellitus. Transl.Res 2010;155(1):6-9. View abstract.

30879            Zembron-Lacny, A., Ostapiuk, J., and Szyszka, K. Effects of sulphur-containing compounds on plasma redox status in muscle-damaging exercise. Chin J Physiol 10-31-2009;52(5):289-294. View abstract.

30880            Berkson, B. M., Rubin, D. M., and Berkson, A. J. Revisiting the ALA/N (alpha-lipoic acid/low-dose naltrexone) protocol for people with metastatic and nonmetastatic pancreatic cancer: a report of 3 new cases. Integr Cancer Ther 2009;8(4):416-422. View abstract.

30881            Heinisch, B. B., Francesconi, M., Mittermayer, F., Schaller, G., Gouya, G., Wolzt, M., and Pleiner, J. Alpha-lipoic acid improves vascular endothelial function in patients with type 2 diabetes: a placebo-controlled randomized trial. Eur J Clin Invest 2010;40(2):148-154. View abstract.

30882            Fedin, A. I., Kuznetsov, M. R., Beresten’, N. F., Kuznetsova, V. F., Kholopova, E. A., Ibragimov, T. M., Tugdumov, B. V., and Dubrovin, E. E. [Correction of disordered cerebral blood flow autoregulation in atherosclerosis]. Angiol.Sosud.Khir. 2009;15(3):21-26. View abstract.

30883            Yadav, V., Marracci, G. H., Munar, M. Y., Cherala, G., Stuber, L. E., Alvarez, L., Shinto, L., Koop, D. R., and Bourdette, D. N. Pharmacokinetic study of lipoic acid in multiple sclerosis: comparing mice and human pharmacokinetic parameters. Mult.Scler. 2010;16(4):387-397. View abstract.

30884            Xiang GD, Pu JH, Snu HL, and Zhao LS. Alpha-lipoic acid improves endothelial dysfunction in patients with subclinical hypothyroidism. Exp.Clin Endocrinol.Diabetes 2010;118(9):625-629. View abstract.

30885            Skalska, S., Kucera, P., Goldenberg, Z., Stefek, M., Kyselova, Z., Jariabka, P., Gajdosikova, A., Klobucnikova, K., Traubner, P., and Stolc, S. Neuropathy in a rat model of mild diabetes induced by multiple low doses of streptozotocin: effects of the antioxidant stobadine in comparison with a high-dose alpha-lipoic acid treatment. Gen.Physiol Biophys 2010;29(1):50-58. View abstract.

30886            Mijnhout, G. S., Alkhalaf, A., Kleefstra, N., and Bilo, H. J. Alpha lipoic acid: a new treatment for neuropathic pain in patients with diabetes? Neth.J Med 2010;68(4):158-162. View abstract.

30887            Cagini, C., Leontiadis, A., Ricci, M. A., Bartolini, A., Dragoni, A., and Pellegrino, R. M. Study of alpha-lipoic acid penetration in the human aqueous after topical administration. Clin Experiment.Ophthalmol. 2010;38(6):572-576. View abstract.

30888            Najm, W. and Lie, D. Herbals used for diabetes, obesity, and metabolic syndrome. Prim.Care 2010;37(2):237-254. View abstract.

30889            Palacka, P., Kucharska, J., Murin, J., Dostalova, K., Okkelova, A., Cizova, M., Waczulikova, I., Moricova, S., and Gvozdjakova, A. Complementary therapy in diabetic patients with chronic complications: a pilot study. Bratisl.Lek.Listy 2010;111(4):205-211. View abstract.

30890            Deslauriers, J., Lefrancois, M., Larouche, A., Sarret, P., and Grignon, S. Antipsychotic-induced DRD2 upregulation and its prevention by alpha-lipoic acid in SH-SY5Y neuroblastoma cells. Synapse 2011;65(4):321-331. View abstract.

30891            Navarese, E. P., Mollo, R., and Buffon, A. Effect of alpha lipoic acid on cardiac autonomic dysfunction and platelet reactivity in type 1 diabetes: rationale and design of the AUTOnomic function and platelet REACTivity trial (AUTO-REACT protocol). Diabetes Res Clin Pract. 2011;92(3):375-379. View abstract.

30892            Salinthone, S., Yadav, V., Schillace, R. V., Bourdette, D. N., and Carr, D. W. Lipoic acid attenuates inflammation via cAMP and protein kinase A signaling. PLoS.One. 2010;5(9) View abstract.

30893            Guais, A., Baronzio, G., Sanders, E., Campion, F., Mainini, C., Fiorentini, G., Montagnani, F., Behzadi, M., Schwartz, L., and Abolhassani, M. Adding a combination of hydroxycitrate and lipoic acid (METABLOC) to chemotherapy improves effectiveness against tumor development: experimental results and case report. Invest New Drugs 2012;30(1):200-211. View abstract.

30894            Milazzo, L., Menzaghi, B., Caramma, I., Nasi, M., Sangaletti, O., Cesari, M., Zanone, Poma B., Cossarizza, A., Antinori, S., and Galli, M. Effect of antioxidants on mitochondrial function in HIV-1-related lipoatrophy: a pilot study. AIDS Res.Hum.Retroviruses 2010;26(11):1207-1214. View abstract.

30895            Ramos, L. F., Kane, J., McMonagle, E., Le, P., Wu, P., Shintani, A., Ikizler, T. A., and Himmelfarb, J. Effects of combination tocopherols and alpha lipoic acid therapy on oxidative stress and inflammatory biomarkers in chronic kidney disease. J Ren Nutr 2011;21(3):211-218. View abstract.

30896            Xiang, G., Pu, J., Yue, L., Hou, J., and Sun, H. alpha-lipoic acid can improve endothelial dysfunction in subjects with impaired fasting glucose. Metabolism 2011;60(4):480-485. View abstract.

30897            Becker, S., Schmidt, C., Berghaus, A., Tschiesner, U., Olzowy, B., and Reichel, O. Does laryngopharyngeal reflux cause intraoral burning sensations? A preliminary study. Eur Arch.Otorhinolaryngol. 2011;268(9):1375-1381. View abstract.

30898            Flora, S. J. Arsenic-induced oxidative stress and its reversibility. Free Radic.Biol.Med 7-15-2011;51(2):257-281. View abstract.

30899            Ridruejo, E., Castiglioni, T., and Silva, M. O. Thioctic acid-induced acute cholestatic hepatitis. Ann Pharmacother. 2011;45(7-8):e43. View abstract.

30900            Mikami, Y., Shibuya, N., Kimura, Y., Nagahara, N., Ogasawara, Y., and Kimura, H. Thioredoxin and dihydrolipoic acid are required for 3-mercaptopyruvate sulfurtransferase to produce hydrogen sulfide. Biochem J 11-1-2011;439(3):479-485. View abstract.

30901            Xiao, C., Giacca, A., and Lewis, G. F. Short-term oral alpha-lipoic acid does not prevent lipid-induced dysregulation of glucose homeostasis in obese and overweight nondiabetic men. Am J Physiol Endocrinol.Metab 2011;301(4):E736-E741. View abstract.

30902            Lopez-Erauskin, J., Fourcade, S., Galino, J., Ruiz, M., Schluter, A., Naudi, A., Jove, M., Portero-Otin, M., Pamplona, R., Ferrer, I., and Pujol, A. Antioxidants halt axonal degeneration in a mouse model of X-adrenoleukodystrophy. Ann Neurol. 2011;70(1):84-92. View abstract.

30903            Takasaki, J., Ono, K., Yoshiike, Y., Hirohata, M., Ikeda, T., Morinaga, A., Takashima, A., and Yamada, M. Vitamin A has anti-oligomerization effects on amyloid-beta in vitro. J Alzheimers.Dis 2011;27(2):271-280. View abstract.

30904            Zhao, F. and Liu, Z. Q. Comparison of antioxidant effectiveness of lipoic acid and dihydrolipoic acid. J Biochem Mol.Toxicol. 2011;25(4):216-223. View abstract.

30905            Bresciani, E., Bussi, A., Bazzigaluppi, E., and Balestrieri, G. Insulin autoimmune syndrome induced by alpha-lipoic acid in a Caucasian woman: case report. Diabetes Care 2011;34(9):e146. View abstract.

30906            Greenway, F. L., Ingram, D. K., Ravussin, E., Hausmann, M., Smith, S. R., Cox, L., Tomayko, K., and Treadwell, B. V. Loss of taste responds to high-dose biotin treatment. J Am Coll.Nutr 2011;30(3):178-181. View abstract.

30907            Nebbioso, M., Federici, M., Rusciano, D., Evangelista, M., and Pescosolido, N. Oxidative stress in preretinopathic diabetes subjects and antioxidants. Diabetes Technol.Ther 2012;14(3):257-263. View abstract.

30908            Madeddu, C., Dessi, M., Panzone, F., Serpe, R., Antoni, G., Cau, M. C., Montaldo, L., Mela, Q., Mura, M., Astara, G., Tanca, F. M., Maccio, A., and Mantovani, G. Randomized phase III clinical trial of a combined treatment with carnitine + celecoxib +/- megestrol acetate for patients with cancer-related anorexia/cachexia syndrome. Clin Nutr 2012;31(2):176-182. View abstract.

30909            de, Moraes M., do Amaral Bezerra, B. A., da Rocha Neto, P. C., de Oliveira Soares, A. C., Pinto, L. P., and de Lisboa Lopes, Costa A. Randomized trials for the treatment of burning mouth syndrome: an evidence-based review of the literature. J Oral Pathol.Med. 2012;41(4):281-287. View abstract.

30910            McNeilly, A. M., Davison, G. W., Murphy, M. H., Nadeem, N., Trinick, T., Duly, E., Novials, A., and McEneny, J. Effect of alpha-lipoic acid and exercise training on cardiovascular disease risk in obesity with impaired glucose tolerance. Lipids Health Dis 2011;10:217. View abstract.

30911            Mayr, J. A., Zimmermann, F. A., Fauth, C., Bergheim, C., Meierhofer, D., Radmayr, D., Zschocke, J., Koch, J., and Sperl, W. Lipoic acid synthetase deficiency causes neonatal-onset epilepsy, defective mitochondrial energy metabolism, and glycine elevation. Am J Hum.Genet. 12-9-2011;89(6):792-797. View abstract.

30912            Mollo, R., Zaccardi, F., Scalone, G., Scavone, G., Rizzo, P., Navarese, E. P., Manto, A., Pitocco, D., Lanza, G. A., Ghirlanda, G., and Crea, F. Effect of alpha-lipoic acid on platelet reactivity in type 1 diabetic patients. Diabetes Care 2012;35(2):196-197. View abstract.

30913            Rosa, F. T., Zulet, M. A., Marchini, J. S., and Martinez, J. A. Bioactive compounds with effects on inflammation markers in humans. Int J Food Sci Nutr 2012;63(6):749-765. View abstract.

30914            Wray, D. W., Nishiyama, S. K., Harris, R. A., Zhao, J., McDaniel, J., Fjeldstad, A. S., Witman, M. A., Ives, S. J., Barrett-O’Keefe, Z., and Richardson, R. S. Acute reversal of endothelial dysfunction in the elderly after antioxidant consumption. Hypertension 2012;59(4):818-824. View abstract.

30915            Pfeffer, G., Majamaa, K., Turnbull, D. M., Thorburn, D., and Chinnery, P. F. Treatment for mitochondrial disorders. Cochrane Database.Syst.Rev. 2012;4:CD004426. View abstract.

30916            Tsai, F. J., Wang, Y. D., Chen, C. C., Hsieh, C., Cheng, Z. J., and Wu, Y. J. Evaluation of the antioxidative capability of commonly used antioxidants in dermocosmetics by in vivo detection of protein carbonylation in human stratum corneum. J Photochem.Photobiol.B 7-2-2012;112:7-15. View abstract.

30917            Chaparro, L. E., Wiffen, P. J., Moore, R. A., and Gilron, I. Combination pharmacotherapy for the treatment of neuropathic pain in adults. Cochrane Database.Syst.Rev. 2012;7:CD008943. View abstract.

30918            Larkin, J., Bea, L., and Sharma, A. A cost effective complement to managing the vitamin D deficient and anemic dialysis patient in the bundled world. Nephrol.News Issues 2012;26(8):22-4, 26. View abstract.

30919            Scholich, H., Murphy, M. E., and Sies, H. Antioxidant activity of dihydrolipoate against microsomal lipid peroxidation and its dependence on alpha-tocopherol. Biochim.Biophys Acta 2-20-1989;1001(3):256-261. View abstract.

30920            Gal, E. M. Reversal of selective toxicity of (-)-alpha-lipoic acid by thiamine in thiamine-deficient rats. Nature 7-31-1965;207(996):535. View abstract.

30921            Ou, P., Tritschler, H. J., and Wolff, S. P. Thioctic (lipoic) acid: a therapeutic metal-chelating antioxidant? Biochem.Pharmacol. 6-29-1995;50(1):123-126. View abstract.

30922            Constantinescu, A., Pick, U., Handelman, G. J., Haramaki, N., Han, D., Podda, M., Tritschler, H. J., and Packer, L. Reduction and transport of lipoic acid by human erythrocytes. Biochem.Pharmacol. 7-17-1995;50(2):253-261. View abstract.

30923            Maitra, I., Serbinova, E., Trischler, H., and Packer, L. Alpha-lipoic acid prevents buthionine sulfoximine-induced cataract formation in newborn rats. Free Radic.Biol.Med 1995;18(4):823-829. View abstract.

30924            Muller, U. and Krieglstein, J. Prolonged pretreatment with alpha-lipoic acid protects cultured neurons against hypoxic, glutamate-, or iron-induced injury. J Cereb.Blood Flow Metab 1995;15(4):624-630. View abstract.

30925            Han, D., Tritschler, H. J., and Packer, L. Alpha-lipoic acid increases intracellular glutathione in a human T-lymphocyte Jurkat cell line. Biochem Biophys Res Commun. 2-6-1995;207(1):258-264. View abstract.

30926            Podda, M., Tritschler, H. J., Ulrich, H., and Packer, L. Alpha-lipoic acid supplementation prevents symptoms of vitamin E deficiency. Biochem.Biophys.Res.Commun. 10-14-1994;204(1):98-104. View abstract.

30927            Constantinescu, A., Tritschler, H., and Packer, L. Alpha-lipoic acid protects against hemolysis of human erythrocytes induced by peroxyl radicals. Biochem.Mol.Biol.Int. 1994;33(4):669-679. View abstract.

30928            Kawabata, T. and Packer, L. Alpha-lipoate can protect against glycation of serum albumin, but not low density lipoprotein. Biochem.Biophys.Res.Commun. 8-30-1994;203(1):99-104. View abstract.

30929            Handelman, G. J., Han, D., Tritschler, H., and Packer, L. Alpha-lipoic acid reduction by mammalian cells to the dithiol form, and release into the culture medium. Biochem Pharmacol 5-18-1994;47(10):1725-1730. View abstract.

30930            Kahler, W., Kuklinski, B., Ruhlmann, C., and Plotz, C. [Diabetes mellitus--a free radical-associated disease. Results of adjuvant antioxidant supplementation]. Z Gesamte Inn.Med 1993;48(5):223-232. View abstract.

30931            Jacob, S., Streeper, R. S., Fogt, D. L., Hokama, J. Y., Tritschler, H. J., Dietze, G. J., and Henriksen, E. J. The antioxidant alpha-lipoic acid enhances insulin-stimulated glucose metabolism in insulin-resistant rat skeletal muscle. Diabetes 1996;45(8):1024-1029. View abstract.

30932            Gleiter, C. H., Schug, B. S., Hermann, R., Elze, M., Blume, H. H., and Gundert-Remy, U. Influence of food intake on the bioavailability of thioctic acid enantiomers. Eur.J Clin Pharmacol. 1996;50(6):513-514. View abstract.

30933            Estrada, D. E., Ewart, H. S., Tsakiridis, T., Volchuk, A., Ramlal, T., Tritschler, H., and Klip, A. Stimulation of glucose uptake by the natural coenzyme alpha-lipoic acid/thioctic acid: participation of elements of the insulin signaling pathway. Diabetes 1996;45(12):1798-1804. View abstract.

30934            Henriksen, E. J., Jacob, S., Streeper, R. S., Fogt, D. L., Hokama, J. Y., and Tritschler, H. J. Stimulation by alpha-lipoic acid of glucose transport activity in skeletal muscle of lean and obese Zucker rats. Life Sci 1997;61(8):805-812. View abstract.

30935            Bierhaus, A., Chevion, S., Chevion, M., Hofmann, M., Quehenberger, P., Illmer, T., Luther, T., Berentshtein, E., Tritschler, H., Muller, M., Wahl, P., Ziegler, R., and Nawroth, P. P. Advanced glycation end product-induced activation of NF-kappaB is suppressed by alpha-lipoic acid in cultured endothelial cells. Diabetes 1997;46(9):1481-1490. View abstract.

30936            Han, D., Sen, C. K., Roy, S., Kobayashi, M. S., Tritschler, H. J., and Packer, L. Protection against glutamate-induced cytotoxicity in C6 glial cells by thiol antioxidants. Am J Physiol 1997;273(5 Pt 2):R1771-R1778. View abstract.

30937            Eremeeva, M. E. and Silverman, D. J. Effects of the antioxidant alpha-lipoic acid on human umbilical vein endothelial cells infected with Rickettsia rickettsii. Infect.Immun. 1998;66(5):2290-2299. View abstract.

30938            Packer, L. Alpha-lipoic acid: a metabolic antioxidant which regulates NF-kappa B signal transduction and protects against oxidative injury. Drug Metab Rev. 1998;30(2):245-275. View abstract.

30939            Khanna, S., Atalay, M., Lodge, J. K., Laaksonen, D. E., Roy, S., Hanninen, O., Packer, L., and Sen, C. K. Skeletal muscle and liver lipoyllysine content in response to exercise, training and dietary alpha-lipoic acid supplementation. Biochem.Mol.Biol.Int. 1998;46(2):297-306. View abstract.

30940            Obrosova, I., Cao, X., Greene, D. A., and Stevens, M. J. Diabetes-induced changes in lens antioxidant status, glucose utilization and energy metabolism: effect of DL-alpha-lipoic acid. Diabetologia 1998;41(12):1442-1450. View abstract.

30941            Rett K, Wicklmayr M, Ruus P, and et al. Lipoic acid acutely ameliorates insulin sensitivity in obese subjects with type 2 diabetes. Diabetes Und Stoffwechsel 1996;5(3 suppl):59-63.

30942            Nichols TW Jr. Alpha-lipoic acid: biological effects and clinical implications. Alt Med Rev 1997;2(3):177-183.

30943            Rosenberg HR, Culik R. Effect of á-lipoic acid on vitamin C and vitamin E deficiencies. Arch Biochem Biophys 1959;80(1):86-93.

30944            Reichel G, Doberenz M, Both R, and et al. Function of cardiac nerves in diabetics during alpha-lipoic-acid-therapy. J Neurol Sci 1997;150(5):S209.

30945            Lukaszuk, J. Schultz T. Prawitz A. and Hofmann E. R-Alpha Lipoic Acid Effect on HbA1c in Type-2 Diabetics. Journal of Complementary and Integrative Medicine 2009;6(1):1-14.

30946            Mazloom, Z. and Ansar H. The Effect of Alpha-Lipoic Acid on Blood Pressure in Type 2 Diabetics. Iranian Journal of Endocrinology and Metabolism 2009;11(3):245-250.

30947            Kieburtz K, Schifitto G, McDermott M, and et al. A randomized, double-blind, placebo-controlled trial of deprenyl and thioctic acid in human immunodeficiency virus-associated cognitive impairment. Neurology 1998;50(3):645-651.

30948            Schimmelpfennig W, Renger F, Wack R, and et al. [Results of a prospective double-blind study with alpha-lipoic acid against placebo in alcoholic liver damage] (Ergebnisse einer prospektiven Doppelblindstudie mit Alpha-Liponsäure gegen Plazebo bei alkoholischen Leberschäden). Dtsch Gesundheitswes 1983;38(18):690-693.

30949            Rosak C, Ziegler D, Mehnert H, and et al. Local tolerability of intravenously administered alpha-lipoic acid. Munch Med Wochenschr 1994;136(10):36-40.

30950            Evans, JL and Goldfine, ID. Alpha-lipoic acid: a multifunctional antioxidant that improves insulin sensitivity in patients with type 2 diabetes. Diabetes Technology and Therapeutics 2000;2(3):401-413.

30951            Gleiter CH, Hermann R, Wildgrube HJ, and et al. Does impaired gastric emptying in diabetic patients alter the bioavailability of alpha-lipoic acid enantiomers? Therapie 1995;50(suppl):no 403.

30952            Zhao YY. Combined therapeutic effects of -lipoic acid and mecobalamin on diabetic peripheral neuropathy. Journal of Practical Training of Medicine 2008;24:4289-4290.

30953            Zou JJ, Zheng JY Zhao Y Tang W Shi YQ & Liu ZM. Effects and safety of combined therapy of -lipoic acid, mecobalamin and prostaglandin E1 for diabetic peripheral neuropathy. Shanghai Medical Journal 2008;31:364-365.

30954            Huang H, Zhu KS Wang P Qu JC Ji XF & Song M. The effects of lipoic acid and prostaglandin E1 on diabetic peripheral neuropathy. Chinese Journal of Clinical Health 2008;11:29-30.

30955            Zhang XL, Feng YL Zhou BA & Wei GY. Effects of mecobalamin and -lipoic acid on diabetic peripheral neuropathy. Journal of Traditional Chinese Medicine. 2009;24:1104-1105.

30956            Suo LN & Zhang D. Effects of lipoic acid and mecobalamin on diabetic peripheral neuropathy. Journal of Traditional Chinese Medicine. 2009;24:1104-1105.

30957            Li J, Xu QL. Effects of shuxuening and -lipoic acid on diabetic peripheral neuropathy. Journal of Modern Drug Application. 2008;2:49-50.

30958            Wang J, Song W Huang J & Qu YC. Effects of prostaglandin E1 and -lipoic acid on diabetic peripheral neuropathy. Journal of Practical Training of Medicine 2007;23:1325-1326.

30959            Wu YX, Shi F & Ling L. Effects of lipoic acid and prostaglandin E1on diabetic peripheral neuropathy. Journal of Sun Yat-sen University. 2008;29(S3):124-126.

30960            Fu Y. Effects of alpha lipoic acid and mecobalamin on diabetic peripheral neuropathy. Chinese Journal of Practical Internal Medicine. 2008;28:81-83.

30961            Xia W, Zhang L & Wen SL. Effects of alpha-lipoic acid on painful neuropathy of type 2 diabetes. Journal of Henan University. 2008;27:53-54.

30962            Chen LY, Zhang YD & Zhu FY. Effects of alpha lipoic acid and prostaglandin E1 on diabetic peripheral neuropathy. Journal of Practical Diabetology 2008;4:50-51.

30963            Lu YH. Observation of -lipoic acid and ligutrazine curing diabetic peripheral neuropathy. Medical Recapitulate 2009;2:62.

30964            Qiao YC. Effects of lipoic acid on diabetic peripheral neuropathy. Chinese Journal of Clinical Rational Drug Use. 2009;2:62.

30965            Zhou L. Effects of cilostazol and -lipoic acid on diabetic peripheral neuropathy. Journal of Medicine and Health Care. 2009;17:10-11.

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63892            Usha, P. R. and Naidu, M. U. Randomised, double-blind, parallel, placebo-controlled study of oral glucosamine, methylsulfonylmethane and their combination in osteoarthritis. Clin Drug Invest 2004;24:353-363.

63893            Kim, L. S., Axelrod, L. J., Howard, P., Buratovich, N., and Waters, R. F. Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial. Osteoarthritis Cartilage 2006;14(3):286-294.

 

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3504               Klandorf H, et al. Dimethyl sulfoxide modulation of diabetes onset in NOD mice. Diabetes 1998;62:194-7.

8574               Barrager E, Veltmann JR Jr, Schauss AG, Schiller RN. A multicentered, open-label trial on the safety and efficacy of methylsulfonylmethane in the treatment of seasonal allergic rhinitis. J Altern Complement Med 2002;8:167-73. View abstract.

8575               Jacob S, Lawrence RM, Zucker M. The Miracle of MSM: The Natural Solution for Pain. New York: Penguin-Putnam, 1999.

8576               Murav’ev IuV, Venikova MS, Pleskovskaia GN, et al. Effect of dimethyl sulfoxide and dimethyl sulfone on a destructive process in the joints of mice with spontaneous arthritis. Patol Fiziol Eksp Ter 1991;37-9. View abstract.

8577               Allen LV. Methyl sulfonylmethane for snoring. US Pharm 2000;92-4.

10625            Hucker HB, Ahmad PM, Miller EA, et al. Metabolism of dimethyl sulphoxide to dimethyl sulphone in the rat and man. Nature 1966;209:619-20.

12000            Gaby AR. Methylsulfonylmethane as a treatment for seasonal allergic rhinitis: more data needed on pollen counts and questionnaire. J Altern Complement Med 2002;8:229.

12351            Lin A, Nguy CH, Shic F, Ross BD. Accumulation of methylsulfonylmethane in the human brain: identification by multinuclear magnetic resonance spectroscopy. Toxicol Lett 2001;123:169-77. View abstract.

12469            Usha PR, Naidu MUR. Randomised, double-blind, parallel, placebo-controlled study of oral glucosamine, methylsulfonylmethane and their combinations. Clin Drug Invest 2004;24:353-63.

14335            Kim LS, Axelrod LJ, Howard P, et al. Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial. Osteoarthritis Cartilage 2006;14:286-94. View abstract.

17127            Brien S, Prescott P, Lewith G. Meta-analysis of the related nutritional supplements dimethyl sulfoxide and methylsulfonylmethane in the treatment of osteoarthritis of the knee. Evid Based Complement Alternat Med 2009 May 27. [Epub ahead of print]. View abstract.

19312            Debbi EM, Agar G, Fichman G, et al. Efficacy of methylsulfonylmethane supplementation on osteoarthritis of the knee: a randomized controlled study. BMC Complement Altern Med. 2011 Jun 27;11:50. View abstract.

19313            Notarnicola A, Tafuri S, Fusaro L, et al. The “MESACA” study: methylsulfonylmethane and boswellic acids in the treatment of gonarthrosis. Adv Ther. 2011 Oct;28:894-906. View abstract.

19314            Xie Q, Shi R, Xu G, et al. Effects of AR7 Joint Complex on arthralgia for patients with osteoarthritis: results of a three-month study in Shanghai, China. Nutr J. 2008 Oct 27;7:31. View abstract.

19315            Tripathi R, Gupta S, Rai S, et al. Effect of topical application of methylsulfonylmethane (MSM), EDTA on pitting edema and oxidative stress in a double blind, placebo-controlled study. Cell Mol Biol (Noisy-le-grand). 2011 Feb 12;57:62-9. View abstract.

19316            Kalman DS, Feldman S, Scheinberg AR, et al. Influence of methylsulfonylmethane on markers of exercise recovery and performance in healthy men: a pilot study. J Int Soc Sports Nutr. 2012 Sep 27;9:46. View abstract.

19317            Gulick DT, Agarwal M, Josephs J, et al. Effects of MagPro on muscle performance. J Strength Cond Res. 2012 Sep;26:2478-83. View abstract.

19318            Joksimovic N, Spasovski G, Joksimovic V, et al. Efficacy and tolerability of hyaluronic acid, tea tree oil and methyl-sulfonyl-methane in a new gel medical device for treatment of haemorrhoids in a double-blind, placebo-controlled clinical trial. Updates Surg 2012;64:195-201. View abstract.

19319            Berardesca E, Cameli N, Cavallotti C, et al. Combined effects of silymarin and methylsulfonylmethane in the management of rosacea: clinical and instrumental evaluation. J Cosmet Dermatol. 2008 Mar;7:8-14. View abstract.

19320            Barmaki S, Bohlooli S, Khoshkhahesh F, et al. Effect of methylsulfonylmethane supplementation on exercise – Induced muscle damage and total antioxidant capacity. J Sports Med Phys Fitness. 2012 Apr;52:170-4. View abstract.

19321            Notarnicola A, Pesce V, Vicenti G, et al. SWAAT study: extracorporeal shock wave therapy and arginine supplementation and other nutraceuticals for insertional Achilles tendinopathy. Adv Ther. 2012 Sep;29:799-814. View abstract.

19322            Gumina S, Passaretti D, Gurzì MD, et al. Arginine L-alpha-ketoglutarate, methylsulfonylmethane, hydrolyzed type I collagen and bromelain in rotator cuff tear repair: a prospective randomized study. Curr Med Res Opin. 2012 Nov;28:1767-74. View abstract.

19323            Nakhostin-Roohi B, Barmaki S, Khoshkhahesh F, et al. Effect of chronic supplementation with methylsulfonylmethane on oxidative stress following acute exercise in untrained healthy men. J Pharm Pharmacol. 2011 Oct;63:1290-4. View abstract.

19324            Moazzami AA, Zhang JX, Kamal-Eldin A, et al. Nuclear magnetic resonance-based metabolomics enable detection of the effects of a whole grain rye and rye bran diet on the metabolic profile of plasma in prostate cancer patients. J Nutr. 2011 Dec;141:2126-32. View abstract.

47132            Ameye, L. G. and Chee, W. S. Osteoarthritis and nutrition. From nutraceuticals to functional foods: a systematic review of the scientific evidence. Arthritis Res Ther 2006;8(4):R127. View abstract.

47845            Brien, S., Prescott, P., Bashir, N., Lewith, H., and Lewith, G. Systematic review of the nutritional supplements dimethyl sulfoxide (DMSO) and methylsulfonylmethane (MSM) in the treatment of osteoarthritis. Osteoarthritis.Cartilage. 2008;16(11):1277-1288. View abstract.

47901            Layman, D. L. and Jacob, S. W. The absorption, metabolism and excretion of dimethyl sulfoxide by rhesus monkeys. Life Sci 12-23-1985;37(25):2431-2437. View abstract.

63886            Gaby, A. R. Methylsulfonylmethane as a treatment for seasonal allergic rhinitis: more data needed on pollen counts and questionnaire. J.Altern.Complement Med. 2002;8(3):229. View abstract.

63887            Horvath, K., Noker, P. E., Somfai-Relle, S., Glavits, R., Financsek, I., and Schauss, A. G. Toxicity of methylsulfonylmethane in rats. Food Chem Toxicol 2002;40(10):1459-1462. View abstract.

63888            Engelke, U. F., Tangerman, A., Willemsen, M. A., Moskau, D., Loss, S., Mudd, S. H., and Wevers, R. A. Dimethyl sulfone in human cerebrospinal fluid and blood plasma confirmed by one-dimensional (1)H and two-dimensional (1)H-(13)C NMR. NMR Biomed. 2005;18(5):331-336. View abstract.

63889            Lopez, H. L. Nutritional interventions to prevent and treat osteoarthritis. Part II: focus on micronutrients and supportive nutraceuticals. PM.R. 2012;4(5 Suppl):S155-S168. View abstract.

63890            Beilke, M. A., Collins-Lech, C., and Sohnle, P. G. Effects of dimethyl sulfoxide on the oxidative function of human neutrophils. J Lab Clin Med 1987;110(1):91-96. View abstract.

63891            Hucker, H. B., Ahmad, P. M., Miller, E. A., and Brobyn, R. Metabolism of dimethyl sulphoxide to dimethyl sulphone in the rat and man. Nature 2-5-1966;209(5023):619-620. View abstract.

63892            Usha, P. R. and Naidu, M. U. Randomised, double-blind, parallel, placebo-controlled study of oral glucosamine, methylsulfonylmethane and their combination in osteoarthritis. Clin Drug Invest 2004;24:353-363.

63893            Kim, L. S., Axelrod, L. J., Howard, P., Buratovich, N., and Waters, R. F. Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial. Osteoarthritis Cartilage 2006;14(3):286-294.

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2030               Soleas GJ, Diamandis EP, Goldberg DM. Resveratrol: a molecule whose time has come? And gone? Clin Biochem 1997;30:91-113. View abstract.

2279               Truelsen T, Gronbaek M, Schnohr P, et al. Intake of beer, wine, and spirits and risk of stroke: the copenhagen city heart study. Stroke 1998;29:2467-72. View abstract.

2948               Jang M, Cai L, Udeani GO, et al. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science 1997;275:218-20. View abstract.

2949               Pace-Asciak CR, Rounova O, Hahn SE, et al. Wines and grape juices as modulators of platelet aggregation in healthy human subjects. Clin Chim Acta 1996;246:163-82. View abstract.

2950               Bertelli AA, Giovannini L, Bernini W, et al. Antiplatelet activity of cis-resveratrol. Drugs Exp Clin Res 1996;22:61-3. View abstract.

2951               Pace-Asciak CR, Hahn S, Diamandis EP, et al. The red wine phenolics trans-resveratrol and quercetin block human platelet aggregation and eicosanoid synthesis: implications for protection against coronary heart disease. Clin Chim Acta 1995;235:207-19. View abstract.

2952               Bertelli A, Bertelli AA, Gozzini A, Giovannini L. Plasma and tissue resveratrol concentrations and pharmacological activity. Drugs Exp Clin Res 1998;24:133-8. View abstract.

2954               Chen CK, Pace-Asciak CR. Vasorelaxing activity of resveratrol and quercetin in isolated rat aorta. Gen Pharmacol 1996;27:363-6. View abstract.

2956               Davy BM, Melby CL, Beske SD, et al. Oat consumption does not affect resting casual and ambulatory 24-h arterial blood pressure in men with high-normal blood pressure to stage I hypertension. J Nutr 2002;132:394-8.. View abstract.

2958               Huang C, Ma WY, Goranson A, Dong Z. Resveratrol suppresses cell transformation and induces apoptosis through a p53-dependent pathway. Carcinogenesis 1999;20:237-42. View abstract.

2959               Carbo N, Costelli P, Baccino FM, et al. Resveratrol, a natural product present in wine, decreases tumour growth in a rat tumour model. Biochem Biophys Res Commun 1999;254:739-43. View abstract.

2960               Gehm BD, McAndrews JM, Chien PY, Jameson JL. Resveratrol, a polyphenolic compound found in grapes and wine, is an agonist for the estrogen receptor. Proc Natl Acad Sci U S A 1997;94:14138-43. View abstract.

2961               Bertelli AA, Giovannini L, Giannessi D, et al. Antiplatelet activity of synthetic and natural resveratrol in red wine. Int J Tissue React 1995;17:1-3. View abstract.

6126               Holmes-McNary M, Baldwin AS, Jr. Chemopreventive properties of trans-resveratrol are associated with inhibition of activation of the IkappaB kinase. Cancer Res 2000;60:3477-83. View abstract.

7861               Schneider Y, Vincent F, Duranton B, et al. Anti-proliferative effect of resveratrol, a natural component of grapes and wine, on human colonic cancer cells. Cancer Lett 2000;158:85-91.

7862               Kozuki Y, Miura Y, Yagasaki K. Resveratrol suppresses hepatoma cell invasion independently of its anti-proliferative action.Cancer Lett 2001;167:151-6. View abstract.

7863               Laden BP, Porter TD. Resveratrol inhibits human squalene monooxygenase. Nutr Res 2001;21:747-53.

7864               Piver B, Berthou F, Dreano Y, Lucas D. Inhibition of CYP3A, CYP1A and CYP2E1 activities by resveratrol and other non volatile red wine components. Toxicol Lett 2001;125:83-91. View abstract.

7865               Bowers JL, Tyulmenkov VV, Jernigan SC, Klinge CM. Resveratrol acts as a mixed agonist/antagonist for estrogen receptors alpha and beta. Endocrinology 2000;141:3657-67.

7866               Docherty JJ, Fu MM, Stiffler BS, et al. Resveratrol inhibition of herpes simplex virus replication. Antiviral Res 1999;43:145-55. View abstract.

9174               Goldberg DM, Yan J, Soleas GJ. Absorption of three wine-related polyphenols in three different matrices by healthy subjects. Clin Biochem 2003;36:79-87.. View abstract.

12482            Takada Y, Bhardwaj A, Potdar P, Aggarwal BB. Nonsteroidal anti-inflammatory agents differ in their ability to suppress NF-kappaB activation, inhibition of expression of cyclooxygenase-2 and cyclin D1, and abrogation of tumor cell proliferation. Oncogene 2004;23:9247-58. View abstract.

12483            Hwang D, Fischer NH, Jang BC, et al. Inhibition of the expression of inducible cyclooxygenase and proinflammatory cytokines by sesquiterpene lactones in macrophages correlates with the inhibition of MAP kinases. Biochem Biophys Res Commun 1996;226:810-8.. View abstract.

12484            Murias M, Handler N, Erker T, et al. Resveratrol analogues as selective cyclooxygenase-2 inhibitors: synthesis and structure-activity relationship. Bioorg Med Chem 2004;12:5571-8. View abstract.

12626            Zhou S, Koh HL, Gao Y, et al. Herbal bioactivation: the good, the bad and the ugly. Life Sci 2004;74:935-68. View abstract.

15093            Baur JA, Pearson KJ, Price NL, et al. Resveratrol improves health and survival of mice on a high-calorie diet. Nature 2006;444:337-42. View abstract.

15094            Bujanda L, Garcia-Barcina M, Gutierrez-de Juan V, et al. Effect of resveratrol on alcohol-induced mortality and liver lesions in mice. BMC Gastroenterol 2006;6:35. View abstract.

15095            Elmali N, Baysal O, Harma A, et al. Effects of resveratrol in inflammatory arthritis. Inflammation 2007;30:1-6. View abstract.

15096            Mokni M, Limam F, Elkahoui S, et al. Strong cardioprotective effect of resveratrol, a red wine polyphenol, on isolated rat hearts after ischemia/reperfusion injury. Arch Biochem Biophys 2007;457:1-6. View abstract.

15139            Wang Z, Huang Y, Zou J, et al. Effects of red wine and wine polyphenol resveratrol on platelet aggregation in vivo and in vitro. Int J Mol Med 2002;9:77-9. View abstract.

15140            Szewczuk LM, Forti L, Stivala LA, Penning TM. Resveratrol is a peroxidase mediated inactivator of COX-1 but not COX-2: A mechanistic approach to the design of COX-1 selective agents. J Biol Chem 2004;279:22727-37. View abstract.

15141            Martin AR, Villegas I, La Casa C, de la Lastra CA. Resveratrol, a polyphenol found in grapes, suppresses oxidative damage and stimulates apoptosis during early colonic inflammation in rats. Biochem Pharmacol 2004;67:1399-410. View abstract.

15142            Li W, Seifert M, Xu Y, Hock B. Comparative study of estrogenic potencies of estradiol, tamoxifen, bisphenol-A and resveratrol with two in vitro bioassays. Environ Int 2004;30:329-35. View abstract.

15143            Ahmad KA, Clement MV, Hanif IM, Pervaiz S. Resveratrol inhibits drug-induced apoptosis in human leukemia cells by creating an intracellular milieu nonpermissive for death execution. Cancer Res 2004;64:1452-9. View abstract.

15144            Hascalik S, Celik O, Turkoz Y, et al. Resveratrol, a red wine constituent polyphenol, protects from ischemia-reperfusion damage of the ovaries. Gynecol Obstet Invest 2004;57:218-23. View abstract.

15145            Meng X, Maliakal P, Lu H, et al. Urinary and plasma levels of resveratrol and quercetin in humans, mice, and rats after ingestion of pure compounds and grape juice. J Agric Food Chem 2004;52:935-42. View abstract.

15146            Abou-Zeid LA, El-Mowafy AM. Differential recognition of resveratrol isomers by the human estrogen receptor-alpha: molecular dynamics evidence for stereoselective ligand binding. Chirality 2004;16:190-5. View abstract.

15147            Opipari AW Jr, Tan L, Boitano AE, et al. Resveratrol-induced autophagocytosis in ovarian cancer cells. Cancer Res 2004;64:696-703. View abstract.

15148            Zhang Y, Jayaprakasam B, Seeram NP, et al. Insulin secretion and cyclooxygenase enzyme inhibition by cabernet sauvignon grape skin compounds. J Agric Food Chem 2004;52:228-33. View abstract.

15149            Kim YA, Choi BT, Lee YT, et al. Resveratrol inhibits cell proliferation and induces apoptosis of human breast carcinoma MCF-7 cells. Oncol Rep 2004;11:441-6. View abstract.

15150            Ziegler CC, Rainwater L, Whelan J, McEntee MF. Dietary resveratrol does not affect intestinal tumorigenesis in Apc(Min/+) mice. J Nutr 2004;134:5-10. View abstract.

15151            Schriever C, Pendland SL, Mahady GB. Red wine, resveratrol, Chlamydia pneumoniae and the French connection. Atherosclerosis 2003;171:379-80. View abstract.

15152            Gao X, Deeb D, Media J, et al. Immunomodulatory activity of resveratrol: discrepant in vitro and in vivo immunological effects. Biochem Pharmacol 2003;66:2427-35. View abstract.

15153            Savaskan E, Olivieri G, Meier F, et al. Red wine ingredient resveratrol protects from beta-amyloid neurotoxicity. Gerontology 2003;49:380-3. View abstract.

15154            Pervaiz S. Resveratrol: from grapevines to mammalian biology. FASEB J 2003;17:1975-85. View abstract.

15155            Culpitt SV, Rogers DF, Fenwick PS, et al. Inhibition by red wine extract, resveratrol, of cytokine release by alveolar macrophages in COPD. Thorax 2003;58:942-6. View abstract.

15156            Wang Q, Li H, Wang XW, et al. Resveratrol promotes differentiation and induces Fas-independent apoptosis of human medulloblastoma cells. Neurosci Lett 2003;351:83-6. View abstract.

15157            Scarlatti F, Sala G, Somenzi G, et al. Resveratrol induces growth inhibition and apoptosis in metastatic breast cancer cells via de novo ceramide signaling. FASEB J 2003;17:2339-41. View abstract.

15164            Trincheri NF, Nicotra G, Follo C, et al. Resveratrol induces cell death in colorectal cancer cells by a novel pathway involving lysosomal cathepsin D. Carcinogenesis 2007;28:922-31. View abstract.

16053            Lyons MM, Yu C, Toma RB, et al. Resveratrol in raw and baked blueberries and bilberries. J Agric Food Chem 2003;51:5867-70. View abstract.

17099            Boocock DJ, Faust GE, Patel KR, et al. Phase I dose escalation pharmacokinetic study in healthy volunteers of resveratrol, a potential cancer chemopreventive agent. Cancer Epidemiol Biomarkers Prev 2007;16:1246-52. View abstract.

19085            Mueller SO, Simon S, Chae K, et al. Phytoestrogens and their human metabolites show distinct agonistic and antagonistic properties on estrogen receptor alpha (ERalpha) and ERbeta in human cells. Toxicol Sci 2004;80:14-25. View abstract.

30913            Rosa, F. T., Zulet, M. A., Marchini, J. S., and Martinez, J. A. Bioactive compounds with effects on inflammation markers in humans. Int J Food Sci Nutr 2012;63(6):749-765. View abstract.

35459            Karlsen, A., Paur, I., Bohn, S. K., Sakhi, A. K., Borge, G. I., Serafini, M., Erlund, I., Laake, P., Tonstad, S., and Blomhoff, R. Bilberry juice modulates plasma concentration of NF-kappaB related inflammatory markers in subjects at increased risk of CVD. Eur.J.Nutr. 2010;49(6):345-355. View abstract.

44057            Mozaffarieh, M., Grieshaber, M. C., Orgul, S., and Flammer, J. The potential value of natural antioxidative treatment in glaucoma. Surv.Ophthalmol. 2008;53(5):479-505. View abstract.

52937            Hsieh, T. C. and Wu, J. M. Grape-derived chemopreventive agent resveratrol decreases prostate-specific antigen (PSA) expression in LNCaP cells by an androgen receptor (AR)-independent mechanism. Anticancer Res 2000;20(1A):225-228. View abstract.

52945            de, Santi C., Pietrabissa, A., Mosca, F., and Pacifici, G. M. Glucuronidation of resveratrol, a natural product present in grape and wine, in the human liver. Xenobiotica 2000;30(11):1047-1054. View abstract.

52951            Khanna, S., Roy, S., Bagchi, D., Bagchi, M., and Sen, C. K. Upregulation of oxidant-induced VEGF expression in cultured keratinocytes by a grape seed proanthocyanidin extract. Free Radic.Biol.Med 7-1-2001;31(1):38-42. View abstract.

52958            Bhat, K. P. L., Kosmeder, J. W., and Pezzuto, J. M. Biological effects of resveratrol. Antioxid.Redox.Signal. 2001;3(6):1041-1064. View abstract.

52968            Khanna, S., Venojarvi, M., Roy, S., Sharma, N., Trikha, P., Bagchi, D., Bagchi, M., and Sen, C. K. Dermal wound healing properties of redox-active grape seed proanthocyanidins. Free Radic.Biol.Med 10-15-2002;33(8):1089-1096. View abstract.

52987            Piver, B., Berthou, F., Dreano, Y., and Lucas, D. Differential inhibition of human cytochrome P450 enzymes by epsilon-viniferin, the dimer of resveratrol: comparison with resveratrol and polyphenols from alcoholized beverages. Life Sci. 7-18-2003;73(9):1199-1213. View abstract.

52996            Larrosa, M., Tomas-Barberan, F. A., and Espin, J. C. Grape polyphenol resveratrol and the related molecule 4-hydroxystilbene induce growth inhibition, apoptosis, S-phase arrest, and upregulation of cyclins A, E, and B1 in human SK-Mel-28 melanoma cells. J Agric.Food Chem 7-30-2003;51(16):4576-4584. View abstract.

53028            Zern, T. L., Wood, R. J., Greene, C., West, K. L., Liu, Y., Aggarwal, D., Shachter, N. S., and Fernandez, M. L. Grape polyphenols exert a cardioprotective effect in pre- and postmenopausal women by lowering plasma lipids and reducing oxidative stress. J Nutr. 2005;135(8):1911-1917. View abstract.

53036            Lekakis, J., Rallidis, L. S., Andreadou, I., Vamvakou, G., Kazantzoglou, G., Magiatis, P., Skaltsounis, A. L., and Kremastinos, D. T. Polyphenolic compounds from red grapes acutely improve endothelial function in patients with coronary heart disease. Eur.J Cardiovasc.Prev.Rehabil. 2005;12(6):596-600. View abstract.

53125            Leifert, W. R. and Abeywardena, M. Y. Cardioprotective actions of grape polyphenols. Nutr.Res 2008;28(11):729-737. View abstract.

53170            Kamiyama, M., Kishimoto, Y., Tani, M., Andoh, K., Utsunomiya, K., and Kondo, K. Inhibition of low-density lipoprotein oxidation by Nagano purple grape (Vitis viniferaxVitis labrusca). J Nutr.Sci.Vitaminol.(Tokyo) 2009;55(6):471-478. View abstract.

53254            Tome-Carneiro, J., Gonzalvez, M., Larrosa, M., Yanez-Gascon, M. J., Garcia-Almagro, F. J., Ruiz-Ros, J. A., Garcia-Conesa, M. T., Tomas-Barberan, F. A., and Espin, J. C. One-year consumption of a grape nutraceutical containing resveratrol improves the inflammatory and fibrinolytic status of patients in primary prevention of cardiovascular disease. Am J Cardiol. 8-1-2012;110(3):356-363. View abstract.

53256            Tome-Carneiro, J., Gonzalvez, M., Larrosa, M., Garcia-Almagro, F. J., Aviles-Plaza, F., Parra, S., Yanez-Gascon, M. J., Ruiz-Ros, J. A., Garcia-Conesa, M. T., Tomas-Barberan, F. A., and Espin, J. C. Consumption of a grape extract supplement containing resveratrol decreases oxidized LDL and ApoB in patients undergoing primary prevention of cardiovascular disease: a triple-blind, 6-month follow-up, placebo-controlled, randomized trial. Mol.Nutr Food Res 2012;56(5):810-821. View abstract.

53260            De, Groote D., Van, Belleghem K., Deviere, J., Van, Brussel W., Mukaneza, A., and Amininejad, L. Effect of the intake of resveratrol, resveratrol phosphate, and catechin-rich grape seed extract on markers of oxidative stress and gene expression in adult obese subjects. Ann Nutr Metab 2012;61(1):15-24. View abstract.

53264            Rotches-Ribalta, M., Andres-Lacueva, C., Estruch, R., Escribano, E., and Urpi-Sarda, M. Pharmacokinetics of resveratrol metabolic profile in healthy humans after moderate consumption of red wine and grape extract tablets. Pharmacol Res 2012;66(5):375-382. View abstract.

53973            Bakker, G. C., van Erk, M. J., Pellis, L., Wopereis, S., Rubingh, C. M., Cnubben, N. H., Kooistra, T., van, Ommen B., and Hendriks, H. F. An antiinflammatory dietary mix modulates inflammation and oxidative and metabolic stress in overweight men: a nutrigenomics approach. Am.J Clin Nutr. 2010;91(4):1044-1059. View abstract.

56916            Manna, S. K., Mukhopadhyay, A., and Aggarwal, B. B. Resveratrol suppresses TNF-induced activation of nuclear transcription factors NF-kappa B, activator protein-1, and apoptosis: potential role of reactive oxygen intermediates and lipid peroxidation. J Immunol. 6-15-2000;164(12):6509-6519. View abstract.

56920            Banerjee, S., Bueso-Ramos, C., and Aggarwal, B. B. Suppression of 7,12-dimethylbenz(a)anthracene-induced mammary carcinogenesis in rats by resveratrol: role of nuclear factor-kappaB, cyclooxygenase 2, and matrix metalloprotease 9. Cancer Res 9-1-2002;62(17):4945-4954. View abstract.

56943            Kimura, Y., Okuda, H., and Kubo, M. Effects of stilbenes isolated from medicinal plants on arachidonate metabolism and degranulation in human polymorphonuclear leukocytes. J Ethnopharmacol. 1995;45(2):131-139. View abstract.

64633            Rahman, I. Antioxidant therapeutic advances in COPD. Ther.Adv.Respir.Dis. 2008;2(6):351-374. View abstract.

70804            Jang, D. S., Kang, B. S., Ryu, S. Y., Chang, I. M., Min, K. R., and Kim, Y. Inhibitory effects of resveratrol analogs on unopsonized zymosan-induced oxygen radical production. Biochem.Pharmacol. 3-15-1999;57(6):705-712. View abstract.

70805            Miloso, M., Bertelli, A. A., Nicolini, G., and Tredici, G. Resveratrol-induced activation of the mitogen-activated protein kinases, ERK1 and ERK2, in human neuroblastoma SH-SY5Y cells. Neurosci.Lett. 4-2-1999;264(1-3):141-144. View abstract.

70806            Hsieh, T. C. and Wu, J. M. Differential effects on growth, cell cycle arrest, and induction of apoptosis by resveratrol in human prostate cancer cell lines. Exp.Cell Res. 5-25-1999;249(1):109-115. View abstract.

70807            Palmieri, L., Mameli, M., and Ronca, G. Effect of resveratrol and some other natural compounds on tyrosine kinase activity and on cytolysis. Drugs Exp.Clin.Res. 1999;25(2-3):79-85. View abstract.

70808            Calabrese, G. Nonalcoholic compounds of wine: the phytoestrogen resveratrol and moderate red wine consumption during menopause. Drugs Exp.Clin.Res 1999;25(2-3):111-114. View abstract.

70809            Zou, J. G., Huang, Y. Z., Chen, Q., Wei, E. H., Hsieh, T. C., and Wu, J. M. Resveratrol inhibits copper ion-induced and azo compound-initiated oxidative modification of human low density lipoprotein. Biochem.Mol.Biol.Int. 1999;47(6):1089-1096. View abstract.

70810            Lin, J. K. and Tsai, S. H. Chemoprevention of cancer and cardiovascular disease by resveratrol. Proc.Natl.Sci.Counc.Repub.China B 1999;23(3):99-106. View abstract.

70811            Ciolino, H. P. and Yeh, G. C. Inhibition of aryl hydrocarbon-induced cytochrome P-450 1A1 enzyme activity and CYP1A1 expression by resveratrol. Mol.Pharmacol. 1999;56(4):760-767. View abstract.

70812            Casper, R. F., Quesne, M., Rogers, I. M., Shirota, T., Jolivet, A., Milgrom, E., and Savouret, J. F. Resveratrol has antagonist activity on the aryl hydrocarbon receptor: implications for prevention of dioxin toxicity. Mol.Pharmacol. 1999;56(4):784-790. View abstract.

70813            Dobrydneva, Y., Williams, R. L., and Blackmore, P. F. trans-Resveratrol inhibits calcium influx in thrombin-stimulated human platelets. Br.J.Pharmacol. 1999;128(1):149-157. View abstract.

70814            Mitchell, S. H., Zhu, W., and Young, C. Y. Resveratrol inhibits the expression and function of the androgen receptor in LNCaP prostate cancer cells. Cancer Res. 12-1-1999;59(23):5892-5895. View abstract.

70815            Subbaramaiah, K., Michaluart, P., Chung, W. J., Tanabe, T., Telang, N., and Dannenberg, A. J. Resveratrol inhibits cyclooxygenase-2 transcription in human mammary epithelial cells. Ann.N.Y.Acad.Sci. 1999;889:214-223. View abstract.

70816            Martinez, J. and Moreno, J. J. Effect of resveratrol, a natural polyphenolic compound, on reactive oxygen species and prostaglandin production. Biochem.Pharmacol 4-1-2000;59(7):865-870. View abstract.

70817            Klabunde, T., Petrassi, H. M., Oza, V. B., Raman, P., Kelly, J. W., and Sacchettini, J. C. Rational design of potent human transthyretin amyloid disease inhibitors. Nat Struct.Biol. 2000;7(4):312-321. View abstract.

70818            Ballmer, P. E. [The Mediterranean diet--healthy but and still delicious]. Ther.Umsch. 2000;57(3):167-172. View abstract.

70819            Naderali, E. K., Doyle, P. J., and Williams, G. Resveratrol induces vasorelaxation of mesenteric and uterine arteries from female guinea-pigs. Clin Sci (Lond) 2000;98(5):537-543. View abstract.

70820            Mutoh, M., Takahashi, M., Fukuda, K., Matsushima-Hibiya, Y., Mutoh, H., Sugimura, T., and Wakabayashi, K. Suppression of cyclooxygenase-2 promoter-dependent transcriptional activity in colon cancer cells by chemopreventive agents with a resorcin-type structure. Carcinogenesis 2000;21(5):959-963. View abstract.

70821            Mietus-Snyder, M., Gowri, M. S., and Pitas, R. E. Class A scavenger receptor up-regulation in smooth muscle cells by oxidized low density lipoprotein. Enhancement by calcium flux and concurrent cyclooxygenase-2 up-regulation. J Biol.Chem 6-9-2000;275(23):17661-17670. View abstract.

70822            Delmas, D., Jannin, B., Cherkaoui, Malki M., and Latruffe, N. Inhibitory effect of resveratrol on the proliferation of human and rat hepatic derived cell lines. Oncol.Rep. 2000;7(4):847-852. View abstract.

70823            Andlauer, W., Kolb, J., Siebert, K., and Furst, P. Assessment of resveratrol bioavailability in the perfused small intestine of the rat. Drugs Exp.Clin.Res 2000;26(2):47-55. View abstract.

70824            Szende, B., Tyihak, E., and Kiraly-Veghely, Z. Dose-dependent effect of resveratrol on proliferation and apoptosis in endothelial and tumor cell cultures. Exp.Mol.Med. 6-30-2000;32(2):88-92. View abstract.

70825            Bradamante, S., Piccinini, F., Barenghi, L., Bertelli, A. A., De Jonge, R., Beemster, P., and De Jong, J. W. Does resveratrol induce pharmacological preconditioning? Int.J Tissue React. 2000;22(1):1-4. View abstract.

70826            Schneider, Y., Vincent, F., Duranton, B., Badolo, L., Gosse, F., Bergmann, C., Seiler, N., and Raul, F. Anti-proliferative effect of resveratrol, a natural component of grapes and wine, on human colonic cancer cells. Cancer Lett. 9-29-2000;158(1):85-91. View abstract.

70827            Bagchi, D., Bagchi, M., Stohs, S. J., Das, D. K., Ray, S. D., Kuszynski, C. A., Joshi, S. S., and Pruess, H. G. Free radicals and grape seed proanthocyanidin extract: importance in human health and disease prevention. Toxicology 8-7-2000;148(2-3):187-197. View abstract.

70828            Kirk, R. I., Deitch, J. A., Wu, J. M., and Lerea, K. M. Resveratrol decreases early signaling events in washed platelets but has little effect on platalet in whole food. Blood Cells Mol.Dis. 2000;26(2):144-150. View abstract.

70829            Stewart, J. R., Christman, K. L., and O’Brian, C. A. Effects of resveratrol on the autophosphorylation of phorbol ester-responsive protein kinases: inhibition of protein kinase D but not protein kinase C isozyme autophosphorylation. Biochem.Pharmacol. 11-1-2000;60(9):1355-1359. View abstract.

70830            Bowers, J. L., Tyulmenkov, V. V., Jernigan, S. C., and Klinge, C. M. Resveratrol acts as a mixed agonist/antagonist for estrogen receptors alpha and beta. Endocrinology 2000;141(10):3657-3667. View abstract.

70831            Zbikowska, H. M. and Olas, B. Antioxidants with carcinostatic activity (resveratrol, vitamin E and selenium) in modulation of blood platelet adhesion. J Physiol Pharmacol. 2000;51(3):513-520. View abstract.

70832            Burkitt, M. J. and Duncan, J. Effects of trans-resveratrol on copper-dependent hydroxyl-radical formation and DNA damage: evidence for hydroxyl-radical scavenging and a novel, glutathione-sparing mechanism of action. Arch.Biochem.Biophys. 9-15-2000;381(2):253-263. View abstract.

70833            De, Santi C., Pietrabissa, A., Spisni, R., Mosca, F., and Pacifici, G. M. Sulphation of resveratrol, a natural compound present in wine, and its inhibition by natural flavonoids. Xenobiotica 2000;30(9):857-866. View abstract.

70834            Chang, T. K., Lee, W. B., and Ko, H. H. Trans-resveratrol modulates the catalytic activity and mRNA expression of the procarcinogen-activating human cytochrome P450 1B1. Can.J.Physiol Pharmacol. 2000;78(11):874-881. View abstract.

70835            Ahn, K. S., Kim, J. H., Oh, S. R., Ryu, S. Y., and Lee, H. K. Inhibitory activity of stilbenes from medicinal plants on the expression of cell adhesion molecules on THP1 cells. Planta Med. 2000;66(7):641-644. View abstract.

70836            Wang, M. J., Huang, H. M., Hsieh, S. J., Jeng, K. C., and Kuo, J. S. Resveratrol inhibits interleukin-6 production in cortical mixed glial cells under hypoxia/hypoglycemia followed by reoxygenation. J Neuroimmunol. 1-1-2001;112(1-2):28-34. View abstract.

70837            Heredia, A., Davis, C., and Redfield, R. Synergistic inhibition of HIV-1 in activated and resting peripheral blood mononuclear cells, monocyte-derived macrophages, and selected drug-resistant isolates with nucleoside analogues combined with a natural product, resveratrol. J.Acquir.Immune.Defic.Syndr. 11-1-2000;25(3):246-255. View abstract.

70838            Chan, W. K. and Delucchi, A. B. Resveratrol, a red wine constituent, is a mechanism-based inactivator of cytochrome P450 3A4. Life Sci 11-10-2000;67(25):3103-3112. View abstract.

70839            Kampa, M., Hatzoglou, A., Notas, G., Damianaki, A., Bakogeorgou, E., Gemetzi, C., Kouroumalis, E., Martin, P. M., and Castanas, E. Wine antioxidant polyphenols inhibit the proliferation of human prostate cancer cell lines. Nutr.Cancer 2000;37(2):223-233. View abstract.

70840            Hadi, S. M., Asad, S. F., Singh, S., and Ahmad, A. Putative mechanism for anticancer and apoptosis-inducing properties of plant-derived polyphenolic compounds. IUBMB.Life 2000;50(3):167-171. View abstract.

70841            Dong, Z. Effects of food factors on signal transduction pathways. Biofactors 2000;12(1-4):17-28. View abstract.

70842            Giovannini, L., Migliori, M., Longoni, B. M., Das, D. K., Bertelli, A. A., Panichi, V., Filippi, C., and Bertelli, A. Resveratrol, a polyphenol found in wine, reduces ischemia reperfusion injury in rat kidneys. J Cardiovasc.Pharmacol. 2001;37(3):262-270. View abstract.

70843            Jonsson, K. O., Hedin, H. L., and Fowler, C. J. Investigation into the rapid effects of 17 beta-estradiol and neuroactive steroids upon beta-amyloid(25-35)-induced activation of phosphoinositide-specific phospholipase C in human platelets. Methods Find.Exp.Clin.Pharmacol 2000;22(8):615-620. View abstract.

70844            Nicolini, G., Rigolio, R., Miloso, M., Bertelli, A. A., and Tredici, G. Anti-apoptotic effect of trans-resveratrol on paclitaxel-induced apoptosis in the human neuroblastoma SH-SY5Y cell line. Neurosci.Lett. 4-13-2001;302(1):41-44. View abstract.

70845            Mollerup, S., Ovrebo, S., and Haugen, A. Lung carcinogenesis: resveratrol modulates the expression of genes involved in the metabolism of PAH in human bronchial epithelial cells. Int.J.Cancer 4-1-2001;92(1):18-25. View abstract.

70846            Chang, T. K. and Yeung, R. K. Effect of trans-resveratrol on 7-benzyloxy-4-trifluoromethylcoumarin O-dealkylation catalyzed by human recombinant CYP3A4 and CYP3A5. Can.J.Physiol Pharmacol. 2001;79(3):220-226. View abstract.

70847            Shirataki, Y., Motohashi, N., Tani, S., Sakagami, H., Satoh, K., Nakashima, H., Mahapatra, S. K., Ganguly, K., Dastidar, S. G., and Chakrabarty, A. N. In vitro biological activity of prenylflavanones. Anticancer Res 2001;21(1A):275-280. View abstract.

70848            Zhou, C. X., Kong, L. D., Ye, W. C., Cheng, C. H., and Tan, R. X. Inhibition of xanthine and monoamine oxidases by stilbenoids from Veratrum taliense. Planta Med 2001;67(2):158-161. View abstract.

70849            Nakagawa, H., Kiyozuka, Y., Uemura, Y., Senzaki, H., Shikata, N., Hioki, K., and Tsubura, A. Resveratrol inhibits human breast cancer cell growth and may mitigate the effect of linoleic acid, a potent breast cancer cell stimulator. J.Cancer Res.Clin.Oncol. 2001;127(4):258-264. View abstract.

70850            Ahmad, N., Adhami, V. M., Afaq, F., Feyes, D. K., and Mukhtar, H. Resveratrol causes WAF-1/p21-mediated G(1)-phase arrest of cell cycle and induction of apoptosis in human epidermoid carcinoma A431 cells. Clin.Cancer Res. 2001;7(5):1466-1473. View abstract.

70851            Dorrie, J., Gerauer, H., Wachter, Y., and Zunino, S. J. Resveratrol induces extensive apoptosis by depolarizing mitochondrial membranes and activating caspase-9 in acute lymphoblastic leukemia cells. Cancer Res. 6-15-2001;61(12):4731-4739. View abstract.

70852            Soleas, G. J., Yan, J., and Goldberg, D. M. Ultrasensitive assay for three polyphenols (catechin, quercetin and resveratrol) and their conjugates in biological fluids utilizing gas chromatography with mass selective detection. J Chromatogr.B Biomed.Sci.Appl. 6-5-2001;757(1):161-172. View abstract.

70853            Pervaiz, S. Resveratrol–from the bottle to the bedside? Leuk.Lymphoma 2001;40(5-6):491-498. View abstract.

70854            Gusman, J., Malonne, H., and Atassi, G. A reappraisal of the potential chemopreventive and chemotherapeutic properties of resveratrol. Carcinogenesis 2001;22(8):1111-1117. View abstract.

70855            Subbaramaiah, K. and Dannenberg, A. J. Resveratrol inhibits the expression of cyclooxygenase-2 in mammary epithelial cells. Adv.Exp.Med.Biol. 2001;492:147-157. View abstract.

70856            Wolter, F., Akoglu, B., Clausnitzer, A., and Stein, J. Downregulation of the cyclin D1/Cdk4 complex occurs during resveratrol-induced cell cycle arrest in colon cancer cell lines. J.Nutr. 2001;131(8):2197-2203. View abstract.

70857            Igura, K., Ohta, T., Kuroda, Y., and Kaji, K. Resveratrol and quercetin inhibit angiogenesis in vitro. Cancer Lett. 9-28-2001;171(1):11-16. View abstract.

70858            Bhat, K. P. and Pezzuto, J. M. Resveratrol exhibits cytostatic and antiestrogenic properties with human endometrial adenocarcinoma (Ishikawa) cells. Cancer Res. 8-15-2001;61(16):6137-6144. View abstract.

70859            Yoon, K., Pallaroni, L., Stoner, M., Gaido, K., and Safe, S. Differential activation of wild-type and variant forms of estrogen receptor alpha by synthetic and natural estrogenic compounds using a promoter containing three estrogen-responsive elements. J Steroid Biochem.Mol.Biol. 2001;78(1):25-32. View abstract.

70860            Sgambato, A., Ardito, R., Faraglia, B., Boninsegna, A., Wolf, F. I., and Cittadini, A. Resveratrol, a natural phenolic compound, inhibits cell proliferation and prevents oxidative DNA damage. Mutat.Res. 9-20-2001;496(1-2):171-180. View abstract.

70861            Aumont, V., Krisa, S., Battaglia, E., Netter, P., Richard, T., Merillon, J. M., Magdalou, J., and Sabolovic, N. Regioselective and stereospecific glucuronidation of trans- and cis-resveratrol in human. Arch.Biochem.Biophys. 9-15-2001;393(2):281-289. View abstract.

70862            Lee, J. E. and Safe, S. Involvement of a post-transcriptional mechanism in the inhibition of CYP1A1 expression by resveratrol in breast cancer cells. Biochem.Pharmacol. 10-15-2001;62(8):1113-1124. View abstract.

70863            Bhat, K. P., Lantvit, D., Christov, K., Mehta, R. G., Moon, R. C., and Pezzuto, J. M. Estrogenic and antiestrogenic properties of resveratrol in mammary tumor models. Cancer Res. 10-15-2001;61(20):7456-7463. View abstract.

70864            Atten, M. J., Attar, B. M., Milson, T., and Holian, O. Resveratrol-induced inactivation of human gastric adenocarcinoma cells through a protein kinase C-mediated mechanism. Biochem.Pharmacol. 11-15-2001;62(10):1423-1432. View abstract.

70865            Bhavnani, B. R., Cecutti, A., Gerulath, A., Woolever, A. C., and Berco, M. Comparison of the antioxidant effects of equine estrogens, red wine components, vitamin E, and probucol on low-density lipoprotein oxidation in postmenopausal women. Menopause. 2001;8(6):408-419. View abstract.

70866            Falchetti, R., Fuggetta, M. P., Lanzilli, G., Tricarico, M., and Ravagnan, G. Effects of resveratrol on human immune cell function. Life Sci. 11-21-2001;70(1):81-96. View abstract.

70867            Zou, J., Huang, Y., Chen, Q., Wei, E., Cao, K., and Wu, J. M. Effects of resveratrol on oxidative modification of human low density lipoprotein. Chin Med.J.(Engl.) 2000;113(2):99-102. View abstract.

70868            Bertelli, A. A., Baccalini, R., Battaglia, E., Falchi, M., and Ferrero, M. E. Resveratrol inhibits TNF alpha-induced endothelial cell activation. Therapie 2001;56(5):613-616. View abstract.

70869            Serrero, G. and Lu, R. Effect of resveratrol on the expression of autocrine growth modulators in human breast cancer cells. Antioxid.Redox.Signal. 2001;3(6):969-979. View abstract.

70870            Sun, Z. J., Pan, C. E., Liu, H. S., and Wang, G. J. Anti-hepatoma activity of resveratrol in vitro. World J.Gastroenterol. 2002;8(1):79-81. View abstract.

70871            Chan, M. M. Antimicrobial effect of resveratrol on dermatophytes and bacterial pathogens of the skin. Biochem.Pharmacol. 1-15-2002;63(2):99-104. View abstract.

70872            Potter, G. A., Patterson, L. H., Wanogho, E., Perry, P. J., Butler, P. C., Ijaz, T., Ruparelia, K. C., Lamb, J. H., Farmer, P. B., Stanley, L. A., and Burke, M. D. The cancer preventative agent resveratrol is converted to the anticancer agent piceatannol by the cytochrome P450 enzyme CYP1B1. Br.J.Cancer 3-4-2002;86(5):774-778. View abstract.

70873            Baek, S. J., Wilson, L. C., and Eling, T. E. Resveratrol enhances the expression of non-steroidal anti-inflammatory drug-activated gene (NAG-1) by increasing the expression of p53. Carcinogenesis 2002;23(3):425-434. View abstract.

70874            Joe, A. K., Liu, H., Suzui, M., Vural, M. E., Xiao, D., and Weinstein, I. B. Resveratrol induces growth inhibition, S-phase arrest, apoptosis, and changes in biomarker expression in several human cancer cell lines. Clin.Cancer Res. 2002;8(3):893-903. View abstract.

70875            Wang, Z., Zou, J., Huang, Y., Cao, K., Xu, Y., and Wu, J. M. Effect of resveratrol on platelet aggregation in vivo and in vitro. Chin Med.J.(Engl.) 2002;115(3):378-380. View abstract.

70876            Holian, O., Wahid, S., Atten, M. J., and Attar, B. M. Inhibition of gastric cancer cell proliferation by resveratrol: role of nitric oxide. Am.J.Physiol Gastrointest.Liver Physiol 2002;282(5):G809-G816. View abstract.

70877            Ignatowicz, E. and Baer-Dubowska, W. Resveratrol, a natural chemopreventive agent against degenerative diseases. Pol.J.Pharmacol. 2001;53(6):557-569. View abstract.

70878            Sen, C. K., Khanna, S., Gordillo, G., Bagchi, D., Bagchi, M., and Roy, S. Oxygen, oxidants, and antioxidants in wound healing: an emerging paradigm. Ann.N Y.Acad.Sci. 2002;957:239-249. View abstract.

70879            Pietraforte, D., Turco, L., Azzini, E., and Minetti, M. On-line EPR study of free radicals induced by peroxidase/H(2)O(2) in human low-density lipoprotein. Biochim.Biophys Acta 7-11-2002;1583(2):176-184. View abstract.

70880            El Mowafy, A. M., Abou-Zeid, L. A., and Edafiogho, I. Recognition of resveratrol by the human estrogen receptor-alpha: a molecular modeling approach to understand its biological actions. Med.Princ.Pract. 2002;11(2):86-92. View abstract.

70881            Lin, H. Y., Shih, A., Davis, F. B., Tang, H. Y., Martino, L. J., Bennett, J. A., and Davis, P. J. Resveratrol induced serine phosphorylation of p53 causes apoptosis in a mutant p53 prostate cancer cell line. J.Urol. 2002;168(2):748-755. View abstract.

70882            Ferry-Dumazet, H., Garnier, O., Mamani-Matsuda, M., Vercauteren, J., Belloc, F., Billiard, C., Dupouy, M., Thiolat, D., Kolb, J. P., Marit, G., Reiffers, J., and Mossalayi, M. D. Resveratrol inhibits the growth and induces the apoptosis of both normal and leukemic hematopoietic cells. Carcinogenesis 2002;23(8):1327-1333. View abstract.

70883            Dobrydneva, Y., Williams, R. L., Morris, G. Z., and Blackmore, P. F. Dietary phytoestrogens and their synthetic structural analogues as calcium channel blockers in human platelets. J Cardiovasc.Pharmacol 2002;40(3):399-410. View abstract.

70884            Yoon, S. H., Kim, Y. S., Ghim, S. Y., Song, B. H., and Bae, Y. S. Inhibition of protein kinase CKII activity by resveratrol, a natural compound in red wine and grapes. Life Sci. 9-20-2002;71(18):2145-2152. View abstract.

70885            Sharma, M. and Gupta, Y. K. Chronic treatment with trans resveratrol prevents intracerebroventricular streptozotocin induced cognitive impairment and oxidative stress in rats. Life Sci 10-11-2002;71(21):2489-2498. View abstract.

70886            Wallerath, T., Deckert, G., Ternes, T., Anderson, H., Li, H., Witte, K., and Forstermann, U. Resveratrol, a polyphenolic phytoalexin present in red wine, enhances expression and activity of endothelial nitric oxide synthase. Circulation 9-24-2002;106(13):1652-1658. View abstract.

70887            Mahyar-Roemer, M., Kohler, H., and Roemer, K. Role of Bax in resveratrol-induced apoptosis of colorectal carcinoma cells. BMC.Cancer 10-17-2002;2(1):27. View abstract.

70888            Pozo-Guisado, E., Alvarez-Barrientos, A., Mulero-Navarro, S., Santiago-Josefat, B., and Fernandez-Salguero, P. M. The antiproliferative activity of resveratrol results in apoptosis in MCF-7 but not in MDA-MB-231 human breast cancer cells: cell-specific alteration of the cell cycle. Biochem.Pharmacol. 11-1-2002;64(9):1375-1386. View abstract.

70889            Kuo, P. L., Chiang, L. C., and Lin, C. C. Resveratrol- induced apoptosis is mediated by p53-dependent pathway in Hep G2 cells. Life Sci. 11-22-2002;72(1):23-34. View abstract.

70890            Brownson, D. M., Azios, N. G., Fuqua, B. K., Dharmawardhane, S. F., and Mabry, T. J. Flavonoid effects relevant to cancer. J Nutr. 2002;132(11 Suppl):3482S-3489S. View abstract.

70891            Suttnar, J., Masova, L., Scheiner, T., Sorelova, V., and Dyr, J. E. [Role of free radicals in blood platelet activation]. Cas.Lek.Cesk. 9-22-2002;141 Suppl:47-49. View abstract.

70892            Olas, B., Wachowicz, B., Saluk-Juszczak, J., and Zielinski, T. Effect of resveratrol, a natural polyphenolic compound, on platelet activation induced by endotoxin or thrombin. Thromb.Res 8-15-2002;107(3-4):141-145. View abstract.

70893            Yu, C., Shin, Y. G., Chow, A., Li, Y., Kosmeder, J. W., Lee, Y. S., Hirschelman, W. H., Pezzuto, J. M., Mehta, R. G., and van Breemen, R. B. Human, rat, and mouse metabolism of resveratrol. Pharm.Res. 2002;19(12):1907-1914. View abstract.

70894            Liu, G. A. and Zheng, R. L. Protection against damaged DNA in the single cell by polyphenols. Pharmazie 2002;57(12):852-854. View abstract.

70895            Niles, R. M., McFarland, M., Weimer, M. B., Redkar, A., Fu, Y. M., and Meadows, G. G. Resveratrol is a potent inducer of apoptosis in human melanoma cells. Cancer Lett. 2-20-2003;190(2):157-163. View abstract.

70896            Yu, C., Shin, Y. G., Kosmeder, J. W., Pezzuto, J. M., and van Breemen, R. B. Liquid chromatography/tandem mass spectrometric determination of inhibition of human cytochrome P450 isozymes by resveratrol and resveratrol-3-sulfate. Rapid Commun.Mass Spectrom. 2003;17(4):307-313. View abstract.

70897            Levenson, A. S., Gehm, B. D., Pearce, S. T., Horiguchi, J., Simons, L. A., Ward, J. E., III, Jameson, J. L., and Jordan, V. C. Resveratrol acts as an estrogen receptor (ER) agonist in breast cancer cells stably transfected with ER alpha. Int.J.Cancer 5-1-2003;104(5):587-596. View abstract.

70898            Vitrac, X., Desmouliere, A., Brouillaud, B., Krisa, S., Deffieux, G., Barthe, N., Rosenbaum, J., and Merillon, J. M. Distribution of [14C]-trans-resveratrol, a cancer chemopreventive polyphenol, in mouse tissues after oral administration. Life Sci 4-4-2003;72(20):2219-2233. View abstract.

70899            Gerhauser, C., Klimo, K., Heiss, E., Neumann, I., Gamal-Eldeen, A., Knauft, J., Liu, G. Y., Sitthimonchai, S., and Frank, N. Mechanism-based in vitro screening of potential cancer chemopreventive agents. Mutat.Res 2003;523-524:163-172. View abstract.

70900            Zhou, H. B., Yan, Y., Sun, Y. N., and Zhu, J. R. Resveratrol induces apoptosis in human esophageal carcinoma cells. World J.Gastroenterol. 2003;9(3):408-411. View abstract.

70901            Klinge, C. M., Risinger, K. E., Watts, M. B., Beck, V., Eder, R., and Jungbauer, A. Estrogenic activity in white and red wine extracts. J Agric.Food Chem 3-26-2003;51(7):1850-1857. View abstract.

70902            Adhami, V. M., Afaq, F., and Ahmad, N. Suppression of ultraviolet B exposure-mediated activation of NF-kappaB in normal human keratinocytes by resveratrol. Neoplasia. 2003;5(1):74-82. View abstract.

70903            Liang, Y. C., Tsai, S. H., Chen, L., Lin-Shiau, S. Y., and Lin, J. K. Resveratrol-induced G2 arrest through the inhibition of CDK7 and p34CDC2 kinases in colon carcinoma HT29 cells. Biochem.Pharmacol. 4-1-2003;65(7):1053-1060. View abstract.

70904            Wolter, F., Turchanowa, L., and Stein, J. Resveratrol-induced modification of polyamine metabolism is accompanied by induction of c-Fos. Carcinogenesis 2003;24(3):469-474. View abstract.

70905            Estrov, Z., Shishodia, S., Faderl, S., Harris, D., Van, Q., Kantarjian, H. M., Talpaz, M., and Aggarwal, B. B. Resveratrol blocks interleukin-1beta-induced activation of the nuclear transcription factor NF-kappaB, inhibits proliferation, causes S-phase arrest, and induces apoptosis of acute myeloid leukemia cells. Blood 8-1-2003;102(3):987-995. View abstract.

70906            Quinones, A., Dobberstein, K. U., and Rainov, N. G. The egr-1 gene is induced by DNA-damaging agents and non-genotoxic drugs in both normal and neoplastic human cells. Life Sci. 5-16-2003;72(26):2975-2992. View abstract.

70907            Pellegatta, F., Bertelli, A. A., Staels, B., Duhem, C., Fulgenzi, A., and Ferrero, M. E. Different short- and long-term effects of resveratrol on nuclear factor-kappaB phosphorylation and nuclear appearance in human endothelial cells. Am.J.Clin.Nutr. 2003;77(5):1220-1228. View abstract.

70908            Gallo, R., Viglizzo, G., Vecchio, F., and Parodi, A. Allergic contact dermatitis from pentylene glycol in an emollient cream, with possible co-sensitization to resveratrol. Contact Dermatitis 2003;48(3):176-177. View abstract.

70909            Shen, F., Chen, S. J., Dong, X. J., Zhong, H., Li, Y. T., and Cheng, G. F. Suppression of IL-8 gene transcription by resveratrol in phorbol ester treated human monocytic cells. J.Asian Nat.Prod.Res. 2003;5(2):151-157. View abstract.

70910            El Mowafy, A. M. and Alkhalaf, M. Resveratrol activates adenylyl-cyclase in human breast cancer cells: a novel, estrogen receptor-independent cytostatic mechanism. Carcinogenesis 2003;24(5):869-873. View abstract.

70911            Aziz, M. H., Kumar, R., and Ahmad, N. Cancer chemoprevention by resveratrol: in vitro and in vivo studies and the underlying mechanisms (review). Int.J.Oncol. 2003;23(1):17-28. View abstract.

70912            Boscolo, P., del Signore, A., Sabbioni, E., Di Gioacchino, M., Di Giampaolo, L., Reale, M., Conti, P., Paganelli, R., and Giaccio, M. Effects of resveratrol on lymphocyte proliferation and cytokine release. Ann.Clin.Lab Sci. 2003;33(2):226-231. View abstract.

70913            Mahady, G. B., Pendland, S. L., and Chadwick, L. R. Resveratrol and red wine extracts inhibit the growth of CagA+ strains of Helicobacter pylori in vitro. Am.J Gastroenterol. 2003;98(6):1440-1441. View abstract.

70914            Zhuang, H., Kim, Y. S., Koehler, R. C., and Dore, S. Potential mechanism by which resveratrol, a red wine constituent, protects neurons. Ann.N Y.Acad.Sci. 2003;993:276-286. View abstract.

70915            Delmas, D., Rebe, C., Lacour, S., Filomenko, R., Athias, A., Gambert, P., Cherkaoui-Malki, M., Jannin, B., Dubrez-Daloz, L., Latruffe, N., and Solary, E. Resveratrol-induced apoptosis is associated with Fas redistribution in the rafts and the formation of a death-inducing signaling complex in colon cancer cells. J.Biol.Chem. 10-17-2003;278(42):41482-41490. View abstract.

70916            Howitz, K. T., Bitterman, K. J., Cohen, H. Y., Lamming, D. W., Lavu, S., Wood, J. G., Zipkin, R. E., Chung, P., Kisielewski, A., Zhang, L. L., Scherer, B., and Sinclair, D. A. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 9-11-2003;425(6954):191-196. View abstract.

70917            Kim, Y. A., Lee, W. H., Choi, T. H., Rhee, S. H., Park, K. Y., and Choi, Y. H. Involvement of p21WAF1/CIP1, pRB, Bax and NF-kappaB in induction of growth arrest and apoptosis by resveratrol in human lung carcinoma A549 cells. Int.J.Oncol. 2003;23(4):1143-1149. View abstract.

70918            Li, Y. T., Shen, F., Bai, J. Y., and Cheng, G. F. [Inhibition of dexamethasone, indomethacin and resveratrol on matrix metalloproteinase-9 and the mechanism of inhibition]. Yao Xue.Xue.Bao. 2003;38(7):501-504. View abstract.

70919            Cavallaro, A., Ainis, T., Bottari, C., and Fimiani, V. Effect of resveratrol on some activities of isolated and in whole blood human neutrophils. Physiol Res. 2003;52(5):555-562. View abstract.

70920            Lin, M. T., Yen, M. L., Lin, C. Y., and Kuo, M. L. Inhibition of vascular endothelial growth factor-induced angiogenesis by resveratrol through interruption of Src-dependent vascular endothelial cadherin tyrosine phosphorylation. Mol.Pharmacol. 2003;64(5):1029-1036. View abstract.

70921            Mnjoyan, Z. H. and Fujise, K. Profound negative regulatory effects by resveratrol on vascular smooth muscle cells: a role of p53-p21(WAF1/CIP1) pathway. Biochem.Biophys.Res.Commun. 11-14-2003;311(2):546-552. View abstract.

70922            Liu, J. C., Chen, J. J., Chan, P., Cheng, C. F., and Cheng, T. H. Inhibition of cyclic strain-induced endothelin-1 gene expression by resveratrol. Hypertension 2003;42(6):1198-1205. View abstract.

70923            Inoue, H., Jiang, X. F., Katayama, T., Osada, S., Umesono, K., and Namura, S. Brain protection by resveratrol and fenofibrate against stroke requires peroxisome proliferator-activated receptor alpha in mice. Neurosci.Lett. 12-11-2003;352(3):203-206. View abstract.

70924            Li, Y. T., Shen, F., Liu, B. H., and Cheng, G. F. Resveratrol inhibits matrix metalloproteinase-9 transcription in U937 cells. Acta Pharmacol.Sin. 2003;24(11):1167-1171. View abstract.

70925            Kubota, T., Uemura, Y., Kobayashi, M., and Taguchi, H. Combined effects of resveratrol and paclitaxel on lung cancer cells. Anticancer Res. 2003;23(5A):4039-4046. View abstract.

70926            Li, Y., Shin, Y. G., Yu, C., Kosmeder, J. W., Hirschelman, W. H., Pezzuto, J. M., and van Breemen, R. B. Increasing the throughput and productivity of Caco-2 cell permeability assays using liquid chromatography-mass spectrometry: application to resveratrol absorption and metabolism. Comb.Chem.High Throughput.Screen. 2003;6(8):757-767. View abstract.

70927            Fulda, S. and Debatin, K. M. Sensitization for tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by the chemopreventive agent resveratrol. Cancer Res. 1-1-2004;64(1):337-346. View abstract.

70928            Stewart, J. R. and O’Brian, C. A. Resveratrol antagonizes EGFR-dependent Erk1/2 activation in human androgen-independent prostate cancer cells with associated isozyme-selective PKC alpha inhibition. Invest New Drugs 2004;22(2):107-117. View abstract.

70929            Pozo-Guisado, E., Lorenzo-Benayas, M. J., and Fernandez-Salguero, P. M. Resveratrol modulates the phosphoinositide 3-kinase pathway through an estrogen receptor alpha-dependent mechanism: relevance in cell proliferation. Int.J.Cancer 3-20-2004;109(2):167-173. View abstract.

70930            Sale, S., Verschoyle, R. D., Boocock, D., Jones, D. J., Wilsher, N., Ruparelia, K. C., Potter, G. A., Farmer, P. B., Steward, W. P., and Gescher, A. J. Pharmacokinetics in mice and growth-inhibitory properties of the putative cancer chemopreventive agent resveratrol and the synthetic analogue trans 3,4,5,4′-tetramethoxystilbene. Br J Cancer 2-9-2004;90(3):736-744. View abstract.

70931            Cardile, V., Scifo, C., Russo, A., Falsaperla, M., Morgia, G., Motta, M., Renis, M., Imbriani, E., and Silvestre, G. Involvement of HSP70 in resveratrol-induced apoptosis of human prostate cancer. Anticancer Res. 2003;23(6C):4921-4926. View abstract.

70932            Cheung, C. Y., Chen, J., and Chang, T. K. Evaluation of a real-time polymerase chain reaction method for the quantification of CYP1B1 gene expression in MCF-7 human breast carcinoma cells. J Pharmacol Toxicol.Methods 2004;49(2):97-104. View abstract.

70933            Ahmad, K. A., Clement, M. V., and Pervaiz, S. Pro-oxidant activity of low doses of resveratrol inhibits hydrogen peroxide-induced apoptosis. Ann.N.Y.Acad.Sci. 2003;1010:365-373. View abstract.

70934            Gehm, B. D., Levenson, A. S., Liu, H., Lee, E. J., Amundsen, B. M., Cushman, M., Jordan, V. C., and Jameson, J. L. Estrogenic effects of resveratrol in breast cancer cells expressing mutant and wild-type estrogen receptors: role of AF-1 and AF-2. J.Steroid Biochem.Mol.Biol. 2004;88(3):223-234. View abstract.

70935            Chen, Z. H., Hurh, Y. J., Na, H. K., Kim, J. H., Chun, Y. J., Kim, D. H., Kang, K. S., Cho, M. H., and Surh, Y. J. Resveratrol inhibits TCDD-induced expression of CYP1A1 and CYP1B1 and catechol estrogen-mediated oxidative DNA damage in cultured human mammary epithelial cells. Carcinogenesis 2004;25(10):2005-2013. View abstract.

70936            Liontas, A. and Yeger, H. Curcumin and resveratrol induce apoptosis and nuclear translocation and activation of p53 in human neuroblastoma. Anticancer Res 2004;24(2B):987-998. View abstract.

70937            Berge, G., Ovrebo, S., Botnen, I. V., Hewer, A., Phillips, D. H., Haugen, A., and Mollerup, S. Resveratrol inhibits benzo[a]pyrene-DNA adduct formation in human bronchial epithelial cells. Br.J.Cancer 7-19-2004;91(2):333-338. View abstract.

70938            Laux, M. T., Aregullin, M., Berry, J. P., Flanders, J. A., and Rodriguez, E. Identification of a p53-dependent pathway in the induction of apoptosis of human breast cancer cells by the natural product, resveratrol. J.Altern.Complement Med. 2004;10(2):235-239. View abstract.

70939            Liu, J., Wang, Q., Wu, D. C., Wang, X. W., Sun, Y., Chen, X. Y., Zhang, K. L., and Li, H. Differential regulation of CYP1A1 and CYP1B1 expression in resveratrol-treated human medulloblastoma cells. Neurosci.Lett. 6-17-2004;363(3):257-261. View abstract.

70940            Zhang, S., Cao, H. J., Davis, F. B., Tang, H. Y., Davis, P. J., and Lin, H. Y. Oestrogen inhibits resveratrol-induced post-translational modification of p53 and apoptosis in breast cancer cells. Br.J.Cancer 7-5-2004;91(1):178-185. View abstract.

70941            Olas, B., Wachowicz, B., Bald, E., and Glowacki, R. The protective effects of resveratrol against changes in blood platelet thiols induced by platinum compounds. J.Physiol Pharmacol. 2004;55(2):467-476. View abstract.

70942            Wood, J. G., Rogina, B., Lavu, S., Howitz, K., Helfand, S. L., Tatar, M., and Sinclair, D. Sirtuin activators mimic caloric restriction and delay ageing in metazoans. Nature 8-5-2004;430(7000):686-689. View abstract.

70943            Piver, B., Fer, M., Vitrac, X., Merillon, J. M., Dreano, Y., Berthou, F., and Lucas, D. Involvement of cytochrome P450 1A2 in the biotransformation of trans-resveratrol in human liver microsomes. Biochem.Pharmacol. 8-15-2004;68(4):773-782. View abstract.

70944            Cao, Z., Fang, J., Xia, C., Shi, X., and Jiang, B. H. trans-3,4,5′-Trihydroxystibene inhibits hypoxia-inducible factor 1alpha and vascular endothelial growth factor expression in human ovarian cancer cells. Clin.Cancer Res 8-1-2004;10(15):5253-5263. View abstract.

70945            Evers, D. L., Wang, X., Huong, S. M., Huang, D. Y., and Huang, E. S. 3,4′,5-Trihydroxy-trans-stilbene (resveratrol) inhibits human cytomegalovirus replication and virus-induced cellular signaling. Antiviral Res. 2004;63(2):85-95. View abstract.

70946            Jannin, B., Menzel, M., Berlot, J. P., Delmas, D., Lancon, A., and Latruffe, N. Transport of resveratrol, a cancer chemopreventive agent, to cellular targets: plasmatic protein binding and cell uptake. Biochem.Pharmacol. 9-15-2004;68(6):1113-1118. View abstract.

70947            Walle, T., Hsieh, F., DeLegge, M. H., Oatis, J. E., Jr., and Walle, U. K. High absorption but very low bioavailability of oral resveratrol in humans. Drug Metab Dispos. 2004;32(12):1377-1382. View abstract.

70948            Buryanovskyy, L., Fu, Y., Boyd, M., Ma, Y., Hsieh, T. C., Wu, J. M., and Zhang, Z. Crystal structure of quinone reductase 2 in complex with resveratrol. Biochemistry 9-14-2004;43(36):11417-11426. View abstract.

70949            Seaver, B. and Smith, J. R. Inhibition of COX isoforms by nutraceuticals. J Herb.Pharmacother. 2004;4(2):11-18. View abstract.

70950            Wang, Z., Hsieh, T. C., Zhang, Z., Ma, Y., and Wu, J. M. Identification and purification of resveratrol targeting proteins using immobilized resveratrol affinity chromatography. Biochem.Biophys.Res.Commun. 10-22-2004;323(3):743-749. View abstract.

70951            Bianco, N. R., Chaplin, L. J., and Montano, M. M. Differential induction of quinone reductase by phytoestrogens and protection against oestrogen-induced DNA damage. Biochem.J 1-1-2005;385(Pt 1):279-287. View abstract.

70952            Shenouda, N. S., Zhou, C., Browning, J. D., Ansell, P. J., Sakla, M. S., Lubahn, D. B., and MacDonald, R. S. Phytoestrogens in common herbs regulate prostate cancer cell growth in vitro. Nutr.Cancer 2004;49(2):200-208. View abstract.

70953            Aggarwal, B. B., Bhardwaj, A., Aggarwal, R. S., Seeram, N. P., Shishodia, S., and Takada, Y. Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies. Anticancer Res. 2004;24(5A):2783-2840. View abstract.

70954            McCarty, M. F. Potential utility of natural polyphenols for reversing fat-induced insulin resistance. Med.Hypotheses 2005;64(3):628-635. View abstract.

70955            Cao, Y., Fu, Z. D., Wang, F., Liu, H. Y., and Han, R. Anti-angiogenic activity of resveratrol, a natural compound from medicinal plants. J Asian Nat Prod.Res 2005;7(3):205-213. View abstract.

70956            Zhou, H. B., Chen, J. J., Wang, W. X., Cai, J. T., and Du, Q. Anticancer activity of resveratrol on implanted human primary gastric carcinoma cells in nude mice. World J.Gastroenterol. 1-14-2005;11(2):280-284. View abstract.

70957            Baatout, S., Derradji, H., Jacquet, P., and Mergeay, M. Increased radiation sensitivity of an eosinophilic cell line following treatment with epigallocatechin-gallate, resveratrol and curcuma. Int.J Mol.Med. 2005;15(2):337-352. View abstract.

70958            Kaeberlein, M., McDonagh, T., Heltweg, B., Hixon, J., Westman, E. A., Caldwell, S. D., Napper, A., Curtis, R., DiStefano, P. S., Fields, S., Bedalov, A., and Kennedy, B. K. Substrate-specific activation of sirtuins by resveratrol. J Biol.Chem 4-29-2005;280(17):17038-17045. View abstract.

70959            Henry, C., Vitrac, X., Decendit, A., Ennamany, R., Krisa, S., and Merillon, J. M. Cellular uptake and efflux of trans-piceid and its aglycone trans-resveratrol on the apical membrane of human intestinal Caco-2 cells. J Agric.Food Chem 2-9-2005;53(3):798-803. View abstract.

70960            Pozo-Guisado, E., Merino, J. M., Mulero-Navarro, S., Lorenzo-Benayas, M. J., Centeno, F., Alvarez-Barrientos, A., and Fernandez-Salguero, P. M. Resveratrol-induced apoptosis in MCF-7 human breast cancer cells involves a caspase-independent mechanism with downregulation of Bcl-2 and NF-kappaB. Int J Cancer 5-20-2005;115(1):74-84. View abstract.

70961            Provinciali, M., Re, F., Donnini, A., Orlando, F., Bartozzi, B., Di Stasio, G., and Smorlesi, A. Effect of resveratrol on the development of spontaneous mammary tumors in HER-2/neu transgenic mice. Int.J Cancer 5-20-2005;115(1):36-45. View abstract.

70962            Belleri, M., Ribatti, D., Nicoli, S., Cotelli, F., Forti, L., Vannini, V., Stivala, L. A., and Presta, M. Antiangiogenic and vascular-targeting activity of the microtubule-destabilizing trans-resveratrol derivative 3,5,4′-trimethoxystilbene. Mol.Pharmacol 2005;67(5):1451-1459. View abstract.

70963            Molnar, V. and Garai, J. Plant-derived anti-inflammatory compounds affect MIF tautomerase activity. Int.Immunopharmacol. 2005;5(5):849-856. View abstract.

70964            Monthakantirat, O., De Eknamkul, W., Umehara, K., Yoshinaga, Y., Miyase, T., Warashina, T., and Noguchi, H. Phenolic constituents of the rhizomes of the Thai medicinal plant Belamcanda chinensis with proliferative activity for two breast cancer cell lines. J Nat Prod. 2005;68(3):361-364. View abstract.

70965            Azios, N. G. and Dharmawardhane, S. F. Resveratrol and estradiol exert disparate effects on cell migration, cell surface actin structures, and focal adhesion assembly in MDA-MB-231 human breast cancer cells. Neoplasia. 2005;7(2):128-140. View abstract.

70966            Galfi, P., Jakus, J., Molnar, T., Neogrady, S., and Csordas, A. Divergent effects of resveratrol, a polyphenolic phytostilbene, on free radical levels and type of cell death induced by the histone deacetylase inhibitors butyrate and trichostatin A. J Steroid Biochem.Mol.Biol. 2005;94(1-3):39-47. View abstract.

70967            Poolman, T. M., Ng, L. L., Farmer, P. B., and Manson, M. M. Inhibition of the respiratory burst by resveratrol in human monocytes: correlation with inhibition of PI3K signaling. Free Radic.Biol.Med. 7-1-2005;39(1):118-132. View abstract.

70968            Ma, Z. H. and Ma, Q. Y. Resveratrol: a medical drug for acute pancreatitis. World J Gastroenterol. 6-7-2005;11(21):3171-3174. View abstract.

70969            Hougee, S., Faber, J., Sanders, A., de Jong, R. B., van den Berg, W. B., Garssen, J., Hoijer, M. A., and Smit, H. F. Selective COX-2 inhibition by a Pterocarpus marsupium extract characterized by pterostilbene, and its activity in healthy human volunteers. Planta Med 2005;71(5):387-392. View abstract.

70970            Deby-Dupont, G., Mouithys-Mickalad, A., Serteyn, D., Lamy, M., and Deby, C. Resveratrol and curcumin reduce the respiratory burst of Chlamydia-primed THP-1 cells. Biochem.Biophys.Res Commun. 7-22-2005;333(1):21-27. View abstract.

70971            Jung, H. J., Hwang, I. A., Sung, W. S., Kang, H., Kang, B. S., Seu, Y. B., and Lee, D. G. Fungicidal effect of resveratrol on human infectious fungi. Arch Pharm Res 2005;28(5):557-560. View abstract.

70972            Ishii, Y., Ishida, T., Mutoh, J., Yamada, H., and Oguri, K. [Possible candidates for the compound which is expected to attenuate dioxin toxicity]. Fukuoka Igaku Zasshi 2005;96(5):204-213. View abstract.

70973            Rakici, O., Kiziltepe, U., Coskun, B., Aslamaci, S., and Akar, F. Effects of resveratrol on vascular tone and endothelial function of human saphenous vein and internal mammary artery. Int.J Cardiol 11-2-2005;105(2):209-215. View abstract.

70974            Cruz, M. N., Luksha, L., Logman, H., Poston, L., Agewall, S., and Kublickiene, K. Acute responses to phytoestrogens in small arteries from men with coronary heart disease. Am J Physiol Heart Circ.Physiol 2006;290(5):H1969-H1975. View abstract.

70975            Valenzano, D. R., Terzibasi, E., Genade, T., Cattaneo, A., Domenici, L., and Cellerino, A. Resveratrol prolongs lifespan and retards the onset of age-related markers in a short-lived vertebrate. Curr Biol 2-7-2006;16(3):296-300. View abstract.

70976            Zamora-Ros, R., Urpi-Sarda, M., Lamuela-Raventos, R. M., Estruch, R., Vazquez-Agell, M., Serrano-Martinez, M., Jaeger, W., and Andres-Lacueva, C. Diagnostic performance of urinary resveratrol metabolites as a biomarker of moderate wine consumption. Clin.Chem. 2006;52(7):1373-1380. View abstract.

70977            Baur, J. A. and Sinclair, D. A. Therapeutic potential of resveratrol: the in vivo evidence. Nat Rev Drug Discov. 2006;5(6):493-506. View abstract.

70978            Fragopoulou, E., Nomikos, T., Karantonis, H. C., Apostolakis, C., Pliakis, E., Samiotaki, M., Panayotou, G., and Antonopoulou, S. Biological activity of acetylated phenolic compounds. J.Agric.Food Chem. 1-10-2007;55(1):80-89. View abstract.

70979            Gruber, J., Tang, S. Y., and Halliwell, B. Evidence for a trade-off between survival and fitness caused by resveratrol treatment of Caenorhabditis elegans. Ann N Y.Acad Sci 2007;1100:530-542. View abstract.

70980            Bass, T. M., Weinkove, D., Houthoofd, K., Gems, D., and Partridge, L. Effects of resveratrol on lifespan in Drosophila melanogaster and Caenorhabditis elegans. Mech.Ageing Dev 2007;128(10):546-552. View abstract.

70981            Das, S. and Das, D. K. Anti-inflammatory responses of resveratrol. Inflamm.Allergy Drug Targets. 2007;6(3):168-173. View abstract.

70982            Nicholson, S. K., Tucker, G. A., and Brameld, J. M. Effects of dietary polyphenols on gene expression in human vascular endothelial cells. Proc.Nutr.Soc 2008;67(1):42-47. View abstract.

70983            Yu, H. P., Hsu, J. C., Hwang, T. L., Yen, C. H., and Lau, Y. T. Resveratrol attenuates hepatic injury after trauma-hemorrhage via estrogen receptor-related pathway. Shock 2008;30(3):324-328. View abstract.

70984            Chen, C. Y. and Blumberg, J. B. Phytochemical composition of nuts. Asia Pac.J Clin.Nutr. 2008;17 Suppl 1:329-332. View abstract.

70985            Biswas, S. and Rahman, I. Modulation of steroid activity in chronic inflammation: a novel anti-inflammatory role for curcumin. Mol.Nutr.Food Res 2008;52(9):987-994. View abstract.

70986            Elliott, P. J. and Jirousek, M. Sirtuins: novel targets for metabolic disease. Curr.Opin.Investig.Drugs 2008;9(4):371-378. View abstract.

70987            Rossi, L., Mazzitelli, S., Arciello, M., Capo, C. R., and Rotilio, G. Benefits from dietary polyphenols for brain aging and Alzheimer’s disease. Neurochem.Res 2008;33(12):2390-2400. View abstract.

70988            Guarente, L. Sirtuins in aging and disease. Cold Spring Harb.Symp.Quant.Biol. 2007;72:483-488. View abstract.

70989            Pirola, L. and Frojdo, S. Resveratrol: one molecule, many targets. IUBMB.Life 2008;60(5):323-332. View abstract.

70990            Deng, J. Y., Hsieh, P. S., Huang, J. P., Lu, L. S., and Hung, L. M. Activation of estrogen receptor is crucial for resveratrol-stimulating muscular glucose uptake via both insulin-dependent and -independent pathways. Diabetes 2008;57(7):1814-1823. View abstract.

70991            Zheng, G. H. and Li, H. Q. [Effects of garlic oil combined with resveratrol on inducting of apoptosis and expression of Fas, bcl-2 and bax in human gastric cancer cell line]. Zhonghua Yu Fang Yi.Xue.Za Zhi. 2008;42(1):39-42. View abstract.

70992            Raval, A. P., Lin, H. W., Dave, K. R., Defazio, R. A., Della, Morte D., Kim, E. J., and Perez-Pinzon, M. A. Resveratrol and ischemic preconditioning in the brain. Curr.Med Chem. 2008;15(15):1545-1551. View abstract.

70993            Liu, L., Wang, Y., Lam, K. S., and Xu, A. Moderate wine consumption in the prevention of metabolic syndrome and its related medical complications. Endocr.Metab Immune.Disord Drug Targets. 2008;8(2):89-98. View abstract.

70994            Kundu, J. K. and Surh, Y. J. Cancer chemopreventive and therapeutic potential of resveratrol: mechanistic perspectives. Cancer Lett. 10-8-2008;269(2):243-261. View abstract.

70995            Venkatesan, B., Ghosh-Choudhury, N., Das, F., Mahimainathan, L., Kamat, A., Kasinath, B. S., Abboud, H. E., and Choudhury, G. G. Resveratrol inhibits PDGF receptor mitogenic signaling in mesangial cells: role of PTP1B. FASEB J 2008;22(10):3469-3482. View abstract.

70996            Dong, W., Li, N., Gao, D., Zhen, H., Zhang, X., and Li, F. Resveratrol attenuates ischemic brain damage in the delayed phase after stroke and induces messenger RNA and protein express for angiogenic factors. J Vasc.Surg. 2008;48(3):709-714. View abstract.

70997            Jiang, W. J. Sirtuins: novel targets for metabolic disease in drug development. Biochem.Biophys.Res Commun. 8-29-2008;373(3):341-344. View abstract.

70997            Jiang, W. J. Sirtuins: novel targets for metabolic disease in drug development. Biochem.Biophys.Res Commun. 8-29-2008;373(3):341-344. View abstract.

70998            Pearson, K. J., Baur, J. A., Lewis, K. N., Peshkin, L., Price, N. L., Labinskyy, N., Swindell, W. R., Kamara, D., Minor, R. K., Perez, E., Jamieson, H. A., Zhang, Y., Dunn, S. R., Sharma, K., Pleshko, N., Woollett, L. A., Csiszar, A., Ikeno, Y., Le Couteur, D., Elliott, P. J., Becker, K. G., Navas, P., Ingram, D. K., Wolf, N. S., Ungvari, Z., Sinclair, D. A., and de Cabo, R. Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. Cell Metab 2008;8(2):157-168. View abstract.

70999            Singletary, K. and Milner, J. Diet, autophagy, and cancer: a review. Cancer Epidemiol.Biomarkers Prev. 2008;17(7):1596-1610. View abstract.

71000            Calabrese, V., Cornelius, C., Mancuso, C., Pennisi, G., Calafato, S., Bellia, F., Bates, T. E., Giuffrida Stella, A. M., Schapira, T., Dinkova Kostova, A. T., and Rizzarelli, E. Cellular stress response: a novel target for chemoprevention and nutritional neuroprotection in aging, neurodegenerative disorders and longevity. Neurochem.Res 2008;33(12):2444-2471. View abstract.

71001            Fan, E., Jiang, S., Zhang, L., and Bai, Y. Molecular mechanism of apoptosis induction by resveratrol, a natural cancer chemopreventive agent. Int.J Vitam.Nutr.Res 2008;78(1):3-8. View abstract.

71002            Roupe, K. A., Remsberg, C. M., Yanez, J. A., and Davies, N. M. Pharmacometrics of stilbenes: seguing towards the clinic. Curr.Clin.Pharmacol. 2006;1(1):81-101. View abstract.

71003            Udenigwe, C. C., Ramprasath, V. R., Aluko, R. E., and Jones, P. J. Potential of resveratrol in anticancer and anti-inflammatory therapy. Nutr.Rev. 2008;66(8):445-454. View abstract.

71004            Rocha-Gonzalez, H. I., Ambriz-Tututi, M., and Granados-Soto, V. Resveratrol: a natural compound with pharmacological potential in neurodegenerative diseases. CNS.Neurosci.Ther 2008;14(3):234-247. View abstract.

71005            Orallo, F. Trans-resveratrol: a magical elixir of eternal youth? Curr.Med Chem. 2008;15(19):1887-1898. View abstract.

71006            Gresele, P., Pignatelli, P., Guglielmini, G., Carnevale, R., Mezzasoma, A. M., Ghiselli, A., Momi, S., and Violi, F. Resveratrol, at concentrations attainable with moderate wine consumption, stimulates human platelet nitric oxide production. J Nutr. 2008;138(9):1602-1608. View abstract.

71007            Kris-Etherton, P. M., Hu, F. B., Ros, E., and Sabate, J. The role of tree nuts and peanuts in the prevention of coronary heart disease: multiple potential mechanisms. J Nutr. 2008;138(9):1746S-1751S. View abstract.

71008            Dudley, J. I., Lekli, I., Mukherjee, S., Das, M., Bertelli, A. A., and Das, D. K. Does white wine qualify for French paradox? Comparison of the cardioprotective effects of red and white wines and their constituents: resveratrol, tyrosol, and hydroxytyrosol. J Agric.Food Chem. 10-22-2008;56(20):9362-9373. View abstract.

71009            Knutson, M. D. and Leeuwenburgh, C. Resveratrol and novel potent activators of SIRT1: effects on aging and age-related diseases. Nutr.Rev. 2008;66(10):591-596. View abstract.

71010            Rimando, A. M. and Suh, N. Biological/chemopreventive activity of stilbenes and their effect on colon cancer. Planta Med 2008;74(13):1635-1643. View abstract.

71011            Askanas, V. and Engel, W. K. Inclusion-body myositis: muscle-fiber molecular pathology and possible pathogenic significance of its similarity to Alzheimer’s and Parkinson’s disease brains. Acta Neuropathol. 2008;116(6):583-595. View abstract.

71012            Vaz-da-Silva, M., Loureiro, A. I., Falcao, A., Nunes, T., Rocha, J. F., Fernandes-Lopes, C., Soares, E., Wright, L., Almeida, L., and Soares-da-Silva, P. Effect of food on the pharmacokinetic profile of trans-resveratrol. Int.J Clin.Pharmacol.Ther 2008;46(11):564-570. View abstract.

71013            Li, X., Phillips, F. M., An, H. S., Ellman, M., Thonar, E. J., Wu, W., Park, D., and Im, H. J. The action of resveratrol, a phytoestrogen found in grapes, on the intervertebral disc. Spine (Phila Pa 1976.) 11-15-2008;33(24):2586-2595. View abstract.

71014            Valderrama, X., Rapin, N., and Misra, V. Zhangfei, a novel regulator of the human nerve growth factor receptor, trkA. J Neurovirol. 2008;14(5):425-436. View abstract.

71015            Fan, E., Zhang, L., Jiang, S., and Bai, Y. Beneficial effects of resveratrol on atherosclerosis. J Med Food 2008;11(4):610-614. View abstract.

71016            Vingtdeux, V., Dreses-Werringloer, U., Zhao, H., Davies, P., and Marambaud, P. Therapeutic potential of resveratrol in Alzheimer’s disease. BMC.Neurosci. 2008;9 Suppl 2:S6. View abstract.

71017            Almeida, L., Vaz-da-Silva, M., Falcao, A., Soares, E., Costa, R., Loureiro, A. I., Fernandes-Lopes, C., Rocha, J. F., Nunes, T., Wright, L., and Soares-da-Silva, P. Pharmacokinetic and safety profile of trans-resveratrol in a rising multiple-dose study in healthy volunteers. Mol.Nutr.Food Res 2009;53 Suppl 1:S7-15. View abstract.

71018            Mainardi, T., Kapoor, S., and Bielory, L. Complementary and alternative medicine: herbs, phytochemicals and vitamins and their immunologic effects. J Allergy Clin.Immunol. 2009;123(2):283-294. View abstract.

71019            Bastianetto, S., Dumont, Y., Han, Y., and Quirion, R. Comparative neuroprotective properties of stilbene and catechin analogs: action via a plasma membrane receptor site? CNS.Neurosci.Ther 2009;15(1):76-83. View abstract.

71020            Dolinsky, V. W., Chan, A. Y., Robillard, Frayne, I, Light, P. E., Des, Rosiers C., and Dyck, J. R. Resveratrol prevents the prohypertrophic effects of oxidative stress on LKB1. Circulation 3-31-2009;119(12):1643-1652. View abstract.

71021            Woodall, C. E., Li, Y., Liu, Q. H., Wo, J., and Martin, R. C. Chemoprevention of metaplasia initiation and carcinogenic progression to esophageal adenocarcinoma by resveratrol supplementation. Anticancer Drugs 2009;20(6):437-443. View abstract.

71022            Bournival, J., Quessy, P., and Martinoli, M. G. Protective effects of resveratrol and quercetin against MPP+ -induced oxidative stress act by modulating markers of apoptotic death in dopaminergic neurons. Cell Mol.Neurobiol. 2009;29(8):1169-1180. View abstract.

71023            Zhang, H., Zhang, J., Ungvari, Z., and Zhang, C. Resveratrol improves endothelial function: role of TNF{alpha} and vascular oxidative stress. Arterioscler.Thromb.Vasc.Biol. 2009;29(8):1164-1171. View abstract.

71024            Ranney, A. and Petro, M. S. Resveratrol protects spatial learning in middle-aged C57BL/6 mice from effects of ethanol. Behav.Pharmacol. 2009;20(4):330-336. View abstract.

71025            Csiszar, A., Labinskyy, N., Olson, S., Pinto, J. T., Gupte, S., Wu, J. M., Hu, F., Ballabh, P., Podlutsky, A., Losonczy, G., de, Cabo R., Mathew, R., Wolin, M. S., and Ungvari, Z. Resveratrol prevents monocrotaline-induced pulmonary hypertension in rats. Hypertension 2009;54(3):668-675. View abstract.

71026            Jha, R. K., Ma, Q., Sha, H., and Palikhe, M. Protective effect of resveratrol in severe acute pancreatitis-induced brain injury. Pancreas 2009;38(8):947-953. View abstract.

71027            Ramadori, G., Gautron, L., Fujikawa, T., Vianna, C. R., Elmquist, J. K., and Coppari, R. Central administration of resveratrol improves diet-induced diabetes. Endocrinology 2009;150(12):5326-5333. View abstract.

71028            Um, J. H., Park, S. J., Kang, H., Yang, S., Foretz, M., McBurney, M. W., Kim, M. K., Viollet, B., and Chung, J. H. AMP-activated protein kinase-deficient mice are resistant to the metabolic effects of resveratrol. Diabetes 2010;59(3):554-563. View abstract.

71029            Gagliano, N., Aldini, G., Colombo, G., Rossi, R., Colombo, R., Gioia, M., Milzani, A., and Dalle-Donne, I. The potential of resveratrol against human gliomas. Anticancer Drugs 2010;21(2):140-150. View abstract.

71030            Kim, J., Lee, H. J., and Lee, K. W. Naturally occurring phytochemicals for the prevention of Alzheimer’s disease. J Neurochem. 2010;112(6):1415-1430. View abstract.

71031            Guo, J. P., Yu, S., and McGeer, P. L. Simple in vitro assays to identify amyloid-beta aggregation blockers for Alzheimer’s disease therapy. J Alzheimers.Dis. 2010;19(4):1359-1370. View abstract.

71032            Albani, D., Polito, L., and Forloni, G. Sirtuins as novel targets for Alzheimer’s disease and other neurodegenerative disorders: experimental and genetic evidence. J Alzheimers.Dis 2010;19(1):11-26. View abstract.

71033            Yu, H. P., Hwang, T. L., Hwang, T. L., Yen, C. H., and Lau, Y. T. Resveratrol prevents endothelial dysfunction and aortic superoxide production after trauma hemorrhage through estrogen receptor-dependent hemeoxygenase-1 pathway. Crit Care Med 2010;38(4):1147-1154. View abstract.

71034            Huang, P. H., Chen, Y. H., Tsai, H. Y., Chen, J. S., Wu, T. C., Lin, F. Y., Sata, M., Chen, J. W., and Lin, S. J. Intake of red wine increases the number and functional capacity of circulating endothelial progenitor cells by enhancing nitric oxide bioavailability. Arterioscler.Thromb.Vasc.Biol. 2010;30(4):869-877. View abstract.

71035            Fullerton, M. D. and Steinberg, G. R. SIRT1 takes a backseat to AMPK in the regulation of insulin sensitivity by resveratrol. Diabetes 2010;59(3):551-553. View abstract.

71036            Das, D. K., Mukherjee, S., and Ray, D. Resveratrol and red wine, healthy heart and longevity. Heart Fail.Rev. 2010;15(5):467-477. View abstract.

71037            Sun, A. Y., Wang, Q., Simonyi, A., and Sun, G. Y. Resveratrol as a therapeutic agent for neurodegenerative diseases. Mol.Neurobiol. 2010;41(2-3):375-383. View abstract.

71038            Daffner, K. R. Promoting successful cognitive aging: a comprehensive review. J Alzheimers.Dis 2010;19(4):1101-1122. View abstract.

71039            Kennedy, D. O., Wightman, E. L., Reay, J. L., Lietz, G., Okello, E. J., Wilde, A., and Haskell, C. F. Effects of resveratrol on cerebral blood flow variables and cognitive performance in humans: a double-blind, placebo-controlled, crossover investigation. Am J Clin.Nutr. 2010;91(6):1590-1597. View abstract.

71040            Le Couteur, D. G. and Sinclair, D. A. A blueprint for developing therapeutic approaches that increase healthspan and delay death. J Gerontol.A Biol.Sci.Med Sci. 2010;65(7):693-694. View abstract.

71041            Guha, P., Dey, A., Dhyani, M. V., Sen, R., Chatterjee, M., Chattopadhyay, S., and Bandyopadhyay, S. K. Calpain and caspase orchestrated death signal to accomplish apoptosis induced by resveratrol and its novel analog hydroxystilbene-1 [correction of hydroxstilbene-1] in cancer cells. J Pharmacol.Exp.Ther 2010;334(2):381-394. View abstract.

71042            la, Porte C., Voduc, N., Zhang, G., Seguin, I., Tardiff, D., Singhal, N., and Cameron, D. W. Steady-State pharmacokinetics and tolerability of trans-resveratrol 2000 mg twice daily with food, quercetin and alcohol (ethanol) in healthy human subjects. Clin.Pharmacokinet. 2010;49(7):449-454. View abstract.

71043            Ghanim, H., Sia, C. L., Abuaysheh, S., Korzeniewski, K., Patnaik, P., Marumganti, A., Chaudhuri, A., and Dandona, P. An antiinflammatory and reactive oxygen species suppressive effects of an extract of Polygonum cuspidatum containing resveratrol. J Clin.Endocrinol.Metab 2010;95(9):E1-E8. View abstract.

71044            Dubey, R. K., Jackson, E. K., Gillespie, D. G., Zacharia, L. C., Imthurn, B., and Rosselli, M. Resveratrol, a red wine constituent, blocks the antimitogenic effects of estradiol on human female coronary artery smooth muscle cells. J Clin.Endocrinol.Metab 2010;95(9):E9-17. View abstract.

71045            Wong, R. H., Howe, P. R., Buckley, J. D., Coates, A. M., Kunz, I., and Berry, N. M. Acute resveratrol supplementation improves flow-mediated dilatation in overweight/obese individuals with mildly elevated blood pressure. Nutr.Metab Cardiovasc.Dis 2011;21(11):851-856. View abstract.

71046            Perdew, G. H., Hollingshead, B. D., Dinatale, B. C., Morales, J. L., Labrecque, M. P., Takhar, M. K., Tam, K. J., and Beischlag, T. V. Estrogen receptor expression is required for low-dose resveratrol-mediated repression of aryl hydrocarbon receptor activity. J Pharmacol.Exp.Ther 2010;335(2):273-283. View abstract.

71047            Chow, H. H., Garland, L. L., Hsu, C. H., Vining, D. R., Chew, W. M., Miller, J. A., Perloff, M., Crowell, J. A., and Alberts, D. S. Resveratrol modulates drug- and carcinogen-metabolizing enzymes in a healthy volunteer study. Cancer Prev.Res (Phila) 2010;3(9):1168-1175. View abstract.

71048            Knobloch, J., Sibbing, B., Jungck, D., Lin, Y., Urban, K., Stoelben, E., Strauch, J., and Koch, A. Resveratrol impairs the release of steroid-resistant inflammatory cytokines from human airway smooth muscle cells in chronic obstructive pulmonary disease. J Pharmacol.Exp.Ther 2010;335(3):788-798. View abstract.

71049            Robich, M. P., Osipov, R. M., Nezafat, R., Feng, J., Clements, R. T., Bianchi, C., Boodhwani, M., Coady, M. A., Laham, R. J., and Sellke, F. W. Resveratrol improves myocardial perfusion in a swine model of hypercholesterolemia and chronic myocardial ischemia. Circulation 9-14-2010;122(11 Suppl):S142-S149. View abstract.

71050            Patel, K. R., Brown, V. A., Jones, D. J., Britton, R. G., Hemingway, D., Miller, A. S., West, K. P., Booth, T. D., Perloff, M., Crowell, J. A., Brenner, D. E., Steward, W. P., Gescher, A. J., and Brown, K. Clinical pharmacology of resveratrol and its metabolites in colorectal cancer patients. Cancer Res 10-1-2010;70(19):7392-7399. View abstract.

71051            Guha, P., Dey, A., Sen, R., Chatterjee, M., Chattopadhyay, S., and Bandyopadhyay, S. K. Intracellular GSH depletion triggered mitochondrial Bax translocation to accomplish resveratrol-induced apoptosis in the U937 cell line. J Pharmacol.Exp.Ther 2011;336(1):206-214. View abstract.

71052            Brown, V. A., Patel, K. R., Viskaduraki, M., Crowell, J. A., Perloff, M., Booth, T. D., Vasilinin, G., Sen, A., Schinas, A. M., Piccirilli, G., Brown, K., Steward, W. P., Gescher, A. J., and Brenner, D. E. Repeat dose study of the cancer chemopreventive agent resveratrol in healthy volunteers: safety, pharmacokinetics, and effect on the insulin-like growth factor axis. Cancer Res 11-15-2010;70(22):9003-9011. View abstract.

71053            Xiang, H., Dai, K., Luo, Q., Duan, W., and Xie, Y. A sensitive resveratrol assay with a simple probe methylene blue by resonance light scattering technique. Spectrochim.Acta A Mol.Biomol.Spectrosc. 2011;78(1):307-312. View abstract.

71054            Seo, J. S., Moon, M. H., Jeong, J. K., Seol, J. W., Lee, Y. J., Park, B. H., and Park, S. Y. SIRT1, a histone deacetylase, regulates prion protein-induced neuronal cell death. Neurobiol.Aging 2012;33(6):1110-1120. View abstract.

71055            Shindler, K. S., Ventura, E., Dutt, M., Elliott, P., Fitzgerald, D. C., and Rostami, A. Oral resveratrol reduces neuronal damage in a model of multiple sclerosis. J Neuroophthalmol. 2010;30(4):328-339. View abstract.

71056            Das, D. K. Commentary on ‘resveratrol commonly displays hormesis: occurrence and biomedical significance’ by Calabrese et al. Hum.Exp.Toxicol. 2010;29(12):1016-1017. View abstract.

71057            Busanello, A., Barbosa, N. B., Peroza, L. R., Farias, L. E., Burger, M. E., Barreto, K. P., and Fachinetto, R. Resveratrol protects against a model of vacuous chewing movements induced by reserpine in mice. Behav.Pharmacol. 2011;22(1):71-75. View abstract.

71058            Yu, H. P., Hwang, T. L., Hsieh, P. W., and Lau, Y. T. Role of estrogen receptor-dependent upregulation of P38 MAPK/heme oxygenase 1 in resveratrol-mediated attenuation of intestinal injury after trauma-hemorrhage. Shock 2011;35(5):517-523. View abstract.

71059            Hsu, M. H., Savas, U., Lasker, J. M., and Johnson, E. F. Genistein, resveratrol, and 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside induce cytochrome P450 4F2 expression through an AMP-activated protein kinase-dependent pathway. J Pharmacol.Exp.Ther 2011;337(1):125-136. View abstract.

71060            Petrovski, G., Gurusamy, N., and Das, D. K. Resveratrol in cardiovascular health and disease. Ann.N.Y.Acad.Sci. 2011;1215:22-33. View abstract.

71061            Mukhopadhyay, P., Pacher, P., and Das, D. K. MicroRNA signatures of resveratrol in the ischemic heart. Ann.N.Y.Acad.Sci. 2011;1215:109-116. View abstract.

71062            Kitada, M., Kume, S., Imaizumi, N., and Koya, D. Resveratrol improves oxidative stress and protects against diabetic nephropathy through normalization of Mn-SOD dysfunction in AMPK/SIRT1-independent pathway. Diabetes 2011;60(2):634-643. View abstract.

71063            Ghanim, H., Sia, C. L., Korzeniewski, K., Lohano, T., Abuaysheh, S., Marumganti, A., Chaudhuri, A., and Dandona, P. A resveratrol and polyphenol preparation suppresses oxidative and inflammatory stress response to a high-fat, high-carbohydrate meal. J Clin.Endocrinol.Metab 2011;96(5):1409-1414. View abstract.

71064            Fabbrocini, G., Staibano, S., De, Rosa G., Battimiello, V., Fardella, N., Ilardi, G., La Rotonda, M. I., Longobardi, A., Mazzella, M., Siano, M., Pastore, F., De, Vita, V, Vecchione, M. L., and Ayala, F. Resveratrol-containing gel for the treatment of acne vulgaris: a single-blind, vehicle-controlled, pilot study. Am J Clin.Dermatol 4-1-2011;12(2):133-141. View abstract.

71065            Ungvari, Z., Sonntag, W. E., de, Cabo R., Baur, J. A., and Csiszar, A. Mitochondrial protection by resveratrol. Exerc.Sport Sci.Rev. 2011;39(3):128-132. View abstract.

71066            Brasnyo, P., Molnar, G. A., Mohas, M., Marko, L., Laczy, B., Cseh, J., Mikolas, E., Szijarto, I. A., Merei, A., Halmai, R., Meszaros, L. G., Sumegi, B., and Wittmann, I. Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients. Br J Nutr. 2011;106(3):383-389. View abstract.

71067            Das, D. K., Mukherjee, S., and Ray, D. Erratum to: resveratrol and red wine, healthy heart and longevity. Heart Fail.Rev. 2011;16(4):425-435. View abstract.

71068            Bhattacharya, S., Darjatmoko, S. R., and Polans, A. S. Resveratrol modulates the malignant properties of cutaneous melanoma through changes in the activation and attenuation of the antiapoptotic protooncogenic protein Akt/PKB. Melanoma Res 2011;21(3):180-187. View abstract.

71069            Kaneko, H., Anzai, T., Morisawa, M., Kohno, T., Nagai, T., Anzai, A., Takahashi, T., Shimoda, M., Sasaki, A., Maekawa, Y., Yoshimura, K., Aoki, H., Tsubota, K., Yoshikawa, T., Okada, Y., Ogawa, S., and Fukuda, K. Resveratrol prevents the development of abdominal aortic aneurysm through attenuation of inflammation, oxidative stress, and neovascularization. Atherosclerosis 2011;217(2):350-357. View abstract.

71070            Wuertz, K., Quero, L., Sekiguchi, M., Klawitter, M., Nerlich, A., Konno, S., Kikuchi, S., and Boos, N. The red wine polyphenol resveratrol shows promising potential for the treatment of nucleus pulposus-mediated pain in vitro and in vivo. Spine (Phila Pa 1976.) 10-1-2011;36(21):E1373-E1384. View abstract.

71071            Bastianetto, S., Krantic, S., Chabot, J. G., and Quirion, R. Possible involvement of programmed cell death pathways in the neuroprotective action of polyphenols. Curr.Alzheimer Res 2011;8(5):445-451. View abstract.

71072            Santos, A. C., Veiga, F., and Ribeiro, A. J. New delivery systems to improve the bioavailability of resveratrol. Expert.Opin.Drug Deliv. 2011;8(8):973-990. View abstract.

71073            Howells, L. M., Berry, D. P., Elliott, P. J., Jacobson, E. W., Hoffmann, E., Hegarty, B., Brown, K., Steward, W. P., and Gescher, A. J. Phase I randomized, double-blind pilot study of micronized resveratrol (SRT501) in patients with hepatic metastases–safety, pharmacokinetics, and pharmacodynamics. Cancer Prev.Res (Phila) 2011;4(9):1419-1425. View abstract.

71074            Snyder, S. A., Gollner, A., and Chiriac, M. I. Regioselective reactions for programmable resveratrol oligomer synthesis. Nature 6-23-2011;474(7352):461-466. View abstract.

71075            Vang, O., Ahmad, N., Baile, C. A., Baur, J. A., Brown, K., Csiszar, A., Das, D. K., Delmas, D., Gottfried, C., Lin, H. Y., Ma, Q. Y., Mukhopadhyay, P., Nalini, N., Pezzuto, J. M., Richard, T., Shukla, Y., Surh, Y. J., Szekeres, T., Szkudelski, T., Walle, T., and Wu, J. M. What is new for an old molecule? Systematic review and recommendations on the use of resveratrol. PLoS.One. 2011;6(6):e19881. View abstract.

71076            Burgess, T. A., Robich, M. P., Chu, L. M., Bianchi, C., and Sellke, F. W. Improving glucose metabolism with resveratrol in a swine model of metabolic syndrome through alteration of signaling pathways in the liver and skeletal muscle. Arch.Surg. 2011;146(5):556-564. View abstract.

71077            Stefanska, B., Salame, P., Bednarek, A., and Fabianowska-Majewska, K. Comparative effects of retinoic acid, vitamin D and resveratrol alone and in combination with adenosine analogues on methylation and expression of phosphatase and tensin homologue tumour suppressor gene in breast cancer cells. Br.J.Nutr. 2012;107(6):781-790. View abstract.

71078            Dolinsky, V. W., Rueda-Clausen, C. F., Morton, J. S., Davidge, S. T., and Dyck, J. R. Continued postnatal administration of resveratrol prevents diet-induced metabolic syndrome in rat offspring born growth restricted. Diabetes 2011;60(9):2274-2284. View abstract.

71079            Das, J., Pany, S., and Majhi, A. Chemical modifications of resveratrol for improved protein kinase C alpha activity. Bioorg.Med Chem. 9-15-2011;19(18):5321-5333. View abstract.

71080            Knight, C. M., Gutierrez-Juarez, R., Lam, T. K., Arrieta-Cruz, I., Huang, L., Schwartz, G., Barzilai, N., and Rossetti, L. Mediobasal hypothalamic SIRT1 is essential for resveratrol’s effects on insulin action in rats. Diabetes 2011;60(11):2691-2700. View abstract.

71081            Xuzhu, G., Komai-Koma, M., Leung, B. P., Howe, H. S., McSharry, C., McInnes, I. B., and Xu, D. Resveratrol modulates murine collagen-induced arthritis by inhibiting Th17 and B-cell function. Ann.Rheum.Dis 2012;71(1):129-135. View abstract.

71082            Yanez, M., Galan, L., Matias-Guiu, J., Vela, A., Guerrero, A., and Garcia, A. G. CSF from amyotrophic lateral sclerosis patients produces glutamate independent death of rat motor brain cortical neurons: protection by resveratrol but not riluzole. Brain Res 11-14-2011;1423:77-86. View abstract.

71083            Di, Liberto, V, Makela, J., Korhonen, L., Olivieri, M., Tselykh, T., Malkia, A., Do, Thi H., Belluardo, N., Lindholm, D., and Mudo, G. Involvement of estrogen receptors in the resveratrol-mediated increase in dopamine transporter in human dopaminergic neurons and in striatum of female mice. Neuropharmacology 2012;62(2):1011-1018. View abstract.

71084            Kiskova, T., Ekmekcioglu, C., Garajova, M., Orendas, P., Bojkova, B., Bobrov, N., Jager, W., Kassayova, M., and Thalhammer, T. A combination of resveratrol and melatonin exerts chemopreventive effects in N-methyl-N-nitrosourea-induced rat mammary carcinogenesis. Eur.J Cancer Prev. 2012;21(2):163-170. View abstract.

71085            Timmers, S., Konings, E., Bilet, L., Houtkooper, R. H., van de Weijer, T., Goossens, G. H., Hoeks, J., van der Krieken, S., Ryu, D., Kersten, S., Moonen-Kornips, E., Hesselink, M. K., Kunz, I., Schrauwen-Hinderling, V. B., Blaak, E. E., Auwerx, J., and Schrauwen, P. Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans. Cell Metab 11-2-2011;14(5):612-622. View abstract.

71086            Fujitaka, K., Otani, H., Jo, F., Jo, H., Nomura, E., Iwasaki, M., Nishikawa, M., Iwasaka, T., and Das, D. K. Modified resveratrol Longevinex improves endothelial function in adults with metabolic syndrome receiving standard treatment. Nutr.Res 2011;31(11):842-847. View abstract.

71087            Lukiw, W. J. NF-small ka, CyrillicB-regulated micro RNAs (miRNAs) in primary human brain cells. Exp.Neurol. 2012;235(2):484-490. View abstract.

71088            Girbovan, C., Morin, L., and Plamondon, H. Repeated resveratrol administration confers lasting protection against neuronal damage but induces dose-related alterations of behavioral impairments after global ischemia. Behav.Pharmacol. 2012;23(1):1-13. View abstract.

71089            Wang, Z., Li, W., Meng, X., and Jia, B. Resveratrol induces gastric cancer cell apoptosis via reactive oxygen species, but independent of sirtuin1. Clin.Exp.Pharmacol.Physiol 2012;39(3):227-232. View abstract.

71090            Crandall, J. P., Oram, V., Trandafirescu, G., Reid, M., Kishore, P., Hawkins, M., Cohen, H. W., and Barzilai, N. Pilot study of resveratrol in older adults with impaired glucose tolerance. J.Gerontol.A Biol.Sci.Med.Sci. 2012;67(12):1307-1312. View abstract.

71091            Roehr, B. Cardiovascular researcher fabricated data in studies of red wine. BMJ 2012;344:e406. View abstract.

71092            Zhu, W., Qin, W., Zhang, K., Rottinghaus, G. E., Chen, Y. C., Kliethermes, B., and Sauter, E. R. Trans-resveratrol alters mammary promoter hypermethylation in women at increased risk for breast cancer. Nutr.Cancer 2012;64(3):393-400. View abstract.

71093            Aluyen, J. K., Ton, Q. N., Tran, T., Yang, A. E., Gottlieb, H. B., and Bellanger, R. A. Resveratrol: potential as anticancer agent. J.Diet.Suppl 2012;9(1):45-56. View abstract.

71094            Timmers, S., Auwerx, J., and Schrauwen, P. The journey of resveratrol from yeast to human. Aging (Albany.NY) 2012;4(3):146-158. View abstract.

71095            Zamora-Ros, R., Urpi-Sarda, M., Lamuela-Raventos, R. M., Martinez-Gonzalez, M. A., Salas-Salvado, J., Aros, F., Fito, M., Lapetra, J., Estruch, R., and Andres-Lacueva, C. High urinary levels of resveratrol metabolites are associated with a reduction in the prevalence of cardiovascular risk factors in high-risk patients. Pharmacol.Res. 2012;65(6):615-620. View abstract.

71096            Hector, K. L., Lagisz, M., and Nakagawa, S. The effect of resveratrol on longevity across species: a meta-analysis. Biol.Lett. 10-23-2012;8(5):790-793. View abstract.

71097            Bhatt, J. K., Thomas, S., and Nanjan, M. J. Resveratrol supplementation improves glycemic control in type 2 diabetes mellitus. Nutr.Res. 2012;32(7):537-541. View abstract.

71098            Cheung, T. M., Ganatra, M. P., Peters, E. B., and Truskey, G. A. Effect of cellular senescence on the albumin permeability of blood-derived endothelial cells. Am.J.Physiol Heart Circ.Physiol 12-1-2012;303(11):H1374-H1383. View abstract.

71099            Gronbaek, M., Deis, A., Sorensen, T. I., Becker, U., Schnohr, P., and Jensen, G. Mortality associated with moderate intakes of wine, beer, or spirits. BMJ 5-6-1995;310(6988):1165-1169. View abstract.

71100            Orsini, F., Pelizzoni, F., Verotta, L., Aburjai, T., and Rogers, C. B. Isolation, synthesis, and antiplatelet aggregation activity of resveratrol 3-O-beta-D-glucopyranoside and related compounds. J.Nat.Prod. 1997;60(11):1082-1087. View abstract.

71101            Fontecave, M., Lepoivre, M., Elleingand, E., Gerez, C., and Guittet, O. Resveratrol, a remarkable inhibitor of ribonucleotide reductase. FEBS Lett. 1-16-1998;421(3):277-279. View abstract.

71102            Mgbonyebi, O. P., Russo, J., and Russo, I. H. Antiproliferative effect of synthetic resveratrol on human breast epithelial cells. Int.J.Oncol. 1998;12(4):865-869. View abstract.

71103            Rotondo, S., Rajtar, G., Manarini, S., Celardo, A., Rotillo, D., de Gaetano, G., Evangelista, V., and Cerletti, C. Effect of trans-resveratrol, a natural polyphenolic compound, on human polymorphonuclear leukocyte function. Br.J.Pharmacol. 1998;123(8):1691-1699. View abstract.

71104            Subbaramaiah, K., Chung, W. J., Michaluart, P., Telang, N., Tanabe, T., Inoue, H., Jang, M., Pezzuto, J. M., and Dannenberg, A. J. Resveratrol inhibits cyclooxygenase-2 transcription and activity in phorbol ester-treated human mammary epithelial cells. J.Biol.Chem. 8-21-1998;273(34):21875-21882. View abstract.

71105            Ciolino, H. P., Daschner, P. J., and Yeh, G. C. Resveratrol inhibits transcription of CYP1A1 in vitro by preventing activation of the aryl hydrocarbon receptor. Cancer Res. 12-15-1998;58(24):5707-5712. View abstract.

71106            Pendurthi, U. R., Williams, J. T., and Rao, L. V. Resveratrol, a polyphenolic compound found in wine, inhibits tissue factor expression in vascular cells : A possible mechanism for the cardiovascular benefits associated with moderate consumption of wine. Arterioscler.Thromb.Vasc.Biol 1999;19(2):419-426. View abstract.

71107            Marques, L., Bargut, T., Pires, L., Lopes, G., Eleutherio, E., Donangelo, C., and Koury, J. Resveratrol Supplementation, Immunological Indices And Total Antioxidant Capacity In Athletes: 2089. Medicine & Science in Sports & Exercise 2009;41(5)

71108            Jackson, J., Ryan, M. J., and Hao, Y. Long-Term Resveratrol Supplementation Mediates Oxidative Stress, but not Sarcopenia Aged Mice: 2814. Medicine & Science in Sports & Exercise 2010;

71109            Grujic Milanovic, J., Mihailovic-Stanojevic, N., Miloradovic, Z., Jacevic, V., Milosavljevic, I., Milanovic, S., Ivanov, M., and Jovovic, D. J. RESVERATROL REDUCES BLOOD PRESSURE, CHANGES OF ANTIOXIDANT ENZYME ACTIVITY AND HISTOLOGICAL PARAMETERS IN EXPERIMENTAL MODEL OF MALIGNANT HYPERTENSION PP.29.171. Journal of Hypertension 2010;28

71110            Bost, J., Smoliga, J. M., Bost, K. M., and Maroon, J. C. Three Months Oral Supplementation of a Unique Polyphenol Mixture Improves Physical and Neurocognitive Performance Indicators in Sedentary Adults: 2205. Medicine & Science in Sports & Exercise 2008;40(5):S246.

71111            Steigerwald, M. D., Fisk, M. Z., Smoliga, J. M., and Rundell, K. W. Effects Of Resveratrol On Oxidative Stress And Vascular Function Following Exercise In Simulated Air Pollution: 2645. Medicine & Science in Sports & Exercise 2011;43(5)

71112            Pregliasco, F. and Cogo, R. [Antioxidant and immunomodulating compounds in older people undergoing seasonal influenza vaccination improve serological response and reduce tract respiratory episodes] L’uso di sostanze antiossidanti ed immunomodulanti in una popolazione anziana so. Cochrane Central Register of Controlled Trials 2010;

71113            Han, Y. N., Ryn, S. Y., and Han, B. H. Antioxidant activity of resveratrol closely correlated with its monoamine oxidase-A inhibitory activity. Arch.Pharmacol.Res. 1990;13:132.

71114            Seely, K. A. Cannabinoid receptor inverse agonists as novel therapeutic agents.” The Sciences and Engineering. The Sciences and Engineering 2009;70(4-B)

71115            Fukuhara, S., Okuda, H., Yamamoto, K., Nakayama, J., Takao, T., Miyagawa, Y., Tsujimura, A., Nonomura, N., and Okuyama, A. RESVERATROL, A POLYPHENOLIC SIRT1 ACTIVATOR, IMPROVES ERECTILE FUNCTION IN STREPTOZOTOCIN INDUCED DIABETIC RATS: 875. Journal of Urology 2010;

71116            Chung, H. R., Tomayko, E. J., Wu, P. T., Cachia, A. J., Cortez, F. T., and Wilund, K. R. Resveratrol and Exercise May Improve Kidney Disease Co-morbidities in a Model of Uremia. Medicine & Science in Sports & Exercise 2010;

71117            Sommer, S. P., Sommer, S., Sinha, B., Schafer, D., Otto, C., Aleksic, I., Mehdorn, A. S., and Leyh, R. Resveratrol Ameliorates Mitochondrial and Tissue Damage in Pulmonary Ischemia Reperfusion Injury. CHEST journal 2011;140(4):659A.

71118            Schreiber, L., McAnulty, S., McAnulty, L., Rowe, B., Hosick, P., Wrieden, J., Hudson, M., Quindry, J., Nieman, D., and Henson, D. Resveratrol and Catechin Administration Blunts Exercise-Induced Oxidative Stress and Cytokine IL-8: 1570. Medicine & Science in Sports & Exercise 2008;40(5):S246.

71119            Klink, J. C., Poulton, S., Antonelli, J., Potter, M. Q., Jayachandran, J., Tewari, A. K., Febbo, P. G., Pizzo, S. V., and Freedland, S. RESVERATROL ALTERS PROSTATE CANCER XENOGRAFT GROWTH: 724. Journal of Urology 2009;181(4)

71120            Yoon, S. J., Cho, K. S., Lee, Y. H., Kim, D. S., and Hong, S. J. RESVERATROL INHIBITS CXCR4 MEDIATED TUMOR GROWTH AND MIGRATION OF HUMAN KIDNEY CANCER CELL IN VITRO AND IN VIVO: 428. Journal of Urology 2009;181(4):153-154.

71121            Samuel, S. K., Kai, L., and Levenson, A. S. A NOVEL EPIGENETIC MECHANISM OF RESVERATROL: REVERSAL OF METASTASIS-ASSOCIATED PROTEIN 1-MEDIATED DEACETYLATION OF P53 IN PROSTATE CANCER: 1441. Journal of Urology 2009;181(4):515.

71122            Quero, L., Klawitter, M., Plewnia, A., Klasen, J., Boos, N., and Wuertz, K. NOVEL TREATMENT OPTIONS FOR DISCOGENIC BACK PAIN: THE RED WINE POLYPHENOL RESVERATROL INHIBITS EXPRESSION OF PROINFLAMMATORY CYTOKINES AND MATRIX DEGRADING ENZYMES IN INTERVERTEBRAL DISC CELLS: GP12. Spine: Affiliated Society Meeting Abstracts 2010;

71123            Gordon, B. S. Resveratrol’s Effect On Inflammation Associated With Muscle Degeneration/regeneration: A Dosage Trial: 1614. Medicine & Science in Sports & Exercise 2011;

71124            Kuno, A., Hori, Y., Tanno, M., Kouzu, H., Takahito, I., Daisuke, S., Yoshiyuki, H., and Tetsuji, M. Long-Term Treatment with the SIRT1 Activator Resveratrol Ameliorates Cardiomyopathy in Dystrophin-Deficient Mice. Circulation 2011;124

71125            Kanamori, H., Takemura, G., Goto, K., Maruyama, R., Tsujimoto, A., Ogino, A., Takeyama, T., Kawaguchi, T., Watanabe, T., Morishita, K., Fujiwara, T., Fujiwara, H., Seishima, M., and Minatoguchi, S. Resveratrol Brings About Reverse Remodeling In The Heart With A Large Old Myocardial Infarction Through Autophagy Activating amp Kinase Pathway. Circulation 2011;124

71126            Antonio, A. M. The protective effects of the antioxidant alpha-lipoic acid against ethanol-mediated toxicity in fetal rhombencephalic neurons. The Sciences and Engineering 2011;71(11-B)

71127            Jackson, J. R. Resveratrol Preserves Muscles Mass, Force Output And Mediates Oxidative Stress In Gastrocnemius Muscles From Hindlimb Suspended Rats: 972. Medicine & Science in Sports & Exercise 2009;41(5)

71128            Picchione, K. E. Understanding hyperexcitability of dorsal root ganglion neurons. The Sciences and Engineering 2011;72(4-B)

71129            Gersting, J. A. Prostaglandin endoperoxide synthase types 1 and 2: Ontogenetic expression and effects of inhibition on the basal and estrogen stimulated fetal ovine hypothalamus-pituitary adrenal axis. The Sciences and Engineering 2011;71(8-B)

71130            Guarnieri, R., Pappacoda, A., and Solitro, S. [A resveratrol containing compound reduces oxidative stress and ameliorates clinical symptoms in COPD subjects] Un composto a base di resveratrolo riduce lo stress ossidativo e migliora la sintomatologia clinica in soggetti con BPCO. Cochrane Central Register of Controlled Trials 2009;

71131            Hudson, G. M., Shelmadine, B., Cooke, M., Genovese, J., Greenwood, M., and Willoughby, D. S. Resveratrol Supplementation And Changes In Glucose, Insulin, And mRNA Expression Following Exercise In Overweight Females: 2467. Medicine & Science in Sports & Exercise 2011;43(5)

 

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35446            Zadok, D., Levy, Y., and Glovinsky, Y. The effect of anthocyanosides in a multiple oral dose on night vision. Eye (Lond) 1999;13 ( Pt 6):734-736. View abstract.

35455            Erlund, I., Koli, R., Alfthan, G., Marniemi, J., Puukka, P., Mustonen, P., Mattila, P., and Jula, A. Favorable effects of berry consumption on platelet function, blood pressure, and HDL cholesterol. Am J Clin Nutr 2008;87(2):323-331. View abstract.

35456            Steigerwalt, R. D., Gianni, B., Paolo, M., Bombardelli, E., Burki, C., and Schonlau, F. Effects of Mirtogenol on ocular blood flow and intraocular hypertension in asymptomatic subjects. Mol Vis 2008;14:1288-1292. View abstract.

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35463            Lehtonen, H. M., Suomela, J. P., Tahvonen, R., Yang, B., Venojarvi, M., Viikari, J., and Kallio, H. Different berries and berry fractions have various but slightly positive effects on the associated variables of metabolic diseases on overweight and obese women. Eur J Clin Nutr 2011;65(3):394-401. View abstract.

35468            Lankinen, M., Schwab, U., Kolehmainen, M., Paananen, J., Poutanen, K., Mykkanen, H., Seppanen-Laakso, T., Gylling, H., Uusitupa, M., and Oresic, M. Whole grain products, fish and bilberries alter glucose and lipid metabolism in a randomized, controlled trial: the Sysdimet study. PLoS One 2011;6(8):e22646. View abstract.

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5381               Parnis FX, Coleman RE, Harper PG, et al. A randomised double-blind placebo controlled clinical trial assessing the tolerability and efficacy of glutathione as an adjuvant to escalating doses of cisplatin in the treatment of advanced ovarian cancer. Eur J Cancer 1995;31A:1721. View abstract.

5382               Cascinu S, Frontini L, Comella G, et al. Intensive weekly chemotherapy is not effective in advanced pancreatic cancer patients: a report from the Italian Group for the Study of Dig. Tract Cancer (GISCAD). Br J Cancer 1999;79(3-4):491-4. View abstract.

5383               Cascinu S, Labianca R, Alessandroni P, et al. Intensive weekly chemotherapy for advanced gastric cancer using fluorouracil, cisplatin, epi-doxorubicin, 6S-leucovorin, glutathione, and filgrastim: a report from the Italian Group for the Study of Digestive Tract Cancer. J Clin Oncol 1997;15:3313-9. View abstract.

5384               Lenzi A, Culasso F, Gandini L, Placebo-controlled, double-blind, cross-over trial of glutathione therapy in male infertility. Hum Reprod 1993;8:1657-62. View abstract.

5386               Powers SK, Hamilton K. Antioxidants and exercise. Clin Sports Med 1999;18:525-36. View abstract.

5387               Anderson ME. Glutathione: an overview of biosynthesis and modulation. Chem Biol Interact 1998;24;111-112:1-14.

5388               Lu SC. Regulation of hepatic glutathione synthesis: current concepts and controversies. FASEB J 1999;13:1169-83. View abstract.

5389               Amores-Sanchez MI, Medina MA. Glutamine, as a precursor of glutathione, and oxidative stress. Mol Genet Metab 1999;67:100-5. View abstract.

5392               Ruffmann R, Wendel A. GSH rescue by N-acetylcysteine. Klin Wochenschr 1991;69:857-62. View abstract.

5393               Droge W, Holm E. Role of cysteine and glutathione in HIV infection and other diseases associated with muscle wasting and immunological dysfunction. FASEB J 1997;11:1077-89. View abstract.

5394               Herzenberg LA, De Rosa SC, Dubs JG, et al. Glutathione deficiency is associated with impaired survival in HIV disease. Proc Natl Acad Sci USA 1997;94:1967-72. View abstract.

5395               Samiec PS, Drews-Botsch C, Flagg EW, et al. Glutathione in human plasma: decline in association with aging, age-related macular degeneration, and diabetes. Free Radic Biol Med 1998;24:699-704. View abstract.

5396               Bains JS, Shaw CA. Neurodegenerative disorders in humans: the role of glutathione in oxidative stress-mediated neuronal death. Brain Res Brain Res Rev 1997;25:335-58. View abstract.

5397               Loguercio C, Di Pierro M. The role of glutathione in the gastrointestinal tract: a review. Ital J Gastroenterol Hepatol 1999;31:401-7. View abstract.

5398               Powers SK, Ji LL, Leeuwenburgh C. Exercise training-induced alterations in skeletal muscle antioxidant capacity: a brief review. Med Sci Sports Exerc 1999;31:987-97. View abstract.

 

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832                 Ghio S, de Servi S, Perotti R, et al. Different susceptibility to the development of nitroglycerin tolerance in the arterial and venous circulation in humans- effects of N-acetylcysteine administration. Circulation 1992;86:798-802. View abstract.

1341               Jepsen S, Hansen AB. The influence of N-acetylcysteine on the measurement of prothrombin time and activated partial thromboplastin time in healthy subjects. Scand J Clin Lab Invest 1994;54:543-7. View abstract.

1539               De Rosa SC, Zaretsky MD, Dubs JG, et al. N-acetylcysteine replenishes glutathione in HIV infection. Eur J Clin Invest 2000;30:915-29.

1705               van Zandwijk N. N-acetylcysteine for lung cancer prevention. Chest 1995;107:1437-41. View abstract.

1710               van Zandwijk N, Dalesio O, Pastorino U, et al. EUROSCAN, a randomized trial of vitamin A and N-acetylcysteine in patients with head and neck cancer or lung cancer. For the European Organization for Research and Treatment of Cancer Head and Neck and Lung Cancer Cooperative Groups. J Natl Cancer Inst 2000;92:977-86. View abstract.

1711               Horowitz RS, Dart RC, Jarvie DR, et al. Placental transfer of N-acetylcysteine following human maternal acetaminophen toxicity. J Toxicol Clin Toxicol 1997;35:447-51. View abstract.

1716               Bailey B, McGuigan MA. Management of anaphylactoid reactions to intravenous N-acetylcysteine. Ann Emerg Med 1998;31:710-5. View abstract.

1752               Holt S, Goodier D, Marley R, et al. Improvement in renal function in hepatorenal syndrome with N-acetylcysteine. Lancet 1999;353:294-5. View abstract.

1755               Spiller HA, Krenzelok EP, Grande GA, et al. A prospective evaluation of the effect of activated charcoal before oral N-acetylcysteine in acetaminophen overdose. Ann Emerg Med 1994;23:519-23. View abstract.

1761               Kelly GS. Clinical applications of N-acetylcysteine. Altern Med Rev 1998;3:114-27. View abstract.

1762               Chyka PA, Butler AY, Holliman BJ, Herman MI. Utility of acetylcysteine in treating poisonings and adverse drug reactions. Drug Saf 2000;22:123-48. View abstract.

1763               Gillissen A, Nowak D. Characterization of N-acetylcysteine and ambroxol in anti-oxidant therapy. Respir Med 1998;92:609-23. View abstract.

1765               Marchetti G, Lodola E, Licciardello L, Colombo A. Use of N-acetylcysteine in the management of coronary artery diseases. Cardiologia 1999;44:633-7. View abstract.

1767               Morini M, Cai T, Aluigi MG, et al. The role of the thiol N-acetylcysteine in the prevention of tumor invasion and angiogenesis. Int J Biol Markers 1999;14:268-71. View abstract.

2245               Ardissino D, Merlini PA, Savonitto S, et al. Effect of transdermal nitroglycerin or N-acetylcysteine, or both, in the long-term treatment of unstable angina pectoris. J Am Coll Cardiol 1997;29:941-7. View abstract.

2246               Horowitz JD, Henry CA, Syrjanen ML, et al. Nitroglycerine/N-acetylcysteine in the management of unstable angina pectoris. Eur Heart J 1988;9:95-100. View abstract.

2252               Unverferth DV, Jagadeesh JM, Unverferth Bj, et al. Attempt to prevent doxorubicin-induced acute human myocardial morphologic damage with acetylcysteine. J Natl Cancer Inst 1983;71:917-20. View abstract.

2253               Dresdale AR, Barr LH, Bonow RO, et al. Prospective randomized study of the role of N-acetyl cysteine in reversing doxorubicin-induced cardiomyopathy. Am J Clin Oncol 1982;5:657-63. View abstract.

2254               Louwerse ES, Weverling GJ, Bossuyt PM, et al. Randomized, double-blind, controlled trial of acetylcysteine in amyotrophic lateral sclerosis. Arch Neurol 1995;52:559-64. View abstract.

2256               Wiklund O, Fager G, Andersson A, et al. N-acetylcysteine treatment lowers plasma homocysteine but not serum lipoprotein(a) levels. Atherosclerosis 1996;119:99-106. View abstract.

2257               Kroon AA, Demacker PN, Stalenhoef AF. N-acetylcysteine and serum concentrations of lipoprotein(a). J Intern Med 1991;230:519-26. View abstract.

2258               Bostom AG, Shemin D, Yoburn D, et al. Lack of effect of oral N-acetylcysteine on the acute dialysis-related lowering of total plasma homocysteine in hemodialysis patients. Atherosclerosis 1996;120:241-4. View abstract.

2259               Hurd RW, Wilder BJ, Helveston WR, et al. Treatment of four siblings with progressive myoclonus epilepsy of the Unverricht-Lundborg type with N-acetylcysteine. Neurology 1996;47:1264-8. View abstract.

2260               De Flora S, Grassi C, Carati L. Attenuation of influenza-like symptomatology and improvement of cell-mediated immunity with long-term N-acetylcysteine treatment. Eur Respir J 1997;10:1535-41. View abstract.

2280               Iversen HK. N-acetylcysteine enhances nitroglycerin-induced headache and cranial arterial responses. Clin Pharmacol Ther 1992;52:125-33. View abstract.

2281               Hogan JC, Lewis MJ, Henderson AH. N-acetylcysteine fails to attenuate haemodynamic tolerance to glyceryl trinitrate in healthy volunteers. Br J Clin Pharmacol 1989;28:421-6. View abstract.

2282               Hogan JC, Lewis MJ, Henderson AH. Chronic administration of N-acetylcysteine fails to prevent nitrate tolerance in patients with stable angina pectoris. Br J Clin Pharmacol 1990;30:573-7. View abstract.

3974               Redondo P, Bauza A. Topical N-acetylcysteine for lamellar ichthyosis. Lancet 1999;354:1880. View abstract.

3975               Sekharam M, Trotti A, Cunnick JM, Wu J. Suppression of fibroblast cell cycle progression in G1 phase by N-acetylcysteine. Toxicol Appl Pharmacol 1998;149:210-6. View abstract.

5052               Vadoud-Seyedi J, de Dobbeleer G, Simonart T. Treatment of haemodialysis-associated pseudoporphyria with N-acetylcysteine: report of two cases. Br J Dermatol 2000;142:580-1. View abstract.

5808               Holoye PY, Duelge J, Hansen RM, et al. Prophylaxis of Ifosamide toxicity with oral acetylcysteine. Semin Oncol 1983;10:66-71. View abstract.

6176               Grandjean EM, Berthet P, Ruffmann R, Leuenberger P. Efficacy of oral long-term N-acetylcysteine in chronic bronchopulmonary disease: a meta-analysis of published double-blind, placebo-controlled clinical trials. Clin Ther 2000;22:209-21. View abstract.

6611               Tepel M, van der Giet M, Schwarzfeld C, et al. Prevention of radiographic-contrast-agent-induced reductions in renal function by acetylcysteine. N Engl J Med 2000;343:180-4. View abstract.

7868               Behr J, Maier K, Degenkolb B, et al. Antioxidative and clinical effects of high-dose N-acetylcysteine in fibrosing alveolitis. Adjunctive therapy to maintenance immunosuppression. Am J Respir Crit Care Med 1997;156:1897-901. View abstract.

7869               Tenenbein PK, Sitar DS, Tenenbein M. Interaction between N-acetylcysteine and activated charcoal: implications for the treatment of acetaminophen poisoning. Pharmacotherapy 2001;21:1331-6. View abstract.

7870               Adair JC, Knoefel JE, Morgan N. Controlled trial of N-acetylcysteine for patients with probable Alzheimer’s disease. Neurology 2001;57:1515-7. View abstract.

7871               Molnar Z, Shearer E, Lowe D. N-Acetylcysteine treatment to prevent the progression of multisystem organ failure: a prospective, randomized, placebo-controlled study. Crit Care Med 1999;27:1100-4. View abstract.

7872               Arstall MA, Yang J, Stafford I, et al. N-acetylcysteine in combination with nitroglycerin and streptokinase for the treatment of evolving acute myocardial infarction. Safety and biochemical effects. Circulation 1995;92:2855-62. View abstract.

7873               Estensen RD, Levy M, Klopp SJ, et al. N-acetylcysteine suppression of the proliferative index in the colon of patients with previous adenomatous colonic polyps. Cancer Lett 1999;147:109-14. View abstract.

7874               Weinbroum AA, Rudick V, Ben-Abraham R, Karchevski E. N-acetyl-L-cysteine for preventing lung reperfusion injury after liver ischemia-reperfusion: a possible dual protective mechanism in a dose-response study. Transplantation 2000;69:853-9. View abstract.

10268            Morgan LR, Holdiness MR, Gillen LE. N-acetylcysteine: its bioavailability and interaction with ifosfamide metabolites. Semin Oncol 1983;10:56-61.

10269            Morgan LR, Donley PJ, Harrison EF, Hunter HL. The control of ifosfamide-induced hematuria with N-acetylcysteine in patients with advanced carcinoma of the lung. Semin Oncol 1982;9:71-4.

10270            Loehrer PJ Sr, Birch R, Kramer BS, et al. Ifosfamide plus N-acetylcysteine in the treatment of small cell and non-small cell carcinoma of the lung: a Southeastern Cancer Study Group Trial. Cancer Treat Rep 1986;70:919-20.

10271            Loehrer PJ, Williams SD, Einhorn LH. N-acetylcysteine and ifosfamide in the treatment of unresectable pancreatic adenocarcinoma and refractory testicular cancer. Semin Oncol 1983;10:72-5.

10272            Anfossi G, Russo I, Massucco P, et al. N-acetyl-L-cysteine exerts direct anti-aggregating effect on human platelets. Eur J Clin Invest 2001;31:452-61.. View abstract.

10428            Shyu KG, Cheng JJ, Kuan P. Acetylcysteine protects against acute renal damage in patients with abnormal renal function undergoing a coronary procedure. J Am Coll Cardiol 2002;40:1383-8.. View abstract.

10429            Pela R, Calcagni AM, Subiaco S, et al. N-acetylcysteine reduces the exacerbation rate in patients with moderate to severe COPD. Respiration 1999;66:495-500.. View abstract.

10430            Tepel M, van der Giet M, Statz M, et al. The antioxidant acetylcysteine reduces cardiovascular events in patients with end-stage renal failure: a randomized, controlled trial. Circulation 2003;107:992-5.. View abstract.

10748            Munshi NC, Loehrer PJ Sr, Williams SD, et al. Comparison of N-acetylcysteine and mesna as uroprotectors with ifosfamide combination chemotherapy in refractory germ cell tumors. Invest New Drugs 1992;10:159-163.. View abstract.

11430            Oldemeyer JB, Biddle WP, Wurdeman RL, et al. Acetylcysteine in the prevention of contrast-induced nephropathy after coronary angiography. Am Heart J 2003;146:E23. . View abstract.

15528            Kopke RD, Jackson RL, Coleman JKM, et al. NAC for noise: From the bench top to the clinic. Hear Res 2007;226:114-25. View abstract.

15529            Lorito G, Giordano P, Prosser S, et al. Noise-induced hearing loss: a study on the pharmacological protection in the Sprague Dawley rat with N-acetyl-cysteine. Acta Otorhinolaryngol Ital 2006;26:133-9. View abstract.

15531            Dickey DT, Muldoon LL, Kraemer DF, Neuwelt EA. Protection against cisplatin-induced ototoxicity by N-acetylcysteine in a rat model. Hear Res 2004;193:25-30. View abstract.

15532            Duan M, Qiu J, Laurell G, et al, Dose and time-dependent protection of the antioxidant N-L-acetycysteine against impulse noise trauma. Hear Res 2004;192:1-9. View abstract.

15533            Kopke RD, Weisskopf PA, Boone JL, et al. Reduction of noise-induced hearing loss using L-NAC and salicylate in the chinchilla. Hear Res 2000;149:138-146. View abstract.

16840            Grant JE, Odlaug BL, Kim SW. N-acetylcysteine, a glutamate modulator, in the treatment of trichotillomania: a double-blind, placebo-controlled study. Arch Gen Psychiatry 2009;66:756-63. View abstract.

30845            McCormick, R. K. Osteoporosis: integrating biomarkers and other diagnostic correlates into the management of bone fragility. Altern.Med Rev. 2007;12(2):113-145. View abstract.

30847            Moreira, P. I., Harris, P. L., Zhu, X., Santos, M. S., Oliveira, C. R., Smith, M. A., and Perry, G. Lipoic acid and N-acetyl cysteine decrease mitochondrial-related oxidative stress in Alzheimer disease patient fibroblasts. J Alzheimers.Dis 2007;12(2):195-206. View abstract.

34035            Noonan, D. M., Benelli, R., and Albini, A. Angiogenesis and cancer prevention: a vision. Recent Results Cancer Res 2007;174:219-224. View abstract.

34583            Minder, E. I., Schneider-Yin, X., Steurer, J., and Bachmann, L. M. A systematic review of treatment options for dermal photosensitivity in erythropoietic protoporphyria. Cell Mol.Biol.(Noisy.-le-grand) 2009;55(1):84-97. View abstract.

36849            Banner, W., Jr., Koch, M., Capin, D. M., Hopf, S. B., Chang, S., and Tong, T. G. Experimental chelation therapy in chromium, lead, and boron intoxication with N-acetylcysteine and other compounds. Toxicol.Appl.Pharmacol 3-30-1986;83(1):142-147. View abstract.

44016            van Dalen, E. C., Caron, H. N., Dickinson, H. O., and Kremer, L. C. Cardioprotective interventions for cancer patients receiving anthracyclines. Cochrane.Database.Syst.Rev. 2008;(2):CD003917. View abstract.

58498            Block, K. I., Koch, A. C., Mead, M. N., Tothy, P. K., Newman, R. A., and Gyllenhaal, C. Impact of antioxidant supplementation on chemotherapeutic toxicity: a systematic review of the evidence from randomized controlled trials. Int.J Cancer 9-15-2008;123(6):1227-1239. View abstract.

58553            Chan, A., Paskavitz, J., Remington, R., Rasmussen, S., and Shea, T. B. Efficacy of a vitamin/nutriceutical formulation for early-stage Alzheimer’s disease: a 1-year, open-label pilot study with an 16-month caregiver extension. Am.J Alzheimers.Dis Other Demen. 12-20-2008;23(6):571-585. View abstract.

58555            Remington, R., Chan, A., Paskavitz, J., and Shea, T. B. Efficacy of a vitamin/nutriceutical formulation for moderate-stage to later-stage Alzheimer’s disease: a placebo-controlled pilot study. Am.J Alzheimers.Dis Other Demen. 2009;24(1):27-33. View abstract.

61392            Stewart, S., Prince, M., Bassendine, M., Hudson, M., James, O., Jones, D., Record, C., and Day, C. P. A randomized trial of antioxidant therapy alone or with corticosteroids in acute alcoholic hepatitis. J Hepatol. 2007;47(2):277-283. View abstract.

64406            Duijvestijn, Y. C. and Brand, P. L. Systematic review of N-acetylcysteine in cystic fibrosis. Acta Paediatr. 1999;88(1):38-41. View abstract.

64407            Tariq, M., Morais, C., Sobki, S., Al, Sulaiman M., and Al, Khader A. N-acetylcysteine attenuates cyclosporin-induced nephrotoxicity in rats. Nephrol.Dial.Transplant. 1999;14(4):923-929. View abstract.

64408            Miyajima, A., Nakashima, J., Tachibana, M., Nakamura, K., Hayakawa, M., and Murai, M. N-acetylcysteine modifies cis-dichlorodiammineplatinum-induced effects in bladder cancer cells. Jpn J Cancer Res 1999;90(5):565-570. View abstract.

64409            Jiang, B., Haverty, M., and Brecher, P. N-acetyl-L-cysteine enhances interleukin-1beta-induced nitric oxide synthase expression. Hypertension 1999;34(4 Pt 1):574-579. View abstract.

64410            Ventura, P., Panini, R., Pasini, M. C., Scarpetta, G., and Salvioli, G. N -Acetyl-cysteine reduces homocysteine plasma levels after single intravenous administration by increasing thiols urinary excretion. Pharmacol.Res. 1999;40(4):345-350. View abstract.

64411            Buckley, N. A., Whyte, I. M., O’Connell, D. L., and Dawson, A. H. Activated charcoal reduces the need for N-acetylcysteine treatment after acetaminophen (paracetamol) overdose. J Toxicol.Clin Toxicol. 1999;37(6):753-757. View abstract.

64412            Buckley, N. A., Whyte, I. M., O’Connell, D. L., and Dawson, A. H. Oral or intravenous N-acetylcysteine: which is the treatment of choice for acetaminophen (paracetamol) poisoning? J Toxicol.Clin Toxicol. 1999;37(6):759-767. View abstract.

64413            Woo, O. F., Mueller, P. D., Olson, K. R., Anderson, I. B., and Kim, S. Y. Shorter duration of oral N-acetylcysteine therapy for acute acetaminophen overdose. Ann Emerg.Med 2000;35(4):363-368. View abstract.

64414            Redondo, P., Bandres, E., Solano, T., Okroujnov, I., and Garcia-Foncillas, J. Vascular endothelial growth factor (VEGF) and melanoma. N-acetylcysteine downregulates VEGF production in vitro. Cytokine 2000;12(4):374-378. View abstract.

64415            Mantovani, G., Maccio, A., Melis, G., Mura, L., Massa, E., and Mudu, M. C. Restoration of functional defects in peripheral blood mononuclear cells isolated from cancer patients by thiol antioxidants alpha-lipoic acid and N-acetyl cysteine. Int.J.Cancer 6-15-2000;86(6):842-847. View abstract.

64416            Flescher, E. and Fingrut, O. Suppression of interleukin 2 biosynthesis by three modes of oxidative cellular stress: selective prevention by N-acetyl cysteine. Cytokine 2000;12(5):495-498. View abstract.

64417            Stanislawski, L., Soheili-Majd, E., Perianin, A., and Goldberg, M. Dental restorative biomaterials induce glutathione depletion in cultured human gingival fibroblast: protective effect of N-acetyl cysteine. J.Biomed.Mater.Res. 9-5-2000;51(3):469-474. View abstract.

64418            Grant, P. R., Black, A., Garcia, N., Prieto, J., and Garson, J. A. Combination therapy with interferon-alpha plus N-acetyl cysteine for chronic hepatitis C: a placebo controlled double-blind multicentre study. J.Med.Virol. 2000;61(4):439-442. View abstract.

64419            Stey, C., Steurer, J., Bachmann, S., Medici, T. C., and Tramer, M. R. The effect of oral N-acetylcysteine in chronic bronchitis: a quantitative systematic review. Eur.Respir.J 2000;16(2):253-262. View abstract.

64420            De Rosa, S. C., Zaretsky, M. D., Dubs, J. G., Roederer, M., Anderson, M., Green, A., Mitra, D., Watanabe, N., Nakamura, H., Tjioe, I., Deresinski, S. C., Moore, W. A., Ela, S. W., Parks, D., Herzenberg, L. A., and Herzenberg, L. A. N-acetylcysteine replenishes glutathione in HIV infection. Eur.J Clin Invest 2000;30(10):915-929. View abstract.

64421            D’Agostini, F., Balansky, R. M., Camoirano, A., and De, Flora S. Interactions between N-acetylcysteine and ascorbic acid in modulating mutagenesis and carcinogenesis. Int J Cancer 12-1-2000;88(5):702-707. View abstract.

64422            Gon, Y., Hashimoto, S., Nakayama, T., Matsumoto, K., Koura, T., Takeshita, I., and Horie, T. N-acetyl-L-cysteine inhibits bleomycin-induced interleukin-8 secretion by bronchial epithelial cells. Respirology. 2000;5(4):309-313. View abstract.

64423            Weinbroum, A. A., Kluger, Y., Ben, Abraham R., Shapira, I., Karchevski, E., and Rudick, V. Lung preconditioning with N-acetyl-L-cysteine prevents reperfusion injury after liver no flow-reflow: a dose-response study. Transplantation 1-27-2001;71(2):300-306. View abstract.

64424            Neri, S., Ierna, D., Antoci, S., Campanile, E., D’Amico, R. A., and Noto, R. Association of alpha-interferon and acetyl cysteine in patients with chronic C hepatitis. Panminerva Med 2000;42(3):187-192. View abstract.

64425            Kusano, C., Takao, S., Noma, H., Yoh, H., Aikou, T., Okumura, H., Akiyama, S., Kawamura, M., Makino, M., and Baba, M. N-acetyl cysteine inhibits cell cycle progression in pancreatic carcinoma cells. Hum.Cell 2000;13(4):213-220. View abstract.

64426            Rumack, B. H. and Matthew, H. Acetaminophen poisoning and toxicity. Pediatrics 1975;55(6):871-876. View abstract.

64427            Tolley, D. A. and Castro, J. E. Cyclophosphamide-induced cystitis of the urinary bladder of rats and its treatment. Proc R.Soc Med 1975;68(3):169-170. View abstract.

64428            Tandon, S. K., Prasad, S., and Singh, S. Chelation in metal intoxication: influence of cysteine or N-acetyl cysteine on the efficacy of 2,3-dimercaptopropane-1-sulphonate in the treatment of cadmium toxicity. J Appl Toxicol 2002;22(1):67-71. View abstract.

64429            Diaz-Sandoval, L. J., Kosowsky, B. D., and Losordo, D. W. Acetylcysteine to prevent angiography-related renal tissue injury (the APART trial). Am J Cardiol. 2-1-2002;89(3):356-358. View abstract.

64430            Van Schooten, F. J., Nia, A. B., De Flora, S., D’Agostini, F., Izzotti, A., Camoirano, A., Balm, A. J., Dallinga, J. W., Bast, A., Haenen, G. R., Van’t Veer, L., Baas, P., Sakai, H., and van Zandwijk, N. Effects of oral administration of N-acetyl-L-cysteine: a multi- biomarker study in smokers. Cancer Epidemiol.Biomarkers Prev. 2002;11(2):167-175. View abstract.

64431            Tozawa, K., Okamoto, T., Hayashi, Y., Sasaki, S., Kawai, N., and Kohri, K. N-acetyl-L-cysteine enhances chemotherapeutic effect on prostate cancer cells. Urol.Res 2002;30(1):53-58. View abstract.

64432            Pajonk, F., Riess, K., Sommer, A., and McBride, W. H. N-acetyl-L-cysteine inhibits 26S proteasome function: implications for effects on NF-kappaB activation. Free Radic.Biol Med 3-15-2002;32(6):536-543. View abstract.

64433            Rumack, B. H. Acetaminophen hepatotoxicity: the first 35 years. J Toxicol.Clin Toxicol. 2002;40(1):3-20. View abstract.

64434            James, L. P., Wells, E., Beard, R. H., and Farrar, H. C. Predictors of outcome after acetaminophen poisoning in children and adolescents. J Pediatr 2002;140(5):522-526. View abstract.

64435            Fulghesu, A. M., Ciampelli, M., Muzj, G., Belosi, C., Selvaggi, L., Ayala, G. F., and Lanzone, A. N-acetyl-cysteine treatment improves insulin sensitivity in women with polycystic ovary syndrome. Fertil.Steril. 2002;77(6):1128-1135. View abstract.

64436            Wijnen, M. H., Roumen, R. M., Vader, H. L., and Goris, R. J. A multiantioxidant supplementation reduces damage from ischaemia reperfusion in patients after lower torso ischaemia. A randomised trial. Eur.J Vasc.Endovasc.Surg 2002;23(6):486-490. View abstract.

64437            Briguori, C., Manganelli, F., Scarpato, P., Elia, P. P., Golia, B., Riviezzo, G., Lepore, S., Librera, M., Villari, B., Colombo, A., and Ricciardelli, B. Acetylcysteine and contrast agent-associated nephrotoxicity. J Am Coll.Cardiol. 7-17-2002;40(2):298-303. View abstract.

64438            Allaqaband, S., Tumuluri, R., Malik, A. M., Gupta, A., Volkert, P., Shalev, Y., and Bajwa, T. K. Prospective randomized study of N-acetylcysteine, fenoldopam, and saline for prevention of radiocontrast-induced nephropathy. Catheter.Cardiovasc.Interv. 2002;57(3):279-283. View abstract.

64439            Durham, J. D., Caputo, C., Dokko, J., Zaharakis, T., Pahlavan, M., Keltz, J., Dutka, P., Marzo, K., Maesaka, J. K., and Fishbane, S. A randomized controlled trial of N-acetylcysteine to prevent contrast nephropathy in cardiac angiography. Kidney Int 2002;62(6):2202-2207. View abstract.

64440            Vallero, A., Cesano, G., Pozzato, M., Garbo, R., Minelli, M., Quarello, F., and Formica, M. [Contrast nephropathy in cardiac procedures: no advantages with prophylactic use of N-acetylcysteine (NAC)]. G.Ital.Nefrol. 2002;19(5):529-533. View abstract.

64441            Kay, J., Chow, W. H., Chan, T. M., Lo, S. K., Kwok, O. H., Yip, A., Fan, K., Lee, C. H., and Lam, W. F. Acetylcysteine for prevention of acute deterioration of renal function following elective coronary angiography and intervention: a randomized controlled trial. JAMA 2-5-2003;289(5):553-558. View abstract.

64442            Lappas, M., Permezel, M., and Rice, G. E. N-Acetyl-cysteine inhibits phospholipid metabolism, proinflammatory cytokine release, protease activity, and nuclear factor-kappaB deoxyribonucleic acid-binding activity in human fetal membranes in vitro. J.Clin.Endocrinol.Metab 2003;88(4):1723-1729. View abstract.

64443            Molnar, Z., Szakmany, T., and Koszegi, T. Prophylactic N-acetylcysteine decreases serum CRP but not PCT levels and microalbuminuria following major abdominal surgery. A prospective, randomised, double-blinded, placebo-controlled clinical trial. Intensive Care Med 2003;29(5):749-755. View abstract.

64444            Baker, C. S., Wragg, A., Kumar, S., De, Palma R., Baker, L. R., and Knight, C. J. A rapid protocol for the prevention of contrast-induced renal dysfunction: the RAPPID study. J Am.Coll.Cardiol. 6-18-2003;41(12):2114-2118. View abstract.

64445            Alsalim, W. and Fadel, M. Towards evidence based emergency medicine: best BETs from the Manchester Royal Infirmary. Oral methionine compared with intravenous n-acetyl cysteine for paracetamol overdose. Emerg.Med.J. 2003;20(4):366-367. View abstract.

64446            Kinter, A. L., Poli, G., and Fauci, A. S. N-acetyl-cysteine is a potent suppressor of human immunodeficiency virus transcription in persistently infected cells. Trans.Assoc.Am.Physicians 1992;105:36-43. View abstract.

64447            Ballke, E. H., Wiersbitzky, S., Mahner, B., and Konig, A. The effect of N-acetyl-cysteine (Mucosolvin) on the transmural potential difference of the mucosa in children. Padiatr.Grenzgeb. 1992;31(2):97-101. View abstract.

64448            Bijlmer-Iest, J. C., Baart, de la Faille, van Asbeck, B. S., van, Hattum J., van, Weelden H., Marx, J. J., and Koningsberger, J. C. Protoporphyrin photosensitivity cannot be attenuated by oral N-acetylcysteine. Photodermatol.Photoimmunol.Photomed. 1992;9(6):245-249. View abstract.

64449            Sunman, W., Hughes, A. D., and Sever, P. S. Anaphylactoid response to intravenous acetylcysteine. Lancet 5-16-1992;339(8803):1231-1232. View abstract.

64450            Reynard, K., Riley, A., and Walker, B. E. Respiratory arrest after N-acetylcysteine for paracetamol overdose. Lancet 9-12-1992;340(8820):675. View abstract.

64451            REAS, H. W. The effect of N-acetylcysteine on the viscosity of tracheobronchial secretions in cystic fibrosis of the pancreas. J Pediatr 1963;62:31-35. View abstract.

64452            WEBB, W. R. Clinical evaluaton of a new mucolytic agent, acetyl-cysteine. J Thorac.Cardiovasc.Surg 1962;44:330-343. View abstract.

64453            de, Quay B., Malinverni, R., and Lauterburg, B. H. Glutathione depletion in HIV-infected patients: role of cysteine deficiency and effect of oral N-acetylcysteine. AIDS 1992;6(8):815-819. View abstract.

64454            Sheffner, A. L., Medler, E. M., JACOBS, L. W., and Sarett, H. P. THE IN VITRO REDUCTION IN VISCOSITY OF HUMAN TRACHEOBRONCHIAL SECRETIONS BY ACETYLCYSTEINE. Am Rev.Respir.Dis. 1964;90:721-729. View abstract.

64455            BERNSTEIN, I. L. and AUSDENMOORE, R. W. IATROGENIC BRONCHOSPASM OCCURRING DURING CLINICAL TRIALS OF A NEW MUCOLYTIC AGENT, ACETYLCYSTEINE. Dis.Chest 1964;46:469-473. View abstract.

64456            REAS, H. W. THE USE OF N-ACETYLCYSTEINE IN THE TREATMENT OF CYSTIC FIBROSIS. J Pediatr 1964;65:542-557. View abstract.

64457            STAMM, S. J. and DOCTER, J. CLINICAL EVALUATION OF ACETYLCYSTEINE AS A MUCOLYTIC AGENT IN CYSTIC FIBROSIS. Dis.Chest 1965;47:414-420. View abstract.

64458            MacNeill, B. D., Harding, S. A., Bazari, H., Patton, K. K., Colon-Hernadez, P., DeJoseph, D., and Jang, I. K. Prophylaxis of contrast-induced nephropathy in patients undergoing coronary angiography. Catheter.Cardiovasc.Interv. 2003;60(4):458-461. View abstract.

64459            Efrati, S., Dishy, V., Averbukh, M., Blatt, A., Krakover, R., Weisgarten, J., Morrow, J. D., Stein, M. C., and Golik, A. The effect of N-acetylcysteine on renal function, nitric oxide, and oxidative stress after angiography. Kidney Int 2003;64(6):2182-2187. View abstract.

64460            Ahola, T., Lapatto, R., Raivio, K. O., Selander, B., Stigson, L., Jonsson, B., Jonsbo, F., Esberg, G., Stovring, S., Kjartansson, S., Stiris, T., Lossius, K., Virkola, K., and Fellman, V. N-acetylcysteine does not prevent bronchopulmonary dysplasia in immature infants: a randomized controlled trial. J Pediatr 2003;143(6):713-719. View abstract.

64461            Tossios, P., Bloch, W., Huebner, A., Raji, M. R., Dodos, F., Klass, O., Suedkamp, M., Kasper, S. M., Hellmich, M., and Mehlhorn, U. N-acetylcysteine prevents reactive oxygen species-mediated myocardial stress in patients undergoing cardiac surgery: results of a randomized, double-blind, placebo-controlled clinical trial. J Thorac.Cardiovasc.Surg 2003;126(5):1513-1520. View abstract.

64462            Gunduz, H., Karabay, O., Tamer, A., Ozaras, R., Mert, A., and Tabak, O. F. N-acetyl cysteine therapy in acute viral hepatitis. World J.Gastroenterol. 2003;9(12):2698-2700. View abstract.

64463            Kefer, J. M., Hanet, C. E., Boitte, S., Wilmotte, L., and De, Kock M. Acetylcysteine, coronary procedure and prevention of contrast-induced worsening of renal function: which benefit for which patient? Acta Cardiol. 2003;58(6):555-560. View abstract.

64464            Eren, N., Cakir, O., Oruc, A., Kaya, Z., and Erdinc, L. Effects of N-acetylcysteine on pulmonary function in patients undergoing coronary artery bypass surgery with cardiopulmonary bypass. Perfusion 2003;18(6):345-350. View abstract.

64465            Kleinveld, H. A., Demacker, P. N., and Stalenhoef, A. F. Failure of N-acetylcysteine to reduce low-density lipoprotein oxidizability in healthy subjects. Eur.J Clin Pharmacol 1992;43(6):639-642. View abstract.

64466            Goldenberg, I., Shechter, M., Matetzky, S., Jonas, M., Adam, M., Pres, H., Elian, D., Agranat, O., Schwammenthal, E., and Guetta, V. Oral acetylcysteine as an adjunct to saline hydration for the prevention of contrast-induced nephropathy following coronary angiography. A randomized controlled trial and review of the current literature. Eur.Heart J 2004;25(3):212-218. View abstract.

64467            Reid, D. and Hazell, W. Paracetamol poisoning: which nomogram should we use? Emerg.Med (Fremantle.) 2003;15(5-6):486-496. View abstract.

64468            Sucu, N., Cinel, I., Unlu, A., Aytacoglu, B., Tamer, L., Kocak, Z., Karaca, K., Gul, A., Dikmengil, M., Atik, U., and Oral, U. N-acetylcysteine for preventing pump-induced oxidoinflammatory response during cardiopulmonary bypass. Surg Today 2004;34(3):237-242. View abstract.

64469            Majano, P. L., Medina, J., Zubia, I., Sunyer, L., Lara-Pezzi, E., Maldonado-Rodriguez, A., Lopez-Cabrera, M., and Moreno-Otero, R. N-Acetyl-cysteine modulates inducible nitric oxide synthase gene expression in human hepatocytes. J.Hepatol. 2004;40(4):632-637. View abstract.

64470            Agarwal, A., Munoz-Najar, U., Klueh, U., Shih, S. C., and Claffey, K. P. N-acetyl-cysteine promotes angiostatin production and vascular collapse in an orthotopic model of breast cancer. Am.J.Pathol. 2004;164(5):1683-1696. View abstract.

64471            Fung, J. W., Szeto, C. C., Chan, W. W., Kum, L. C., Chan, A. K., Wong, J. T., Wu, E. B., Yip, G. W., Chan, J. Y., Yu, C. M., Woo, K. S., and Sanderson, J. E. Effect of N-acetylcysteine for prevention of contrast nephropathy in patients with moderate to severe renal insufficiency: a randomized trial. Am.J Kidney Dis. 2004;43(5):801-808. View abstract.

64472            Kilic-Okman, T. and Kucuk, M. N-acetyl-cysteine treatment for polycystic ovary syndrome. Int.J.Gynaecol.Obstet. 2004;85(3):296-297. View abstract.

64473            Ochoa, A., Pellizzon, G., Addala, S., Grines, C., Isayenko, Y., Boura, J., Rempinski, D., O’Neill, W., and Kahn, J. Abbreviated dosing of N-acetylcysteine prevents contrast-induced nephropathy after elective and urgent coronary angiography and intervention. J Interv.Cardiol. 2004;17(3):159-165. View abstract.

64474            El, Mahmoud R., Le, Feuvre C., Le Quan Sang, K. H., Helft, G., Beygui, F., Batisse, J. P., and Metzger, J. P. [Absence of nephro-protective effect of acetylcysteine in patients with chronic renal failure investigated by coronary angiography]. Arch Mal Coeur Vaiss. 2003;96(12):1157-1161. View abstract.

64475            Webb, J. G., Pate, G. E., Humphries, K. H., Buller, C. E., Shalansky, S., Al, Shamari A., Sutander, A., Williams, T., Fox, R. S., and Levin, A. A randomized controlled trial of intravenous N-acetylcysteine for the prevention of contrast-induced nephropathy after cardiac catheterization: lack of effect. Am.Heart J 2004;148(3):422-429. View abstract.

64476            Peristeris, P., Clark, B. D., Gatti, S., Faggioni, R., Mantovani, A., Mengozzi, M., Orencole, S. F., Sironi, M., and Ghezzi, P. N-acetylcysteine and glutathione as inhibitors of tumor necrosis factor production. Cell Immunol. 1992;140(2):390-399. View abstract.

64477            Tsai, C. L., Chang, W. T., Weng, T. I., Fang, C. C., and Chen, W. J. Acute acetaminophen intoxication in Taiwan: outcomes and risk factors. J Formos.Med Assoc. 2004;103(11):830-835. View abstract.

64478            Huynh, H. Q., Couper, R. T., Tran, C. D., Moore, L., Kelso, R., and Butler, R. N. N-acetylcysteine, a novel treatment for Helicobacter pylori infection. Dig.Dis.Sci 2004;49(11-12):1853-1861. View abstract.

64479            Azmus, A. D., Gottschall, C., Manica, A., Manica, J., Duro, K., Frey, M., Bulcao, L., and Lima, C. Effectiveness of acetylcysteine in prevention of contrast nephropathy. J Invasive.Cardiol. 2005;17(2):80-84. View abstract.

64480            Rizk, A. Y., Bedaiwy, M. A., and Al Inany, H. G. N-acetyl-cysteine is a novel adjuvant to clomiphene citrate in clomiphene citrate-resistant patients with polycystic ovary syndrome. Fertil.Steril. 2005;83(2):367-370. View abstract.

64481            Kerr, F., Dawson, A., Whyte, I. M., Buckley, N., Murray, L., Graudins, A., Chan, B., and Trudinger, B. The Australasian Clinical Toxicology Investigators Collaboration randomized trial of different loading infusion rates of N-acetylcysteine. Ann Emerg.Med 2005;45(4):402-408. View abstract.

64482            Treitinger, A., Spada, C., Masokawa, I. Y., Verdi, J. C., Van Der Sander, Silveira M., Luis, M. C., Reis, M., Ferreira, S. I., and Abdalla, D. S. Effect of N-acetyl-L-cysteine on lymphocyte apoptosis, lymphocyte viability, TNF-alpha and IL-8 in HIV-infected patients undergoing anti-retroviral treatment. Braz.J Infect.Dis 2004;8(5):363-371. View abstract.

64483            Decramer, M., Rutten-van, Molken M., Dekhuijzen, P. N., Troosters, T., van, Herwaarden C., Pellegrino, R., van Schayck, C. P., Olivieri, D., Del, Donno M., De, Backer W., Lankhorst, I., and Ardia, A. Effects of N-acetylcysteine on outcomes in chronic obstructive pulmonary disease (Bronchitis Randomized on NAC Cost-Utility Study, BRONCUS): a randomised placebo-controlled trial. Lancet 4-30-2005;365(9470):1552-1560. View abstract.

64484            Tsai, C. L., Chang, W. T., Weng, T. I., Fang, C. C., and Walson, P. D. A patient-tailored N-acetylcysteine protocol for acute acetaminophen intoxication. Clin Ther 2005;27(3):336-341. View abstract.

64485            Saricaoglu, F., Dal, D., Salman, A. E., Atay, O. A., Doral, M. N., Salman, M. A., Kilinc, K., and Aypar, U. Effect of low-dose N-acetyl-cysteine infusion on tourniquet-induced ischaemia-reperfusion injury in arthroscopic knee surgery. Acta Anaesthesiol.Scand 2005;49(6):847-851. View abstract.

64486            Khan, A. W., Fuller, B. J., Shah, S. R., Davidson, B. R., and Rolles, K. A prospective randomized trial of N-acetyl cysteine administration during cold preservation of the donor liver for transplantation. Ann.Hepatol 2005;4(2):121-126. View abstract.

64487            Burns, K. E., Chu, M. W., Novick, R. J., Fox, S. A., Gallo, K., Martin, C. M., Stitt, L. W., Heidenheim, A. P., Myers, M. L., and Moist, L. Perioperative N-acetylcysteine to prevent renal dysfunction in high-risk patients undergoing cabg surgery: a randomized controlled trial. JAMA 7-20-2005;294(3):342-350. View abstract.

64488            Sivilotti, M. L., Good, A. M., Yarema, M. C., Juurlink, D. N., and Johnson, D. W. A new predictor of toxicity following acetaminophen overdose based on pretreatment exposure. Clin Toxicol.(Phila) 2005;43(4):229-234. View abstract.

64489            Ng, T. M., Shurmur, S. W., Silver, M., Nissen, L. R., O’Leary, E. L., Rigmaiden, R. S., Cieciorka, M., Porter, L. L., Ineck, B. A., Kline, M. E., and Puumala, S. E. Comparison of N-acetylcysteine and fenoldopam for preventing contrast-induced nephropathy (CAFCIN). Int J Cardiol. 5-24-2006;109(3):322-328. View abstract.

64490            Bibi, H., Seifert, B., Oullette, M., and Belik, J. Intratracheal N-acetylcysteine use in infants with chronic lung disease. Acta Paediatr. 1992;81(4):335-339. View abstract.

64491            Fischer, U. M., Tossios, P., and Mehlhorn, U. Renal protection by radical scavenging in cardiac surgery patients. Curr Med Res Opin. 2005;21(8):1161-1164. View abstract.

64492            Jepsen, S., Herlevsen, P., Knudsen, P., Bud, M. I., and Klausen, N. O. Antioxidant treatment with N-acetylcysteine during adult respiratory distress syndrome: a prospective, randomized, placebo-controlled study. Crit Care Med 1992;20(7):918-923. View abstract.

64493            Roes, E. M., Raijmakers, M. T., Boo, T. M., Zusterzeel, P. L., Merkus, H. M., Peters, W. H., and Steegers, E. A. Oral N-acetylcysteine administration does not stabilise the process of established severe preeclampsia. Eur.J Obstet.Gynecol.Reprod.Biol 2006;127(1):61-67. View abstract.

64494            Ayonrinde, O. T., Phelps, G. J., Hurley, J. C., and Ayonrinde, O. A. Paracetamol overdose and hepatotoxicity at a regional Australian hospital: a 4-year experience. Intern Med J 2005;35(11):655-660. View abstract.

64495            Foschino Barbaro, M. P., Serviddio, G., Resta, O., Rollo, T., Tamborra, R., Elisiana, Carpagnano G., Vendemiale, G., and Altomare, E. Oxygen therapy at low flow causes oxidative stress in chronic obstructive pulmonary disease: Prevention by N-acetyl cysteine. Free Radic.Res 2005;39(10):1111-1118. View abstract.

64496            Krishna, M. and Lalmuanpuii, J. Helicobacter pylori treatment. South.Med J 2005;98(11):1068. View abstract.

64497            Gurbuz, A. K., Ozel, A. M., Ozturk, R., Yildirim, S., Yazgan, Y., and Demirturk, L. Effect of N-acetyl cysteine on Helicobacter pylori. South.Med J 2005;98(11):1095-1097. View abstract.

64498            Fung, J. W. S. C., Chan, W., Kum, W., and et al. Can N-acetylcysteine really prevent contrast-induced nephropathy in patients with chronic renal insufficiency? A randomized study and pooled analysis. Eur Heart J 2003;24(S136) View abstract.

64499            Sadowska, A. M., Keenoy, B., Vertongen, T., Schippers, G., Radomska-Lesniewska, D., Heytens, E., and De Backer, W. A. Effect of N-acetylcysteine on neutrophil activation markers in healthy volunteers: in vivo and in vitro study. Pharmacol Res 2006;53(3):216-225. View abstract.

64500            Koramaz, I., Pulathan, Z., Usta, S., Karahan, S. C., Alver, A., Yaris, E., Kalyoncu, N. I., and Ozcan, F. Cardioprotective effect of cold-blood cardioplegia enriched with N-acetylcysteine during coronary artery bypass grafting. Ann Thorac.Surg 2006;81(2):613-618. View abstract.

64501            Spiller, H. A., Winter, M. L., Klein-Schwartz, W., and Bangh, S. A. Efficacy of activated charcoal administered more than four hours after acetaminophen overdose. J Emerg.Med 2006;30(1):1-5. View abstract.

64502            Yesilbursa, D., Serdar, A., Senturk, T., Serdar, Z., Sag, S., and Cordan, J. Effect of N-acetylcysteine on oxidative stress and ventricular function in patients with myocardial infarction. Heart Vessels 2006;21(1):33-37. View abstract.

64503            Orhan, G., Yapici, N., Yuksel, M., Sargin, M., Senay, S., Yalcin, A. S., Aykac, Z., and Aka, S. A. Effects of N-acetylcysteine on myocardial ischemia-reperfusion injury in bypass surgery. Heart Vessels 2006;21(1):42-47. View abstract.

64504            LaRowe, S. D., Mardikian, P., Malcolm, R., Myrick, H., Kalivas, P., McFarland, K., Saladin, M., McRae, A., and Brady, K. Safety and tolerability of N-acetylcysteine in cocaine-dependent individuals. Am J Addict. 2006;15(1):105-110. View abstract.

64505            Lin, P. C., Lee, M. Y., Wang, W. S., Yen, C. C., Chao, T. C., Hsiao, L. T., Yang, M. H., Chen, P. M., Lin, K. P., and Chiou, T. J. N-acetylcysteine has neuroprotective effects against oxaliplatin-based adjuvant chemotherapy in colon cancer patients: preliminary data. Support.Care Cancer 2006;14(5):484-487. View abstract.

64506            Sadowska, A. M., Manuel, Y. Keenoy, and De Backer, W. A. Antioxidant and anti-inflammatory efficacy of NAC in the treatment of COPD: discordant in vitro and in vivo dose-effects: a review. Pulm.Pharmacol Ther 2007;20(1):9-22. View abstract.

64507            Manov, I., Motanis, H., Frumin, I., and Iancu, T. C. Hepatotoxicity of anti-inflammatory and analgesic drugs: ultrastructural aspects. Acta Pharmacol Sin. 2006;27(3):259-272. View abstract.

64508            Sandhu, C., Belli, A. M., and Oliveira, D. B. The role of N-acetylcysteine in the prevention of contrast-induced nephrotoxicity. Cardiovasc.Intervent.Radiol. 2006;29(3):344-347. View abstract.

64509            Macedo, E., Abdulkader, R., Castro, I., Sobrinho, A. C., Yu, L., and Vieira, J. M., Jr. Lack of protection of N-acetylcysteine (NAC) in acute renal failure related to elective aortic aneurysm repair-a randomized controlled trial. Nephrol.Dial.Transplant. 2006;21(7):1863-1869. View abstract.

64510            Tirouvanziam, R., Conrad, C. K., Bottiglieri, T., Herzenberg, L. A., Moss, R. B., and Herzenberg, L. A. High-dose oral N-acetylcysteine, a glutathione prodrug, modulates inflammation in cystic fibrosis. Proc Natl.Acad.Sci U.S.A 3-21-2006;103(12):4628-4633. View abstract.

64511            Niemi, T. T., Munsterhjelm, E., Poyhia, R., Hynninen, M. S., and Salmenpera, M. T. The effect of N-acetylcysteine on blood coagulation and platelet function in patients undergoing open repair of abdominal aortic aneurysm. Blood Coagul.Fibrinolysis 2006;17(1):29-34. View abstract.

64512            Pannu, N. and Tonelli, M. Strategies to reduce the risk of contrast nephropathy: an evidence-based approach. Curr Opin.Nephrol.Hypertens. 2006;15(3):285-290. View abstract.

64513            Brok, J., Buckley, N., and Gluud, C. Interventions for paracetamol (acetaminophen) overdose. Cochrane Database.Syst.Rev. 2006;(2):CD003328. View abstract.

64514            Coyle, L. C., Rodriguez, A., Jeschke, R. E., Simon-Lee, A., Abbott, K. C., and Taylor, A. J. Acetylcysteine In Diabetes (AID): a randomized study of acetylcysteine for the prevention of contrast nephropathy in diabetics. Am Heart J 2006;151(5):1032-12. View abstract.

64515            Melzer, J., Saller, R., Schapowal, A., and Brignoli, R. Systematic review of clinical data with BNO-101 (Sinupret) in the treatment of sinusitis. Forsch Komplement.Med (2006.) 2006;13(2):78-87. View abstract.

64516            Gavish, D. and Breslow, J. L. Lipoprotein(a) reduction by N-acetylcysteine. Lancet 1-26-1991;337(8735):203-204. View abstract.

64517            Hynninen, M. S., Niemi, T. T., Poyhia, R., Raininko, E. I., Salmenpera, M. T., Lepantalo, M. J., Railo, M. J., and Tallgren, M. K. N-acetylcysteine for the prevention of kidney injury in abdominal aortic surgery: a randomized, double-blind, placebo-controlled trial. Anesth.Analg. 2006;102(6):1638-1645. View abstract.

64518            Lameire, N. H. Contrast-induced nephropathy–prevention and risk reduction. Nephrol.Dial.Transplant. 2006;21(6):i11-i23. View abstract.

64519            Girardi, G. and Elias, M. M. Effectiveness of N-acetylcysteine in protecting against mercuric chloride-induced nephrotoxicity. Toxicology 4-8-1991;67(2):155-164. View abstract.

64520            Kramer, S., Dreisbach, L., Lockwood, J., Baldwin, K., Kopke, R., Scranton, S., and O’Leary, M. Efficacy of the antioxidant N-acetylcysteine (NAC) in protecting ears exposed to loud music. J Am Acad.Audiol. 2006;17(4):265-278. View abstract.

64521            Meschi, M., Detrenis, S., Musini, S., Strada, E., and Savazzi, G. Facts and fallacies concerning the prevention of contrast medium-induced nephropathy. Crit Care Med 2006;34(8):2060-2068. View abstract.

64522            Milewski, J., Rydzewska, G., Degowska, M., Kierzkiewicz, M., and Rydzewski, A. N-acetylcysteine does not prevent post-endoscopic retrograde cholangiopancreatography hyperamylasemia and acute pancreatitis. World J Gastroenterol. 6-21-2006;12(23):3751-3755. View abstract.

64523            Rahman, I. and Kilty, I. Antioxidant therapeutic targets in COPD. Curr.Drug Targets. 2006;7(6):707-720. View abstract.

64524            Pannu, N., Wiebe, N., and Tonelli, M. Prophylaxis strategies for contrast-induced nephropathy. JAMA 6-21-2006;295(23):2765-2779. View abstract.

64525            Marenzi, G., Assanelli, E., Marana, I., Lauri, G., Campodonico, J., Grazi, M., De, Metrio M., Galli, S., Fabbiocchi, F., Montorsi, P., Veglia, F., and Bartorelli, A. L. N-acetylcysteine and contrast-induced nephropathy in primary angioplasty. N.Engl.J Med 6-29-2006;354(26):2773-2782. View abstract.

64526            Baker, C. S., Wragg, A., Kumar, S., De, Palma R., Baker, L. R., and Knight, C. J. A rapid protocol for the prevention of contrast-induced renal dysfunction: the RAPPID study. J Am Coll.Cardiol. 6-18-2003;41(12):2114-2118. View abstract.

64527            Rahman, I. and Adcock, I. M. Oxidative stress and redox regulation of lung inflammation in COPD. Eur.Respir.J 2006;28(1):219-242. View abstract.

64528            Badawy, A., Baker El, Nashar A., and El, Totongy M. Clomiphene citrate plus N-acetyl cysteine versus clomiphene citrate for augmenting ovulation in the management of unexplained infertility: a randomized double-blind controlled trial. Fertil.Steril. 2006;86(3):647-650. View abstract.

64529            McKenna, M. J., Medved, I., Goodman, C. A., Brown, M. J., Bjorksten, A. R., Murphy, K. T., Petersen, A. C., Sostaric, S., and Gong, X. N-acetylcysteine attenuates the decline in muscle Na+,K+-pump activity and delays fatigue during prolonged exercise in humans. J Physiol 10-1-2006;576(Pt 1):279-288. View abstract.

64530            Lucantoni, G., Pietraforte, D., Matarrese, P., Gambardella, L., Metere, A., Paone, G., Bianchi, E. L., and Straface, E. The red blood cell as a biosensor for monitoring oxidative imbalance in chronic obstructive pulmonary disease: an ex vivo and in vitro study. Antioxid.Redox.Signal. 2006;8(7-8):1171-1182. View abstract.

64531            Ristikankare, A., Kuitunen, T., Kuitunen, A., Uotila, L., Vento, A., Suojaranta-Ylinen, R., Salmenpera, M., and Poyhia, R. Lack of renoprotective effect of i.v. N-acetylcysteine in patients with chronic renal failure undergoing cardiac surgery. Br J Anaesth. 2006;97(5):611-616. View abstract.

64532            Glantzounis, G. K., Yang, W., Koti, R. S., Mikhailidis, D. P., Seifalian, A. M., and Davidson, B. R. The role of thiols in liver ischemia-reperfusion injury. Curr Pharm Des 2006;12(23):2891-2901. View abstract.

64533            Inoue, S., Yamamoto, I., Akieda, K., Sekiguchi, H., Otuka, H., Morita, S., Nakagawa, Y., and Inokuchi, S. [Alcohol abuse case of severe liver dysfunction induced by acetaminophen poisoning which was diagnosed as non-hepatic toxicity on admission]. Chudoku.Kenkyu 2006;19(3):265-271. View abstract.

64534            Stacul, F., Adam, A., Becker, C. R., Davidson, C., Lameire, N., McCullough, P. A., and Tumlin, J. Strategies to reduce the risk of contrast-induced nephropathy. Am J Cardiol. 9-18-2006;98(6A):59K-77K. View abstract.

64535            Schultz, M. J., Baas, M. C., van der Sluijs, H. P., Stamkot, G. A., and Smit, W. N-acetylcysteine and other preventive measures for contrast-induced nephropathy in the intensive care unit. Curr Med Chem. 2006;13(21):2565-2570. View abstract.

64536            Ege, T., Eskiocak, S., Edis, M., and Duran, E. The role of N-acetylcysteine in lower extremity ischemia/reperfusions. J Cardiovasc.Surg (Torino) 2006;47(5):563-568. View abstract.

64537            Kalebic, T., Kinter, A., Poli, G., Anderson, M. E., Meister, A., and Fauci, A. S. Suppression of human immunodeficiency virus expression in chronically infected monocytic cells by glutathione, glutathione ester, and N-acetylcysteine. Proc Natl.Acad.Sci U.S.A 2-1-1991;88(3):986-990. View abstract.

64538            Moore, N. N., Lapsley, M., Norden, A. G., Firth, J. D., Gaunt, M. E., Varty, K., and Boyle, J. R. Does N-acetylcysteine prevent contrast-induced nephropathy during endovascular AAA repair? A randomized controlled pilot study. J Endovasc.Ther 2006;13(5):660-666. View abstract.

64539            Soghier, L. M. and Brion, L. P. Cysteine, cystine or N-acetylcysteine supplementation in parenterally fed neonates. Cochrane.Database.Syst.Rev. 2006;(4):CD004869. View abstract.

64540            Rumiris, D., Purwosunu, Y., Wibowo, N., Farina, A., and Sekizawa, A. Lower rate of preeclampsia after antioxidant supplementation in pregnant women with low antioxidant status. Hypertens.Pregnancy. 2006;25(3):241-253. View abstract.

64541            Mardikian, P. N., LaRowe, S. D., Hedden, S., Kalivas, P. W., and Malcolm, R. J. An open-label trial of N-acetylcysteine for the treatment of cocaine dependence: a pilot study. Prog.Neuropsychopharmacol.Biol Psychiatry 3-30-2007;31(2):389-394. View abstract.

64542            Thaha, M., Yogiantoro, M., and Tomino, Y. Intravenous N-acetylcysteine during haemodialysis reduces the plasma concentration of homocysteine in patients with end-stage renal disease. Clin Drug Investig. 2006;26(4):195-202. View abstract.

64543            Lawlor, D. K., Moist, L., DeRose, G., Harris, K. A., Lovell, M. B., Kribs, S. W., Elliot, J., and Forbes, T. L. Prevention of contrast-induced nephropathy in vascular surgery patients. Ann Vasc.Surg 2007;21(5):593-597. View abstract.

64544            El-Hamamsy, I., Stevens, L. M., Carrier, M., Pellerin, M., Bouchard, D., Demers, P., Cartier, R., Page, P., and Perrault, L. P. Effect of intravenous N-acetylcysteine on outcomes after coronary artery bypass surgery: a randomized, double-blind, placebo-controlled clinical trial. J Thorac.Cardiovasc.Surg 2007;133(1):7-12. View abstract.

64545            Komisarof, J. A., Gilkey, G. M., Peters, D. M., Koudelka, C. W., Meyer, M. M., and Smith, S. M. N-acetylcysteine for patients with prolonged hypotension as prophylaxis for acute renal failure (NEPHRON). Crit Care Med 2007;35(2):435-441. View abstract.

64546            Boesgaard, S., Aldershvile, J., and Poulsen, H. E. Preventive administration of intravenous N-acetylcysteine and development of tolerance to isosorbide dinitrate in patients with angina pectoris. Circulation 1992;85(1):143-149. View abstract.

64547            Tolar, J., Orchard, P. J., Bjoraker, K. J., Ziegler, R. S., Shapiro, E. G., and Charnas, L. N-acetyl-L-cysteine improves outcome of advanced cerebral adrenoleukodystrophy. Bone Marrow Transplant. 2007;39(4):211-215. View abstract.

64548            Thanopoulou, E., Baltayiannis, N., and Lykogianni, V. Nutritional aspects regarding lung cancer chemoprevention. J BUON. 2006;11(1):7-20. View abstract.

64549            Khashab, M., Tector, A. J., and Kwo, P. Y. Epidemiology of acute liver failure. Curr Gastroenterol.Rep. 2007;9(1):66-73. View abstract.

64550            Elnashar, A., Fahmy, M., Mansour, A., and Ibrahim, K. N-acetyl cysteine vs. metformin in treatment of clomiphene citrate-resistant polycystic ovary syndrome: a prospective randomized controlled study. Fertil.Steril. 2007;88(2):406-409. View abstract.

64551            Siriwardena, A. K., Mason, J. M., Balachandra, S., Bagul, A., Galloway, S., Formela, L., Hardman, J. G., and Jamdar, S. Randomised, double blind, placebo controlled trial of intravenous antioxidant (n-acetylcysteine, selenium, vitamin C) therapy in severe acute pancreatitis. Gut 2007;56(10):1439-1444. View abstract.

64552            Sutherland, E. R., Crapo, J. D., and Bowler, R. P. N-acetylcysteine and exacerbations of chronic obstructive pulmonary disease. COPD. 2006;3(4):195-202. View abstract.

64553            Badawy, A., State, O., and Abdelgawad, S. N-Acetyl cysteine and clomiphene citrate for induction of ovulation in polycystic ovary syndrome: a cross-over trial. Acta Obstet.Gynecol.Scand 2007;86(2):218-222. View abstract.

64554            Recio-Mayoral, A., Chaparro, M., Prado, B., Cozar, R., Mendez, I., Banerjee, D., Kaski, J. C., Cubero, J., and Cruz, J. M. The reno-protective effect of hydration with sodium bicarbonate plus N-acetylcysteine in patients undergoing emergency percutaneous coronary intervention: the RENO Study. J.Am.Coll.Cardiol. 3-27-2007;49(12):1283-1288. View abstract.

64555            Haase, M., Haase-Fielitz, A., Bagshaw, S. M., Reade, M. C., Morgera, S., Seevenayagam, S., Matalanis, G., Buxton, B., Doolan, L., and Bellomo, R. Phase II, randomized, controlled trial of high-dose N-acetylcysteine in high-risk cardiac surgery patients. Crit Care Med 2007;35(5):1324-1331. View abstract.

64556            Henke, M. O. and Ratjen, F. Mucolytics in cystic fibrosis. Paediatr.Respir.Rev. 2007;8(1):24-29. View abstract.

64557            Grant, J. E., Kim, S. W., and Odlaug, B. L. N-acetyl cysteine, a glutamate-modulating agent, in the treatment of pathological gambling: a pilot study. Biol Psychiatry 9-15-2007;62(6):652-657. View abstract.

64558            Al-Ghonaim, M. and Pannu, N. Prevention and treatment of contrast-induced nephropathy. Tech.Vasc.Interv.Radiol. 2006;9(2):42-49. View abstract.

64559            di Mario, F., Cavallaro, L. G., Nouvenne, A., Stefani, N., Cavestro, G. M., Iori, V., Maino, M., Comparato, G., Fanigliulo, L., Morana, E., Pilotto, A., Martelli, L., Martelli, M., Leandro, G., and Franze, A. A curcumin-based 1-week triple therapy for eradication of Helicobacter pylori infection: something to learn from failure? Helicobacter. 2007;12(3):238-243. View abstract.

64560            Sandhu, C., Belli, A. M., and Oliveira, D. B. The role of N-acetylcysteine in the prevention of contrast-induced nephrotoxicity. Cardiovasc.Intervent.Radiol. 2006;29(3):344-347. View abstract.

64561            Zagler, A., Azadpour, M., Mercado, C., and Hennekens, C. H. N-acetylcysteine and contrast-induced nephropathy: a meta-analysis of 13 randomized trials. Am Heart J 2006;151(1):140-145. View abstract.

64562            Grimble, G. K. Adverse gastrointestinal effects of arginine and related amino acids. J Nutr 2007;137(6 Suppl 2):1693S-1701S. View abstract.

64563            LaRowe, S. D., Myrick, H., Hedden, S., Mardikian, P., Saladin, M., McRae, A., Brady, K., Kalivas, P. W., and Malcolm, R. Is cocaine desire reduced by N-acetylcysteine? Am J Psychiatry 2007;164(7):1115-1117. View abstract.

64564            Gawenda, M., Moller, A., Wassmer, G., and Brunkwall, J. [Prophylaxis of contrast-induced nephropathy with N-acetylcysteine]. Zentralbl.Chir 2007;132(3):227-231. View abstract.

64565            Sahin, G., Yalcin, A. U., and Akcar, N. Effect of N-acetylcysteine on endothelial dysfunction in dialysis patients. Blood Purif. 2007;25(4):309-315. View abstract.

64566            Chen, N., Aleksa, K., Woodland, C., Rieder, M., and Koren, G. Prevention of ifosfamide nephrotoxicity by N-acetylcysteine: clinical pharmacokinetic considerations. Can J Clin Pharmacol 2007;14(2):e246-e250. View abstract.

64567            Rosner, M. H. and Okusa, M. D. Acute kidney injury associated with cardiac surgery. Clin J Am Soc Nephrol. 2006;1(1):19-32. View abstract.

64568            Gass, J. T. and Olive, M. F. Glutamatergic substrates of drug addiction and alcoholism. Biochem.Pharmacol 1-1-2008;75(1):218-265. View abstract.

64569            Poletti, P. A., Saudan, P., Platon, A., Mermillod, B., Sautter, A. M., Vermeulen, B., Sarasin, F. P., Becker, C. D., and Martin, P. Y. I.v. N-acetylcysteine and emergency CT: use of serum creatinine and cystatin C as markers of radiocontrast nephrotoxicity. AJR Am J Roentgenol. 2007;189(3):687-692. View abstract.

64570            Rogers, D. F. Mucoactive agents for airway mucus hypersecretory diseases. Respir.Care 2007;52(9):1176-1193. View abstract.

64571            Ozcan, E. E., Guneri, S., Akdeniz, B., Akyildiz, I. Z., Senaslan, O., Baris, N., Aslan, O., and Badak, O. Sodium bicarbonate, N-acetylcysteine, and saline for prevention of radiocontrast-induced nephropathy. A comparison of 3 regimens for protecting contrast-induced nephropathy in patients undergoing coronary procedures. A single-center prospective controlled trial. Am Heart J 2007;154(3):539-544. View abstract.

64572            Larson, A. M. Acetaminophen hepatotoxicity. Clin Liver Dis. 2007;11(3):525-48, vi. View abstract.

64573            Baranska-Kosakowska, A., Zakliczynski, M., Przybylski, R., and Zembala, M. Role of N-acetylcysteine on renal function in patients after orthotopic heart transplantation undergoing coronary angiography. Transplant.Proc 2007;39(9):2853-2855. View abstract.

64574            Erley, C. [Iodinated contrast agent-induced nephropathy]. Radiologe 2007;47(9):761-767. View abstract.

64575            Barreto, R. Prevention of contrast-induced nephropathy: the rational use of sodium bicarbonate. Nephrol.Nurs.J 2007;34(4):417-421. View abstract.

64576            Sanders, K. M., Kotowicz, M. A., and Nicholson, G. C. Potential role of the antioxidant N-acetylcysteine in slowing bone resorption in early post-menopausal women: a pilot study. Transl.Res 2007;150(4):215. View abstract.

64577            Boogaard, R., de Jongste, J. C., and Merkus, P. J. Pharmacotherapy of impaired mucociliary clearance in non-CF pediatric lung disease. A review of the literature. Pediatr Pulmonol. 2007;42(11):989-1001. View abstract.

64578            Wijeysundera, D. N., Beattie, W. S., Rao, V., Granton, J. T., and Chan, C. T. N-acetylcysteine for preventing acute kidney injury in cardiac surgery patients with pre-existing moderate renal insufficiency. Can J Anaesth. 2007;54(11):872-881. View abstract.

64579            Soltan-Sharifi, M. S., Mojtahedzadeh, M., Najafi, A., Reza, Khajavi M., Reza, Rouini M., Moradi, M., Mohammadirad, A., and Abdollahi, M. Improvement by N-acetylcysteine of acute respiratory distress syndrome through increasing intracellular glutathione, and extracellular thiol molecules and anti-oxidant power: evidence for underlying toxicological mechanisms. Hum Exp.Toxicol. 2007;26(9):697-703. View abstract.

64580            Zoccali, C., Mallamaci, F., and Tripepi, G. It is important to lower homocysteine in dialysis patients. Semin.Dial. 2007;20(6):530-533. View abstract.

64581            Gonzales, D. A., Norsworthy, K. J., Kern, S. J., Banks, S., Sieving, P. C., Star, R. A., Natanson, C., and Danner, R. L. A meta-analysis of N-acetylcysteine in contrast-induced nephrotoxicity: unsupervised clustering to resolve heterogeneity. BMC.Med 2007;5:32. View abstract.

64582            Fishbane, S. N-acetylcysteine in the prevention of contrast-induced nephropathy. Clin J Am Soc Nephrol. 2008;3(1):281-287. View abstract.

64583            Lavoie, S., Murray, M. M., Deppen, P., Knyazeva, M. G., Berk, M., Boulat, O., Bovet, P., Bush, A. I., Conus, P., Copolov, D., Fornari, E., Meuli, R., Solida, A., Vianin, P., Cuenod, M., Buclin, T., and Do, K. Q. Glutathione precursor, N-acetyl-cysteine, improves mismatch negativity in schizophrenia patients. Neuropsychopharmacology 2008;33(9):2187-2199. View abstract.

64584            Ferreira, L. F. and Reid, M. B. Muscle-derived ROS and thiol regulation in muscle fatigue. J Appl Physiol 2008;104(3):853-860. View abstract.

64585            Maioli, M., Toso, A., Leoncini, M., Gallopin, M., Tedeschi, D., Micheletti, C., and Bellandi, F. Sodium bicarbonate versus saline for the prevention of contrast-induced nephropathy in patients with renal dysfunction undergoing coronary angiography or intervention. J Am Coll.Cardiol. 8-19-2008;52(8):599-604. View abstract.

64586            Shohrati, M., Aslani, J., Eshraghi, M., Alaedini, F., and Ghanei, M. Therapeutics effect of N-acetyl cysteine on mustard gas exposed patients: evaluating clinical aspect in patients with impaired pulmonary function test. Respir.Med 2008;102(3):443-448. View abstract.

64587            Aliavi, A. L. and Kurbanova, G. A. [Nitric oxide metabolism in the inclusion of N-acetylcysteine into the complex therapy of patients with community-acquired pneumonia]. Probl.Tuberk.Bolezn.Legk. 2007;(9):20-24. View abstract.

64588            Sadowska, A. M., Verbraecken, J., Darquennes, K., and De Backer, W. A. Role of N-acetylcysteine in the management of COPD. Int J Chron.Obstruct.Pulmon.Dis. 2006;1(4):425-434. View abstract.

64589            Dekhuijzen, P. N. and van Beurden, W. J. The role for N-acetylcysteine in the management of COPD. Int J Chron.Obstruct.Pulmon.Dis. 2006;1(2):99-106. View abstract.

64590            Rahman, I. Antioxidant therapies in COPD. Int.J Chron.Obstruct.Pulmon.Dis. 2006;1(1):15-29. View abstract.

64591            Mroz, R. M., Noparlik, J., Chyczewska, E., Braszko, J. J., and Holownia, A. [Histone dependent signalization during pharmacotherapy of chronic obstructive pulmonary disease]. Pneumonol.Alergol.Pol. 2007;75(4):375-382. View abstract.

64592            Sisillo, E., Ceriani, R., Bortone, F., Juliano, G., Salvi, L., Veglia, F., Fiorentini, C., and Marenzi, G. N-acetylcysteine for prevention of acute renal failure in patients with chronic renal insufficiency undergoing cardiac surgery: a prospective, randomized, clinical trial. Crit Care Med 2008;36(1):81-86. View abstract.

64593            Aslam, S. Cardiovascular disease in dialysis patients: do some antihypertensive drugs have specific antioxidant effects or is it just blood pressure reduction? Does antioxidant treatment reduce the risk for cardiovascular disease? Curr Opin.Nephrol.Hypertens. 2008;17(1):99-105. View abstract.

64594            Hoshino, Y. and Mishima, M. Redox-based therapeutics for lung diseases. Antioxid.Redox.Signal. 2008;10(4):701-704. View abstract.

64595            Reid, M. B. Free radicals and muscle fatigue: Of ROS, canaries, and the IOC. Free Radic.Biol Med 1-15-2008;44(2):169-179. View abstract.

64596            Yilmaz, H., Sahin, S., Sayar, N., Tangurek, B., Yilmaz, M., Nurkalem, Z., Onturk, E., Cakmak, N., and Bolca, O. Effects of folic acid and N-acetylcysteine on plasma homocysteine levels and endothelial function in patients with coronary artery disease. Acta Cardiol. 2007;62(6):579-585. View abstract.

64597            de Boer, W. I., Yao, H., and Rahman, I. Future therapeutic treatment of COPD: struggle between oxidants and cytokines. Int J Chron.Obstruct.Pulmon.Dis. 2007;2(3):205-228. View abstract.

64598            Ozaydin, M., Peker, O., Erdogan, D., Kapan, S., Turker, Y., Varol, E., Ozguner, F., Dogan, A., and Ibrisim, E. N-acetylcysteine for the prevention of postoperative atrial fibrillation: a prospective, randomized, placebo-controlled pilot study. Eur.Heart J 2008;29(5):625-631. View abstract.

64599            Vats, P., Singh, V. K., Singh, S. N., and Singh, S. B. High altitude induced anorexia: effect of changes in leptin and oxidative stress levels. Nutr Neurosci. 2007;10(5-6):243-249. View abstract.

64600            Stenstrom, D. A., Muldoon, L. L., Armijo-Medina, H., Watnick, S., Doolittle, N. D., Kaufman, J. A., Peterson, D. R., Bubalo, J., and Neuwelt, E. A. N-acetylcysteine use to prevent contrast medium-induced nephropathy: premature phase III trials. J Vasc.Interv.Radiol. 2008;19(3):309-318. View abstract.

64601            Mazer, M. and Perrone, J. Acetaminophen-induced nephrotoxicity: pathophysiology, clinical manifestations, and management. J Med Toxicol. 2008;4(1):2-6. View abstract.

64602            Ivanovski, O., Nikolov, I. G., Drueke, B. T., and Massy, A. Z. Atherosclerosis and vascular calcification in uraemia – a new experimental model. Prilozi. 2007;28(2):11-24. View abstract.

64603            Venkataraman, R. Can we prevent acute kidney injury? Crit Care Med 2008;36(4 Suppl):S166-S171. View abstract.

64604            Barr, L. F. and Kolodner, K. N-acetylcysteine and fenoldopam protect the renal function of patients with chronic renal insufficiency undergoing cardiac surgery. Crit Care Med 2008;36(5):1427-1435. View abstract.

64605            Berk, M., Copolov, D., Dean, O., Lu, K., Jeavons, S., Schapkaitz, I., Anderson-Hunt, M., Judd, F., Katz, F., Katz, P., Ording-Jespersen, S., Little, J., Conus, P., Cuenod, M., Do, K. Q., and Bush, A. I. N-acetyl cysteine as a glutathione precursor for schizophrenia–a double-blind, randomized, placebo-controlled trial. Biol Psychiatry 9-1-2008;64(5):361-368. View abstract.

64606            Guijarro, L. G., Mate, J., Gisbert, J. P., Perez-Calle, J. L., Marin-Jimenez, I., Arriaza, E., Olleros, T., Delgado, M., Castillejo, M. S., Prieto-Merino, D., Gonzalez, Lara, V, and Pena, A. S. N-acetyl-L-cysteine combined with mesalamine in the treatment of ulcerative colitis: randomized, placebo-controlled pilot study. World J Gastroenterol. 5-14-2008;14(18):2851-2857. View abstract.

64607            Adabag, A. S., Ishani, A., Koneswaran, S., Johnson, D. J., Kelly, R. F., Ward, H. B., McFalls, E. O., Bloomfield, H. E., and Chandrashekhar, Y. Utility of N-acetylcysteine to prevent acute kidney injury after cardiac surgery: a randomized controlled trial. Am Heart J 2008;155(6):1143-1149. View abstract.

64608            Berk, M., Copolov, D. L., Dean, O., Lu, K., Jeavons, S., Schapkaitz, I., Anderson-Hunt, M., and Bush, A. I. N-acetyl cysteine for depressive symptoms in bipolar disorder–a double-blind randomized placebo-controlled trial. Biol Psychiatry 9-15-2008;64(6):468-475. View abstract.

64609            Kuleci, S., Hanta, I., Kocabas, A., and Canacankatan, N. The effect of different treatment modalities on oxidative stress in COPD. Adv.Ther 2008;25(7):710-717. View abstract.

64610            Ho, K. M. and Morgan, D. J. Meta-analysis of N-acetylcysteine to prevent acute renal failure after major surgery. Am J Kidney Dis. 2009;53(1):33-40. View abstract.

64611            Peker, O., Peker, T., Erdogan, D., Ozaydin, M., Kapan, S., Sutcu, R., and Ibrisim, E. Effects of intravenous N-acetylcysteine on periprocedural myocardial injury after on-pump coronary artery by-pass grafting. J Cardiovasc.Surg (Torino) 2008;49(4):527-531. View abstract.

64612            Maioli, M., Toso, A., Leoncini, M., Gallopin, M., Tedeschi, D., Micheletti, C., and Bellandi, F. Sodium bicarbonate versus saline for the prevention of contrast-induced nephropathy in patients with renal dysfunction undergoing coronary angiography or intervention. J.Am.Coll.Cardiol. 8-19-2008;52(8):599-604. View abstract.

64613            Bridgeman, M. M., Marsden, M., MacNee, W., Flenley, D. C., and Ryle, A. P. Cysteine and glutathione concentrations in plasma and bronchoalveolar lavage fluid after treatment with N-acetylcysteine. Thorax 1991;46(1):39-42. View abstract.

64614            Ghanei, M., Shohrati, M., Jafari, M., Ghaderi, S., Alaeddini, F., and Aslani, J. N-acetylcysteine improves the clinical conditions of mustard gas-exposed patients with normal pulmonary function test. Basic Clin Pharmacol Toxicol. 2008;103(5):428-432. View abstract.

64615            Shahin, A. Y., Hassanin, I. M., Ismail, A. M., Kruessel, J. S., and Hirchenhain, J. Effect of oral N-acetyl cysteine on recurrent preterm labor following treatment for bacterial vaginosis. Int J Gynaecol.Obstet. 2009;104(1):44-48. View abstract.

64616            Amin, A. F., Shaaban, O. M., and Bediawy, M. A. N-acetyl cysteine for treatment of recurrent unexplained pregnancy loss. Reprod.Biomed.Online. 2008;17(5):722-726. View abstract.

64617            Carbonell, N., Blasco, M., Sanjuan, R., Perez-Sancho, E., Sanchis, J., Insa, L., Bodi, V., Nunez, J., Garcia-Ramon, R., and Miguel, A. Intravenous N-acetylcysteine for preventing contrast-induced nephropathy: a randomised trial. Int J Cardiol. 1-31-2007;115(1):57-62. View abstract.

64618            Kelly, M. K., Wicker, R. J., Barstow, T. J., and Harms, C. A. Effects of N-acetylcysteine on respiratory muscle fatigue during heavy exercise. Respir.Physiol Neurobiol. 1-1-2009;165(1):67-72. View abstract.

64619            Moradi, M., Mojtahedzadeh, M., Mandegari, A., Soltan-Sharifi, M. S., Najafi, A., Khajavi, M. R., Hajibabayee, M., and Ghahremani, M. H. The role of glutathione-S-transferase polymorphisms on clinical outcome of ALI/ARDS patient treated with N-acetylcysteine. Respir.Med 2009;103(3):434-441. View abstract.

64620            Santiago, F. M., Bueno, P., Olmedo, C., Muffak-Granero, K., Comino, A., Serradilla, M., Mansilla, A., Villar, J. M., Garrote, D., and Ferron, J. A. Effect of N-acetylcysteine administration on intraoperative plasma levels of interleukin-4 and interleukin-10 in liver transplant recipients. Transplant.Proc 2008;40(9):2978-2980. View abstract.

64621            ten Dam, M. A. and Wetzels, J. F. Toxicity of contrast media: an update. Neth.J Med 2008;66(10):416-422. View abstract.

64622            Harrison, P. M., Wendon, J. A., Gimson, A. E., Alexander, G. J., and Williams, R. Improvement by acetylcysteine of hemodynamics and oxygen transport in fulminant hepatic failure. N.Engl.J Med 6-27-1991;324(26):1852-1857. View abstract.

64623            Heng, A. E., Cellarier, E., Aublet-Cuvelier, B., Decalf, V., Motreff, P., Marcaggi, X., Deteix, P., and Souweine, B. Is treatment with N-acetylcysteine to prevent contrast-induced nephropathy when using bicarbonate hydration out of date? Clin Nephrol. 2008;70(6):475-484. View abstract.

64624            Naughton, F., Wijeysundera, D., Karkouti, K., Tait, G., and Beattie, W. S. N-acetylcysteine to reduce renal failure after cardiac surgery: a systematic review and meta-analysis. Can J Anaesth. 2008;55(12):827-835. View abstract.

64625            Hart, A. M., Terenghi, G., and Wiberg, M. Neuronal death after peripheral nerve injury and experimental strategies for neuroprotection. Neurol.Res. 2008;30(10):999-1011. View abstract.

64626            Safarinejad, M. R. and Safarinejad, S. Efficacy of selenium and/or N-acetyl-cysteine for improving semen parameters in infertile men: a double-blind, placebo controlled, randomized study. J Urol. 2009;181(2):741-751. View abstract.

64627            Renke, M., Tylicki, L., Rutkowski, P., Larczynski, W., Aleksandrowicz, E., Lysiak-Szydlowska, W., and Rutkowski, B. The effect of N-acetylcysteine on proteinuria and markers of tubular injury in non-diabetic patients with chronic kidney disease. A placebo-controlled, randomized, open, cross-over study. Kidney Blood Press Res 2008;31(6):404-410. View abstract.

64628            Nigwekar, S. U. and Kandula, P. N-acetylcysteine in cardiovascular-surgery-associated renal failure: a meta-analysis. Ann Thorac.Surg 2009;87(1):139-147. View abstract.

64629            Koksal, H., Rahman, A., Burma, O., Halifeoglu, I., and Bayar, M. K. The effects of low dose N-acetylcysteine (NAC) as an adjunct to cardioplegia in coronary artery bypass surgery. Anadolu.Kardiyol.Derg. 2008;8(6):437-443. View abstract.

64630            Charunwatthana, P., Abul, Faiz M., Ruangveerayut, R., Maude, R. J., Rahman, M. R., Roberts, L. J., Moore, K., Bin, Yunus E., Hoque, M. G., Hasan, M. U., Lee, S. J., Pukrittayakamee, S., Newton, P. N., White, N. J., Day, N. P., and Dondorp, A. M. N-acetylcysteine as adjunctive treatment in severe malaria: a randomized, double-blinded placebo-controlled clinical trial. Crit Care Med 2009;37(2):516-522. View abstract.

64631            Leung, K. S. and Cottler, L. B. Treatment of pathological gambling. Curr Opin.Psychiatry 2009;22(1):69-74. View abstract.

64632            Dal, Negro R., Visconti, M., Trevisan, F., Bertacco, S., Micheletto, C., and Tognella, S. Erdosteine enhances airway response to salbutamol in patients with mild-to-moderate COPD. Ther Adv.Respir.Dis. 2008;2(5):271-277. View abstract.

64633            Rahman, I. Antioxidant therapeutic advances in COPD. Ther.Adv.Respir.Dis. 2008;2(6):351-374. View abstract.

64634            Uys, J. D. and LaLumiere, R. T. Glutamate: the new frontier in pharmacotherapy for cocaine addiction. CNS.Neurol.Disord.Drug Targets. 2008;7(5):482-491. View abstract.

64635            Baker, W. L., Anglade, M. W., Baker, E. L., White, C. M., Kluger, J., and Coleman, C. I. Use of N-acetylcysteine to reduce post-cardiothoracic surgery complications: a meta-analysis. Eur.J Cardiothorac.Surg 2009;35(3):521-527. View abstract.

64636            Nash, E. F., Stephenson, A., Ratjen, F., and Tullis, E. Nebulized and oral thiol derivatives for pulmonary disease in cystic fibrosis. Cochrane.Database.Syst.Rev. 2009;(1):CD007168. View abstract.

64637            Chun, L. J., Tong, M. J., Busuttil, R. W., and Hiatt, J. R. Acetaminophen hepatotoxicity and acute liver failure. J Clin Gastroenterol. 2009;43(4):342-349. View abstract.

64638            Rodrigues, A. J., Evora, P. R., Bassetto, S., Alves, L., Jr., Scorzoni, Filho A., Origuela, E. A., and Vicente, W. V. Blood cardioplegia with N-acetylcysteine may reduce coronary endothelial activation and myocardial oxidative stress. Heart Surg Forum 2009;12(1):E44-E48. View abstract.

64639            Jo, S. H., Koo, B. K., Park, J. S., Kang, H. J., Kim, Y. J., Kim, H. L., Chae, I. H., Choi, D. J., Sohn, D. W., Oh, B. H., Park, Y. B., Choi, Y. S., and Kim, H. S. N-acetylcysteine versus AScorbic acid for preventing contrast-Induced nephropathy in patients with renal insufficiency undergoing coronary angiography NASPI study-a prospective randomized controlled trial. Am Heart J 2009;157(3):576-583. View abstract.

64640            Horl, W. H. [Contrast induced nephropathy]. Wien.Klin.Wochenschr. 2009;121(1-2):15-32. View abstract.

64641            Sandilands, E. A. and Bateman, D. N. Adverse reactions associated with acetylcysteine. Clin Toxicol.(Phila) 2009;47(2):81-88. View abstract.

64642            Smilkstein, M. J., Bronstein, A. C., Linden, C., Augenstein, W. L., Kulig, K. W., and Rumack, B. H. Acetaminophen overdose: a 48-hour intravenous N-acetylcysteine treatment protocol. Ann Emerg.Med 1991;20(10):1058-1063. View abstract.

64643            de Gussem, E. M., Snijder, R. J., Disch, F. J., Zanen, P., Westermann, C. J., and Mager, J. J. The effect of N-acetylcysteine on epistaxis and quality of life in patients with HHT: a pilot study. Rhinology 2009;47(1):85-88. View abstract.

64644            Wijeysundera, D. N., Karkouti, K., Rao, V., Granton, J. T., Chan, C. T., Raban, R., Carroll, J., Poonawala, H., and Beattie, W. S. N-acetylcysteine is associated with increased blood loss and blood product utilization during cardiac surgery. Crit Care Med 2009;37(6):1929-1934. View abstract.

64645            Keays, R., Harrison, P. M., Wendon, J. A., Forbes, A., Gove, C., Alexander, G. J., and Williams, R. Intravenous acetylcysteine in paracetamol induced fulminant hepatic failure: a prospective controlled trial. BMJ 10-26-1991;303(6809):1026-1029. View abstract.

64646            Harrison, P. M., Keays, R., Bray, G. P., Alexander, G. J., and Williams, R. Improved outcome of paracetamol-induced fulminant hepatic failure by late administration of acetylcysteine. Lancet 6-30-1990;335(8705):1572-1573. View abstract.

64647            Holdiness, M. R. Clinical pharmacokinetics of N-acetylcysteine. Clin Pharmacokinet. 1991;20(2):123-134. View abstract.

64648            Lopez, R. A., Tornwall, M. S., Henagan, J. M., Smith, G. S., and Miller, T. A. N-acetyl-cysteine: protective agent or promoter of gastric damage? Proc Soc Exp.Biol Med 1991;197(3):273-278. View abstract.

64649            Roederer, M., Staal, F. J., Raju, P. A., Ela, S. W., Herzenberg, L. A., and Herzenberg, L. A. Cytokine-stimulated human immunodeficiency virus replication is inhibited by N-acetyl-L-cysteine. Proc Natl.Acad.Sci U.S.A 1990;87(12):4884-4888. View abstract.

64650            Parker, D., White, J. P., Paton, D., and Routledge, P. A. Safety of late acetylcysteine treatment in paracetamol poisoning. Hum Exp.Toxicol. 1990;9(1):25-27. View abstract.

64651            Robinson, N., Brattsand, R., and Dahlback, M. Effect of oral N-acetylcysteine (NAC) on volume and albumin content of respiratory tract fluid but not on epithelial secretory cell number in “smoking” rats. Eur.Respir.J 1990;3(3):304-310. View abstract.

64652            Beckett, G. J., Donovan, J. W., Hussey, A. J., Proudfoot, A. T., and Prescott, L. F. Intravenous N-acetylcysteine, hepatotoxicity and plasma glutathione S-transferase in patients with paracetamol overdosage. Hum Exp.Toxicol. 1990;9(3):183-186. View abstract.

64653            Dorsch, W., Auch, E., and Powerlowicz, P. Adverse effects of acetylcysteine on human and guinea pig bronchial asthma in vivo and on human fibroblasts and leukocytes in vitro. Int Arch Allergy Appl Immunol. 1987;82(1):33-39. View abstract.

64654            Wu, J., Levy, E. M., and Black, P. H. 2-Mercaptoethanol and n-acetylcysteine enhance T cell colony formation in AIDS and ARC. Clin Exp.Immunol. 1989;77(1):7-10. View abstract.

64655            Sjodin, K., Nilsson, E., Hallberg, A., and Tunek, A. Metabolism of N-acetyl-L-cysteine. Some structural requirements for the deacetylation and consequences for the oral bioavailability. Biochem.Pharmacol 11-15-1989;38(22):3981-3985. View abstract.

64656            Prescott, L. F., Donovan, J. W., Jarvie, D. R., and Proudfoot, A. T. The disposition and kinetics of intravenous N-acetylcysteine in patients with paracetamol overdosage. Eur.J Clin Pharmacol 1989;37(5):501-506. View abstract.

64657            Stafanger, G. and Koch, C. N-acetylcysteine in cystic fibrosis and Pseudomonas aeruginosa infection: clinical score, spirometry and ciliary motility. Eur.Respir.J 1989;2(3):234-237. View abstract.

64658            Dawson, A. H., Henry, D. A., and McEwen, J. Adverse reactions to N-acetylcysteine during treatment for paracetamol poisoning. Med J Aust. 3-20-1989;150(6):329-331. View abstract.

64659            Burgunder, J. M., Varriale, A., and Lauterburg, B. H. Effect of N-acetylcysteine on plasma cysteine and glutathione following paracetamol administration. Eur.J Clin Pharmacol 1989;36(2):127-131. View abstract.

64660            De, Caro L., Ghizzi, A., Costa, R., Longo, A., Ventresca, G. P., and Lodola, E. Pharmacokinetics and bioavailability of oral acetylcysteine in healthy volunteers. Arzneimittelforschung. 1989;39(3):382-386. View abstract.

64661            Badawy, A. H., Abdel Aal, S. F., and Samour, S. A. Liver injury associated with N-acetylcysteine administration. J Egypt.Soc Parasitol. 1989;19(2):563-571. View abstract.

64662            Linden, M., Wieslander, E., Eklund, A., Larsson, K., and Brattsand, R. Effects of oral N-acetylcysteine on cell content and macrophage function in bronchoalveolar lavage from healthy smokers. Eur.Respir.J 1988;1(7):645-650. View abstract.

64663            Eklund, A., Eriksson, O., Hakansson, L., Larsson, K., Ohlsson, K., Venge, P., Bergstrand, H., Bjornson, A., Brattsand, R., Glennow, C., and . Oral N-acetylcysteine reduces selected humoral markers of inflammatory cell activity in BAL fluid from healthy smokers: correlation to effects on cellular variables. Eur.Respir.J 1988;1(9):832-838. View abstract.

64664            Oral N-acetylcysteine and exacerbation rates in patients with chronic bronchitis and severe airways obstruction. British Thoracic Society Research Committee. Thorax 1985;40(11):832-835. View abstract.

64665            Braganza, J. M., Holmes, A. M., Morton, A. R., Stalley, L., Ku, R., and Kisher, R. Acetylcysteine to treat complications of pancreatitis. Lancet 4-19-1986;1(8486):914-915. View abstract.

64666            Endo, A. and Watanabe, T. Analysis of protective activity of N-acetylcysteine against teratogenicity of heavy metals. Reprod.Toxicol. 1988;2(2):141-144. View abstract.

64667            Smilkstein, M. J., Knapp, G. L., Kulig, K. W., and Rumack, B. H. Efficacy of oral N-acetylcysteine in the treatment of acetaminophen overdose. Analysis of the national multicenter study (1976 to 1985). N.Engl.J Med 12-15-1988;319(24):1557-1562. View abstract.

64668            Winniford, M. D., Kennedy, P. L., Wells, P. J., and Hillis, L. D. Potentiation of nitroglycerin-induced coronary dilatation by N-acetylcysteine. Circulation 1986;73(1):138-142. View abstract.

64669            Horowitz, J. D., Henry, C. A., Syrjanen, M. L., Louis, W. J., Fish, R. D., Smith, T. W., and Antman, E. M. Combined use of nitroglycerin and N-acetylcysteine in the management of unstable angina pectoris. Circulation 1988;77(4):787-794. View abstract.

64670            Powell, S. R. and McCay, P. B. Inhibition of doxorubicin-initiated membrane damage by N-acetylcysteine: possible mediation by a thiol-dependent, cytosolic inhibitor of lipid peroxidation. Toxicol.Appl Pharmacol 1988;96(2):175-184. View abstract.

64671            Stafanger, G., Garne, S., Howitz, P., Morkassel, E., and Koch, C. The clinical effect and the effect on the ciliary motility of oral N-acetylcysteine in patients with cystic fibrosis and primary ciliary dyskinesia. Eur.Respir.J 1988;1(2):161-167. View abstract.

64672            Rasmussen, J. B. and Glennow, C. Reduction in days of illness after long-term treatment with N-acetylcysteine controlled-release tablets in patients with chronic bronchitis. Eur.Respir.J 1988;1(4):351-355. View abstract.

64673            Walters, M. T., Rubin, C. E., Keightley, S. J., Ward, C. D., and Cawley, M. I. A double-blind, cross-over, study of oral N-acetylcysteine in Sjogren’s syndrome. Scand J Rheumatol.Suppl 1986;61:253-258. View abstract.

64674            Cato, A., Goldstein, I., and Millman, M. A double-blind parallel study of acetylcysteine-isoproterenol and saline-isoproterenol in patients with chronic obstructive lung disease. J Int Med Res 1977;5(3):175-183. View abstract.

64675            Parr, G. D. and Huitson, A. Oral Fabrol (oral N-acetyl-cysteine) in chronic bronchitis. Br.J.Dis.Chest 1987;81(4):341-348. View abstract.

64676            Rogers, D. F., Godfrey, R. W., Majumdar, S., and Jeffery, P. K. Oral N-acetylcysteine speeds reversal of cigarette smoke-induced mucous cell hyperplasia in the rat. Exp.Lung Res 1988;14(1):19-35. View abstract.

64677            Jensen, T., Kharazmi, A., Schiotz, P. O., Nielsen, H., Stenvang, Pedersen S., Stafanger, G., Koch, C., and Hoiby, N. Effect of oral N-acetylcysteine administration on human blood neutrophil and monocyte function. APMIS 1988;96(1):62-67. View abstract.

64678            Olsson, B., Johansson, M., Gabrielsson, J., and Bolme, P. Pharmacokinetics and bioavailability of reduced and oxidized N-acetylcysteine. Eur.J Clin Pharmacol 1988;34(1):77-82. View abstract.

64679            Kharazmi, A., Nielsen, H., and Schiotz, P. O. N-acetylcysteine inhibits human neutrophil and monocyte chemotaxis and oxidative metabolism. Int J Immunopharmacol. 1988;10(1):39-46. View abstract.

64680            Forman, M. B., Puett, D. W., Cates, C. U., McCroskey, D. E., Beckman, J. K., Greene, H. L., and Virmani, R. Glutathione redox pathway and reperfusion injury. Effect of N-acetylcysteine on infarct size and ventricular function. Circulation 1988;78(1):202-213. View abstract.

64681            Cotgreave, I. A. and Moldeus, P. Methodologies for the analysis of reduced and oxidized N-acetylcysteine in biological systems. Biopharm.Drug Dispos. 1987;8(4):365-375. View abstract.

64682            Rogers, D. F. and Jeffery, P. K. Inhibition by oral N-acetylcysteine of cigarette smoke-induced “bronchitis” in the rat. Exp.Lung Res 1986;10(3):267-283. View abstract.

64683            Wilpart, M., Speder, A., and Roberfroid, M. Anti-initiation activity of N-acetylcysteine in experimental colonic carcinogenesis. Cancer Lett 1986;31(3):319-324. View abstract.

64684            Borgstrom, L., Kagedal, B., and Paulsen, O. Pharmacokinetics of N-acetylcysteine in man. Eur.J Clin Pharmacol 1986;31(2):217-222. View abstract.

64685            Millar, A. B., Pavia, D., Agnew, J. E., Lopez-Vidriero, M. T., Lauque, D., and Clarke, S. W. Effect of oral N-acetylcysteine on mucus clearance. Br J Dis.Chest 1985;79(3):262-266. View abstract.

64686            Ratjen, F., Wonne, R., Posselt, H. G., Stover, B., Hofmann, D., and Bender, S. W. A double-blind placebo controlled trial with oral ambroxol and N-acetylcysteine for mucolytic treatment in cystic fibrosis. Eur.J Pediatr 1985;144(4):374-378. View abstract.

64687            Bowles, W. H. and Goral, V. Clinical trial of the anti-plaque activity of a mucolytic agent, N-Acetyl Cysteine. Dent.Hyg.(Chic.) 1985;59(10):454-456. View abstract.

64688            Verstraeten, J. M. Mucolytic treatment in chronic obstructive pulmonary disease. Double-blind comparative clinical trial with N-acetylcysteine, bromhexine and placebo. Acta Tuberc.Pneumol.Belg. 1979;70(1):71-80. View abstract.

64689            Low, P. M., Dulfano, M. J., Luk, C. K., and Finch, P. J. Effect of N-acetylcysteine on the ciliary beat frequency of human bronchial explants. Ann Allergy 1985;54(4):273-275. View abstract.

64690            Liu, A. J. and Richardson, M. A. Effects of N-acetylcysteine on experimentally induced esophageal lye injury. Ann Otol.Rhinol.Laryngol. 1985;94(5 Pt 1):477-482. View abstract.

64691            Pratt, S. and Ioannides, C. Mechanism of the protective action of n-acetylcysteine and methionine against paracetamol toxicity in the hamster. Arch Toxicol. 1985;57(3):173-177. View abstract.

64692            Grater, W. C. and Cato, A. Double-blind study of acetylcysteine-isoproterenol and saline-isoproterenol in non-hospitalized patients with asthma. Curr Ther Res Clin Exp. 1973;15(9):660-671. View abstract.

64693            Mitchell, J. R., Thorgeirsson, S. S., Potter, W. Z., Jollow, D. J., and Keiser, H. Acetaminophen-induced hepatic injury: protective role of glutathione in man and rationale for therapy. Clin Pharmacol Ther 1974;16(4):676-684. View abstract.

64694            Bellomo, G., Giudice, S., and Ganci, C. [Comparative study of the efficacy of acetylcysteine in oral and intramuscular administration in acute respiratory diseases in pediatrics]. Minerva Pediatr 5-26-1973;25(19):844-849. View abstract.

64695            Grassi, C., Morandini, G. C., and Frigerio, G. Clinical evaluation of systemic acetylcysteine by different routes of administration. Curr Ther Res Clin Exp. 1973;15(4):165-179. View abstract.

64696            Pulle, D. F., Glass, P., and Dulfano, M. J. A controlled study of the safety and efficacy of acetylcysteine-isoproterenol combination. Curr Ther Res Clin Exp. 1970;12(8):485-492. View abstract.

64697            Biscatti, G., Bruschelli, M., Damonte, G., and Capozzi, F. [Controlled studies of the clinical effects of acetylcysteine in oral administration in respiratory infections in pediatrics]. Minerva Pediatr 7-28-1972;24(26):1075-1084. View abstract.

64698            Gottschalk, B. [Therapy of mucoviscidosis using aerosols]. Dtsch.Gesundheitsw. 6-15-1972;27(24):1121-1124. View abstract.

64699            Dano, G. Bronchospasm caused by acetylcysteine in children with bronchial asthma. Acta Allergol. 1971;26(3):181-190. View abstract.

64700            Chodosh, S. and Medici, T. C. The bronchial epithelium in chronic bronchitis. I. Exfoliative cytology during stable, acute bacterial infection and recovery phases. Am Rev.Respir.Dis. 1971;104(6):888-898. View abstract.

64701            Prescott, L. F., Illingworth, R. N., Critchley, J. A., Stewart, M. J., Adam, R. D., and Proudfoot, A. T. Intravenous N-acetylcystine: the treatment of choice for paracetamol poisoning. Br Med J 11-3-1979;2(6198):1097-1100. View abstract.

64702            Shaw, A. Safety of N-acetylcysteine in treatment of meconium obstruction of the newborn. J Pediatr Surg 1969;4(1):119-125. View abstract.

64703            Howatt, W. F. and DeMuth, G. R. A double-blind study of the use of acetylcysteine in patients with cystic fibrosis. Univ Mich.Med Cent.J 1966;32(2):82-85. View abstract.

64704            Hirsch, S. R. and Kory, R. C. An evaluation of the effect of nebulized N-acetylcysteine on sputum consistency. J Allergy 1967;39(5):265-273. View abstract.

64705            Absolon, M. J. and Brown, C. A. Acetylcysteine in kerato-conjunctivitis sicca. Br J Ophthalmol. 1968;52(4):310-316. View abstract.

64706            Peterson, R. G. and Rumack, B. H. Treating acute acetaminophen poisoning with acetylcysteine. JAMA 5-30-1977;237(22):2406-2407. View abstract.

64707            Millman, M. and Grundon, W. Use of acetylcysteine in bronchial asthma and emphysema. J Asthma Res 1969;6(4):199-209. View abstract.

64708            Stephan, U. and Sitzmann, F. C. [On a new possibility of treating pulmonary complications of mucoviscidosis]. Dtsch.Med Wochenschr. 12-3-1965;90(49):2192-2197. View abstract.

64709            Denton, R., Kwart, H., and Litt, M. N-acetylcysteine in cystic fibrosis. Mechanical and chemical factors in treatment by aerosol. Am Rev.Respir.Dis. 1967;95(4):643-651. View abstract.

64710            Vale, J. A. and Wheeler, D. C. Anaphylactoid reaction to acetylcysteine. Lancet 10-30-1982;2(8305):988. View abstract.

64711            Mant, T. G., Tempowski, J. H., Volans, G. N., and Talbot, J. C. Adverse reactions to acetylcysteine and effects of overdose. Br Med J (Clin Res Ed) 7-28-1984;289(6439):217-219. View abstract.

64712            Myers, C., Bonow, R., Palmeri, S., Jenkins, J., Corden, B., Locker, G., Doroshow, J., and Epstein, S. A randomized controlled trial assessing the prevention of doxorubicin cardiomyopathy by N-acetylcysteine. Semin.Oncol 1983;10(1 Suppl 1):53-55. View abstract.

64713            Miller, L. F. and Rumack, B. H. Clinical safety of high oral doses of acetylcysteine. Semin.Oncol 1983;10(1 Suppl 1):76-85. View abstract.

64714            Boman, G., Backer, U., Larsson, S., Melander, B., and Wahlander, L. Oral acetylcysteine reduces exacerbation rate in chronic bronchitis: report of a trial organized by the Swedish Society for Pulmonary Diseases. Eur J Respir.Dis 1983;64(6):405-415. View abstract.

64715            Tattersall, A. B., Bridgman, K. M., and Huitson, A. Irish general practice study of acetylcysteine (Fabrol) in chronic bronchitis. J Int Med Res 1984;12(2):96-101. View abstract.

64716            Romano, C., Gargani, G. F., Minicucci, L., and Nantron, M. [Controlled clinical study on the activity of a new mucoregulating drug in obstructive bronchial pathology with a marked hypersecretory feature. The pediatric experience]. Minerva Pediatr 2-15-1984;36(3):127-138. View abstract.

64717            Jackson, I. M., Barnes, J., and Cooksey, P. Efficacy and tolerability of oral acetylcysteine (Fabrol) in chronic bronchitis: a double-blind placebo controlled study. J Int Med Res 1984;12(3):198-206. View abstract.

64718            Ho, S. W. and Beilin, L. J. Asthma associated with N-acetylcysteine infusion and paracetamol poisoning: report of two cases. Br Med J (Clin Res Ed) 9-24-1983;287(6396):876-877. View abstract.

64719            Vale, J. A. and Buckley, B. M. Asthma associated with N-acetylcysteine infusion and paracetamol poisoning. Br Med J (Clin Res Ed) 10-22-1983;287(6400):1223. View abstract.

64720            Bateman, D. N., Woodhouse, K. W., and Rawlins, M. D. Adverse reactions to N-acetylcysteine. Hum Toxicol. 1984;3(5):393-398. View abstract.

64721            Gervais, S., Lussier-Labelle, F., and Beaudet, G. Anaphylactoid reaction to acetylcysteine. Clin Pharm 1984;3(6):586-587. View abstract.

64722            Peterson, R. G. and Rumack, B. H. Toxicity of acetaminophen overdose. JACEP. 1978;7(5):202-205. View abstract.

64723            Rodenstein, D., DeCoster, A., and Gazzaniga, A. Pharmacokinetics of oral acetylcysteine: absorption, binding and metabolism in patients with respiratory disorders. Clin Pharmacokinet. 1978;3(3):247-254. View abstract.

64724            Tattersall, A. B., Bridgman, K. M., and Huitson, A. Acetylcysteine (Fabrol) in chronic bronchitis–a study in general practice. J Int Med Res 1983;11(5):279-284. View abstract.

64725            Johnston, R. E., Hawkins, H. C., and Weikel, J. H., Jr. The toxicity of N-acetylcysteine in laboratory animals. Semin.Oncol 1983;10(1 Suppl 1):17-24. View abstract.

64726            Casola, G. and vanSonnenberg, E. Skin damage from acetylcysteine leak during percutaneous abscess drainage. Radiology 1984;152(1):233. View abstract.

64727            N-acetylcysteine (NAC): a significant chemoprotective adjunct. Proceedings of a symposium, September 8 and 10, 1982. Semin.Oncol 1983;10(1 Suppl 1):1-92. View abstract.

64728            Gurtoo, H. L., Marinello, A. J., Berrigan, M. J., Bansal, S. K., Paul, B., Pavelic, Z. P., and Struck, R. F. Effect of thiols on toxicity and carcinostatic activity of cyclophosphamide. Semin.Oncol 1983;10(1 Suppl 1):35-45. View abstract.

64729            Morgan, L. R., Holdiness, M. R., and Gillen, L. E. N-acetylcysteine: its bioavailability and interaction with ifosfamide metabolites. Semin.Oncol 1983;10(1 Suppl 1):56-61. View abstract.

64730            Slavik, M. and Saiers, J. H. Phase I clinical study of acetylcysteine’s preventing ifosfamide-induced hematuria. Semin.Oncol 1983;10(1 Suppl 1):62-65. View abstract.

64731            Levy, L. and Vredevoe, D. L. The effect of N-acetylcysteine on cyclophosphamide immunoregulation and antitumor activity. Semin.Oncol 1983;10(1 Suppl 1):7-16. View abstract.

64732            Unverferth, B. J., Magorien, R. D., Balcerzak, S. P., Leier, C. V., and Unverferth, D. V. Early changes in human myocardial nuclei after doxorubicin. Cancer 7-15-1983;52(2):215-221. View abstract.

64733            Stephan, U., Bowing, B., Goering, U., Wiesemann, H. G., Reinhardt, M., Hirche, H., and Brandt, H. Acetylcysteine in the oral mucolytic treatment of cystic fibrosis. Eur.J Respir.Dis.Suppl 1980;111:127-131. View abstract.

64734            Steil, E. and Niessen, K. H. Expiratory ventilatory capacity measurements in children with cystic fibrosis treated by oral acetylcysteine. Eur.J Respir.Dis.Suppl 1980;111:132-133. View abstract.

64735            Gotz, M., Kraemer, R., Kerrebijn, K. F., and Popow, C. Oral acetylcysteine in cystic fibrosis. A co-operative study. Eur.J Respir.Dis.Suppl 1980;111:122-126. View abstract.

64736            Marini, U., Visconti, G., Spotti, D., and Geniram, A. Controlled endoscopic study on gastroduodenal safety of acetylcysteine after oral administration. Eur.J Respir.Dis.Suppl 1980;111:147-150. View abstract.

64737            Brocard, H., Charpin, J., and Germouty, J. [Multicenter, double-blind study of oral acetylcysteine vs. placebo]. Eur.J Respir.Dis.Suppl 1980;111:65-69. View abstract.

64738            Aylward, M., Maddock, J., and Dewland, P. Clinical evaluation of acetylcysteine in the treatment of patients with chronic obstructive bronchitis: a balanced double-blind trial with placebo control. Eur.J Respir.Dis.Suppl 1980;111:81-89. View abstract.

64739            Long-term oral acetylcysteine in chronic bronchitis. a double-blind controlled study. Eur.J Respir.Dis.Suppl 1980;111:93-108. View abstract.

64740            Mitchell, E. A. and Elliott, R. B. Controlled trial of oral N-acetylcysteine in cystic fibrosis. Aust.Paediatr.J 1982;18(1):40-42. View abstract.

64741            Prescott, L. F., Park, J., Ballantyne, A., Adriaenssens, P., and Proudfoot, A. T. Treatment of paracetamol (acetaminophen) poisoning with N-acetylcysteine. Lancet 8-27-1977;2(8035):432-434. View abstract.

64742            Morgan, L. R., Donley, P. J., Harrison, E. F., and Hunter, H. L. The control of ifosfamide-induced hematuria with N-acetylcysteine in patients with advanced carcinoma of the lung. Semin.Oncol 1982;9(4 Suppl 1):71-74. View abstract.

64743            Dietzsch, H. J., Berger, G., Gottschalk, B., Leupold, W., Mittenzwey, K. W., Rupprecht, E., and Wunderlich, P. [Experiences with oral N-acetyl-cysteine treatment in children suffering from cystic fibrosis (author's transl)]. Z.Erkr.Atmungsorgane. 1980;155(1):109-113. View abstract.

64744            Oh, T. E. and Shenfield, G. M. Intravenous N-acetylcysteine for paracetamol poisoning. Med J Aust. 6-28-1980;1(13):664-665. View abstract.

64745            Rumack, B. H., Peterson, R. C., Koch, G. G., and Amara, I. A. Acetaminophen overdose. 662 cases with evaluation of oral acetylcysteine treatment. Arch Intern Med 2-23-1981;141(3 Spec No):380-385. View abstract.

64746            Prescott, L. F. Treatment of severe acetaminophen poisoning with intravenous acetylcysteine. Arch Intern Med 2-23-1981;141(3 Spec No):386-389. View abstract.

64747            Rivabene, R., Viora, M., Matarrese, P., Rainaldi, G., D’Ambrosio, A., and Malorni, W. N-acetyl-cysteine enhances cell adhesion properties of epithelial and lymphoid cells. Cell Biol.Int. 1995;19(8):681-686. View abstract.

64748            Zhang, H., Spapen, H., Nguyen, D. N., Rogiers, P., Bakker, J., and Vincent, J. L. Effects of N-acetyl-L-cysteine on regional blood flow during endotoxic shock. Eur.Surg Res 1995;27(5):292-300. View abstract.

64749            Roberts, R. L., Aroda, V. R., and Ank, B. J. N-acetylcysteine enhances antibody-dependent cellular cytotoxicity in neutrophils and mononuclear cells from healthy adults and human immunodeficiency virus-infected patients. J Infect.Dis. 1995;172(6):1492-1502. View abstract.

64750            Dekhuijzen, P. N. and Van Herwaarden, C. L. Effect of N-acetyl cysteine on thiol levels. Thorax 1995;50(2):215. View abstract.

64751            Malorni, W., Rivabene, R., and Matarrese, P. The antioxidant N-acetyl-cysteine protects cultured epithelial cells from menadione-induced cytopathology. Chem.Biol.Interact. 5-19-1995;96(2):113-123. View abstract.

64752            Witschi, A., Junker, E., Schranz, C., Speck, R. F., and Lauterburg, B. H. Supplementation of N-acetylcysteine fails to increase glutathione in lymphocytes and plasma of patients with AIDS. AIDS Res Hum Retroviruses 1995;11(1):141-143. View abstract.

64753            Burkhart, K. K., Janco, N., Kulig, K. W., and Rumack, B. H. Cimetidine as adjunctive treatment for acetaminophen overdose. Hum Exp.Toxicol. 1995;14(3):299-304. View abstract.

64754            Hultberg, B., Andersson, A., Masson, P., Larson, M., and Tunek, A. Plasma homocysteine and thiol compound fractions after oral administration of N-acetylcysteine. Scand J Clin Lab Invest 1994;54(6):417-422. View abstract.

64755            Grassi, C. and Morandini, G. C. A controlled trial of intermittent oral acetylcysteine in the long-term treatment of chronic bronchitis. Eur.J Clin Pharmacol 3-22-1976;09(5-6):393-396. View abstract.

64756            Norris, P. G., Baker, C. S., Roberts, J. E., and Hawk, J. L. Treatment of erythropoietic protoporphyria with N-acetylcysteine. Arch Dermatol 1995;131(3):354-355. View abstract.

64757            Bakker, J., Zhang, H., Depierreux, M., van, Asbeck S., and Vincent, J. L. Effects of N-acetylcysteine in endotoxic shock. J Crit Care 1994;9(4):236-243. View abstract.

64758            Kinscherf, R., Fischbach, T., Mihm, S., Roth, S., Hohenhaus-Sievert, E., Weiss, C., Edler, L., Bartsch, P., and Droge, W. Effect of glutathione depletion and oral N-acetyl-cysteine treatment on CD4+ and CD8+ cells. FASEB J. 4-1-1994;8(6):448-451. View abstract.

64759            Chan, T. Y. and Critchley, J. A. Adverse reactions to intravenous N-acetylcysteine in Chinese patients with paracetamol (acetaminophen) poisoning. Hum Exp.Toxicol. 1994;13(8):542-544. View abstract.

64760            Spies, C. D., Reinhart, K., Witt, I., Meier-Hellmann, A., Hannemann, L., Bredle, D. L., and Schaffartzik, W. Influence of N-acetylcysteine on indirect indicators of tissue oxygenation in septic shock patients: results from a prospective, randomized, double-blind study. Crit Care Med 1994;22(11):1738-1746. View abstract.

64761            Jones, A. L., Bangash, I. H., Bouchier, I. A., and Hayes, P. C. Portal and systemic haemodynamic action of N-acetylcysteine in patients with stable cirrhosis. Gut 1994;35(9):1290-1293. View abstract.

64762            Hansen, N. C., Skriver, A., Brorsen-Riis, L., Balslov, S., Evald, T., Maltbaek, N., Gunnersen, G., Garsdal, P., Sander, P., Pedersen, J. Z., and . Orally administered N-acetylcysteine may improve general well-being in patients with mild chronic bronchitis. Respir.Med 1994;88(7):531-535. View abstract.

64763            Reid, M. B., Stokic, D. S., Koch, S. M., Khawli, F. A., and Leis, A. A. N-acetylcysteine inhibits muscle fatigue in humans. J Clin Invest 1994;94(6):2468-2474. View abstract.

64764            Chodosh, S., Baigelman, W., Medici, T. C., and Enslein, K. Long-term home use of acetylcysteine in chronic bronchitis. Curr Ther Res Clin Exp. 1975;17(4):319-334. View abstract.

64765            Bridgeman, M. M., Marsden, M., Selby, C., Morrison, D., and MacNee, W. Effect of N-acetyl cysteine on the concentrations of thiols in plasma, bronchoalveolar lavage fluid, and lung tissue. Thorax 1994;49(7):670-675. View abstract.

64766            Vecchiarelli, A., Dottorini, M., Pietrella, D., Cociani, C., Eslami, A., Todisco, T., and Bistoni, F. Macrophage activation by N-acetyl-cysteine in COPD patients. Chest 1994;105(3):806-811. View abstract.

64767            Riise, G. C., Larsson, S., Larsson, P., Jeansson, S., and Andersson, B. A. The intrabronchial microbial flora in chronic bronchitis patients: a target for N-acetylcysteine therapy? Eur.Respir.J 1994;7(1):94-101. View abstract.

64768            Zhang, H., Spapen, H., Nguyen, D. N., Benlabed, M., Buurman, W. A., and Vincent, J. L. Protective effects of N-acetyl-L-cysteine in endotoxemia. Am.J.Physiol 1994;266(5 Pt 2):H1746-H1754. View abstract.

64769            Yim, C. Y., Hibbs, J. B., Jr., McGregor, J. R., Galinsky, R. E., and Samlowski, W. E. Use of N-acetyl cysteine to increase intracellular glutathione during the induction of antitumor responses by IL-2. J Immunol. 6-15-1994;152(12):5796-5805. View abstract.

64770            Beloqui, O., Prieto, J., Suarez, M., Gil, B., Qian, C. H., Garcia, N., and Civeira, M. P. N-acetyl cysteine enhances the response to interferon-alpha in chronic hepatitis C: a pilot study. J.Interferon Res. 1993;13(4):279-282. View abstract.

64771            Suter, P. M., Domenighetti, G., Schaller, M. D., Laverriere, M. C., Ritz, R., and Perret, C. N-acetylcysteine enhances recovery from acute lung injury in man. A randomized, double-blind, placebo-controlled clinical study. Chest 1994;105(1):190-194. View abstract.

64772            Ornaghi, F., Ferrini, S., Prati, M., and Giavini, E. The protective effects of N-acetyl-L-cysteine against methyl mercury embryotoxicity in mice. Fundam.Appl Toxicol. 1993;20(4):437-445. View abstract.

64773            Eylar, E. H., Baez, I., Vazquez, A., and Yamamura, Y. N-acetylcysteine (NAC) enhances interleukin-2 but suppresses interleukin-4 secretion from normal and HIV+ CD4+ T-cells. Cell Mol.Biol (Noisy.-le-grand) 1995;41 Suppl 1:S35-S40. View abstract.

64774            Kottgen, M., Busch, A. E., Hug, M. J., Greger, R., and Kunzelmann, K. N-Acetyl-L-cysteine and its derivatives activate a Cl- conductance in epithelial cells. Pflugers Arch 1996;431(4):549-555. View abstract.

64775            Hida, W., Shindoh, C., Satoh, J., Sagara, M., Kikuchi, Y., Toyota, T., and Shirato, K. N-acetylcysteine inhibits loss of diaphragm function in streptozotocin-treated rats. Am J Respir.Crit Care Med 1996;153(6 Pt 1):1875-1879. View abstract.

64776            Spies, C., Giese, C., Meier-Hellmann, A., Specht, M., Hannemann, L., Schaffartzik, W., and Reinhart, K. [The effect of prophylactically administered n-acetylcysteine on clinical indicators for tissue oxygenation during hyperoxic ventilation in cardiac risk patients]. Anaesthesist 1996;45(4):343-350. View abstract.

64777            Malorni, W., Matarrese, P., Rivabene, R., Paradisi, S., and Donelli, G. Antioxidant N-acetyl-cysteine increasing cell adhesion capability could facilitate the biocompatibility processes. Biomaterials 1996;17(9):921-928. View abstract.

64778            Sochman, J., Vrbska, J., Musilova, B., and Rocek, M. Infarct Size Limitation: acute N-acetylcysteine defense (ISLAND trial): preliminary analysis and report after the first 30 patients. Clin Cardiol. 1996;19(2):94-100. View abstract.

64779            Akerlund, B., Jarstrand, C., Lindeke, B., Sonnerborg, A., Akerblad, A. C., and Rasool, O. Effect of N-acetylcysteine(NAC) treatment on HIV-1 infection: a double-blind placebo-controlled trial. Eur.J Clin Pharmacol 1996;50(6):457-461. View abstract.

64780            Chirkov, Y. Y. and Horowitz, J. D. N-Acetylcysteine potentiates nitroglycerin-induced reversal of platelet aggregation. J Cardiovasc.Pharmacol 1996;28(3):375-380. View abstract.

64781            Hershkovitz, E., Shorer, Z., Levitas, A., and Tal, A. Status epilepticus following intravenous N-acetylcysteine therapy. Isr.J Med Sci 1996;32(11):1102-1104. View abstract.

64782            DiMari, J., Megyesi, J., Udvarhelyi, N., Price, P., Davis, R., and Safirstein, R. N-acetyl cysteine ameliorates ischemic renal failure. Am J Physiol 1997;272(3 Pt 2):F292-F298. View abstract.

64783            Chen, P., Bauer, G., Mitchell, J., Factor, R., Markham, R., and Schwartz, D. H. N-acetyl-cysteine and L-2-oxothiazolidine-4-carboxylic acid enhance contact-dependent growth of HIV in resting peripheral blood mononuclear cells (PBMC) in vitro and increase recovery of HIV from human-PBMC SCID mice. AIDS 1997;11(1):33-41. View abstract.

64784            Johnston, S. C. and Pelletier, L. L., Jr. Enhanced hepatotoxicity of acetaminophen in the alcoholic patient. Two case reports and a review of the literature. Medicine (Baltimore) 1997;76(3):185-191. View abstract.

64785            Bernard, G. R., Wheeler, A. P., Arons, M. M., Morris, P. E., Paz, H. L., Russell, J. A., and Wright, P. E. A trial of antioxidants N-acetylcysteine and procysteine in ARDS. The Antioxidant in ARDS Study Group. Chest 1997;112(1):164-172. View abstract.

64786            Stavem, K. [Anaphylactic reaction to N-acetylcysteine after poisoning with paracetamol]. Tidsskr.Nor Laegeforen. 5-30-1997;117(14):2038-2039. View abstract.

64787            Delneste, Y., Jeannin, P., Potier, L., Romero, P., and Bonnefoy, J. Y. N-acetyl-L-cysteine exhibits antitumoral activity by increasing tumor necrosis factor alpha-dependent T-cell cytotoxicity. Blood 8-1-1997;90(3):1124-1132. View abstract.

64788            Jones, A. L., Jarvie, D. R., Simpson, D., Hayes, P. C., and Prescott, L. F. Pharmacokinetics of N-acetylcysteine are altered in patients with chronic liver disease. Aliment.Pharmacol Ther 1997;11(4):787-791. View abstract.

64789            Walton, N. G., Mann, T. A., and Shaw, K. M. Anaphylactoid reaction to N-acetylcysteine. Lancet 12-15-1979;2(8155):1298. View abstract.

64790            Sheikh-Hamad, D., Timmins, K., and Jalali, Z. Cisplatin-induced renal toxicity: possible reversal by N-acetylcysteine treatment. J Am Soc Nephrol. 1997;8(10):1640-1644. View abstract.

64791            Akerlund, B., Tynell, E., Bratt, G., Bielenstein, M., and Lidman, C. N-acetylcysteine treatment and the risk of toxic reactions to trimethoprim-sulphamethoxazole in primary Pneumocystis carinii prophylaxis in HIV-infected patients. J Infect. 1997;35(2):143-147. View abstract.

64792            Travaline, J. M., Sudarshan, S., Roy, B. G., Cordova, F., Leyenson, V., and Criner, G. J. Effect of N-acetylcysteine on human diaphragm strength and fatigability. Am J Respir.Crit Care Med 1997;156(5):1567-1571. View abstract.

64793            Urban, T., Akerlund, B., Jarstrand, C., and Lindeke, B. Neutrophil function and glutathione-peroxidase (GSH-px) activity in healthy individuals after treatment with N-acetyl-L-cysteine. Biomed.Pharmacother. 1997;51(9):388-390. View abstract.

64794            Perry, H. E. and Shannon, M. W. Efficacy of oral versus intravenous N-acetylcysteine in acetaminophen overdose: results of an open-label, clinical trial. J Pediatr 1998;132(1):149-152. View abstract.

64795            Tecklin, J. S. and Holsclaw, D. S., Jr. Bronchial drainage with aerosol medications in cystic fibrosis. Phys.Ther 1976;56(9):999-1003. View abstract.

64796            Salom, M. G., Ramirez, P., Carbonell, L. F., Lopez, Conesa E., Cartagena, J., Quesada, T., Parrilla, P., and Fenoy, F. J. Protective effect of N-acetyl-L-cysteine on the renal failure induced by inferior vena cava occlusion. Transplantation 5-27-1998;65(10):1315-1321. View abstract.

64797            Spapen, H., Zhang, H., Demanet, C., Vleminckx, W., Vincent, J. L., and Huyghens, L. Does N-acetyl-L-cysteine influence cytokine response during early human septic shock? Chest 1998;113(6):1616-1624. View abstract.

64798            Look, M. P., Rockstroh, J. K., Rao, G. S., Barton, S., Lemoch, H., Kaiser, R., Kupfer, B., Sudhop, T., Spengler, U., and Sauerbruch, T. Sodium selenite and N-acetylcysteine in antiretroviral-naive HIV-1-infected patients: a randomized, controlled pilot study. Eur.J Clin Invest 1998;28(5):389-397. View abstract.

64799            Cimino, L., Belisario, M. A., Intrieri, M., D’Ascoli, B., Sacchetti, L., Salvatore, F., and Budillon, G. Effect of N-acetyl-cysteine on lymphomonocyte glutathione and response to interferon treatment in C-virus chronic hepatitis. Ital.J.Gastroenterol.Hepatol. 1998;30(2):189-193. View abstract.

64800            Rattan, A. K. and Arad, Y. Temporal and kinetic determinants of the inhibition of LDL oxidation by N-acetylcysteine (NAC). Atherosclerosis 1998;138(2):319-327. View abstract.

64801            Salahudeen, A., Poovala, V., Parry, W., Pande, R., Kanji, V., Ansari, N., Morrow, J., and Roberts, J. Cisplatin induces N-acetyl cysteine suppressible F2-isoprostane production and injury in renal tubular epithelial cells. J.Am.Soc.Nephrol. 1998;9(8):1448-1455. View abstract.

64802            Binet, H., Simonart, T., Van Vooren, J. P., Heenen, M., Liesnard, C., Delforge, M. L., Farber, C. M., and Parent, D. Porphyria cutanea tarda in a human immunodeficiency virus-infected patient: treatment with N-acetyl-cysteine. Int.J.Dermatol. 1998;37(9):718-719. View abstract.

64803            Walmsley, S. L., Khorasheh, S., Singer, J., and Djurdjev, O. A randomized trial of N-acetylcysteine for prevention of trimethoprim-sulfamethoxazole hypersensitivity reactions in Pneumocystis carinii pneumonia prophylaxis (CTN 057). Canadian HIV Trials Network 057 Study Group. J Acquir.Immune.Defic.Syndr.Hum Retrovirol. 12-15-1998;19(5):498-505. View abstract.

64804            Shaikh, Z. A., Vu, T. T., and Zaman, K. Oxidative stress as a mechanism of chronic cadmium-induced hepatotoxicity and renal toxicity and protection by antioxidants. Toxicol.Appl Pharmacol 2-1-1999;154(3):256-263. View abstract.

64805            Webb, J. G., Pate, G. E., Humphries, K. H., Buller, C. E., Shalansky, S., Al, Shamari A., Sutander, A., Williams, T., Fox, R. S., and Levin, A. A randomized controlled trial of intravenous N-acetylcysteine for the prevention of contrast-induced nephropathy after cardiac catheterization: lack of effect. Am Heart J 2004;148(3):422-429.

64806            Oldemeyer, J. B. C. E, Wuderman, R., Packard, K., and et al. Prophylactic acetylcysteine is not effective in preventing contrast-induced nephropathy following coronary angiography. J Am Coll.Cardiol. 2002;84A.

64807            Goldenberg, I. J. M., Matetzki, S., Schechter, M, and et al. Contrast-associated nephropathy and clinical outcome of patients with chronic renal insufficiency undergoing cardiac catheterization: lack of additive benefit of acetylcysteine to saline hydration. J Am Coll.Cardiol. 2003;41:537A.

64808            Pate, G. H. K, Shamaria, A., Williams, and et al. Intravenous acetylcysteine in the prevention of contrast induced nephropathy following coronary angiography. Circulation 2003;107:IV-445.

64809            Bariffi, F. and Seccia, A. Ricerca controllata doppio-cieca sull’ attivita dell’ acetilcisteina per via orale in campo bronco-pneumologico. Clin.Ter. 1973;66:311-320.

64810            Lemy-Debois, N., Frigerio, G., and Lualdi, P. Oral acetylcysteine in bronchopulmonary disease. Comparative clinical trial with bromhexine. Acta Ther 1978;4(2):125-132.

64811            Kory, R. C., Hirsch, S. R., and Giraldo, J. Nebulization of N-acetylcysteine combined with a bronchodilator in patients with chronic bronchitis. A controlled study. Chest 1968;54(6):504-509.

64812            Nahir, A. M., Scharf, J. M., and Szargel, R. Effects of oral N-acetylcysteine on both ocular and oral manifestations of Sjogren’s Syndrome. Curr Ther Res 1989;46:187-192.

64813            Charley, G., Dean, B. S., and Krenzelok, E. P. Oral N-acetylcysteine-induced urticaria: a case report. Vet.Hum Toxicol. 1987;29:477.

64814            Semerdjian, R. and et al. Acute changes in airway resistance as an index of drug effects. Clin Res 1967;15:434.

64815            van Zandwijk, N., Maas, L. M., Breedijk, A., Godschalk, R. W. L., Sakai, H., Wigbout, G., Baas, P., Van’t Veer, L., De Flora, S., and Van Schooten, F. J. Aromatic DNA adduct levels in alveolar macrophages and lymphocytes of smoking volunteers; Effects of N-acetylcysteine (NAC) supplementation. Lung Cancer 1997;18(Suppl 1):187.

64816            Sridharan S, Ramamurthy N, and Shyamala CS. In vitro evaluation of the anticancer effect of N-acetylcysteine on oral carcinoma cell line. Indian Journal of Pharmacology 2001;33:343-349.

64817            Walker RE, Lane HC, and Boenning CM. The safety, pharmacokinetics, and antiviral activity of N-acetylcysteine in HIV-infected individuals. J Cell Biochem Suppl 1992;16:89.

64818            Gepts, L. Oral acetylcysteine treatment in exacerbation of chronic bronchitis in 49 patients. Eur J Respir.Dis 1980;61(Suppl 111):109.

64819            Ravez, P., Delwarte, J., Lebert, P., and et al. Short treatment of respiratory disorders with an oral mucolytic agent. Double-blind study with acetycysteine vs. placebo. Eur J Respir.Dis 1980;61(Suppl 111):76.

64820            Meister, R. Langzeittherapie mit Acetylcystein Retard-Tabletten bei Patienten mit chronischer Bronchitis. Eine doppelblinde-placebokontrollierte Studie. Forum Prakt Allg Arzt 1986;25:18-22.

64821            Poder, G., Puskas, J., Kelemen, J., Kiss, A. G., and Cserhati, E. N-Acetylcystein bei chronisch-obstruktiver Bronchitis. Therapiewoche 1984;34:7047-7052.

64822            Henneghien, C., Remacle, P., and Bruart, J. Study of the Nacetylcysteine (NAC) by oral or intravenous administration in chronic bronchitis. Curr Ther Res 1983;34:750-756.

64823            Braum, D. Randomisierte Vergleichsstudie Sinupret Dragées vs. Fluimucil Granulat bei akuter und chronischer Sinusitis. 1986;

64824            Baran, D. Klinischer Doppelblindversuch mit oralem Acetylcystein und Placebo bei zystischer Fibrose. Therapiewoche 1980;30:2034-2039.

64825            Andreana, A., Zampino, R., Tonziello, A., Adinolfi, L. E., Utili, R., and Ruggiero, G. Treatment with N-acetylcysteine (NAC) or ofloxacin (OFLO) as adjunct to INFN failed to achieve response in chronic hepatitis C patients non responding to IFN alone: a phase II study. Hepatology 1997;26:218.

64826            Loutrianakis, E., Stella, D., Hussain, A., Lewis, B., Steen, L., Sochanski, M., Leya, F., and Grassman, E. Randomized comparison of fenoldopam and N-acetylcysteine to saline in the prevention of radiocontrast induced nephropathy. J Am Coll.Cardiol. 2003;41:327A.

64827            Gomes, V. O., Caramori, P., Lasevitch, R., Brizolara, A., Nery, P., Araujo, A., Hemesath, M., and Brito, F. S. Jr. Prevention of contrast-induced nephropathy with N-acetylcysteine in patients undergoing coronary angiography: a randomized multicenter trial. Circulation 2003;108:IV-460.

64828            Nguyen-Ho, P., Dzavik, V., Seidelin, P., Daly, P., Ross, J., McLaughlin, P., Ing, D., Barolet, A., Schwartz, L., and Miner, S. E. N-acetylcysteine does not prevent long-term clinical events despite reducing periprocedural contrast-associated nephropathy. Circulation 2003;108:IV-445.

64829            Agrawal, M., Wodlinger, A. M., Huggins, C. E., Tudor, G. E., Pieper, J. A., O’Reilly, K. P., Denu-Ciocca, C. J., Stouffer, G. A., and Ohman, E. M. Effect of Nacetylcysteine on serum creatinine concentration in patients with chronic renal insufficiency who are undergoing coronary

 


 

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2364               Skubitz KM, Anderson PM. Oral glutamine to prevent chemotherapy induced stomatitis: a pilot study. J Lab Clin Med 1996;127:223-8.. View abstract.

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2366               Ziegler TR, Young LS, Benfell K, et al. Clinical and metabolic efficacy of glutamine-supplemented parenteral nutrition after bone marrow transplantation. A randomized, double-blind, controlled study. Ann Intern Med 1992;116:821-8.. View abstract.

2368               Anderson PM, Ramsay NK, Shu XO, et al. Effect of low-dose oral glutamine on painful stomatitis during bone marrow transplantation. Bone Marrow Transplant 1998;22:339-44.. View abstract.

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2703               Scolapio JS. Effect of growth hormone, glutamine, and diet on body composition in short bowel syndrome: a randomized, controlled study. JPEN J Parenter Enteral Nutr 1999;23:309-12.. View abstract.

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5448               Powell-Tuck J, Jamieson CP, Bettany GE, et al. A double blind, randomised, controlled trial of glutamine supplementation in parenteral nutrition. Gut 1999;45:82-8.. View abstract.

5449               Houdijk AP, Rijnsburger ER, Jansen J, et al. Randomised trial of glutamine-enriched enteral nutrition on infectious morbidity in patients with multiple trauma. Lancet 1998;352:772-6.. View abstract.

5450               Jones C, Palmer TE, Griffiths RD. Randomized clinical outcome study of critically ill patients given glutamine-supplemented enteral nutrition. Nutrition 1999;15:108-15.. View abstract.

5451               Schloerb PR, Skikne BS. Oral and parenteral glutamine in bone marrow transplantation: a randomized, double-blind study. JPEN J Parenter Enteral Nutr 1999;23:117-22.. View abstract.

5452               Brown SA, Goringe A, Fegan C, et al. Parenteral glutamine protects hepatic function during bone marrow transplantation. Bone Marrow Transplant 1998;22:281-4.. View abstract.

5453               Ziegler TR, Bye RL, Persinger RL, et al. Effects of glutamine supplementation on circulating lymphocytes after bone marrow transplantation: a pilot study. Am J Med Sci 1998;315:4-10.. View abstract.

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5457               Bowtell JL, Gelly K, Jackman ML, et al. Effect of oral glutamine on whole body carbohydrate storage during recovery from exhaustive exercise. J Appl Physiol 1999;86:1770-7. View abstract.

5458               Decker-Baumann C, Buhl K, Frohmuller S, et al. Reduction of chemotherapy-induced side-effects by parenteral glutamine supplementation in patients with metastatic colorectal cancer. Eur J Cancer 1999;35:202-7.. View abstract.

5460               Niihara Y, Zerez CR, Akiyama DS, et al. Oral L-glutamine therapy for sickle cell anemia: I. Subjective clinical improvement and favorable change in red cell NAD redox potential. Am J Hematol 1998;58:117-21. View abstract.

5461               Noyer CM, Simon D, Borczuk A, et al. A double-blind placebo-controlled pilot study of glutamine therapy for abnormal intestinal permeability in patients with AIDS. Am J Gastroenterol 1998;93:972-5.. View abstract.

5462               Okuno SH, Woodhouse CO, Loprinzi CL, et al. Phase III controlled evaluation of glutamine for decreasing stomatitis in patients receiving fluorouracil (5-FU)-based chemotherapy. Am J Clin Oncol 1999;22:258-61. View abstract.

5464               Castell LM, Newsholme EA. Glutamine and the effects of exhaustive exercise upon the immune response. Can J Physiol Pharmacol 1998;76:524-32.. View abstract.

5465               Antonio J, Street C. Glutamine: a potentially useful supplement for athletes. Can J Appl Physiol 1999;24:1-14.. View abstract.

5466               Walsh NP, Blannin AK, Robson PJ, Gleeson M. Glutamine, exercise and immune function. Links and possible mechanisms. Sports Med 1998;26:177-91.. View abstract.

5467               Griffiths RD. Glutamine: establishing clinical indications. Curr Opin Clin Nutr Metab Care 1999;2:177-82.. View abstract.

5468               Sacks GS. Glutamine supplementation in catabolic patients. Ann Pharmacother 1999;33:348-54.. View abstract.

5469               Miller AL. Therapeutic considerations of L-glutamine: a review of the literature. Altern Med Rev 1999;4:239-48.. View abstract.

5470               Amores-Sanchez MI, Medina MA. Glutamine, as a precursor of glutathione, and oxidative stress. Mol Genet Metab 1999;67:100-5.. View abstract.

6256               Akobeng AK, Miller V, Stanton J, et al. Double-blind, randomized, controlled trial of glutamine-enriched polymeric diet in the treatment of active Crohn’s disease. J Pediatr Gastroenterol Nutr 2000;30:78-84.. View abstract.

6433               Savarese D, Boucher J, Corey B, et al. Glutamine treatment of paclitaxel-induced myalgias and arthralgias [letter]. J Clin Oncol 1998;16:3918-9.

7233               Bozzetti F, Biganzoli L, Gavazzi C, et al. Glutamine supplementation in cancer patients receiving chemotherapy: a double-blind randomized study. Nutrition 1997;13:748-51.. View abstract.

7235               Savarese D, Al-Zoubi A, Boucher J. Glutamine for irinotecan diarrhea. J Clin Oncol 2000;18:450-1.

7285               Daniele B, Perrone F, Gallo C, et al. Oral glutamine in the prevention of fluorouracil induced intestinal toxicity: a double blind, placebo controlled, randomised trial. Gut 2001;48:28-33.. View abstract.

7288               Robert G. Petit II, Chris French. Phase III Clinical Trial Design Considerations for Oral Treatments of Chemotherapy-Induced Mucositis: AES-14 (Uptake-Facilitated L-Glutamine) Pivotal Studies. 2001 ASCO Annual Meeting. Abstract #2954. Available at: http://www.asco.org/ac/1,1003,_12-002636-00_18-0010-00_19-002954,00.asp.

7291               Mebane AH. L-Glutamine and mania. Am J Psychiatry 984;141:1302-3.

7292               Meldrum BS. Glutamate as a neurotransmitter in the brain: review of physiology and pathology. J Nutr 2000;130:1007S-15S.. View abstract.

7293               Garlick PJ. Assessment of the safety of glutamine and other amino acids. J Nutr 2001;131:2556S-61S.. View abstract.

7294               Chapman AG. Glutamate and epilepsy. J Nutr 2000;130:1043S-5S.. View abstract.

7295               van Zaanen HC, van der Lelie H, Timmer JG, et al. Parenteral glutamine dipeptide supplementation does not ameliorate chemotherapy-induced toxicity. Cancer 1994;74:2879-84.. View abstract.

7296               Coghlin Dickson TM, Wong RM, Negrin RS, et al. Effect of oral glutamine supplementation during bone marrow transplantation. JPEN J Parenter Enteral Nutr 2000;24:61-6.. View abstract.

7297               Zoli G, Care M, Falco F, et al. Effect of oral glutamine on intestinal permeability and nutritional status in Crohn’s disease [abstract]. Gastroenterology 1995;108:A766.

7298               Ribeiro Junior H, Ribeiro T, Mattos A, et al. Treatment of acute diarrhea with oral rehydration solutions containing glutamine. J Am Coll Nutr 1994;13:251-5.. View abstract.

7299               van der Hulst RR, van Kreel BK, von Meyenfeldt MF, et al. Glutamine and the preservation of gut integrity. Lancet 1993;341:1363-5.. View abstract.

7300               Jian ZM, Cao JD, Zhu XG, et al. The impact of alanyl-glutamine on clinical safety, nitrogen balance, intestinal permeability, and clinical outcome in postoperative patients: a randomized, double-blind, controlled study of 120 patients. JPEN J Parenter Enteral Nutr 1999;23:S62-6.. View abstract.

7309               Chuntrasakul C, Siltharm S, Sarasombath S, et al. Metabolic and immune effects of dietary arginine, glutamine and omega-3 fatty acids supplementation in immunocompromised patients. J Med Assoc Thai 1998;81:334-43.. View abstract.

7310               Clark RH, Feleke G, Din M, et al. Nutritional treatment for acquired immunodeficiency virus-associated wasting using beta-hydroxy beta-methylbutyrate, glutamine, and arginine: a randomized, double-blind, placebo-controlled study. JPEN J Parenter Enteral Nutr 2000;24:133-9.. View abstract.

7729               Shabert JK, Winslow C, Lacey JM, Wilmore DW. Glutamine-antioxidant supplementation increases body cell mass in AIDS patients with weight loss: a randomized, double-blind controlled trial. Nutrition 1999;15:860-4.. View abstract.

7730               Scolapio JS, McGreevy K, Tennyson GS, Burnett OL. Effect of glutamine in short-bowel syndrome. Clin Nutr 2001;20:319-23.. View abstract.

7731               Alverdy JC. Effects of glutamine-supplemented diets on immunology of the gut. JPEN J Parenter Enteral Nutr 1990;14:109S-13S.. View abstract.

7732               Mertes N, Schulzki C, Goeters C, et al. Cost containment through L-alanyl-L-glutamine supplemented total parenteral nutrition after major abdominal surgery: a prospective randomized double-blind controlled study. Clin Nutr 2000;19:395-401.. View abstract.

7733               Reeds PJ, Burrin DG. Glutamine and the bowel. J Nutr 2001;131:2505S-8S.. View abstract.

7734               Newsholme P. Why is L-glutamine metabolism important to cells of the immune system in health, postinjury, surgery or infection? J Nutr 2001;131:2515S-22S.. View abstract.

7735               Wilmore DW. The effect of glutamine supplementation in patients following elective surgery and accidental injury. J Nutr 2001;131:2543S-9S.. View abstract.

7736               Kusumoto I. Industrial production of L-glutamine. J Nutr 2001;131:2552S-5S.. View abstract.

7737               Furst P. New developments in glutamine delivery. J Nutr 2001;131:2562S-8S.. View abstract.

7738               Ziegler TR. Glutamine supplementation in cancer patients receiving bone marrow transplantation and high dose chemotherapy. J Nutr 2001;131:2578S-84S.. View abstract.

7739               Medina MA. Glutamine and cancer. J Nutr 2001;131:2539S-42S.. View abstract.

7740               Neu J. Glutamine in the fetus and critically ill low birth weight neonate: metabolism and mechanism of action. J Nutr 2001;131:2585S-9S.. View abstract.

8182               Holecek M. Relation between glutamine, branched-chain amino acids, and protein metabolism. Nutrition 2002;18:130-3.. View abstract.

8183               Khogali SE, Pringle SD, Weryk BV, Rennie MJ. Is glutamine beneficial in ischemic heart disease? Nutrition 2002;18:123-6.. View abstract.

8184               Ziegler TR, Bazargan N, Galloway JR. Glutamine supplemented nutrition support: saving nitrogen and saving money? Clin Nutr 2000;19:375-7.

8185               Szkudlarek J, Jeppesen PB, Mortensen PB. Effect of high dose growth hormone with glutamine and no change in diet on intestinal absorption in short bowel patients: a randomised, double blind, crossover, placebo controlled study. Gut 2000;47:199-205.. View abstract.

8186               Umpleby AM, Carroll PV, Russell-Jones DL, et al. Glutamine supplementation and GH/IGF-I treatment in critically ill patients: effects on glutamine metabolism and protein balance. Nutrition 2002;18:127-9.. View abstract.

10225            Furukawa S, Saito H, Inoue T, et al. Supplemental glutamine augments phagocytosis and reactive oxygen intermediate production by neutrophils and monocytes from postoperative patients in vitro. Nutrition 2000;16:323-9.. View abstract.

10655            Rees C, Oppong K, Mardini H, et al. Effect of L-Ornithine-L-Aspartate on patients with and without TIPS undergoing glutamine challenge: a double blind, placebo controlled trial. Gut 2000;47:571-4.. View abstract.

11364            Ward E, Picton S, Reid U, et al. Oral glutamine in paediatric oncology patients: a dose finding study. Eur J Clin Nutr 2003;57:31-6. View abstract.

13773            Vierck JL, Icenoggle DL, Bucci L, Dodson MV. The effects of ergogenic compounds on myogenic satellite cells. Med Sci Sports Exerc 2003;35:769-76. View abstract.

15726            Falk DJ, Heelan KA, Thyfault JP, Koch AJ. Effects of effervescent creatine, ribose, and glutamine supplementation on muscular strength, muscular endurance, and body composition. Strength Cond Res 2003;17:810-6. View abstract.

46601            Lehmkuhl, M., Malone, M., Justice, B., Trone, G., Pistilli, E., Vinci, D., Haff, E. E., Kilgore, J. L., and Haff, G. G. The effects of 8 weeks of creatine monohydrate and glutamine supplementation on body composition and performance measures. J Strength.Cond.Res 2003;17(3):425-438. View abstract.

46657            Escolar, D. M., Buyse, G., Henricson, E., Leshner, R., Florence, J., Mayhew, J., Tesi-Rocha, C., Gorni, K., Pasquali, L., Patel, K. M., McCarter, R., Huang, J., Mayhew, T., Bertorini, T., Carlo, J., Connolly, A. M., Clemens, P. R., Goemans, N., Iannaccone, S. T., Igarashi, M., Nevo, Y., Pestronk, A., Subramony, S. H., Vedanarayanan, V. V., and Wessel, H. CINRG randomized controlled trial of creatine and glutamine in Duchenne muscular dystrophy. Ann Neurol 2005;58(1):151-155. View abstract.

52253            Jacobi, C. A., Ordemann, J., Zuckermann, H., Docke, W., Volk, H. D., and Muller, J. M. [The influence of alanyl-glutamine on immunologic functions and morbidity in postoperative total parenteral nutrition. Preliminary results of a prospective randomized trial]. Zentralbl.Chir 1999;124(3):199-205. View abstract.

52254            Aosasa, S., Mochizuki, H., Yamamoto, T., Ono, S., and Ichikura, T. A clinical study of the effectiveness of oral glutamine supplementation during total parenteral nutrition: influence on mesenteric mononuclear cells. JPEN J.Parenter.Enteral Nutr. 1999;23(5 Suppl):S41-S44. View abstract.

52255            Neu, J., DeMarco, V., and Weiss, M. Glutamine supplementation in low-birth-weight infants: mechanisms of action. JPEN J.Parenter.Enteral Nutr. 1999;23(5 Suppl):S49-S51. View abstract.

52256            Houdijk, A. P., Nijveldt, R. J., and van Leeuwen, P. A. Glutamine-enriched enteral feeding in trauma patients: reduced infectious morbidity is not related to changes in endocrine and metabolic responses. JPEN J.Parenter.Enteral Nutr. 1999;23(5 Suppl):S52-S58. View abstract.

52257            Barbosa, E., Moreira, E. A., Goes, J. E., and Faintuch, J. Pilot study with a glutamine-supplemented enteral formula in critically ill infants. Rev.Hosp.Clin.Fac.Med.Sao Paulo 1999;54(1):21-24. View abstract.

52258            Pertkiewicz, M., Slotwinski, R., Majewska, K., and Szczygiel, B. [Clinical evaluation of amino acid solution]. Pol.Merkur Lekarski. 1999;7(41):211-214. View abstract.

52259            van Hall, G., Saris, W. H., van de Schoor, P. A., and Wagenmakers, A. J. The effect of free glutamine and peptide ingestion on the rate of muscle glycogen resynthesis in man. Int.J.Sports Med. 2000;21(1):25-30. View abstract.

52260            Huang, E. Y., Leung, S. W., Wang, C. J., Chen, H. C., Sun, L. M., Fang, F. M., Yeh, S. A., Hsu, H. C., and Hsiung, C. Y. Oral glutamine to alleviate radiation-induced oral mucositis: a pilot randomized trial. Int.J.Radiat.Oncol.Biol.Phys. 2-1-2000;46(3):535-539. View abstract.

52261            Walsh, N. P., Blannin, A. K., Bishop, N. C., Robson, P. J., and Gleeson, M. Effect of oral glutamine supplementation on human neutrophil lipopolysaccharide-stimulated degranulation following prolonged exercise. Int.J.Sport Nutr.Exerc.Metab 2000;10(1):39-50. View abstract.

52262            Haisch, M., Fukagawa, N. K., and Matthews, D. E. Oxidation of glutamine by the splanchnic bed in humans. Am.J.Physiol Endocrinol.Metab 2000;278(4):E593-E602. View abstract.

52263            Gore, D. C. and Jahoor, F. Deficiency in peripheral glutamine production in pediatric patients with burns. J.Burn Care Rehabil. 2000;21(2):171-177. View abstract.

52264            Claeyssens, S., Bouteloup-Demange, C., Gachon, P., Hecketsweiler, B., Lerebours, E., Lavoinne, A., and Dechelotte, P. Effect of enteral glutamine on leucine, phenylalanine and glutamine metabolism in hypercortisolemic subjects. Am.J.Physiol Endocrinol.Metab 2000;278(5):E817-E824. View abstract.

52265            Akobeng, A. K., Miller, V., Thomas, A. G., and Richmond, K. Glutamine supplementation and intestinal permeability in Crohn’s disease. JPEN J.Parenter.Enteral Nutr. 2000;24(3):196. View abstract.

52266            van Acker, B. A., Hulsewe, K. W., Wagenmakers, A. J., von Meyenfeldt, M. F., and Soeters, P. B. Response of glutamine metabolism to glutamine-supplemented parenteral nutrition. Am.J.Clin.Nutr. 2000;72(3):790-795. View abstract.

52267            Canovas, G., Leon-Sanz, M., Gomez, P., Valero, M. A., Gomis, P., and La Huerta, J. J. Oral glutamine supplements in autologous hematopoietic transplant: impact on gastrointestinal toxicity and plasma protein levels. Haematologica 2000;85(11):1229-1230. View abstract.

52268            Spittler, A., Sautner, T., Gornikiewicz, A., Manhart, N., Oehler, R., Bergmann, M., Fugger, R., and Roth, E. Postoperative glycyl-glutamine infusion reduces immunosuppression: partial prevention of the surgery induced decrease in HLA-DR expression on monocytes. Clin.Nutr. 2001;20(1):37-42. View abstract.

52269            Boza, J. J., Dangin, M., Moennoz, D., Montigon, F., Vuichoud, J., Jarret, A., Pouteau, E., Gremaud, G., Oguey-Araymon, S., Courtois, D., Woupeyi, A., Finot, P. A., and Ballevre, O. Free and protein-bound glutamine have identical splanchnic extraction in healthy human volunteers. Am.J.Physiol Gastrointest.Liver Physiol 2001;281(1):G267-G274. View abstract.

52270            Yoshida, S., Kaibara, A., Ishibashi, N., and Shirouzu, K. Glutamine supplementation in cancer patients. Nutrition 2001;17(9):766-768. View abstract.

52271            Krzywkowski, K., Petersen, E. W., Ostrowski, K., Kristensen, J. H., Boza, J., and Pedersen, B. K. Effect of glutamine supplementation on exercise-induced changes in lymphocyte function. Am.J.Physiol Cell Physiol 2001;281(4):C1259-C1265. View abstract.

52272            Wischmeyer, P. E., Lynch, J., Liedel, J., Wolfson, R., Riehm, J., Gottlieb, L., and Kahana, M. Glutamine administration reduces Gram-negative bacteremia in severely burned patients: a prospective, randomized, double-blind trial versus isonitrogenous control. Crit Care Med. 2001;29(11):2075-2080. View abstract.

52273            Zhou, Y., Jiang, Z., and Sun, Y. [Glutamine dipeptide enriched enteral nutrition improving gut permeability in sever burns]. Zhonghua Yi.Xue.Za Zhi. 1999;79(11):825-827. View abstract.

52274            Velasco, N., Hernandez, G., Wainstein, C., Castillo, L., Maiz, A., Lopez, F., Guzman, S., Bugedo, G., Acosta, A. M., and Bruhn, A. Influence of polymeric enteral nutrition supplemented with different doses of glutamine on gut permeability in critically ill patients. Nutrition 2001;17(11-12):907-911. View abstract.

52275            Neri, A., Mariani, F., Piccolomini, A., Testa, M., Vuolo, G., and Di Cosmo, L. Glutamine-supplemented total parenteral nutrition in major abdominal surgery. Nutrition 2001;17(11-12):968-969. View abstract.

52276            des, Robert C., Le Bacquer, O., Piloquet, H., Roze, J. C., and Darmaun, D. Acute effects of intravenous glutamine supplementation on protein metabolism in very low birth weight infants: a stable isotope study. Pediatr.Res. 2002;51(1):87-93. View abstract.

52277            Candow, D. G., Chilibeck, P. D., Burke, D. G., Davison, K. S., and Smith-Palmer, T. Effect of glutamine supplementation combined with resistance training in young adults. Eur.J.Appl.Physiol 2001;86(2):142-149. View abstract.

52278            Antonio, J., Sanders, M. S., Kalman, D., Woodgate, D., and Street, C. The effects of high-dose glutamine ingestion on weightlifting performance. J.Strength.Cond.Res. 2002;16(1):157-160. View abstract.

52279            Chen, G., Xie, W., and Jiang, H. [Clinical observation of the protective effect of oral feeding of glutamine granules on intestinal mucous membrane]. Zhonghua Shao Shang Za Zhi. 2001;17(4):210-211. View abstract.

52280            May, P. E., Barber, A., D’Olimpio, J. T., Hourihane, A., and Abumrad, N. N. Reversal of cancer-related wasting using oral supplementation with a combination of beta-hydroxy-beta-methylbutyrate, arginine, and glutamine. Am.J.Surg. 2002;183(4):471-479. View abstract.

52281            Berg, A., Forsberg, E., and Wernerman, J. The local vascular tolerance to an intravenous infusion of a concentrated glutamine solution in ICU patients. Clin.Nutr. 2002;21(2):135-139. View abstract.

52282            Heuschen, U. A., Allemeyer, E. H., Hinz, U., Langer, K., Heuschen, G., Decker-Baumann, C., Herfarth, C., and Stern, J. Glutamine distribution in patients with ulcerative colitis and in patients with familial adenomatous polyposis coli before and after restorative proctocolectomy. Int.J.Colorectal Dis. 2002;17(4):245-252. View abstract.

52283            Griffiths, R. D., Allen, K. D., Andrews, F. J., and Jones, C. Infection, multiple organ failure, and survival in the intensive care unit: influence of glutamine-supplemented parenteral nutrition on acquired infection. Nutrition 2002;18(7-8):546-552. View abstract.

52284            Lin, M. T., Kung, S. P., Yeh, S. L., Lin, C., Lin, T. H., Chen, K. H., Liaw, K. Y., Lee, P. H., Chang, K. J., and Chen, W. J. The effect of glutamine-supplemented total parenteral nutrition on nitrogen economy depends on severity of diseases in surgical patients. Clin.Nutr. 2002;21(3):213-218. View abstract.

52285            Buchman, A. L. Glutamine for short-bowel syndrome. Curr.Gastroenterol.Rep. 2002;4(4):321. View abstract.

52286            Williams, J. Z., Abumrad, N., and Barbul, A. Effect of a specialized amino acid mixture on human collagen deposition. Ann.Surg. 2002;236(3):369-374. View abstract.

52287            Boelens, P. G., Houdijk, A. P., Fonk, J. C., Nijveldt, R. J., Ferwerda, C. C., von Blomberg-van der Flier BM, Thijs, L. G., Haarman, H. J., Puyana, J. C., and van Leeuwen, P. A. Glutamine-enriched enteral nutrition increases HLA-DR expression on monocytes of trauma patients. J.Nutr. 2002;132(9):2580-2586. View abstract.

52288            Conejero, R., Bonet, A., Grau, T., Esteban, A., Mesejo, A., Montejo, J. C., Lopez, J., and Acosta, J. A. Effect of a glutamine-enriched enteral diet on intestinal permeability and infectious morbidity at 28 days in critically ill patients with systemic inflammatory response syndrome: a randomized, single-blind, prospective, multicenter study. Nutrition 2002;18(9):716-721. View abstract.

52289            Goeters, C., Wenn, A., Mertes, N., Wempe, C., Van Aken, H., Stehle, P., and Bone, H. G. Parenteral L-alanyl-L-glutamine improves 6-month outcome in critically ill patients. Crit Care Med. 2002;30(9):2032-2037. View abstract.

52290            Ockenga, J., Borchert, K., Rifai, K., Manns, M. P., and Bischoff, S. C. Effect of glutamine-enriched total parenteral nutrition in patients with acute pancreatitis. Clin.Nutr. 2002;21(5):409-416. View abstract.

52291            Hallay, J., Kovacs, G., Kiss, Sz S., Farkas, M., Lakos, G., Sipka, S., Bodolay, E., and Sapy, P. Changes in the nutritional state and immune-serological parameters of esophagectomized patients fed jejunaly with glutamine-poor and glutamine-rich nutriments. Hepatogastroenterology 2002;49(48):1555-1559. View abstract.

52292            Pytlik, R., Benes, P., Patorkova, M., Chocenska, E., Gregora, E., Prochazka, B., and Kozak, T. Standardized parenteral alanyl-glutamine dipeptide supplementation is not beneficial in autologous transplant patients: a randomized, double-blind, placebo controlled study. Bone Marrow Transplant. 2002;30(12):953-961. View abstract.

52293            Exner, R., Tamandl, D., Goetzinger, P., Mittlboeck, M., Fuegger, R., Sautner, T., Spittler, A., and Roth, E. Perioperative GLY-GLN infusion diminishes the surgery-induced period of immunosuppression: accelerated restoration of the lipopolysaccharide-stimulated tumor necrosis factor-alpha response. Ann.Surg. 2003;237(1):110-115. View abstract.

52294            Boelens, P. G., Houdijk, A. P., de Thouars, H. N., Teerlink, T., van Engeland, M. I., Haarman, H. J., and van Leeuwen, P. A. Plasma taurine concentrations increase after enteral glutamine supplementation in trauma patients and stressed rats. Am.J.Clin.Nutr. 2003;77(1):250-256. View abstract.

52295            Pytlik, R., Gregora, E., Benes, P., and Kozak, T. [Effect of parenteral glutamine on restoration of lymphocyte subpopulations after high-dose chemotherapy and autologous hematopoietic cell transplantation: data from a double-blind randomized study]. Epidemiol.Mikrobiol.Imunol. 2002;51(4):152-155. View abstract.

52296            Poindexter, B. B., Ehrenkranz, R. A., Stoll, B. J., Koch, M. A., Wright, L. L., Oh, W., Papile, L. A., Bauer, C. R., Carlo, W. A., Donovan, E. F., Fanaroff, A. A., Korones, S. B., Laptook, A. R., Shankaran, S., Stevenson, D. K., Tyson, J. E., and Lemons, J. A. Effect of parenteral glutamine supplementation on plasma amino acid concentrations in extremely low-birth-weight infants. Am.J.Clin.Nutr. 2003;77(3):737-743. View abstract.

52297            Piccirillo, N., De Matteis, S., Laurenti, L., Chiusolo, P., Sora, F., Pittiruti, M., Rutella, S., Cicconi, S., Fiorini, A., D’Onofrio, G., Leone, G., and Sica, S. Glutamine-enriched parenteral nutrition after autologous peripheral blood stem cell transplantation: effects on immune reconstitution and mucositis. Haematologica 2003;88(2):192-200. View abstract.

52298            Flaring, U. B., Rooyackers, O. E., Wernerman, J., and Hammarqvist, F. Glutamine attenuates post-traumatic glutathione depletion in human muscle. Clin.Sci.(Lond) 2003;104(3):275-282. View abstract.

52299            Hiscock, N., Petersen, E. W., Krzywkowski, K., Boza, J., Halkjaer-Kristensen, J., and Pedersen, B. K. Glutamine supplementation further enhances exercise-induced plasma IL-6. J.Appl.Physiol 2003;95(1):145-148. View abstract.

52300            Zhou, Y., Sun, Y., Jiang, Z., He, G., and Yang, N. [The effects of glutamine dipeptide on the improvement of endotoxemia in severely burned patients]. Zhonghua Shao Shang Za Zhi. 2002;18(6):343-345. View abstract.

52301            Coeffier, M., Claeyssens, S., Hecketsweiler, B., Lavoinne, A., Ducrotte, P., and Dechelotte, P. Enteral glutamine stimulates protein synthesis and decreases ubiquitin mRNA level in human gut mucosa. Am.J.Physiol Gastrointest.Liver Physiol 2003;285(2):G266-G273. View abstract.

52302            Mercier, A., Eurin, D., Poulet-Young, V., Marret, S., and Dechelotte, P. Effect of enteral supplementation with glutamine on mesenteric blood flow in premature neonates. Clin.Nutr. 2003;22(2):133-137. View abstract.

52303            Kozelsky, T. F., Meyers, G. E., Sloan, J. A., Shanahan, T. G., Dick, S. J., Moore, R. L., Engeler, G. P., Frank, A. R., McKone, T. K., Urias, R. E., Pilepich, M. V., Novotny, P. J., and Martenson, J. A. Phase III double-blind study of glutamine versus placebo for the prevention of acute diarrhea in patients receiving pelvic radiation therapy. J.Clin.Oncol. 5-1-2003;21(9):1669-1674. View abstract.

52304            Carroll, P. V., Jackson, N. C., Russell-Jones, D. L., Treacher, D. F., Sonksen, P. H., and Umpleby, A. M. Combined growth hormone/insulin-like growth factor I in addition to glutamine-supplemented TPN results in net protein anabolism in critical illness. Am.J.Physiol Endocrinol.Metab 2004;286(1):E151-E157. View abstract.

52305            Vaughn, P., Thomas, P., Clark, R., and Neu, J. Enteral glutamine supplementation and morbidity in low birth weight infants. J.Pediatr. 2003;142(6):662-668. View abstract.

52306            Zhu, M., Tang, D., Zhao, X., Cao, J., Wei, J., Chen, Y., Xiao, L., and Sun, Q. [Impact of glutamine of gut permeability and clinical prognosis on the aging patients undergoing gastric-intestinal operation]. Zhongguo Yi.Xue.Ke.Xue.Yuan Xue.Bao. 2000;22(5):425-427. View abstract.

52307            Zhou, Y. P., Jiang, Z. M., Sun, Y. H., Wang, X. R., Ma, E. L., and Wilmore, D. The effect of supplemental enteral glutamine on plasma levels, gut function, and outcome in severe burns: a randomized, double-blind, controlled clinical trial. JPEN J.Parenter.Enteral Nutr. 2003;27(4):241-245. View abstract.

52308            Hall, J. C., Dobb, G., Hall, J., de Sousa, R., Brennan, L., and McCauley, R. A prospective randomized trial of enteral glutamine in critical illness. Intensive Care Med. 2003;29(10):1710-1716. View abstract.

52309            Cunha, W. D., Friedler, G., Vaisberg, M., Egami, M. I., and Costa Rosa, L. F. Immunosuppression in undernourished rats: the effect of glutamine supplementation. Clin.Nutr. 2003;22(5):453-457. View abstract.

52310            M’bemba, J., Cynober, L., de, Bandt P., Taverna, M., Chevalier, A., Bardin, C., Slama, G., and Selam, J. L. Effects of dipeptide administration on hypoglycaemic counterregulation in type 1 diabetes. Diabetes Metab 2003;29(4 Pt 1):412-417. View abstract.

52311            Garrel, D., Patenaude, J., Nedelec, B., Samson, L., Dorais, J., Champoux, J., D’Elia, M., and Bernier, J. Decreased mortality and infectious morbidity in adult burn patients given enteral glutamine supplements: a prospective, controlled, randomized clinical trial. Crit Care Med. 2003;31(10):2444-2449. View abstract.

52312            Thompson, S. W., McClure, B. G., and Tubman, T. R. A randomized, controlled trial of parenteral glutamine in ill, very low birth-weight neonates. J.Pediatr.Gastroenterol.Nutr. 2003;37(5):550-553. View abstract.

52313            Huffman, F. G. and Walgren, M. E. L-glutamine supplementation improves nelfinavir-associated diarrhea in HIV-infected individuals. HIV.Clin.Trials 2003;4(5):324-329. View abstract.

52314            Arwert, L. I., Deijen, J. B., and Drent, M. L. Effects of an oral mixture containing glycine, glutamine and niacin on memory, GH and IGF-I secretion in middle-aged and elderly subjects. Nutr.Neurosci. 2003;6(5):269-275. View abstract.

52315            Tjader, I., Rooyackers, O., Forsberg, A. M., Vesali, R. F., Garlick, P. J., and Wernerman, J. Effects on skeletal muscle of intravenous glutamine supplementation to ICU patients. Intensive Care Med. 2004;30(2):266-275. View abstract.

52316            Fuentes-Orozco, C., Anaya-Prado, R., Gonzalez-Ojeda, A., Arenas-Marquez, H., Cabrera-Pivaral, C., Cervantes-Guevara, G., and Barrera-Zepeda, L. M. L-alanyl-L-glutamine-supplemented parenteral nutrition improves infectious morbidity in secondary peritonitis. Clin.Nutr. 2004;23(1):13-21. View abstract.

52317            Sax, H. C. Clinical and metabolic efficacy of glutamine-supplemented parenteral nutrition after bone marrow transplantation. A randomized, double-blind, controlled study. JPEN J.Parenter.Enteral Nutr. 1992;16(6):589-590. View abstract.

52318            Parimi, P. S., Devapatla, S., Gruca, L. L., Amini, S. B., Hanson, R. W., and Kalhan, S. C. Effect of enteral glutamine or glycine on whole-body nitrogen kinetics in very-low-birth-weight infants. Am.J.Clin.Nutr. 2004;79(3):402-409. View abstract.

52319            Scheid, C., Hermann, K., Kremer, G., Holsing, A., Heck, G., Fuchs, M., Waldschmidt, D., Herrmann, H. J., Sohngen, D., Diehl, V., and Schwenk, A. Randomized, double-blind, controlled study of glycyl-glutamine-dipeptide in the parenteral nutrition of patients with acute leukemia undergoing intensive chemotherapy. Nutrition 2004;20(3):249-254. View abstract.

52320            Lai, Y. N., Yeh, S. L., Lin, M. T., Shang, H. F., Yeh, C. L., and Chen, W. J. Glutamine supplementation enhances mucosal immunity in rats with Gut-Derived sepsis. Nutrition 2004;20(3):286-291. View abstract.

52321            Darmaun, D., Hayes, V., Schaeffer, D., Welch, S., and Mauras, N. Effects of glutamine and recombinant human growth hormone on protein metabolism in prepubertal children with cystic fibrosis. J.Clin.Endocrinol.Metab 2004;89(3):1146-1152. View abstract.

52322            Peng, X., Yan, H., You, Z., Wang, P., and Wang, S. Effects of enteral supplementation with glutamine granules on intestinal mucosal barrier function in severe burned patients. Burns 2004;30(2):135-139. View abstract.

52323            Yalcin, S. S., Yurdakok, K., Tezcan, I., and Oner, L. Effect of glutamine supplementation on diarrhea, interleukin-8 and secretory immunoglobulin A in children with acute diarrhea. J.Pediatr.Gastroenterol.Nutr. 2004;38(5):494-501. View abstract.

52324            Krieger, J. W., Crowe, M., and Blank, S. E. Chronic glutamine supplementation increases nasal but not salivary IgA during 9 days of interval training. J.Appl.Physiol 2004;97(2):585-591. View abstract.

52325            Poindexter, B. B., Ehrenkranz, R. A., Stoll, B. J., Wright, L. L., Poole, W. K., Oh, W., Bauer, C. R., Papile, L. A., Tyson, J. E., Carlo, W. A., Laptook, A. R., Narendran, V., Stevenson, D. K., Fanaroff, A. A., Korones, S. B., Shankaran, S., Finer, N. N., and Lemons, J. A. Parenteral glutamine supplementation does not reduce the risk of mortality or late-onset sepsis in extremely low birth weight infants. Pediatrics 2004;113(5):1209-1215. View abstract.

52326            Peng, X., You, Z. Y., Huang, X. K., Zhang, S. Q., He, G. Z., Xie, W. G., and Quan, Z. F. [Effects of glutamine granules on protein metabolism in trauma patients]. Zhonghua Wai Ke.Za Zhi. 4-7-2004;42(7):406-409. View abstract.

52327            Boelens, P. G., Houdijk, A. P., Fonk, J. C., Puyana, J. C., Haarman, H. J., von Blomberg-van der Flier ME, and van Leeuwen, P. A. Glutamine-enriched enteral nutrition increases in vitro interferon-gamma production but does not influence the in vivo specific antibody response to KLH after severe trauma. A prospective, double blind, randomized clinical study. Clin.Nutr. 2004;23(3):391-400. View abstract.

52328            Sheridan, R. L., Prelack, K., Yu, Y. M., Lydon, M., Petras, L., Young, V. R., and Tompkins, R. G. Short-term enteral glutamine does not enhance protein accretion in burned children: a stable isotope study. Surgery 2004;135(6):671-678. View abstract.

52329            Quan, Z. F., Yang, C., Li, N., and Li, J. S. Effect of glutamine on change in early postoperative intestinal permeability and its relation to systemic inflammatory response. World J.Gastroenterol. 7-1-2004;10(13):1992-1994. View abstract.

52330            Duggan, C., Stark, A. R., Auestad, N., Collier, S., Fulhan, J., Gura, K., Utter, S., Teixeira-Pinto, A., Donovan, K., and Lund, D. Glutamine supplementation in infants with gastrointestinal disease: a randomized, placebo-controlled pilot trial. Nutrition 2004;20(9):752-756. View abstract.

52331            Jacobson, S. D., Loprinzi, C. L., Sloan, J. A., Wilke, J. L., Novotny, P. J., Okuno, S. H., Jatoi, A., and Moynihan, T. J. Glutamine does not prevent paclitaxel-associated myalgias and arthralgias. J.Support.Oncol. 2003;1(4):274-278. View abstract.

52332            van den Berg, A., van Elburg, R. M., Twisk, J. W., and Fetter, W. P. Glutamine-enriched enteral nutrition in very low birth weight infants. Design of a double-blind randomised controlled trial [ISRCTN73254583]. BMC.Pediatr. 9-1-2004;4:17. View abstract.

52333            Hulsewe, K. W., van Acker, B. A., Hameeteman, W., van der Hulst, R. R., Vainas, T., Arends, J. W., van Kreel, B. K., von Meyenfeldt, M. F., and Soeters, P. B. Does glutamine-enriched parenteral nutrition really affect intestinal morphology and gut permeability? Clin.Nutr. 2004;23(5):1217-1225. View abstract.

52334            Williams, R., Olivi, S., Li, C. S., Storm, M., Cremer, L., Mackert, P., and Wang, W. Oral glutamine supplementation decreases resting energy expenditure in children and adolescents with sickle cell anemia. J.Pediatr.Hematol.Oncol. 2004;26(10):619-625. View abstract.

52335            Lima, A. A., Brito, L. F., Ribeiro, H. B., Martins, M. C., Lustosa, A. P., Rocha, E. M., Lima, N. L., Monte, C. M., and Guerrant, R. L. Intestinal barrier function and weight gain in malnourished children taking glutamine supplemented enteral formula. J Pediatr.Gastroenterol.Nutr. 2005;40(1):28-35. View abstract.

52336            Coeffier, M., Hecketsweiler, B., Hecketsweiler, P., and Dechelotte, P. Effect of glutamine on water and sodium absorption in human jejunum at baseline and during PGE1-induced secretion. J Appl.Physiol 2005;98(6):2163-2168. View abstract.

52337            Peng, X., Yan, H., You, Z., Wang, P., and Wang, S. Clinical and protein metabolic efficacy of glutamine granules-supplemented enteral nutrition in severely burned patients. Burns 2005;31(3):342-346. View abstract.

52338            Albers, M. J., Steyerberg, E. W., Hazebroek, F. W., Mourik, M., Borsboom, G. J., Rietveld, T., Huijmans, J. G., and Tibboel, D. Glutamine supplementation of parenteral nutrition does not improve intestinal permeability, nitrogen balance, or outcome in newborns and infants undergoing digestive-tract surgery: results from a double-blind, randomized, controlled trial. Ann.Surg. 2005;241(4):599-606. View abstract.

52339            Kalhan, S. C., Parimi, P. S., Gruca, L. L., and Hanson, R. W. Glutamine supplement with parenteral nutrition decreases whole body proteolysis in low birth weight infants. J Pediatr. 2005;146(5):642-647. View abstract.

52340            Marcora, S., Lemmey, A., and Maddison, P. Dietary treatment of rheumatoid cachexia with beta-hydroxy-beta-methylbutyrate, glutamine and arginine: a randomised controlled trial. Clin.Nutr. 2005;24(3):442-454. View abstract.

52341            Klek, S., Kulig, J., Szczepanik, A. M., Jedrys, J., and Kolodziejczyk, P. The clinical value of parenteral immunonutrition in surgical patients. Acta Chir Belg. 2005;105(2):175-179. View abstract.

52342            van den Berg, A., van Elburg, R. M., Westerbeek, E. A., Twisk, J. W., and Fetter, W. P. Glutamine-enriched enteral nutrition in very-low-birth-weight infants and effects on feeding tolerance and infectious morbidity: a randomized controlled trial. Am.J Clin.Nutr. 2005;81(6):1397-1404. View abstract.

52343            Ziegler, T. R., Ogden, L. G., Singleton, K. D., Luo, M., Fernandez-Estivariz, C., Griffith, D. P., Galloway, J. R., and Wischmeyer, P. E. Parenteral glutamine increases serum heat shock protein 70 in critically ill patients. Intensive Care Med 2005;31(8):1079-1086. View abstract.

52344            Stubblefield, M. D., Vahdat, L. T., Balmaceda, C. M., Troxel, A. B., Hesdorffer, C. S., and Gooch, C. L. Glutamine as a neuroprotective agent in high-dose paclitaxel-induced peripheral neuropathy: a clinical and electrophysiologic study. Clin.Oncol.(R.Coll.Radiol.) 2005;17(4):271-276. View abstract.

52345            Rogeri, P. S. and Costa Rosa, L. F. Plasma glutamine concentration in spinal cord injured patients. Life Sci 9-23-2005;77(19):2351-2360. View abstract.

52346            Iwashita, S., Williams, P., Jabbour, K., Ueda, T., Kobayashi, H., Baier, S., and Flakoll, P. J. Impact of glutamine supplementation on glucose homeostasis during and after exercise. J Appl.Physiol 2005;99(5):1858-1865. View abstract.

52347            Yao, G. X., Xue, X. B., Jiang, Z. M., Yang, N. F., and Wilmore, D. W. Effects of perioperative parenteral glutamine-dipeptide supplementation on plasma endotoxin level, plasma endotoxin inactivation capacity and clinical outcome. Clin.Nutr. 2005;24(4):510-515. View abstract.

52348            Ockenga, J., Borchert, K., Stuber, E., Lochs, H., Manns, M. P., and Bischoff, S. C. Glutamine-enriched total parenteral nutrition in patients with inflammatory bowel disease. Eur.J Clin.Nutr. 2005;59(11):1302-1309. View abstract.

52349            Aquino, V. M., Harvey, A. R., Garvin, J. H., Godder, K. T., Nieder, M. L., Adams, R. H., Jackson, G. B., and Sandler, E. S. A double-blind randomized placebo-controlled study of oral glutamine in the prevention of mucositis in children undergoing hematopoietic stem cell transplantation: a pediatric blood and marrow transplant consortium study. Bone Marrow Transplant. 2005;36(7):611-616. View abstract.

52350            Blijlevens, N. M., Donnelly, J. P., Naber, A. H., Schattenberg, A. V., and DePauw, B. E. A randomised, double-blinded, placebo-controlled, pilot study of parenteral glutamine for allogeneic stem cell transplant patients. Support.Care Cancer 2005;13(10):790-796. View abstract.

52351            Byrne, T. A., Wilmore, D. W., Iyer, K., Dibaise, J., Clancy, K., Robinson, M. K., Chang, P., Gertner, J. M., and Lautz, D. Growth hormone, glutamine, and an optimal diet reduces parenteral nutrition in patients with short bowel syndrome: a prospective, randomized, placebo-controlled, double-blind clinical trial. Ann.Surg. 2005;242(5):655-661. View abstract.

52352            Kadrofske, M. M., Parimi, P. S., Gruca, L. L., and Kalhan, S. C. Effect of intravenous amino acids on glutamine and protein kinetics in low-birth-weight preterm infants during the immediate neonatal period. Am.J Physiol Endocrinol.Metab 2006;290(4):E622-E630. View abstract.

52353            Lin, M. T., Kung, S. P., Yeh, S. L., Liaw, K. Y., Wang, M. Y., Kuo, M. L., Lee, P. H., and Chen, W. J. Glutamine-supplemented total parenteral nutrition attenuates plasma interleukin-6 in surgical patients with lower disease severity. World J Gastroenterol. 10-21-2005;11(39):6197-6201. View abstract.

52354            Schulman, A. S., Willcutts, K. F., Claridge, J. A., Evans, H. L., Radigan, A. E., O’Donnell, K. B., Camden, J. R., Chong, T. W., McElearney, S. T., Smith, R. L., Gazoni, L. M., Farinholt, H. M., Heuser, C. C., Lowson, S. M., Schirmer, B. D., Young, J. S., and Sawyer, R. G. Does the addition of glutamine to enteral feeds affect patient mortality? Crit Care Med 2005;33(11):2501-2506. View abstract.

52355            Sykorova, A., Horacek, J., Zak, P., Kmonicek, M., Bukac, J., and Maly, J. A randomized, double blind comparative study of prophylactic parenteral nutritional support with or without glutamine in autologous stem cell transplantation for hematological malignancies — three years’ follow-up. Neoplasma 2005;52(6):476-482. View abstract.

52356            Kargotich, S., Rowbottom, D. G., Keast, D., Goodman, C., Dawson, B., and Morton, A. R. Plasma glutamine changes after high-intensity exercise in elite male swimmers. Res.Sports Med 2005;13(1):7-21. View abstract.

52357            Ohtani, M., Sugita, M., and Maruyama, K. Amino acid mixture improves training efficiency in athletes. J Nutr. 2006;136(2):538S-543S. View abstract.

52358            Bakalar, B., Duska, F., Pachl, J., Fric, M., Otahal, M., Pazout, J., and Andel, M. Parenterally administered dipeptide alanyl-glutamine prevents worsening of insulin sensitivity in multiple-trauma patients. Crit Care Med 2006;34(2):381-386. View abstract.

52359            Dechelotte, P., Hasselmann, M., Cynober, L., Allaouchiche, B., Coeffier, M., Hecketsweiler, B., Merle, V., Mazerolles, M., Samba, D., Guillou, Y. M., Petit, J., Mansoor, O., Colas, G., Cohendy, R., Barnoud, D., Czernichow, P., and Bleichner, G. L-alanyl-L-glutamine dipeptide-supplemented total parenteral nutrition reduces infectious complications and glucose intolerance in critically ill patients: the French controlled, randomized, double-blind, multicenter study. Crit Care Med 2006;34(3):598-604. View abstract.

52360            Schulman, A. S., Willcutts, K. F., Claridge, J. A., O’Donnell, K. B., Radigan, A. E., Evans, H. L., McElearney, S. T., Hedrick, T. L., Lowson, S. M., Schirmer, B. D., Young, J. S., and Sawyer, R. G. Does enteral glutamine supplementation decrease infectious morbidity? Surg.Infect.(Larchmt.) 2006;7(1):29-35. View abstract.

52361            Iwashita, S., Mikus, C., Baier, S., and Flakoll, P. J. Glutamine supplementation increases postprandial energy expenditure and fat oxidation in humans. JPEN J Parenter.Enteral Nutr. 2006;30(2):76-80. View abstract.

52362            Bober-Olesinska, K. and Kornacka, M. K. [Effects of glutamine supplemented parenteral nutrition on the incidence of necrotizing enterocolitis, nosocomial sepsis and length of hospital stay in very low birth weight infants]. Med Wieku.Rozwoj. 2005;9(3 Pt 1):325-333. View abstract.

52363            Mok, E., Eleouet-Da, Violante C., Daubrosse, C., Gottrand, F., Rigal, O., Fontan, J. E., Cuisset, J. M., Guilhot, J., and Hankard, R. Oral glutamine and amino acid supplementation inhibit whole-body protein degradation in children with Duchenne muscular dystrophy. Am.J Clin.Nutr. 2006;83(4):823-828. View abstract.

52364            Poindexter, B. B., Langer, J. C., Dusick, A. M., and Ehrenkranz, R. A. Early provision of parenteral amino acids in extremely low birth weight infants: relation to growth and neurodevelopmental outcome. J Pediatr. 2006;148(3):300-305. View abstract.

52365            Juretic, A., Spagnoli, G. C., Horig, H., Babst, R., von, Bremen K., Harder, F., and Heberer, M. Glutamine requirements in the generation of lymphokine-activated killer cells. Clin.Nutr. 1994;13(1):42-49. View abstract.

52366            Giris, M., Erbil, Y., Dogru-Abbasoglu, S., Yanik, B. T., Alis, H., Olgac, V., and Toker, G. A. The effect of heme oxygenase-1 induction by glutamine on TNBS-induced colitis. The effect of glutamine on TNBS colitis. Int J Colorectal Dis. 2007;22(6):591-599. View abstract.

52367            Prada, P. O., Hirabara, S. M., de Souza, C. T., Schenka, A. A., Zecchin, H. G., Vassallo, J., Velloso, L. A., Carneiro, E., Carvalheira, J. B., Curi, R., and Saad, M. J. L-glutamine supplementation induces insulin resistance in adipose tissue and improves insulin signalling in liver and muscle of rats with diet-induced obesity. Diabetologia 2007;50(9):1949-1959. View abstract.

52368            Vicario, M., Amat, C., Rivero, M., Moreto, M., and Pelegri, C. Dietary glutamine affects mucosal functions in rats with mild DSS-induced colitis. J Nutr. 2007;137(8):1931-1937. View abstract.

52369            Dechelotte, P., Darmaun, D., Rongier, M., Hecketsweiler, B., Rigal, O., and Desjeux, J. F. Absorption and metabolic effects of enterally administered glutamine in humans. Am.J.Physiol 1991;260(5 Pt 1):G677-G682. View abstract.

52370            Scheltinga, M. R., Young, L. S., Benfell, K., Bye, R. L., Ziegler, T. R., Santos, A. A., Antin, J. H., Schloerb, P. R., and Wilmore, D. W. Glutamine-enriched intravenous feedings attenuate extracellular fluid expansion after a standard stress. Ann.Surg. 1991;214(4):385-393. View abstract.

52371            Hammarqvist, F., Wernerman, J., von der, Decken A., and Vinnars, E. Alanyl-glutamine counteracts the depletion of free glutamine and the postoperative decline in protein synthesis in skeletal muscle. Ann.Surg. 1990;212(5):637-644. View abstract.

52372            Stehle, P., Zander, J., Mertes, N., Albers, S., Puchstein, C., Lawin, P., and Furst, P. Effect of parenteral glutamine peptide supplements on muscle glutamine loss and nitrogen balance after major surgery. Lancet 2-4-1989;1(8632):231-233. View abstract.

52373            Albers, S., Wernerman, J., Stehle, P., Vinnars, E., and Furst, P. Availability of amino acids supplied by constant intravenous infusion of synthetic dipeptides in healthy man. Clin.Sci (Lond) 1989;76(6):643-648. View abstract.

52374            Albers, S., Wernerman, J., Stehle, P., Vinnars, E., and Furst, P. Availability of amino acids supplied intravenously in healthy man as synthetic dipeptides: kinetic evaluation of L-alanyl-L-glutamine and glycyl-L-tyrosine. Clin.Sci.(Lond) 1988;75(5):463-468. View abstract.

52375            Hankard, R. G., Darmaun, D., Sager, B. K., D’Amore, D., Parsons, W. R., and Haymond, M. Response of glutamine metabolism to exogenous glutamine in humans. Am.J.Physiol 1995;269(4 Pt 1):E663-E670. View abstract.

52376            Welbourne, T. C. Increased plasma bicarbonate and growth hormone after an oral glutamine load. Am.J.Clin.Nutr. 1995;61(5):1058-1061. View abstract.

52377            Petersson, B., von der, Decken A., Vinnars, E., and Wernerman, J. Long-term effects of postoperative total parenteral nutrition supplemented with glycylglutamine on subjective fatigue and muscle protein synthesis. Br.J Surg. 1994;81(10):1520-1523. View abstract.

52378            Keast, D., Arstein, D., Harper, W., Fry, R. W., and Morton, A. R. Depression of plasma glutamine concentration after exercise stress and its possible influence on the immune system. Med.J.Aust. 1-2-1995;162(1):15-18. View abstract.

52379            Petersson, B., Waller, S. O., Vinnars, E., and Wernerman, J. Long-term effect of glycyl-glutamine after elective surgery on free amino acids in muscle. JPEN J.Parenter.Enteral Nutr. 1994;18(4):320-325. View abstract.

52380            Tremel, H., Kienle, B., Weilemann, L. S., Stehle, P., and Furst, P. Glutamine dipeptide-supplemented parenteral nutrition maintains intestinal function in the critically ill. Gastroenterology 1994;107(6):1595-1601. View abstract.

52381            MacBurney, M., Young, L. S., Ziegler, T. R., and Wilmore, D. W. A cost-evaluation of glutamine-supplemented parenteral nutrition in adult bone marrow transplant patients. J.Am.Diet.Assoc. 1994;94(11):1263-1266. View abstract.

52382            Goeters, C., Mertes, N., Kuhmann, M., Lange, V., Dietl, K. H., and Lawin, P. [Safety and tolerance of a new dipeptide-containing amino acid solution DP-Gln 20 versus a conventional amino acid solution Vamin 18EF in patients after elective colon surgery]. Anasthesiol.Intensivmed.Notfallmed.Schmerzther. 1994;29(3):146-149. View abstract.

52383            O’Riordain, M. G., Fearon, K. C., Ross, J. A., Rogers, P., Falconer, J. S., Bartolo, D. C., Garden, O. J., and Carter, D. C. Glutamine-supplemented total parenteral nutrition enhances T-lymphocyte response in surgical patients undergoing colorectal resection. Ann.Surg. 1994;220(2):212-221. View abstract.

52384            Ott, M., Schmidt, J., Young, B., Ott, L., Kryscio, R., and McClain, C. Nutritional and metabolic variables correlate with amino acid forearm flux in patients with severe head injury. Crit Care Med 1994;22(3):393-398. View abstract.

52385            Schloerb, P. R. and Amare, M. Total parenteral nutrition with glutamine in bone marrow transplantation and other clinical applications (a randomized, double-blind study). JPEN J.Parenter.Enteral Nutr. 1993;17(5):407-413. View abstract.

52386            Young, L. S., Bye, R., Scheltinga, M., Ziegler, T. R., Jacobs, D. O., and Wilmore, D. W. Patients receiving glutamine-supplemented intravenous feedings report an improvement in mood. JPEN J.Parenter.Enteral Nutr. 1993;17(5):422-427. View abstract.

52387            Wischmeyer, P., Pemberton, J. H., and Phillips, S. F. Chronic pouchitis after ileal pouch-anal anastomosis: responses to butyrate and glutamine suppositories in a pilot study. Mayo Clin.Proc. 1993;68(10):978-981. View abstract.

52388            Inoue, Y., Espat, N. J., Frohnapple, D. J., Epstein, H., Copeland, E. M., and Souba, W. W. Effect of total parenteral nutrition on amino acid and glucose transport by the human small intestine. Ann.Surg. 1993;217(6):604-612. View abstract.

52389            Long, C. L., Borghesi, L., Stahl, R., Clark, J. A., Geiger, J. W., DiRienzo, D. B., Weis, J. K., Laws, H. L., and Blakemore, W. S. Impact of enteral feeding of a glutamine-supplemented formula on the hypoaminoacidemic response in trauma patients. J.Trauma 1996;40(1):97-102. View abstract.

52390            Morais, A. A., Santos, J. E., and Faintuch, J. [Comparative study of arginine and glutamine supplements in malnourished surgical patients]. Rev.Hosp.Clin.Fac.Med.Sao Paulo 1995;50(5):276-279. View abstract.

52391            Espat, N. J., Watkins, K. T., Lind, D. S., Weis, J. K., Copeland, E. M., and Souba, W. W. Dietary modulation of amino acid transport in rat and human liver. J Surg.Res. 1996;63(1):263-268. View abstract.

52392            van der Hulst, R. R., von Meyenfeldt, M. F., Deutz, N. E., Stockbrugger, R. W., and Soeters, P. B. The effect of glutamine administration on intestinal glutamine content. J.Surg.Res. 2-15-1996;61(1):30-34. View abstract.

52393            Lacey, J. M., Crouch, J. B., Benfell, K., Ringer, S. A., Wilmore, C. K., Maguire, D., and Wilmore, D. W. The effects of glutamine-supplemented parenteral nutrition in premature infants. JPEN J.Parenter.Enteral Nutr. 1996;20(1):74-80. View abstract.

52394            Castell, L. M., Poortmans, J. R., and Newsholme, E. A. Does glutamine have a role in reducing infections in athletes? Eur.J.Appl.Physiol Occup.Physiol 1996;73(5):488-490. View abstract.

52395            van Loon, F. P., Banik, A. K., Nath, S. K., Patra, F. C., Wahed, M. A., Darmaun, D., Desjeux, J. F., and Mahalanabis, D. The effect of L-glutamine on salt and water absorption: a jejunal perfusion study in cholera in humans. Eur.J.Gastroenterol.Hepatol. 1996;8(5):443-448. View abstract.

52396            Jensen, G. L., Miller, R. H., Talabiska, D. G., Fish, J., and Gianferante, L. A double-blind, prospective, randomized study of glutamine-enriched compared with standard peptide-based feeding in critically ill patients. Am.J.Clin.Nutr. 1996;64(4):615-621. View abstract.

52397            Kinscherf, R., Hack, V., Fischbach, T., Friedmann, B., Weiss, C., Edler, L., Bartsch, P., and Droge, W. Low plasma glutamine in combination with high glutamate levels indicate risk for loss of body cell mass in healthy individuals: the effect of N-acetyl-cysteine. J.Mol.Med. 1996;74(7):393-400. View abstract.

52398            Himmelseher, S., Pfenninger, E., and Herrmann, P. Cerebrospinal and plasma amino acid concentrations after administration of i.v. glycyl-glutamine and glycyl-tyrosine containing amino acid solutions in humans. JPEN J.Parenter.Enteral Nutr. 1996;20(4):281-286. View abstract.

52399            Palmer, T. E., Griffiths, R. D., and Jones, C. Effect of parenteral L-glutamine on muscle in the very severely ill. Nutrition 1996;12(5):316-320. View abstract.

52400            Hankard, R. G., Haymond, M. W., and Darmaun, D. Effect of glutamine on leucine metabolism in humans. Am.J.Physiol 1996;271(4 Pt 1):E748-E754. View abstract.

52401            Weingartmann, G., Fridrich, P., Mauritz, W., Gotzinger, P., Mittlbock, M., Germann, P., Karner, J., and Roth, E. Safety and efficacy of increasing dosages of glycyl-glutamine for total parenteral nutrition in polytrauma patients. Wien.Klin.Wochenschr. 1996;108(21):683-688. View abstract.

52402            O’Riordain, M. G., De Beaux, A., and Fearon, K. C. Effect of glutamine on immune function in the surgical patient. Nutrition 1996;12(11-12 Suppl):S82-S84. View abstract.

52403            Castell, L. M., Poortmans, J. R., Leclercq, R., Brasseur, M., Duchateau, J., and Newsholme, E. A. Some aspects of the acute phase response after a marathon race, and the effects of glutamine supplementation. Eur.J.Appl.Physiol Occup.Physiol 1997;75(1):47-53. View abstract.

52404            Darmaun, D., Roig, J. C., Auestad, N., Sager, B. K., and Neu, J. Glutamine metabolism in very low birth weight infants. Pediatr.Res. 1997;41(3):391-396. View abstract.

52405            Morlion, B. J., Siedhoff, H. P., Joosten, U., Koller, M., Konig, W., Furst, P., and Puchstein, C. [Immunomodulation after parenteral glutamine administration in colorectal surgery]. Langenbecks Arch.Chir Suppl Kongressbd. 1996;113:342-344. View abstract.

52406            Suojaranta-Ylinen, R., Ruokonen, E., Pulkki, K., Mertsola, J., and Takala, J. Preoperative glutamine loading does not prevent endotoxemia in cardiac surgery. Acta Anaesthesiol.Scand. 1997;41(3):385-391. View abstract.

52407            Muscaritoli, M., Micozzi, A., Conversano, L., Martino, P., Petti, M. C., Cartoni, C., Cascino, A., and Rossi-Fanelli, F. Oral glutamine in the prevention of chemotherapy-induced gastrointestinal toxicity. Eur.J.Cancer 1997;33(2):319-320. View abstract.

52408            Griffiths, R. D., Jones, C., and Palmer, T. E. Six-month outcome of critically ill patients given glutamine-supplemented parenteral nutrition. Nutrition 1997;13(4):295-302. View abstract.

52409            Griffiths, R. D. Outcome of critically ill patients after supplementation with glutamine. Nutrition 1997;13(7-8):752-754. View abstract.

52410            Neu, J., Roig, J. C., Meetze, W. H., Veerman, M., Carter, C., Millsaps, M., Bowling, D., Dallas, M. J., Sleasman, J., Knight, T., and Auestad, N. Enteral glutamine supplementation for very low birth weight infants decreases morbidity. J.Pediatr. 1997;131(5):691-699. View abstract.

52411            van der Hulst, R. R., von Meyenfeldt, M. F., Tiebosch, A., Buurman, W. A., and Soeters, P. B. Glutamine and intestinal immune cells in humans. JPEN J.Parenter.Enteral Nutr. 1997;21(6):310-315. View abstract.

52412            de Beaux, A. C., O’Riordain, M. G., Ross, J. A., Jodozi, L., Carter, D. C., and Fearon, K. C. Glutamine-supplemented total parenteral nutrition reduces blood mononuclear cell interleukin-8 release in severe acute pancreatitis. Nutrition 1998;14(3):261-265. View abstract.

52413            van Acker, B. A., Hulsewe, K. W., Wagenmakers, A. J., Deutz, N. E., van Kreel, B. K., Halliday, D., Matthews, D. E., Soeters, P. B., and von Meyenfeldt, M. F. Absence of glutamine isotopic steady state: implications for the assessment of whole-body glutamine production rate. Clin.Sci.(Lond) 1998;95(3):339-346. View abstract.

52414            Borel, M. J., Williams, P. E., Jabbour, K., Levenhagen, D., Kaizer, E., and Flakoll, P. J. Parenteral glutamine infusion alters insulin-mediated glucose metabolism. JPEN J Parenter.Enteral Nutr. 1998;22(5):280-285. View abstract.

52415            Powell-Tuck, J. Total parenteral nutrition with glutamine dipeptide shortened hospital stays and improved immune status and nitrogen economy after major abdominal surgery. Gut 1999;44(2):155. View abstract.

52416            Jacobi, C. A., Ordemann, J., Zuckermann, H., Docke, W., Volk, H. D., and Muller, J. M. [Effect of alanyl-glutamine in postoperative total parenteral nutrition on postoperative immunosuppression and morbidity. Preliminary results of a prospective randomized study]. Langenbecks Arch.Chir Suppl Kongressbd. 1998;115:605-611. View abstract.

Frequently Asked Questions

How does Dermagen function?

With its select range of ingredients Dermagen improves the condition of the skin by detoxifying and nourishing. It also enhances smoothness by increasing elasticity.

Does Dermagen minimise acne?

Acne is primarily due to excess sebum (oil) production. The skin-friendly mineral Zinc, is the most common natural ingredient known to alleviate this condition. Its inclusion is therefore important to regulate the skin’s oil gland activity. Vitamin A, also included in the formula, is essential to prevent bacteria induced acne.

Will Dermagen correct skin pigmentation?

Dermagen contains Pycnogenol and Glutathione. Reports conclude that both these  ingredients have the ability to correct hyper-pigmentation, lighten dark spots and reduce the visible effects of photo-aging caused by UV light damage and hormonal fluctuations.

 Can Dermagen be used by both men and women?

Yes.

Since the product does not interfere with endocrine metabolism it can safely be used by both genders.

How long do I have to use Dermagen before seeing results?

Dermagen is formulated for both short and long-term effect. The initial benefits are evident within 21 days, but longer term use is recommended for ongoing improvement and also to sustain the beneficial effect.

It generally takes a month to correct the body’s nutritional deficiency initially, which in certain cases is the underlying cause. Once the essential nutrient balance in the body has been restored then only will the product’s full benefits become evident.

Results also depend on other variables which include certain skin disorders, their severity, diet, lifestyle, metabolic and genetic factors.

Does Dermagen have clinical research to support its claims?

Dermagen is supported by a team of clinical researchers and doctors. It is authenticated by clinical evidence and each of its ingredients has proven health benefits. All  products developed by Fusion Laboratories conform to the stringent regulations, processing and quality control criteria of the relevant authorities in the countries in which they are marketed.

Can I use Dermagen in conjunction with my medication?

The concomitant use of some medications may be associated with mild side effects.  Please consult your physician prior to use as he/she has access to your medical records and can provide the most accurate advice.

Is Dermagen safe and are there any side effects?

Dermagen is completely safe and does not have any known adverse side effects. However individuals who may be sensitive to any of the ingredients should exercise caution. Dermagen has a well-established safety profile. To validate its safety, Fusion Labs have submitted documentation for registration and manufactures the product under the Good Manufacturing Practices (GMP) standards, in a fully controlled facility. This ensures purity, stability of its ingredients and accuracy of the final product. If, for any reason, Dermagen does not meet stringent pharmaceutical standards, the product is not approved for release from our facility.

Why should I use the product?

Proven Benefits:

  • Detoxifies the skin
  • Treats certain skin disorders
  • Enhances skin clarity
  • Improves skin tone and elasticity
  • Reduces visible signs of ageing

Why choose Dermagen over other skin supplements?

  • Dermagen is the only Luxury, Premier Multi-Nutrient.
  • Fusion Laboratories sources the highest quality ingredients and uses the most advanced technology/research to develop its products.
  • Dermagen has superior product formulation. Its smart and balanced formula is specially designed to allow for optimal absorption and efficacy.
  • None of the ingredients have been tested on animals.
  • We do not use artificial flavours or preservatives.

Testimonials

“Trichotin and Dermagen have delivered exactly what they said it can, for my hair and skin. Thank you Fusion Laboratories, for these phenomenal products which have become part of my daily regime.”
Candice van der Merwe
Model and IFBB Fitness Champ

As for Dermagen, I was super impressed with how smooth my skin started looking. It also helped me fight the terrible breakouts that I had become subject too. Thankfully I am back to having days where I just put on some mascara and lip gloss as my skin looks healthy and doesn’t need the cover-up. Its definitely two thumbs up from me for these two products. I’m super happy with the results and the ease of use and would definitely recommend it to all my friends. In fact, I have.”
Chantal Riley
Modelling and Pageantry Magazine Editor

“Trichotin and Dermagen gave me confidence in my hair and skin condition knowing that I am taking care of it from the inside out. With styling and makeup being done regularly I know that I have a secret that protects against damage, so that I can look and feel my best. Thank you Fusion Laboratories for these incredible products. I can’t go without them .”
Lezinka de Meyer
ICE Agency Model

“After the first two weeks of taking Dermagen I already noticed an improvement in the overall smoothness and softness of my entire body’s skin.  Unlike beauty creams, Dermagen works from within which means you’ll notice visible signs of improvement to your entire body. Being a Beauty Blogger I am often switching up my skin care to test new products which can play absolute havoc with my skin, but while taking Trichotin and Dermagen I noticed my skin was far less reactive to products that didn’t agree with me. As with Trichotin, the packaging is utterly luxurious. I have to admit, taking any other supplements or medication feels really ordinary when compared to opening up a frosted glass jar.  I also really love the shiny, bright red colour of the capsules. It is such an amazing feeling when you take these types of supplements and see the great results, it truly does take the chore out of taking them everyday.”
Charlene Smith
Blogger: Gee Whiskers

“As an elite fitness model and athlete, a healthy appearance is essential. With Trichotin and Dermagen I am able to maintain a healthy glow to my hair and skin whilst dieting for competition. This creates the ‘balance’ I need to look great and feel great when I step on stage.”
Catherine de Wet
Model and International Fitness Athlete

“I’ve been using the Trichotin and the Dermagen since we started stocking it and I’m happy.”
Nasrene
Imij Hair

“Great Skin Supplement!!!”
Linda Oosthuizen

“I’ve used other skin tablets before. This is the best…”
Angela van Jaarsveld

“Honestly, its helping preventing acne and clearing my skin. This product is identical to some of the medications I’ve previously used. I definitely recommend this product.”
Danielle O’Brien

“Ive been using it for two months and happy with it. The once a day capsule makes it easy to use and the benefits are good.”
Lebo Khumalo

“By far the best internal or external skin product I’ve used. I’m super impressed !.”
Gwyneth Smith

“WOW! Dermagen is great! Only one month in and I’ve noticed amazing results.”
Priscella Smith

“Fusion Labs has a great product here! It is by far the best skin supplement I have ever used.”
Zahra Kassim

“It’s definitely helped with my dark areas.”
Maureen Viljoen

“Finally a product with all the main skin ingredients in one. I use it daily.”
M Strauss

I love Dermagen. It’s cleared my skin up.
I had developed rosacea this winter and I purchased and started using the capsules at the height of my flare up.  Haven’t had a flare up since.
Anonymous

My skin looks amazing . My pigmentation is clearing , my skin is glowing and looks firmer.
Shamima Desai

“The tablets are working to help keep the skin looking better, than if I wasn’t taking the Dermagen.”
Warrick Port

“I would just like to say that I am extremely impressed with your service, delivery, packaging and personal touch ! I absolutely adore your products and will recommend this to everyone. Thank you for standing out from other companies, keep doing what you doing.”
Mari Oberholzer

All client’s comments are used with permission.